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Ptosis after motorcycle accident.

J Fam Pract 2021 May;70(4):E1-E4

University of Texas Health at San Antonio.

A motorcycle accident precipitated by a health emergency led to loss of eye function. Advanced imaging revealed the diagnosis. Read More

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Genetic etiology of hereditary hearing loss in the Gulf Cooperation Council countries.

Hum Genet 2021 Aug 2. Epub 2021 Aug 2.

Department of Applied Biology, College of Sciences, University of Sharjah, Building W8-Room 107, 27272, Sharjah, United Arab Emirates.

The past 30 years have seen an exponential growth concerning the identification of genes and variants responsible for hereditary hearing loss (HL) worldwide. This has led to a huge gain in our understanding of molecular mechanisms of hearing and deafness, which improved diagnosis for populations with hereditary HL. Many communities around the world, especially in the Middle East and North Africa, have a high prevalence of consanguineous marriages. Read More

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Intracoronary Imaging of a Synergy Megatron Stent Fracture in Ostial Right Coronary Artery.

J Invasive Cardiol 2021 Aug;33(8):E674-E675

Cardiology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain, Avda, Blasco Ibáñez 17, 46010 Valencia-Spain.

The Synergy Megatron stent confers enhanced axial and radial forces, which makes it an ideal choice for ostial and calcified lesions. However, in this case, the stent fractured. The mechanical stress due to severe calcification at the ostium, followed by a swinging segment, probably caused hinge effect and led to a stent fracture. Read More

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Contemporary etiology and prognosis of dilated non-ischemic cardiomyopathy.

Minerva Cardiol Angiol 2021 Aug 2. Epub 2021 Aug 2.

Department of Cardiology, Azienda Sanitaria Universitaria Integrata Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.

Introduction: Non-ischemic dilated cardiomyopathy (NI-DCM) represents a specific etiology of systolic heart failure that usually affect young individuals with a genetic background in up to 40% of cases. Behind the term NI-DCM there is a spectrum of different diseases, and an accurate etiological classification appears pivotal for the clinical management and prognostic stratification of these patients.

Evidence Acquisition: In the last years the prognosis of NI-DCM patients dramatically improved thanks to the progresses in medical treatment/ device therapy and earlier diagnosis especially in familial context. Read More

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Review of COVID-19 Myocarditis in Competitive Athletes: Legitimate Concern or Fake News?

Front Cardiovasc Med 2021 14;8:684780. Epub 2021 Jul 14.

Division of Cardiovascular Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.

Since the first reported case of COVID-19 in December 2019, the global landscape has shifted toward an unrecognizable paradigm. The sports world has not been immune to these ramifications; all major sports leagues have had abbreviated seasons, fan attendance has been eradicated, and athletes have opted out of entire seasons. For these athletes, cardiovascular complications of COVID-19 are particularly concerning, as myocarditis has been implicated in a significant portion of sudden cardiac death (SCD) in athletes (up to 22%). Read More

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: An Uncommon Human Pathogen Causing Infective Endocarditis in a Valve-in-Valve Transcatheter Aortic Valve Replacement.

Case Rep Cardiol 2021 11;2021:5569533. Epub 2021 Jul 11.

Cardiovascular Division, Department of Medicine, VA Caribbean Healthcare System, San Juan, Puerto Rico.

is a fish pathogen and an uncommon cause of human infections. There is a growing body of evidence showing its potential for causing endocarditis especially in those with prior valve surgery. In this case report, we present what we believe is the first case of endocarditis by affecting a valve-in-valve transcatheter aortic valve replacement that was successfully treated. Read More

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Hollow micro and nanostructures for therapeutic and imaging applications.

J Drug Deliv Sci Technol 2020 Dec 14;60. Epub 2020 Sep 14.

Department of Radiology, Stanford School of Medicine, Stanford, CA, USA.

Hollow particles have been extensively used in bioanalytical and biomedical applications for almost two decades due to their unique and tunable optoelectronic properties as well as their significantly high loading capacities. These intrinsic properties led them to be used in various bioimaging applications as contrast agents, controlled delivery (. drugs, nucleic acids and other biomolecules) platforms and photon-triggered therapies (. Read More

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December 2020

Occlusal disharmony and chronic orofacial pain: from clinical observation to animal study.

Authors:
Ye Cao

J Oral Rehabil 2021 Aug 1. Epub 2021 Aug 1.

Department of Prosthodontics, Center for Oral Functional Diagnosis, Treatment and Research, Peking University School and Hospital of Stomatology.

Occlusion can be viewed as the most sensitive susceptor of the central nervous system in the orofacial region and even the whole body. Its inalienable relationships to the temporomandibular joint, the muscles, the stomatognathic system, and even the central nervous system are self-evident. Almost all the dental treatments inevitably change the occlusion, potentially or actually, locally or extensively, immediately or gradually. Read More

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The SARS-CoV-2 (COVID-19) pandemic in hospital: An insight into environmental surfaces contamination, disinfectants' efficiency, and estimation of plastic waste production.

Environ Res 2021 Jul 29:111809. Epub 2021 Jul 29.

Department of Public Health, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran. Electronic address:

The current COVID-19 pandemic that is caused by SARS-CoV-2 has led all the people around the globe to implement preventive measures such as environmental cleaning using alcohol-based materials, and social distancing in order to prevent and minimize viral transmission via fomites. The role of environmental surface contamination in viral transmission in within hospital wards is still debatable, especially considering the spread of new variants of the virus in the world. The present comprehensive study aims to investigate environmental surface contamination in different wards of a hospital as well as the efficacy of two common disinfectants for virus inactivation, and tries to produce an estimate of plastic residue pollution as an environmental side effect of the pandemic. Read More

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Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology.

Clin Epigenetics 2021 Jul 31;13(1):150. Epub 2021 Jul 31.

Cancer Epigenetics Laboratory At the Cancer Cell Biology Group, Institut D'Investigació Sanitària Illes Balears (IdISBa), Carretera de Valldemosa 79, S Building, 1st Floor, 07120, Palma de Mallorca, Spain.

Glioblastoma (GBM) is the most aggressive primary brain tumor, having a poor prognosis and a median overall survival of less than two years. Over the last decade, numerous findings regarding the distinct molecular and genetic profiles of GBM have led to the emergence of several therapeutic approaches. Unfortunately, none of them has proven to be effective against GBM progression and recurrence. Read More

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Health systems, population and patient challenges for achieving universal health coverage for hypertension in Ghana.

Health Policy Plan 2021 Jul 31. Epub 2021 Jul 31.

Department of Management Science, Strathclyde Business School, University of Strathclyde, 199 Cathedral Street, Glasgow G4 0QU, UK.

Ghana has signed on to the United Nations Sustainable Development Goal to achieve universal health coverage (UHC), ensuring that all individuals receive the health care they require without financial hardship. Achieving that goal is a difficult task in any setting. The challenges are further exacerbated by a changing disease landscape, as the burden of non-communicable diseases (NCDs) is increasing and creating a dual burden along with infectious diseases. Read More

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The Difficult Path to Correct Diagnosis of Hepatolithiasis: A Case Report.

Acta Medica (Hradec Kralove) 2021 ;64(2):125-128

Department of Surgery and Transplant Unit, Comenius University in Bratislava, Jessenius Medical Faculty in Martin, University Hospital Martin, Slovak Republic.

Hepatolithiasis is a benign disease, where stones are localized proximal to the confluence of hepatic ducts. The clinical picture may differ depending on whether the stones cause complete, partial, or intermittent biliary obstruction. The course can vary from asymptomatic to fatal, thus, early diagnosis and treatment is critical for a good prognosis. Read More

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January 2021

Ovarian cancer surveillance in the clinical follow up of women with known BRCA1 or BRCA2 pathogenic variants in a large health care system.

Gynecol Oncol 2021 Jul 27. Epub 2021 Jul 27.

Kaiser Permanente Northern California, Division of Research, Oakland, CA, United States of America; Kaiser Permanente Northern California Gynecologic Cancer Program, San Francisco, CA, United States of America. Electronic address:

Objective: To assess CA 125 and transvaginal ultrasound surveillance in women with BRCA1 or BRCA2 pathogenic variants in a pragmatic clinical setting with>1 year follow up.

Methods: Retrospective cohort study in a large integrated health care system of women identified from 1/1/2003 to 12/31/2017 with a BRCA1 or BRCA2 pathogenic variant with at least one intact ovary. Demographic and clinical data were collected from date of genetic testing until oophorectomy, an ovarian cancer diagnosis, or 7/1/2019. Read More

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Implementation of a text-based postpartum blood pressure monitoring program at three different academic sites.

Am J Obstet Gynecol MFM 2021 Jul 27:100446. Epub 2021 Jul 27.

Division of Maternal Fetal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

Background: Up to 30% of patients with hypertensive disorders of pregnancy continue to have elevated blood pressures after delivery, often necessitating medication titration or hospital evaluation in the weeks following hospital discharge. A previous randomized controlled trial demonstrated that remote blood pressure monitoring program resulted in more blood pressures and increased compliance with clinical guidelines in monitoring patients for persistent or worsening postpartum hypertension.

Objective: To measure program participant response rate during the first 10 days after hospital discharge, to assess replicability and scalability of the program, and to evaluate patient satisfaction at 3 distinct sites. Read More

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Genetic errors of immunity distinguish pediatric non-malignant lymphoproliferative disorders.

J Allergy Clin Immunol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pediatrics, Baylor College of Medicine, Houston, TX; Department of Pediatrics, Texas Children's Hospital, Houston, TX; Division of Pediatric Hematology/Oncology, Texas Children's Hospital Cancer Center, Houston, TX. Electronic address:

Background: Pediatric non-malignant lymphoproliferative disorders (PLPD) are clinically and genetically heterogeneous. Long-standing immune dysregulation and lymphoproliferation in children may be life-threatening, and a paucity of data exists to guide evaluation and treatment of children with PLPD.

Objective: The primary objective of this study was to ascertain the spectrum of genomic immunologic defects in PLPD. Read More

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Contribution of phototesting in diagnosis of photodermatoses: retrospective study of 100 cases.

Photodermatol Photoimmunol Photomed 2021 Jul 30. Epub 2021 Jul 30.

Dermatology, allergology and photobiology Department, Grenoble-Alpes University Hospital, France.

Background: Photodermatoses are sun-related inflammatory skin diseases. They usually require phototesting in diagnosis. However fewer and fewer medical centers in France are equipped with photobiological equipment. Read More

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Effect of prenatal screening on trends in perinatal mortality associated with congenital anomalies before and after the introduction of prenatal screening: A population-based study in the Northern Netherlands.

Paediatr Perinat Epidemiol 2021 Jul 30. Epub 2021 Jul 30.

Department of Genetics, EUROCAT Registration Northern Netherlands, University Medical Centre Groningen, Groningen, The Netherlands.

Background: Perinatal mortality in foetuses/children with congenital anomalies remains high. Prenatal diagnosis, essential for risk assessment and organisation of perinatal/postnatal care, offers parents the opportunity to consider the termination of pregnancy. In times of quick changes in prenatal screening programmes, it is relevant to evaluate the effect of prenatal screening on perinatal mortality rates. Read More

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Global research trends of drug-induced liver injury (DILI) in the past two decades: a bibliometric and visualized study.

Ann Palliat Med 2021 Jul 30. Epub 2021 Jul 30.

Department of Surgical Intensive Care Unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Drug-induced liver injury (DILI) has become one of the most common and serious adverse drug reactions owing to its high morbidity and leading cause of hepatic failures, which had attracted great attentions worldwide in the past two decades. A need therefore exists to conduct a bibliometric and visualized analysis of the global research trends on DILI with the aim of identifying the status of current research and prioritize the future research areas.

Methods: Publications related to DILI from 1999 to 2019 were extracted through an electronic search of the Web of Science (WoS) and PubMed databases. Read More

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The competence of village clinicians in the diagnosis and treatment of heart disease in rural China: A nationally representative assessment.

Lancet Reg Health West Pac 2020 Sep 10;2:100026. Epub 2020 Sep 10.

School of Advanced Agricultural Sciences, Peking University, Room 408B, Wangkezhen Building, No. 5, Yiheyuan Road, Haidian, Beijing 100871, China.

Background: While strengthening primary care quality is key to China's health system reforms, evidence to guide this work has been limited, particularly for rural areas. This study provides the first nationally-representative assessment of village doctors' competence in diagnosing and managing presumptive heart disease.

Methods: A cross-sectional study of village clinics was conducted across five provinces. Read More

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September 2020

Secondary Hemophagocytic Lymphohistiocytosis Complicated by a Cavitary Lung Lesion in a Kidney Transplant Recipient.

Case Rep Nephrol Dial 2021 May-Aug;11(2):195-203. Epub 2021 Jul 9.

Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Lodz, Lodz, Poland.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon life-threatening condition caused by an uncontrolled immunological response. It can develop secondary to malignancies, infections, systemic diseases, and immunosuppression. Multiple risk factors may present in kidney transplant recipients; however, the cases of HLH in this population have been described sparsely. Read More

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Cardiac Manifestations in COVID-19 Patients: A Focus on the Pediatric Population.

Can J Infect Dis Med Microbiol 2021 16;2021:5518979. Epub 2021 Jul 16.

Division of Cardiology, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: SARS-CoV-2 is a new strain of the coronavirus family that emerged by the end of 2019 and led to the unpreceded COVID-19 pandemic. The virus affects multiple organs simultaneously and leads to a high rate of morbidity and mortality in all age groups. The cardiovascular system is one of the major affected organ systems. Read More

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Advanced HCC Patient Benefit From Neoantigen Reactive T Cells Based Immunotherapy: A Case Report.

Front Immunol 2021 13;12:685126. Epub 2021 Jul 13.

Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, China.

Advanced hepatocellular carcinoma (HCC) is a highly lethal disease, mainly due to the late stage at diagnosis and its rapid progression. Although patients with advanced HCC can choose targeted therapy or chemotherapy, overall, the treatment response rate is extremely low and the average survival time is one year more or less. But the application of immunotherapy have led to a paradigm shift in the treatment of HCC,such as TILs (tumor infiltrating lymphocytes),Checkpoint blockade (immune Checkpoint blockade), CAR-T(chimeric antigen receptor T cells) and TCR-T (engineered t-cell receptor T cells). Read More

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[Parsonage-Turner syndrome following severe SARS-CoV-2 infection].

Rev Mal Respir 2021 Jun 26. Epub 2021 Jun 26.

Service de pneumologie, hôpital Larrey, CHU de Toulouse, 31059 Toulouse cedex 9, France.

Introduction: Complications following COVID-19 are starting to emerge; neurological disorders are already described in the literature.

Case Report: This case is about a 20-year old male with a severe COVID-19, hospitalized in a Reanimation and Intensive Care Unit with an Acute Respiratory Distress Syndrome, thromboembolic complication and secondary bacterial infection. This patient had a non-specific neurological disorder with a pseudobulbar palsy, (MRI, ENMG and lumbar puncture were normal), associated 4 months later with persistent left shoulder motor deficit and respiratory failure. Read More

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Prolonged Effects of the COVID-19 Pandemic on Sleep Medicine Services-Longitudinal Data from the Swedish Sleep Apnea Registry.

Sleep Med Clin 2021 Sep 1;16(3):409-416. Epub 2021 Jun 1.

Center for Sleep and Vigilance Disorders, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 8B, Box 421, 40530 Gothenburg, Sweden; Respiratory Department, Sleep Disorders Center, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

The worldwide COVID-19 pandemic has affected the operation of health care systems. The direct impact of obstructive sleep apnea (OSA) on COVID-19 infection outcome remains to be elucidated. However, the coincidence of common risk factors for OSA and severe COVID-19 suggests that patients with OSA receiving positive airway pressure therapy may have an advantage relative to those untreated when confronted with a COVID-19 infection. Read More

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September 2021

Gastric amyloidosis presenting as acute upper gastrointestinal bleeding: a case report.

BMC Gastroenterol 2021 Jul 29;21(1):300. Epub 2021 Jul 29.

Department of Medicine, Dalhousie University and Nova Scotia Health, QEII Health Sciences Centre, VG Site, Suite 442 Bethune Building, 1276 South Park Street, Halifax, NS, B3H 2Y9, Canada.

Background: Amyloidosis is characterized by extracellular tissue deposition of fibrils, composed of insoluble low-molecular-weight protein subunits. The type, location, and extent of fibril deposition generates variable clinical manifestations. Gastrointestinal (GI) bleeding due to amyloid deposition is infrequent. Read More

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Diagnostic efficacy of Light-Emitting Diode (LED) Fluorescence based Microscope for the diagnosis of Tuberculous lymphadenitis.

PLoS One 2021 29;16(7):e0255146. Epub 2021 Jul 29.

Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

Background: The comparatively straightforward and cheaper light-emitting diode fluorescent microscope (LEDFM) was suggested by WHO to replace conventional microscope in tuberculosis (TB) laboratories. However, the comparable efficacy of each of those techniques differs from laboratory to laboratory. We investigated the efficacy of LEDFM for the diagnosis of tuberculous lymphadenitis (TBLN) patients. Read More

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Invasive Lobular Breast Cancer: Data to Support Surgical Decision Making.

Ann Surg Oncol 2021 Jul 29. Epub 2021 Jul 29.

Division of Breast Surgery, Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.

Background: Invasive lobular carcinoma (ILC) is thought be a unique entity with higher rates of multifocal/multicentric and bilateral disease. This study aimed to evaluate the true extent of the disease, risk of bilaterality, lymph node involvement, and impact of preoperative imaging to help guide surgical decision making.

Methods: A retrospective analysis identified patients treated for ILC between 2004 and 2017. Read More

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The success of HIV combination prevention: The Dean Street model.

HIV Med 2021 Jul 29. Epub 2021 Jul 29.

Chelsea & Westminster Hospital NHS Foundation Trust, London, UK.

The 56 Dean Street combination prevention model, a strong engagement with the LGBTQI community and flexible services adapted to users' changing needs led to an 80% drop in HIV diagnoses in gay, bisexual and other men who have sex with men (GBMSM) from 2015 to 2017. We describe the service changes at 56 Dean Street since 2012 which resulted in an increase in the frequency of HIV testing, the introduction of pre-exposure prophylaxis, earlier HIV diagnosis and a shorter time to viral suppression in those living with HIV. This model could be adapted to deliver similar results in those settings of high HIV prevalence among GBMSM and where access to technological innovation in healthcare and engagement with the community can be achieved. Read More

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Long Term Effect of Everolimus in Recurrent Thymic Neuroendocrine Neoplasia.

Clin Endocrinol (Oxf) 2021 Jul 29. Epub 2021 Jul 29.

University Hospital Heidelberg, Department of Nuclear Medicine, Im Neuenheimer Feld 400, Heidelberg, Germany.

Purpose: Neuroendocrine neoplasia (NEN) of the thymus is a very rare entity with poor prognosis. No study based standard treatment is established. Usually therapy protocols for bronchopulmonary carcinoids are used. Read More

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Synchronous Small Bowel Gangrene With Pyelonephritis Secondary to Mucormycosis: A Disastrous Complication of COVID-19 Pandemic.

Cureus 2021 Jun 25;13(6):e15911. Epub 2021 Jun 25.

Urology, All India Institute of Medical Sciences, Jodhpur, IND.

Mucormycosis is a rare infection caused by fungi of the order . The infection frequently involves the rhino-cerebral or respiratory system and involvement of the gastrointestinal (GI) tract and kidney are rare. It usually infects immunocompromised individuals due to various causes and an upsurge is hypothesized to be linked with irrational use of steroids during coronavirus disease 2019 (COVID-19) pandemic. Read More

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