72 results match your criteria leaves artocarpus

The effect of S.reticulata, S.cumini, A.heterophyllus, and C.auriculata on controlling the rapid formation of advanced glycation end-products.

J Ayurveda Integr Med 2021 Mar 14. Epub 2021 Mar 14.

Herbal Technology Section (HTS), Industrial Technology Institute (ITI), 363, Bauddhaloka Mawatha, Colombo, 07, Sri Lanka.

Background: The excessive formation of Advanced Glycation End-products (AGEs) by non-enzymatic glycation mediates many health complications in the human body and the formation of AGEs largely accelerated under the hyperglycaemic condition.

Objective: The prospect of the study to assess the strength of inhibiting the rapid AGE formations in four Ayurvedic medicinal plants, namely; Salacia reticulata (stems), Syzygium cumini (barks), Artocarpus heterophyllus (mature leaves) and, Cassia auriculata (flowers).

Materials And Methods: Herbal decoctions of four medicinal plant materials were prepared by simmering with hot water as prescribed by the Ayurvedic medicine. Read More

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Highly Aromatic Flavan-3-ol Derivatives from Palaeotropical Buch.-Ham Possess Radical Scavenging and Antiproliferative Properties.

Molecules 2021 Feb 18;26(4). Epub 2021 Feb 18.

Department of Botany and Biodiversity Research, Faculty of Life Science, University of Vienna, Rennweg 14, A-1030 Vienna, Austria.

Phytochemical investigation of leaves and stembark of collected in Thailand resulted in three yet undescribed isomeric flavan-3-ol derivatives (-), the four known compounds gambircatechol (), (+)-catechin (), (+)-afzelechin () and the stilbene oxyresveratrol (). Compounds to feature 6/6/5/6/5/6 core structures. All structures were deduced by NMR and MS, while density functional theory (DFT) calculations on B3LYP theory level were performed of compounds to to support the stereochemistry in positions 2 and 3 in the C-ring. Read More

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February 2021

Green technologies for the extraction of proteins from jackfruit leaves ( Lam).

Food Sci Biotechnol 2020 Dec 6;29(12):1675-1684. Epub 2020 Oct 6.

National Technologic of Mexico/Technologic Institute of Tepic, 2595 Tecnologico Av., 63175 Tepic, Nayarit Mexico.

The application of emerging technologies such as ultrasound, microwaves and high hydrostatic pressure, allows the extraction of compounds in a sustainable manner from a vegetable matrix with a high value such as jackfruit leaf proteins ( Lam). Currently, the main method of protein extraction is based on the precipitation with the use of an aggressive solvent, therefore it is necessary to optimize extraction methods with a minimum waste production. In the protein extraction of jackfruit leaves, we obtained a content of 84. Read More

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December 2020

Paralogs and off-target sequences improve phylogenetic resolution in a densely-sampled study of the breadfruit genus (Artocarpus, Moraceae).

Syst Biol 2020 Sep 24. Epub 2020 Sep 24.

Chicago Botanic Garden, Negaunee Institute for Plant Conservation Science and Action, 1000 Lake Cook Road, Glencoe, IL, USA.

We present a 517-gene phylogenetic framework for the breadfruit genus Artocarpus (ca. 70 spp., Moraceae), making use of silica-dried leaves from recent fieldwork and herbarium specimens (some up to 106 years old) to achieve 96% taxon sampling. Read More

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September 2020

Safety assessment of fermented jackfruit () pulp and leaves in Sprague-Dawley rats.

Food Sci Nutr 2020 Aug 1;8(8):4370-4378. Epub 2020 Jul 1.

Biotechnology & Nanotechnology Research Centre MARDI Headquarters Persiaran MARDI-UPM Serdang Malaysia.

Fermented jackfruit () extracts were produced using pure symbiotic culture of bacteria and yeast (SCOBY) under controlled fermentation process. Both female and male Sprague-Dawley rats were orally administrated with 4,000 mg/kg of fermented jackfruit pulp and leaves extracts for 28 consecutive days. Body weight of rats was recorded at 1-week interval until necropsy day. Read More

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Prenylated chromones and flavonoids from Artocarpus heterophyllus with their potential antiproliferative and anti-inflammatory activities.

Bioorg Chem 2020 08 20;101:104030. Epub 2020 Jun 20.

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China; Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan Province, Hainan Normal University, Haikou 571158, PR China; Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158, PR China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou 571158, PR China. Electronic address:

Two new prenylated chromones, artoheterophines A (1) and B (2), five known prenylated chromones (3-7), as well as five known biogenetically related prenylated flavonoids (8-12) were isolated and characterized from the stems and leaves of A. heterophyllus. Their chemical structures were unambiguously determined through comprehensive spectral data analyses. Read More

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Characterization and antifungal activity of jackfruit (Artocarpus heterophyllus Lam.) leaf extract obtained using conventional and emerging technologies.

Food Chem 2020 Nov 7;330:127211. Epub 2020 Jun 7.

Laboratorio Integral de Investigación en Alimentos, Tecnológico Nacional de México - Instituto Tecnológico de Tepic, Av. Tecnológico # 2595, C.P. 63195 Tepic, Nayarit, Mexico. Electronic address:

With the current agro-food industry demands for more environmentally-friendly production, the use of natural antifungal compounds extracted by emerging technologies led to a sustainable alternative to control microorganisms. Therefore, the present work aimed to: (i) determine antifungal activity against Colletotrichum gloeosporioides and Penicillium italicum of jackfruit leaf extracts obtained by different methods, and (ii) identify compounds by HPLC-DAD-ESI-MS. Microwave (MAE), high-hydrostatic pressure (HHP) and ultrasound (UAE) assisted extractions were tested, followed by fractionation with different polarity solvents. Read More

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November 2020

Artocarpus altilis extracts as a food-borne pathogen and oxidation inhibitors: RSM, COSMO RS, and molecular docking approaches.

Sci Rep 2020 06 12;10(1):9566. Epub 2020 Jun 12.

Department of Chemistry, Faculty of Science, University Malaysia Terengganu, Mengabang Telipot, 21030, Kuala Terengganu, Terengganu Darul Iman, Malaysia.

Lipid oxidation and microbial contamination are the major factors contributing to food deterioration. Food additives like antioxidants and antibacterials can prevent food spoilage by delaying oxidation and preventing the growth of bacteria. Artocarpus altilis leaves exhibited biological properties that suggested its use as a new source of natural antioxidant and antimicrobial. Read More

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Secondary metabolites from isolated from .

Nat Prod Res 2019 Oct 7:1-5. Epub 2019 Oct 7.

Natural Products Research Group, Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung , Bandung , Indonesia.

Fractionation and purification of the ethyl acetate extract of , an endophytic fungus from the leaves of , yielded one new compound, diaporthindoic acid (), along with seven known compounds (-). The new compound was characterized and established by the basis of extensive spectroscopic methods including NMR (1D and 2D) and HRMS. Compound showed the best citotoxicity against murine leukemia P-388 cells with an IC value of 0. Read More

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October 2019

Anti-cholinesterase potential of diverse botanical families from Malaysia: Evaluation of crude extracts and fractions from liquid-liquid extraction and acid-base fractionation.

J Ethnopharmacol 2019 Dec 13;245:112160. Epub 2019 Aug 13.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia; USM-RIKEN Centre for Aging Science (URICAS), Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia. Electronic address:

Ethnopharmacological Relevance: Enhancement of cholinergic functions in the brain via acetylcholinesterase inhibition is one of the main therapeutic strategies to improve symptoms associated with Alzheimer's or related cognitive deficits. There is a pathophysiological correlation between Alzheimer's and Diabetes Mellitus, as well as inflammation and oxidative stress that may cause cognitive decline.

Aim Of The Study: The present study was intended to evaluate anti-cholinesterase potential of 177 Malaysian plant extracts from 148 species known to have related ethnomedicinal uses such as anti-inflammatory, anti-oxidant, anti-diabetic, epilepsy, headache, memory enhancement and anti-aging. Read More

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December 2019

Comparative anatomy and histochemistry of the leaf blade of two species of Artocarpus.

An Acad Bras Cienc 2019 Feb 14;91(1):e20170922. Epub 2019 Feb 14.

Laboratório de Farmacognosia, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521 Recife, PE, Brazil.

In Brazil, there are two species of Artocarpus that were introduced: Artocarpus altilis (Parkinson) Fosberg, known as fruta-pão, and Artocarpus heterophyllus Lam., known as jaca. Both are used as food and medicine. Read More

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February 2019

Larvicidal and ovicidal activities of Artocarpus blancoi extracts against Aedes aegypti.

Pharm Biol 2019 Dec;57(1):120-124

c Faculty of Pharmacy , Meijo University , Nagoya City , Japan.

Context: Dengue control may be done by targeting its vector. In this study, we used Artocarpus blancoi (Elm.) Merr. Read More

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December 2019

Nutritional and Health Benefits of Jackfruit ( Lam.): A Review.

Int J Food Sci 2019 6;2019:4327183. Epub 2019 Jan 6.

Department of Food Science and Technology, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.

Lam., which is commonly known as jackfruit is a tropical climacteric fruit, belonging to Moraceae family, is native to Western Ghats of India and common in Asia, Africa, and some regions in South America. It is known to be the largest edible fruit in the world. Read More

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January 2019

Nutritional potentialities of some tree leaves based on polyphenols and rumen gas production.

Vet World 2018 Nov 23;11(10):1479-1485. Epub 2018 Oct 23.

Department of Animal Nutrition, Veterinary College, Bengaluru, Karnataka, India.

Aim: The study was conducted to evaluate eight tree leaves based on polyphenolic content and rumen incubation and gas production technique (RIVIGPT) for their nutritive potentiality.

Materials And Methods: Eight selected tree leaves, namely , , spp., , , , , and , were selected for proximate composition, forage fiber fractions, total phenolics (TPs), non-tannin phenols (NTPs), total tannins (TTs), condensed tannins (CTs), and hydrolysable tannins (HTs); RIVIGP with and without polyethylene glycol (PEG); and dry matter digestibility (IVDMD) (modified two stage) analysis was conducted. Read More

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November 2018

Ethnobotanical study on medicinal plants used by local Van Kieu ethnic people of Bac Huong Hoa nature reserve, Vietnam.

J Ethnopharmacol 2019 Mar 6;231:283-294. Epub 2018 Nov 6.

International Biological Material Research Center, Korea Research Institute of Bioscience & Biotechnology, 125, Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: The ethnobotanical survey was carried out in the Bac Huong Hoa Nature Reserve (BHHNR), Vietnam. The Van Kieu ethnic group, the inhabitant of Nature Reserve, is rich in knowledge about the medicinal plants found in the Nature Reserve. However, their knowledge is less documented. Read More

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New geranyl flavonoids from the leaves of Artocarpus communis.

J Nat Med 2018 Jun 24;72(3):632-640. Epub 2018 Feb 24.

Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.

Four new geranyl flavonoids 1-4 and four known flavonoids 5-8 were obtained from the leaves of Artocarpus communis collected in Indonesia. The planar structures of flavonoids were elucidated by analyses of MS and NMR spectroscopic data. Absolute configurations of 1 and 2 were determined by ECD spectroscopy. Read More

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Levels of Blood Glucose and Insulin Expression of Beta-cells in Streptozotocin-induced Diabetic Rats Treated with Ethanolic Extract of Artocarpus altilis Leaves and GABA.

Pak J Biol Sci 2017 ;20(1):28-35

Faculty of Veterinary Medicine, Universitas Gadjah Mada, Jalan Fauna No. 2, Karangmalang, 55281 Yogyakarta, Indonesia.

Background And Objective: Information about the Artocarpus altilis leaf as an antidiabetic associated with the active compounds Gamma Amino Butyric Acid (GABA) is still limited. This study was conducted to determine the effects of ethanolic extract of A. altilis leaves decoction and GABA on blood glucose levels and insulin expression of beta-cells in streptozotocin-induced diabetic rats. Read More

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December 2017

Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase.

Biochem Pharmacol 2017 10 28;142:46-57. Epub 2017 Jun 28.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Korea University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

The roles and significance of signal transducer and activator of transcription 3 (STAT3) in human cancers have been extensively studied and STAT3 is a promising therapeutic target for cancer drug discovery. During the screening of natural products to identify STAT3 inhibitors, we identified geranylnaringenin (CG902), which decreased luciferase activity in a dose-dependent manner. CG902 specifically inhibited STAT3 phosphorylation at Tyr-705 in DU145 prostate cancer cells and decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, and survivin. Read More

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October 2017

Identification of a flavonoid C-glycoside as potent antioxidant.

Free Radic Biol Med 2017 09 3;110:92-101. Epub 2017 Jun 3.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. Electronic address:

Flavonoids have been documented to have good antioxidant activities in vitro. However, reports on the cellular antioxidant activities of flavonoid C-glycosides are very limited. In this work, an apigenin C-glycoside was purified from Artocarpus heterophyllus by column chromatography and was identified to be 2″-O-β-D-xylosylvitexin by nuclear magnetic resonance spectroscopy. Read More

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September 2017

Aqueous extract from leaf of Artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: Negative chronotropic and inotropic effects.

J Ethnopharmacol 2017 May 22;203:163-170. Epub 2017 Mar 22.

Natural Products Institute, University of the West Indies, Mona Campus, Jamaica.

Ethnopharmacological Relevance: The leaves of Artocarpus altilis (Parkinson ex F.A.Zorn, Fosberg) (Moraceae) are used in the management of hypertension; this study assessed the cardio-protective effects of the leaf extract on isoproterenol (ISO) induced myocardial damage in rats. Read More

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n-Hexane Insoluble Fraction of Plantago lanceolata Exerts Anti-Inflammatory Activity in Mice by Inhibiting Cyclooxygenase-2 and Reducing Chemokines Levels.

Sci Pharm 2017 Mar 13;85(1). Epub 2017 Mar 13.

Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.

Inflammation is involved in the progression of many disorders, such as tumors, arthritis, gastritis, and atherosclerosis. Thus, the development of new agents targeting inflammation is still challenging. Medicinal plants have been used traditionally to treat various diseases including inflammation. Read More

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Integration of Traditional and Western Medicine in Vietnamese Populations: A Review of Health Perceptions and Therapies.

Nat Prod Commun 2016 Sep;11(9):1409-1416

In Vietnam, two types of traditional medicine (TM) are practiced: thuoc nam, medicine of the South, and thuoc bac, medicine of the North, both of which are largely based on herbal drugs used by different Vietnamese ethnic groups. This review presents recently published information from various databases regarding TM, especially herbal drugs, and its integration with Western medical practices outside and inside Vietnam. We first discuss the integration of traditional and modem health concepts by Vietnamese immigrants living outside Vietnam. Read More

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September 2016

Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities.

Nat Prod Res 2017 May 26;31(10):1113-1120. Epub 2016 Aug 26.

a Faculty of Science, Department of Chemistry , Universiti Teknologi Malaysia , Johor Bahru , Malaysia.

A new dihydrochalcone, 2',4'-dihydroxy-3,4-(2″,2″-dimethylchromeno)-3'-prenyldihydrochalcone (1) together with 4-hydroxyonchocarpin (2), isobavachalcone (3), 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ-dimethylallyflavone (4), artocarpin (5) and cycloheterophyllin (6) were successfully isolated from the leaves and heartwoods of Artocarpus lowii King (Moraceae). The structures of these compounds were fully characterised using spectroscopic methods and by direct comparison with published data. These compounds were tested for their antioxidant and tyrosinase inhibitory activities. Read More

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In vivo anticancer activity of maesopsin 4-O-β-glucoside isolated from leaves of Artocarpus tonkinensis A. Chev. Ex Gagnep.

Asian Pac J Trop Med 2016 Apr 10;9(4):351-356. Epub 2016 Mar 10.

Institute of Biotechnology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Viet Nam. Electronic address:

Objective: To investigate the antitumor effect of maesopsin 4-O-β-glucoside (TAT2) isolated from the leaves of Artocarpus tonkinensis (A. tonkinensis) A. Chev. Read More

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Breadfruit (Artocarpus altilis) gibberellin 2-oxidase genes in stem elongation and abiotic stress response.

Plant Physiol Biochem 2016 Jan 23;98:81-8. Epub 2015 Nov 23.

Queensland Alliance for Agriculture and Food Innovation, University of Queensland, St Lucia, QLD 4072, Australia; Faculty of Science, Education and Engineering, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.

Breadfruit (Artocarpus altilis) is a traditional staple tree crop in the Oceania. Susceptibility to windstorm damage is a primary constraint on breadfruit cultivation. Significant tree loss due to intense tropical windstorm in the past decades has driven a widespread interest in developing breadfruit with dwarf stature. Read More

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January 2016

Flavonoids from Artocarpus anisophyllus and their bioactivities.

Nat Prod Commun 2015 Mar;10(3):393-6

Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were screened for their antioxidant and tyrosinase inhibitory activities. Read More

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Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells.

Phytother Res 2015 May 13;29(5):749-56. Epub 2015 Feb 13.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, 125 Gwahakro Yoosunggu, Daejeon, 305-600, Republic of Korea.

Artocarpus altilis (Parkinson) Fosberg has traditionally been used in Indonesia for the treatment of liver cirrhosis, hypertension, and diabetes. In many other countries, it is used for the treatment of malaria, yellow fever, and dengue fever. It has been reported that A. Read More

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Gamma sensitivity of forest plants of Western Ghats.

J Environ Radioact 2014 Jun 12;132:100-7. Epub 2014 Mar 12.

Department of Applied Botany, Mangalore University, Mangalagangothri 574199, Karnataka, India. Electronic address:

Seeds of Artocarpus hirsutus Lam., Garcinia xanthochymus Hook., Saraca asoca Roxb. Read More

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Effect of the hot water extract of Artocarpus camansi leaves on 2,4,6-trinitrochlorobenzene (TNCB)-induced contact hypersensitivity in mice.

Biol Pharm Bull 2014 ;37(3):493-7

Graduate School of Pharmacy, Meijo University.

Medicinal plants with reported anti-inflammatory activity could have the potential use as anti-allergens and inhibitors of allergic contact dermatitis reactions produced by allergens and chemicals. Some species from the genus Artocarpus were reported to have anti-inflammatory activity. In the Philippines one local source is Artocarpus camansi BLANCO (Moraceae), which is utilized as an ingredient of their cuisine, and decoction of leaves is used for diabetes and baths of people with rheumatism. Read More

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October 2014

Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity.

Planta Med 2014 Feb 15;80(2-3):193-200. Epub 2014 Jan 15.

Frontier Research Core for Life Sciences, University of Toyama, Toyama, Japan.

Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions is a novel antiausterity strategy in anticancer drug discovery. In this study, the methanolic extract of the leaves of Artocarpus altilis showed 100 % preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions at a concentration of 50 µg/mL. Read More

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February 2014