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Can zirconia crowns be the first restorative choice after endodontic treatment of primary teeth?

Int J Clin Pract 2021 Sep 18:e14888. Epub 2021 Sep 18.

Department of Pediatric Dentistry, Faculty of Dentistry, Erciyes University, Kayseri, Turkey.

Objective: Early loss of primary teeth due to caries can cause temporary or permanent problems, such as occlusion disorders, aesthetic problems, nutritional problems, abnormal habits, and speech disorders. Although the development of restorative materials has led to significant improvements, failures are still frequent. The purpose of this study was to evaluate the success rates of zirconia crown with compare to other crowns for the restoration of endodonticly treated teeth with excessive loss of material. Read More

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September 2021

Thyroid dose estimates for the genome-wide association study of thyroid cancer in persons exposed in Belarus to 131I after the Chernobyl accident.

J Radiat Res 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan.

The Chernobyl accident on 26 April 1986 led to a sharp increase in thyroid cancer (TC) incidence in the individuals exposed to radiation in childhood. The major risk factor for TC was exposure to Iodine-131 (131I). Here, we estimated the thyroid doses due to 131I intake for 2041 participants of the genome-wide association study of TC in Belarusian people exposed to radioactive fallout from the Chernobyl accident. Read More

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September 2021

Electrophoretic deposition of collagen/chitosan films with copper-doped phosphate glasses for orthopaedic implants.

J Colloid Interface Sci 2021 Sep 1;607(Pt 1):869-880. Epub 2021 Sep 1.

Centre for Energy, Materials and Telecommunications, Institut National de la Recherche Scientifique, 1650 Boulevard Lionel-Boulet Varennes, Québec J3X 1S2, Canada. Electronic address:

Coatings with bioactive properties play a key role in the success of orthopaedic implants. Recent studies focused on composite coatings incorporating biocompatible elements that can increase the nucleation of hydroxyapatite (HA), the mineral component of bone, and have promising bioactive and biodegradable properties. Here we report a method of fabricating composite collagen, chitosan and copper-doped phosphate glass (PG) coatings for biomedical applications using electrophoretic deposition (EPD). Read More

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September 2021

Purinergic neurotransmission in the gustatory system.

Auton Neurosci 2021 Sep 11;236:102874. Epub 2021 Sep 11.

Dept. Cell & Developmental Biology, Dept. Otolaryngology, Univ. Colorado School of Medicine, Anschutz Medical Campus, MS 8108, Room L18-11118, RC-1, 12801 E. 17th Ave., Aurora, CO 80045, United States of America.

Taste buds consist of specialized epithelial cells which detect particular tastants and synapse onto the afferent taste nerve innervating the endorgan. The nature of the neurotransmitter released by taste cells onto the nerve fiber was enigmatic early in this century although neurotransmitters for other sensory receptor cell types, e.g. Read More

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September 2021

Graphene oxide toxicity in W flies.

Sci Total Environ 2021 Sep 11;805:150302. Epub 2021 Sep 11.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China; Institute of Quantitative Biology and College of Life Sciences, Zhejiang University, 310058 Hangzhou, China.

The risk of graphene oxide (GO) exposure to various species has been greatly amplified in recent years due to its booming production and applications in various fields. However, a deep understanding of the GO biosafety lags its wide applications. Herein, we used W flies as a model organism to study GO toxicity at relatively low concentrations. Read More

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September 2021

Integrated effects of microbial decomposing inoculant on greenhouse gas emissions, grain yield and economic profit from paddy fields under different water regimes.

Sci Total Environ 2021 Sep 11;805:150295. Epub 2021 Sep 11.

MOA Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River/College of Plant Science & Technology, Huazhong Agricultural University, Wuhan 430070, PR China; Hubei Collaborative Innovation Center for Grain Industry, Yangtze University, Jingzhou 434023, Hubei, PR China. Electronic address:

Few studies have comprehensively evaluated the impacts of microbial decomposing inoculants on greenhouse gas emissions and economic profit from paddy fields under different water regimes. Here, this study evaluated the effects of microbial decomposing inoculant treatments (straw returning without or with microbial decomposing inoculants (S and SMD)) on rice yield, CH and NO emissions, economic profit and net ecosystem economic profit (NEEP) from paddy fields under different water regimes (continuous flooding (CF) and alternate wetting and drying irrigation (AWD)) in central China with a two-year field experiment. Compared with S treatment, SMD treatment significantly increased the rice yield and crop water productivity by 6. Read More

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September 2021

Citizen science: A way forward in tackling the plastic pollution crisis during and beyond the COVID-19 pandemic.

Sci Total Environ 2021 Aug 27;805:149957. Epub 2021 Aug 27.

School for Resource and Environmental Studies, Dalhousie University, Halifax, NS B3H 4R2, Canada.

The COVID-19 pandemic has resulted in an unprecedented surge of production, consumption, and disposal of single-use plastics (SUPs) and personal protective equipment (PPE) by the public. This widespread use of mostly plastic items like face masks and disposable gloves has led to global reports of improper disposal of potentially infectious PPE both in our urban and natural environments. Due to international travel restrictions during the pandemic, many research programs targeted at measuring plastic pollution were halted. Read More

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MALDI-TOF-MS integrated workflow for food authenticity investigations: An untargeted protein-based approach for rapid detection of PDO feta cheese adulteration.

Food Chem 2021 Sep 6;370:131057. Epub 2021 Sep 6.

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. Electronic address:

Advances in Matrix-assisted Laser Desorption/Ionization -Time-Of-Flight Mass Spectrometry (MALDI-TOF-MS) have led to its supremacy for complex assessment of food authenticity studies, like dairy products fraud, holding promise for the discovery of potential authenticity (bio)markers. In this study, an integrated untargeted protein-based workflow in combination with advanced chemometrics is presented, to address authenticity challenges in PDO feta cheese which is legally manufactured by the mixture of sheep/goat milk. Potential markers attributed to specific animal origin were found from protein profiles acquired for authentic feta and white cheeses (prepared from cow milk), belonging to 4 kDa-18. Read More

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September 2021

The impact of SARS-CoV-2 vaccination in Dravet syndrome: A UK survey.

Epilepsy Behav 2021 Aug 21;124:108258. Epub 2021 Aug 21.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire SL9 0RJ, UK. Electronic address:

Background: The COVID-19 pandemic led to the urgent need for accelerated vaccine development. Approved vaccines have proved to be safe and well tolerated across millions of people in the general population. Dravet syndrome (DS) is a severe, early onset, developmental and epileptic encephalopathy. Read More

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Reading and the visual word form area (VWFA) - Management and clinical experience at one epilepsy surgery center.

Epilepsy Behav 2021 Sep 15;124:108274. Epub 2021 Sep 15.

Bielefeld University, Medical School, Department of Epileptology (Krankenhaus Mara), Bielefeld, Germany.

Objective: Presurgical evaluation has no established routine to assess reading competence and to identify essential "not to resect" reading areas. Functional models describe a visual word form area (VWFA) located in the midfusiform gyrus in the dominant ventral occipito-temporal cortex (vOTC) as essential for reading. We demonstrate the relevance and feasibility of invasive VWFA-mapping. Read More

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September 2021

Farming systems influence the compositional, structural, and functional characteristics of the sugarcane-associated microbiome.

Microbiol Res 2021 Sep 9;252:126866. Epub 2021 Sep 9.

Laboratory of Bioinformatics, Department of Agricultural and Environmental Biotechnology, São Paulo State University (UNESP), School of Agricultural and Veterinary Sciences, Jaboticabal, 14884-900, SP, Brazil. Electronic address:

Sugarcane (Saccharum spp.) has been produced worldwide as a relevant source of food and sustainable energy. However, the constant need to increase crop yield has led to excessive use of synthetic agrochemical inputs such as inorganic fertilizers, herbicides, and pesticides in plant cultures. Read More

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September 2021

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.

Eur J Med Chem 2021 Sep 10;226:113823. Epub 2021 Sep 10.

Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, SY23 3DA, United Kingdom. Electronic address:

Schistosomiasis is a neglected disease of poverty that is caused by infection with blood fluke species contained within the genus Schistosoma. For the last 40 years, control of schistosomiasis in endemic regions has predominantly been facilitated by administration of a single drug, praziquantel. Due to limitations in this mono-chemotherapeutic approach for sustaining schistosomiasis control into the future, alternative anti-schistosomal compounds are increasingly being sought by the drug discovery community. Read More

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September 2021

Janus effects of NaCl on structure of egg yolk granules.

Food Chem 2021 Sep 15;371:131077. Epub 2021 Sep 15.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China. Electronic address:

Egg yolk granules are supramolecular assembly of high-density lipoproteins and phosvitin driven by calcium bridges. However, applications of granules are severely restricted by the large particle size and poor water dispersibility. This study revealed the Janus effects of NaCl on structure of granules at varied pH values. Read More

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September 2021

RNAi silencing of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) gene inhibits vitellogenesis in Chinese mitten crab Eriocheir sinensis.

Comp Biochem Physiol A Mol Integr Physiol 2021 Sep 15:111078. Epub 2021 Sep 15.

College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China. Electronic address:

The sesquiterpenoid methyl farnesoate (MF), a de-epoxide form of insect juvenile hormone III (JH III), plays an essential role in regulating many crucial physiological processes in crustaceans including vitellogenesis and reproduction. 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is an important rate-limiting enzyme in the mevalonate pathway, which is critical for the synthesis of JH III and MF. In the present study, a full-length cDNA encoding HMGR (EsHMGR) in Eriocheir sinensis was isolated and characterised. Read More

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September 2021

Innovative Therapies for Neuroblastoma: The Surprisingly Potent Role of Iron Chelation in Up-Regulating Metastasis and Tumor Suppressors and Down-Regulating the Key Oncogene, N-myc.

Pharmacol Res 2021 Sep 15:105889. Epub 2021 Sep 15.

Centre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, 4111, Australia; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. Electronic address:

Iron is an indispensable requirement for essential biological processes in cancer cells. Due to the greater proliferation of neoplastic cells, their demand for iron is considerably higher relative to normal cells, making them highly susceptible to iron depletion. Understanding this sensitive relationship led to research exploring the effect of iron chelation therapy for cancer treatment. Read More

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September 2021

AGEING: NOT ONLY AN AGE-RELATED ISSUE.

Mech Ageing Dev 2021 Sep 15:111568. Epub 2021 Sep 15.

School of Applied Psychology, University College Cork, North Mall Campus, Cork, Ireland. Electronic address:

Developments in the last century have led to an unprecedented increase in life expectancy. These changes open opportunities for humans to grow and develop in healthy and adaptive ways, adding life to years as well as years to life. There are also challenges, however - as we live longer, a greater number of people will experience chronic illness and disability, often linked to lifestyle factors. Read More

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September 2021

Bone-destructive osseous arteriovenous fistula at the jugular bulb mimicking a glomus jugular tumor.

Neurochirurgie 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Some reports have described intraosseous arteriovenous fistulas showing osteolytic changes, but an osseous arteriovenous fistula (AVF) at the jugular bulb showing extensive bone destruction is a very rare disease.

Case Description: A 60-year-old man presented with pulsatile tinnitus and right facial nerve palsy. Radiological imaging showed a large homogenously enhanced osteolytic lesion at the right jugular foramen. Read More

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September 2021

Cancer in Cystic Fibrosis: A Narrative Review of Prevalence, Risk Factors, Screening and Treatment Challenges.

Chest 2021 Sep 15. Epub 2021 Sep 15.

Department of Surgery and Department of Family Medicine, New York Medical College, Valhalla, NY, USA.

Cystic fibrosis is a progressive monogenetic disorder that causes persistent pulmonary disease, but also affects other organ systems including the digestive tract. Recent advances in treatment and care of CF patients including the use of new and highly effective CFTR modulators, have led to a dramatic increase in survival; young patients with CF can now expect to live to or beyond middle age, where cancer is more frequent. CF patients are now known to face an increased risk of digestive tract cancer-particularly cancer of the colon. Read More

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September 2021

Changes in Activity Levels, Physical Functioning, and Fall Risk During the COVID-19 Pandemic.

J Am Geriatr Soc 2021 Sep 18. Epub 2021 Sep 18.

Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI.

Background: Physical function worsens with older age, particularly for sedentary and socially isolated individuals, and this often leads to injuries. Through reductions in physical activity, the COVID-19 pandemic may have worsened physical function and led to higher fall-related risks.

Methods: A nationally representative online survey of 2,006 US adults ages 50-80 was conducted in January 2021 to assess changes in health behaviors (worsened physical activity and less daily time spent on feet), social isolation (lack of companionship and perceived isolation), physical function (mobility and physical conditioning), and falls (falls and fear of falling) since March 2020. Read More

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September 2021

Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitisation.

Clin Exp Allergy 2021 Sep 18. Epub 2021 Sep 18.

Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.

Background: Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitisation as a major determinant.

Objective: We aimed to see if there was an independent association between upper airway inflammatory disorders (UAID) and FeNO, after adjustment for asthma and sensitisation, in a multi-centre population-based study. Read More

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September 2021

Photobiomodulation therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin.

Lasers Med Sci 2021 Sep 18. Epub 2021 Sep 18.

Universidade Nove de Julho, Rua Vergueiro 249, Liberdade - São Paulo/SP, 01504-001, Brazil.

Doxorubicin (DOX) is an anthracycline antibiotic that exhibits high heart toxicity. Human-induced pluripotent stem cell-derived ventricular cardiomyocytes (hiPSC-vCMs) are important in vitro models for testing drug cardiotoxicity. Photobiomodulation therapy (PBMT) is a non-invasive therapy that stimulates cells growth and self-repair using light irradiation. Read More

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September 2021

Clinical features of autosomal recessive polycystic kidney disease in the Japanese population and analysis of splicing in PKHD1 gene for determination of phenotypes.

Clin Exp Nephrol 2021 Sep 18. Epub 2021 Sep 18.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Background: Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1 gene. The clinical spectrum is often more variable than previously considered. We aimed to analyze the clinical features of genetically diagnosed ARPKD in the Japanese population. Read More

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September 2021

DdaSTE12 is involved in trap formation, ring inflation, conidiation, and vegetative growth in the nematode-trapping fungus Drechslerella dactyloides.

Appl Microbiol Biotechnol 2021 Sep 18. Epub 2021 Sep 18.

Department of Microbiology, College of Life Science, Nankai University, Tianjin, 300071, China.

Ste12 transcription factors, downstream of mitogen-activated protein kinase (MAPK) signalling pathways, are exclusively found in the fungal kingdom and regulate fungal mating, development, and pathogenicity. The nematode-trapping fungus Drechslerella dactyloides can capture free-living nematodes using constricting rings by cell inflation within 1 s when stimulated by nematodes entering the rings. The MAPK signalling pathways are involved in the trap formation of nematode-trapping fungi, but their downstream regulation is not clearly understood. Read More

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September 2021

Integrated Pest Management Control of Varroa destructor (Acari: Varroidae), the Most Damaging Pest of (Apis mellifera L. (Hymenoptera: Apidae)) Colonies.

J Insect Sci 2021 Sep;21(5)

Honey Bee Research and Extension Laboratory, Entomology and Nematology Department, University of Florida, Gainesville, FL 32611, USA.

Varroa destructor is among the greatest biological threats to western honey bee (Apis mellifera L.) health worldwide. Beekeepers routinely use chemical treatments to control this parasite, though overuse and mismanagement of these treatments have led to widespread resistance in Varroa populations. Read More

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September 2021

Compound heterozygous KCNV2 variants contribute to cone dystrophy with supernormal rod responses in a Chinese family.

Mol Genet Genomic Med 2021 Sep 18:e1795. Epub 2021 Sep 18.

Department of Medical Genetics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Background: Cone dystrophy with supernormal rod response (CDSRR) is an autosomal recessive retinal disorder characterized by myopia, dyschromatopsia, nyctalopia, photophobia, and nystagmus. CDSRR is caused by mutations in KCNV2, the gene encoding for an electrically silent Kv subunit (Kvs) named Kv8.2. Read More

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September 2021

DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study.

Aging Cell 2021 Sep 18:e13439. Epub 2021 Sep 18.

Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.

Several biomarkers of healthy aging have been proposed in recent years, including the epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting increasingly accurate in predicting the individual biological age. The recently developed "next-generation clock" DNAmGrimAge outperforms "first-generation clocks" in predicting longevity and the onset of many age-related pathological conditions and diseases. Additionally, the total number of stochastic epigenetic mutations (SEMs), also known as the epigenetic mutation load (EML), has been proposed as a complementary DNAm-based biomarker of healthy aging. Read More

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September 2021

Outcomes of nurse-led telecoaching intervention for patients with heart failure: A systematic review and meta-analysis of randomised controlled trials.

J Clin Nurs 2021 Sep 17. Epub 2021 Sep 17.

College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Studies have identified that nurse-led telephone health coaching benefited the continuity of care in patients with heart failure. However, the effect of nurse-led telephone health coaching remains inconclusive among the previous studies.

Aim: This review aimed to determine the effects of nurse-led telecoaching among patients with heart failure. Read More

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September 2021

Responsiveness of hospitals to inpatient and outpatient services in the low- and middle-income countries: A systematic review.

Int J Health Plann Manage 2021 Sep 17. Epub 2021 Sep 17.

Department of Health Economics and Management, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Responsiveness is the ability of health system to satisfy non-clinical people's expectations. This review aimed at assessing responsiveness of hospitals' services in the low- and middle-income countries, and identifying the influencing factors. This systematic review followed the PRISMA guidelines. Read More

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September 2021

Brief Report: Improving Fellow Performance of the Pharmacology Section of the American Society of Clinical Oncology In-Training Exam.

J Cancer Educ 2021 Sep 18. Epub 2021 Sep 18.

Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, CB #7305, Chapel Hill, NC, 27599, USA.

Though the electronic medical record has streamlined the process for ordering chemotherapy and reduced medical error, it has come at the cost of potentially hindering medical oncology fellows' acquisition of basic principles of chemotherapy administration. Recognizing the need for improving fellow knowledge and comfort level in chemotherapy prescription, we created an anticancer therapeutics curriculum for fellows at the University of North Carolina (UNC). The curriculum, which was comprised of a self-assessment, review session, and chemotherapy writing workshop, was offered voluntarily to all UNC fellows planning to take the medical oncology boards. Read More

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September 2021

Polybrominated diphenyl ethers BDE-47 and BDE-99 modulate murine melanoma cell phenotype in vitro.

Environ Sci Pollut Res Int 2021 Sep 17. Epub 2021 Sep 17.

Departamento de Biologia Celular, Universidade Federal do Paraná, PO Box: 19031, CEP, Curitiba, PR, 81531-980, Brazil.

Cancer is one of the leading causes of mortality worldwide. Even with the advances of pharmaceutical industry and treatments, the mortality rate for various types of cancer remains high. In particular, phenotypic alterations of tumor cells concerning drug efflux, migratory and invasive capabilities may represent a hurdle for cancer treatment and contribute to poor prognosis. Read More

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September 2021