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LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer.

Cell Death Dis 2021 May 7;12(5):454. Epub 2021 May 7.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, 410008, Changsha, P. R. China.

Radioresistance continues to be the leading cause of recurrence and metastasis in nasopharyngeal cancer. Long noncoding RNAs are emerging as regulators of DNA damage and radioresistance. LINC-PINT was originally identified as a tumor suppressor in various cancers. Read More

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The limited effect of neural stimulation on visual attention and social cognition in individuals with schizophrenia.

Neuropsychologia 2021 May 4;157:107880. Epub 2021 May 4.

School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA; Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX,, USA.

Background: Research demonstrates a relationship between faulty visual attention and poorer social cognition in schizophrenia. One potential explanatory model suggests abnormal neuromodulation in specific neural networks may result in reduced attention to socially important cues, leading to poorer understanding of another's emotional state or intentions.

Objective: The current study experimentally manipulated neural networks using tDCS to examine this potential causal mechanism. Read More

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Down-regulation of microRNA-125b-2-3p is a risk factor for a poor prognosis in hepatocellular carcinoma.

Bioengineered 2021 Dec;12(1):1627-1641

Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.

Hepatocellular carcinoma (HCC) is a leading cause of mortality in cancer patients, but the association between miR-125b-2-3p and the onset and prognosis of HCC has not been reported in previous studies; thus, the clinicopathological implications of miR-125b-2-3p in HCC require elaboration. To examine the expression of miR-125b-2-3p in HCC, both in-house RT-qPCR and public datasets were used to calculate the standard mean difference (SMD) and the summary receiver operating characteristic (sROC). MiR-125b-2-3p was markedly lower in HCC than in non-tumor tissue as assessed by the in-house RT-qPCR which was confirmed by the integrative analysis showing the SMD being -0. Read More

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December 2021

Health-related guilt in chronic primary pain: A systematic review of evidence.

Br J Health Psychol 2021 May 5. Epub 2021 May 5.

Department of Psychology, Royal Holloway, University of London, Egham, UK.

Purpose: Chronic primary pain conditions are characterized by significant functional disability, emotional distress, and diagnostic uncertainty. Health-related guilt associated with coping and living with chronic pain is poorly understood. There had been no attempts to synthesize findings on health-related guilt across studies. Read More

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Investigation of Mitochondrial Adaptations to Modulation of Carbohydrate Supply during Adipogenesis of 3T3-L1 Cells by Targeted H-NMR Spectroscopy.

Biomolecules 2021 Apr 29;11(5). Epub 2021 Apr 29.

Human Biology and Toxicology Unit, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, UMONS, 20 Place du Parc, 7000 Mons, Belgium.

(1) Background: White adipose tissue (WAT) is a dynamic and plastic tissue showing high sensitivity to carbohydrate supply. In such a context, the WAT may accordingly modulate its mitochondrial metabolic activity. We previously demonstrated that a partial replacement of glucose by galactose in a culture medium of 3T3-L1 cells leads to a poorer adipogenic yield and improved global mitochondrial health. Read More

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Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer.

Front Oncol 2021 16;11:620361. Epub 2021 Apr 16.

School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Colorectal cancer (CRC) is a leading cause of cancer-related deaths. Because of the lack of reliable prognostic and predictive biomarkers for CRC, most patients are often diagnosed at a late stage. The tryptophan-kynurenine pathway plays a crucial role in promoting cancer progression. Read More

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Structural Gray and White Matter Correlates of Awareness in Alzheimer's Disease.

J Alzheimers Dis 2021 Apr 28. Epub 2021 Apr 28.

Department of Psychology, Pontifícia Universidade Católica-Rio, Brazil.

Background: Unawareness of disease is a common feature of Alzheimer's disease (AD), but few studies explored its neural correlates. Additionally, neural correlates according to the object of awareness are unexplored.

Objective: To investigate structural brain correlates in relation to different objects of awareness. Read More

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SIPA1 Is a Modulator of HGF/MET Induced Tumour Metastasis via the Regulation of Tight Junction-Based Cell to Cell Barrier Function.

Cancers (Basel) 2021 Apr 6;13(7). Epub 2021 Apr 6.

Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.

Background: Lung cancer is the leading cause of cancer death. SIPA1 is a mitogen induced GTPase activating protein (GAP) and may hamper cell cycle progression. SIPA1 has been shown to be involved in MET signaling and may contribute to tight junction (TJ) function and cancer metastasis. Read More

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Addressing gaps in adolescent tuberculosis programming and policy in Nigeria from a public health perspective.

Int J Adolesc Med Health 2021 Apr 27. Epub 2021 Apr 27.

National TB and Leprosy Control Programme, Federal Ministry of Health, Abuja, Nigeria.

Objectives: Tuberculosis (TB) is a leading infectious cause of death globally. Of the estimated 10 million people who developed active TB in 2019, 1.8 million (18%) were adolescents and young adults aged 15-24 years. Read More

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Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness.

Front Psychiatry 2021 12;12:643609. Epub 2021 Apr 12.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

The bidirectional relationship between depression and chronic pain is well-recognized, but their clinical management remains challenging. Here we characterize the shared risk factors and outcomes for their comorbidity in the Australian Genetics of Depression cohort study ( = 13,839). Participants completed online questionnaires about chronic pain, psychiatric symptoms, comorbidities, treatment response and general health. Read More

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Pemphigus Vulgaris and Bullous Pemphigoid of the Upper Aerodigestive Tract: A Review Article and Novel Approaches to Management.

ORL J Otorhinolaryngol Relat Spec 2021 Apr 26:1-9. Epub 2021 Apr 26.

Department of Otolaryngology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

Background: Autoimmune bullous diseases are rare conditions characterized by blistering of the skin and mucous membranes. The 2 commonest forms are pemphigus vulgaris and bullous pemphigoid. The oral cavity or oropharynx may be the initial site of presentation or often the only site involved. Read More

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Spatial Ability in Children with Mathematics Learning Disorder (MLD) and Its Impact on Executive Functions.

Dev Neuropsychol 2021 Apr-Jun;46(3):232-248. Epub 2021 Apr 26.

Department of Psychology, Shahid Beheshti University, Tehran, Iran.

Mathematics Learning Disorder (MLD) has been found to be related to impairments in cognitive functions. Spatial ability (SA), which is made up of eight single but unified elements can be assumed to have a leading part in different areas of math skills. The first objective of this study was to explore differences in SA factors in 128 school children of third to sixth grade with and without MLD. Read More

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Unilateral auditory deprivation in humans: Effects on frequency discrimination and auditory memory span in the normal ear.

Hear Res 2021 Jun 9;405:108245. Epub 2021 Apr 9.

Department of Ear, Nose and Throat, GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab 151203, India.

Hearing with one ear is associated with auditory deprivation leading to cortical neuronal reorganization. Despite evidence for substantial effects of unilateral input on cortical and sub-cortical structures, the functional consequences of such alterations on human hearing is underexplored. Unilateral hearing impairment offers a unique model to study the perceptual consequences of cortical reorganization. Read More

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Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma-A 15-Year Retrospective Single-Center Study.

Cancer Manag Res 2021 13;13:3201-3208. Epub 2021 Apr 13.

Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, 100176, People's Republic of China.

Objective: The present study aimed to summarize the clinical data of hepatoblastoma (HB) in infants under one year of age and to analyze the factors that affected the prognoses.

Methods: The clinical data of 132 pediatric patients with a pathologically confirmed HB, aged less than one year and who had visited the Pediatric Single Center of Beijing Tongren Hospital from May 2005 to May 2019, were retrospectively analyzed to summarize the clinical outcomes and prognoses.

Results: The male/female ratio was 1. Read More

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The Association Between Sarcopenia and Postoperative Outcomes Among Older Adults With Hip Fracture: A Systematic Review.

J Appl Gerontol 2021 Apr 17:7334648211006519. Epub 2021 Apr 17.

Department of Orthopedic Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Hip fracture is a serious clinical event with high morbidity and mortality. Sarcopenia is characterized by age-related loss of muscle mass and function, leading to several adverse health outcomes. In this systematic review, no limitation criteria were used for study selection and 327 studies were identified in the initial search. Read More

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Comparison of tracheal resection outcomes at a university hospital vs county hospital setting.

Laryngoscope Investig Otolaryngol 2021 Apr 8;6(2):277-282. Epub 2021 Mar 8.

Department of Otolaryngology-Head and Neck Surgery University of Southern California Los Angeles California USA.

Objectives: To evaluate the role of hospital setting on outcomes in open airway surgery by comparing patients who underwent surgery (cricotracheal resection [CTR] or tracheal resection [TR]) at a publicly funded county hospital vs a private university hospital.

Methods: Retrospective chart review of patients undergoing CTR or TR at two institutions; a private university hospital and a publicly funded county hospital from September 2014 to September 2019. Length of intensive care unit (ICU) stay, total time to discharge, minor and major complications were the primary endpoints. Read More

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Subtype Specific Analyses Reveal Infiltrative Basal Cell Carcinoma Are Highly Interactive With Their Environment.

J Invest Dermatol 2021 Apr 15. Epub 2021 Apr 15.

The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia; Department of Dermatology, Princess Alexandra Hospital Metro-South District, Brisbane, Australia. Electronic address:

Little is known regarding the molecular differences between BCC subtypes, despite clearly distinct phenotypes and clinical outcomes. In particular, infiltrative BCCs have poorer clinical outcomes in terms of response to therapy and propensity for dissemination. In this project we aimed to use exome sequencing and RNA sequencing to identify somatic mutations and molecular pathways leading to infiltrative BCCs. Read More

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Appetite, oral health and weight loss in community-dwelling older men: an observational study from the Concord Health and Ageing in Men Project (CHAMP).

BMC Geriatr 2021 04 16;21(1):255. Epub 2021 Apr 16.

Centre for Education and Research on Ageing, Concord Clinical School, The University of Sydney, and the Ageing and Alzheimer's Institute, Concord Repatriation General Hospital, Sydney Local Health District, Concord, NSW, Australia.

Background: Unintended weight loss and the reduction in appetite are common phenomenon among older people. Reduced appetite has been linked to medication related reductions in saliva production, reduced taste ability and poor oral health. Poor appetite can result in reduced nutrient intake ensuing weight loss. Read More

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Individualized brain development and cognitive outcome in infants with congenital heart disease.

Brain Commun 2021 23;3(2):fcab046. Epub 2021 Mar 23.

Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.

Infants with congenital heart disease are at risk of neurodevelopmental impairments, the origins of which are currently unclear. This study aimed to characterize the relationship between neonatal brain development, cerebral oxygen delivery and neurodevelopmental outcome in infants with congenital heart disease. A cohort of infants with serious or critical congenital heart disease ( = 66;  = 62 born ≥37 weeks) underwent brain MRI before surgery on a 3T scanner situated on the neonatal unit. Read More

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Correlation of expression of Akt1 and E2F1 and their phosphorylated forms in breast cancer patients with clinicopathological parameters.

J Mol Histol 2021 Apr 13. Epub 2021 Apr 13.

Department of Pathology, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman.

Breast cancer is the leading cancer worldwide among women. Traditional clinicopathological prognostic and predictive markers need refining to improve clinical outcomes. This study explored the association between traditional clinicopathological factors and the expression of Akt1 and E2F1 transduction proteins and their phosphorylated forms in breast cancer, to determine their value as novel biomarkers and potential therapeutic targets. Read More

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The association of infant temperament and maternal sensitivity in preterm and full-term infants.

Infant Ment Health J 2021 Apr 9. Epub 2021 Apr 9.

Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.

Infants who experience sensitive caregiving are at lower risk for numerous adverse outcomes. This is especially true for infants born preterm, leading them to be more susceptible to risks associated with poorer quality caregiving. Some research suggests that preterm and full-term infants differ on temperament, which may contribute to these findings. Read More

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Core Decompression with Non Vascularized Fibular Graft as Modern Surgical Treatment of Early Hip Avascular Necrosis.

Mymensingh Med J 2021 Apr;30(2):323-328

Dr Mohammad Tariqul Alam, Assistant Professor, Paediatric Orthopaedics, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:

Cellular death of bone due to impairment of the blood supply leading to collapse resulting in pain, and loss of joint function is known as avascular necrosis (AVN). The head of femur is the most common bone affected by avascular necrosis followed by talus and scaphoid. We evaluate the results of core decompression with non-vascularized fibular graft in avascular necrosis of femoral head. Read More

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Effect of rurality and ethnicity in severity and outcomes in patients with acute pancreatitis.

ANZ J Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of General Surgery, Northland District Health Board, Whangarei, New Zealand.

Background: Previous studies have demonstrated a high incidence of acute pancreatitis (AP) in New Zealand, with Maori having the highest reported incidence worldwide. It is possible that barriers to healthcare exist for rural and Maori patients, leading to poorer outcomes. The aim of this study is to compare differences in severity and outcomes in patients with AP with regards to rurality and ethnicity. Read More

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KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer.

Pathol Int 2021 Apr 5. Epub 2021 Apr 5.

Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. Kinesin Family Member C1 (KIFC1) has been proposed as a promising therapeutic target due to its pivotal role in centrosome clustering to mediate cancer cell progression. This study aimed to analyze the expression and biological function of KIFC1 in CRC. Read More

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Development of a EUCAST disk diffusion method for the susceptibility testing of rapidly growing anaerobic bacteria using Fastidious Anaerobe Agar (FAA): a development study using Bacteroides species.

Clin Microbiol Infect 2021 Apr 2. Epub 2021 Apr 2.

EUCAST Development Laboratory, Växjö, Sweden.

Objectives: Antimicrobial resistance among anaerobic bacteria is increasing, leading to a growing demand for inexpensive and reliable susceptibility testing methods. The aim of this study was to determine the suitability of Fastidious Anaerobe Agar (FAA) as a medium for disk diffusion for rapidly growing anaerobic bacteria.

Methods: Reproducibility of zone diameters and quality of growth were tested using six quality control (QC) strains. Read More

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Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer.

Cancers (Basel) 2021 Mar 25;13(7). Epub 2021 Mar 25.

Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Breast cancer is the most common female cancer. About 70% of breast cancer patients are estrogen receptor α (ERα) positive (ER+) with tamoxifen being the most commonly used anti-endocrine therapy. However, up to 50% of patients who receive tamoxifen suffer recurrence. Read More

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Challenges in Acanthamoeba Keratitis: A Review.

J Clin Med 2021 Mar 1;10(5). Epub 2021 Mar 1.

Ophthalmology Operative Complex Unit, Campus Bio-Medico University Hospital, 00128 Rome, Italy.

To review challenges in the diagnosis and management of Acanthamoeba keratitis (AK), along with prognostic factors, in order to help ophthalmologists avoid misdiagnosis, protracted treatment periods, and long-term negative sequelae, with an overarching goal of improving patient outcomes and quality of life, we examined AK studies published between January 1998 and December 2019. All manuscripts describing clinical manifestations, diagnosis, treatment, prognosis, and challenges in short- and long-term management were included. The diagnosis of AK is often challenging. Read More

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Perseverative Cognition and Snack Choice: An Online Pilot Investigation.

Behav Sci (Basel) 2021 Mar 11;11(3). Epub 2021 Mar 11.

School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.

Perseverative cognition (PC), consisting of worry and rumination, has been consistently linked to a variety of poorer health outcomes, namely via the worsening of stress-induced health risk behaviours. However, research into PC and unhealthy food choice, a key health behaviour, still remains relatively unexplored. In the current pilot investigation, 284 participants were recruited to take part in an online food choice paradigm before completing the Perseverative Thinking Questionnaire (PTQ) and the Brief State Rumination Inventory (BSRI). Read More

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Predictors of weight loss in participants with obesity following bariatric surgery - A prospective longitudinal fMRI study.

Appetite 2021 Mar 29;163:105237. Epub 2021 Mar 29.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany; Feuerlein Center on Translational Addiction Medicine (FCTS), University of Heidelberg, Germany.

Prevalence rates of overweight and obesity are increasing worldwide and are amongst the leading causes of death. Participants with obesity also suffer from poorer mental health with a concomitant reduced quality of life. Bariatric surgery outperforms other existing weight optimization approaches. Read More

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Long-Term Follow-Up After Successful Trabeculectomy: A Case Report of Reversal of Cupping and Recovery of Visual Field Progression.

Cureus 2021 Feb 23;13(2):e13520. Epub 2021 Feb 23.

Ophthalmology, Hiroshima University, Hiroshima, JPN.

Glaucoma is one of the leading causes of blindness worldwide, and reduction of intraocular pressure (IOP) is the only available evidence-based treatment that reduces visual field deterioration in glaucoma. We present a representative case of structural recovery and recovery of visual field progression after successful trabeculectomy (TLE) with long-term follow-up. A 35-year-old woman with glaucoma visited our hospital in 2008. Read More

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February 2021