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A prospective cohort study of ambient air pollution exposure and risk of uterine leiomyomata.

Hum Reprod 2021 May 13. Epub 2021 May 13.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Study Question: To what extent are ambient concentrations of particulate matter <2.5 microns (PM2.5), nitrogen dioxide (NO2) and ozone (O3) associated with risk of self-reported physician-diagnosed uterine leiomyomata (UL)?

Summary Answer: In this large prospective cohort study of Black women, ambient concentrations of O3, but not PM2. Read More

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Long term follow-up of Maduromycosis treatment: A case review.

Int J Surg Case Rep 2021 May 3;82:105956. Epub 2021 May 3.

Orthopedic and Traumatology Departement, Hasanuddin University, Makassar, Indonesia.

Maduromycosis is a rare deep fungal infection characterized by painless progressive destruction of limb caused by either fungal or filamentous bacteria. Its presentation is usually initiated by trivial penetration injury in farmers or laborers, worsen by immunocompromised status. Due to its painless course, this infection will severely destruct and deform hence leading to high morbidity of patient. Read More

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Rationale and Design of the Comparison of Outcomes and Access to Care for Heart Failure (COACH) Trial: A Stepped Wedge Cluster Randomized Trial.

Am Heart J 2021 May 10. Epub 2021 May 10.

Peter Munk Cardiac Centre of the University Health Network, Toronto, Canada; Ted Rogers Centre for Heart Research, Toronto, Canada; University of Toronto, Toronto, Canada.

Background: Heart failure (HF) is an ambulatory care sensitive condition and a leading reason for emergency department (ED) visits and hospitalizations. Improved decision-making and care may enhance safety and efficiency for patients presenting to the ED with acute HF.

Objectives: We will evaluate an intervention comprised of two complementary components: i) the Emergency Heart Failure Mortality Risk Grade simultaneous 7- and 30-day (EHMRG30-ST) risk scores, which will inform admission-discharge decisions, and ii) a rapid outpatient follow-up (RAPID-HF) clinic for low-to-intermediate risk patients on cardiovascular readmissions or death. Read More

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Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure.

Circ Res 2021 May 13;128(10):1468-1486. Epub 2021 May 13.

Division of Cardiology, School of Medicine, University of California San Francisco (J.N.N., J.R.T.), San Francisco, CA.

Acute decompensated heart failure (ADHF) is one of the leading admission diagnoses worldwide, yet it is an entity with incompletely understood pathophysiology and limited therapeutic options. Patients admitted for ADHF have high in-hospital morbidity and mortality, as well as frequent rehospitalizations and subsequent cardiovascular death. This devastating clinical course is partly due to suboptimal medical management of ADHF with persistent congestion upon hospital discharge and inadequate predischarge initiation of life-saving guideline-directed therapies. Read More

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High-Risk Population Based on BC Risk Factors.

Adv Exp Med Biol 2021 ;1187:405-417

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Breast cancer (BC) is the second leading cause of female cancers worldwide in 2018, followed by lung cancer, and the fifth fatal cancer, followed by lung, colorectal, gastric, and liver cancers. The incidence and mortality rates of breast cancer in Western women have been shown to decrease for a long period of time, while the incidence and mortality rates of Asian women are rapidly increasing. The incidence and mortality rates of BC in Western women have been changing to a recent decrease from a fluctuation in rates for a long time, while in Asian women, the incidence and mortality rates have increased rapidly. Read More

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January 2021

gene polymorphisms are associated with the S100B level and Alzheimer's disease risk by altering the miRNA binding capacity.

Aging (Albany NY) 2021 May 12;13. Epub 2021 May 12.

Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.

To examine the role of in genetic susceptibility to Alzheimer's disease (AD), we conducted a case-control study to analyze four polymorphism loci (rs2839364, rs1051169, rs2300403, and rs9722) of the gene and AD risk. We found an independent increased risk of AD in ε4(-) subjects carrying the rs9722 AA-genotype (OR = 2.622, 95% CI = 1. Read More

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Late diagnosis of classic congenital adrenal hyperplasia: long-term consequences during adulthood.

Endocrinol Diabetes Metab Case Rep 2021 May 1;2021. Epub 2021 May 1.

Endocrinology, Diabetes and Metabolism Department, Coimbra Hospital and University Center, Coimbra, Portugal.

Summary: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders related to enzyme deficiencies in the adrenal steroidogenesis pathway leading to impaired corticosteroid biosynthesis. Depending on the extension of enzyme defect, there may be variable severities of CAH - classic and non-classic. We report the case of a 37-year-old male patient with a previously unknown diagnosis of classic CAH referred to Endocrinology evaluation due to class III obesity and insulin resistance. Read More

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Recurrence of Pancreatic Ductal Adenocarcinoma after Complete Histopathological Remission Caused by FOLFIRINOX.

Visc Med 2021 Mar 31;37(2):149-153. Epub 2020 Jul 31.

Department of General and Visceral Surgery, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.

We previously reported 2 cases of pathologic complete response (pCR) of a pancreatic cancer (PC) following neoadjuvant FOLFIRINOX treatment. We now complete our report by a follow-up on both patients. Patient 1 achieved a disease-free survival of 12 months after initial resection until she developed a singular hepatic metastasis. Read More

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Glaucoma in Developing Countries.

Nepal J Ophthalmol 2021 Jan;13(25):112-121

Head, Department of Glaucoma and Research, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.

Glaucoma is a leading cause of blindness worldwide. The diagnosis and management of glaucoma is especially difficult in the developing countries. Lack of cost effective screening strategies, low income, low rates of literacy and inadequate infrastructures and human resources for eye care services are the obstacles for delivering glaucoma service. Read More

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January 2021

Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis.

Cell Death Dis 2021 May 12;12(5):478. Epub 2021 May 12.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

The spermatogenesis process is complex and delicate, and any error in a step may cause spermatogenesis arrest and even male infertility. According to our previous transcriptomic data, CEP70 is highly expressed throughout various stages of human spermatogenesis, especially during the meiosis and deformation stages. CEP70 is present in sperm tails and that it exists in centrosomes as revealed by human centrosome proteomics. Read More

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The role of epigenetic modifications for the pathogenesis of Crohn's disease.

Clin Epigenetics 2021 May 12;13(1):108. Epub 2021 May 12.

Mucosal Immunology Group, Department of Pediatrics, Rostock University Medical Center, Ernst-Heydemann-Str. 8, 18057, Rostock, Germany.

Epigenetics has become a promising field for finding new biomarkers and improving diagnosis, prognosis, and drug response in inflammatory bowel disease. The number of people suffering from inflammatory bowel diseases, especially Crohn's disease, has increased remarkably. Crohn's disease is assumed to be the result of a complex interplay between genetic susceptibility, environmental factors, and altered intestinal microbiota, leading to dysregulation of the innate and adaptive immune response. Read More

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Intersection of Heart Failure and Pregnancy: Beyond Peripartum Cardiomyopathy.

Circ Heart Fail 2021 May 13:CIRCHEARTFAILURE120008223. Epub 2021 May 13.

Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.).

Heart failure (HF) is a leading cause of morbidity and mortality in pregnant women in the United States. Although peripartum cardiomyopathy is the most common diagnosis for pregnant women with HF, women with preexisting cardiomyopathies and systolic dysfunction are also at risk as the hemodynamic demands of pregnancy can lead to decompensation, arrhythmia, and rarely death. The differential diagnosis of HF in pregnancy is broad and includes Takotsubo or stress cardiomyopathy, exacerbation of a preexisting cardiomyopathy, such as familial cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, or left ventricular noncompaction. Read More

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Universal and Programmable Rolling Circle Amplification-CRISPR/Cas12a-Mediated Immobilization-Free Electrochemical Biosensor.

Anal Chem 2021 May 13. Epub 2021 May 13.

Key Laboratory of Luminescence Analysis and Molecular Sensing, School of Chemistry and Chemical Engineering, Southwest University, Tiansheng Road, BeiBei District, Chongqing 400715, P. R. China.

The development of a sensing platform with high sensitivity and specificity, especially programmability and universal applicability, for the detection of clinically relevant molecules is highly valuable for disease monitoring and confirmation but remains a challenge. Here, for the first time, we introduce the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system into an immobilization-free electrochemical biosensing platform for sensitively and specifically detecting the disease-related nucleic acids and small molecules. In this strategy, a modular rolling circle amplification (RCA) is designed to transform and amplify the target recognition event into the universal trigger DNA strand that is used as the trigger to activate the deoxyribonuclease activity of CRISPR/Cas12a for further signal amplification. Read More

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[Risk assessment and management of hepatocellular carcinoma occurrence in patients with chronic hepatitis B in the era of antiviral therapy].

Authors:
H G Xin Q Xie

Zhonghua Gan Zang Bing Za Zhi 2021 Apr;29(4):297-300

Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Chronic hepatitis B (CHB) virus infection remains the leading cause of hepatocellular carcinoma (HCC) in China. Oral antiviral drugs have been shown to significantly reduce the HCC risk in CHB patients, but it cannot completely eliminate the HCC occurrence. Therefore, accurate HCC risk assessment and standardized screening in CHB patients are essential for early diagnosis and improved prognosis. Read More

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Nanobased Platforms for Diagnosis and Treatment of COVID-19: From Benchtop to Bedside.

ACS Biomater Sci Eng 2021 May 12. Epub 2021 May 12.

Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera 56025, Pisa, Italy.

Human respiratory viral infections are the leading cause of morbidity and mortality around the world. Among the various respiratory viruses, coronaviruses (e.g. Read More

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Delayed referral is common even when new-onset diabetes is suspected in children. A Swedish prospective observational study of diabetic ketoacidosis at onset of type 1 diabetes.

Pediatr Diabetes 2021 May 12. Epub 2021 May 12.

Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Introduction: Delayed treatment for new-onset diabetes type 1 (T1D) can lead to diabetic ketoacidosis (DKA) with potentially devastating consequences. This prospective observational study aimed to characterize pediatric patients with DKA at hospital admission, regarding parental awareness of diabetes-related symptoms and delayed referrals from primary health care providers to pediatric emergency wards.

Methods: Patients 0-18 years admitted to hospital with new-onset T1D and DKA between 2015 and 2017 were invited to participate. Read More

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Diagnosis of skin and soft tissue infections using near-infrared spectroscopy.

Acute Med Surg 2021 Jan-Dec;8(1):e642. Epub 2021 May 3.

Department of Emergency and Critical Care Medicine Kitasato University School of Medicine Sagamihara Japan.

Aim: Skin and soft tissue infections are classified into cellulitis and necrotizing fasciitis, which are difficult to distinguish. Necrotizing fasciitis has a poor prognosis and requires immediate intensive care. The diagnostic gold standard is to incise the lesion to determine whether necrosis has reached the fascia. Read More

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Two Similar Cases of a Misdiagnosed Anterior Communicating Aneurysm Rupture.

Case Rep Neurol 2021 Jan-Apr;13(1):218-224. Epub 2021 Apr 6.

Department of Neurosurgery, Na Homolce Hospital, Prague, Czechia.

The misdiagnosis of a ruptured aneurysm directly endangers patient's life and health due to the high risk of rebleeding and its sequelae. In this paper, we present two uncommon cases of anterior communicating artery aneurysm rupture with a relatively small intracerebral bleeding, seemingly without a diffuse subarachnoid hemorrhage (SAH), and a relatively mild clinical presentation. In these cases, the initial diagnosis failed, leading to missed aneurysmal ruptures. Read More

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Sister Mary Joseph Nodules: A Case Report about a Rare Location of Skin Metastasis.

Case Rep Oncol 2021 Jan-Apr;14(1):664-670. Epub 2021 Apr 8.

Department of Medical Oncology, Centre Jean Perrin, Clermont-Ferrand, France.

Umbilical skin metastases (or Sister Mary Joseph nodules) are rare. Their presence typically indicates the late manifestation of deep-seated abdominopelvic malignancy. They occur mainly in gynecological cancers, and gastrointestinal cancers in men. Read More

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Breast Angiosarcoma with a Preoperative Diagnosis of Late Recurrence of Breast Cancer: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):604-609. Epub 2021 Mar 29.

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Angiosarcoma is a malignant mesenchymal tumor characterized by the presence of vascular endothelial cells. Although rare, angiosarcoma developing in the mammary glands has a poor prognosis. We report a case of breast angiosarcoma with a preoperative diagnosis of late recurrence of breast cancer. Read More

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Abdominal Ascites of Unknown Origin: Diagnostic Accuracy of Adenosine Deaminase for Tuberculous Peritonitis.

Case Rep Gastroenterol 2021 Jan-Apr;15(1):418-423. Epub 2021 Apr 6.

Gastroenterology, BronxCare Health System, Bronx, New York, USA.

The occurrence of tuberculosis (TB) is exceedingly rare in the United States (US), and incidence has steadily declined since 1993, but the pace of decline has slowed in recent years. The US TB rate during 2019 declined to 2.7 cases per 100,000 persons, the lowest level on record. Read More

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Fulminant methicillin-sensitive infection: from pinprick to multiorgan failure.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Intensive Care Unit, Aventura Hospital and Medical Center, Aventura, Florida, USA.

A woman in her 60s with diabetes presented to our institution with altered mental status. Preceding symptoms included headaches, nausea and vomiting. One month prior to presentation, she cut her left thumb and developed a pustule, which she occasionally manipulated with a non-sterile needle. Read More

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Molecular detection of Anaplasma phagocytophilum in hair and spleen of cats revealed a possible underestimation of feline vector-borne pathogens.

Res Vet Sci 2021 May 5;137:144-149. Epub 2021 May 5.

Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano Emilia (BO), Italy. Electronic address:

Feline Vector-Borne Diseases show increased global prevalence and some Anaplasma and Ehrlichia species may pose a risk to human health. The diagnosis of Anaplasma and Ehrlichia species infection in cats is achieved by the combined use of different methods as cytologic examination evidencing intracytoplasmic morulae, serologic tests and molecular assays. The peripheral whole blood is considered the sample of choice for Anaplasma and Ehrlichia species DNA detection in cats, but false negative results are reported leading to underestimation of infection prevalence. Read More

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Recurrent Stroke and Fatal Ruptured Mycotic Aneurysm Caused by Invasive Infection.

WMJ 2021 Apr;120(1):82-84

SSM Health Saint Mary's Hospital, Madison, Wisconsin.

Introduction: species are ubiquitous fungi that may cause invasive infection, particularly in immunocompromised patients. Invasive aspergillosis most commonly affects the lungs but can also disseminate to the central nervous system (CNS). Manifestations of CNS aspergillosis include abscesses and, rarely, mycotic aneurysm leading to subarachnoid hemorrhage (SAH). Read More

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Diagnosis and Management of Headache: A Review.

JAMA 2021 May;325(18):1874-1885

Department of Neurology, Weill Cornell Medical College, New York, New York.

Importance: Approximately 90% of people in the US experience headache during their lifetime. Migraine is the second leading cause of years lived with disability worldwide.

Observations: Primary headache disorders are defined as headaches that are unrelated to an underlying medical condition and are categorized into 4 groups: migraine, tension-type headache, trigeminal autonomic cephalalgias, and other primary headache disorders. Read More

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DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4.

Thorac Cancer 2021 May 11. Epub 2021 May 11.

Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Lung cancer is a common tumor and a leading cause of death worldwide. DEAD/H box RNA helicases (DDX) include several family members which regulate mRNA translation in cancer cells. In this study, we demonstrated that DEAD/H box RNA helicase 10 (DDX10) was significantly upregulated in lung cancer tissues compared with adjacent nontumor tissues. Read More

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Risk stratification of indeterminate pulmonary nodules.

Curr Opin Pulm Med 2021 May 10. Epub 2021 May 10.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center Department of Chemistry, Vanderbilt University Cancer Early Detection and Prevention Initiative, Vanderbilt-Ingram Cancer Center Pulmonary and Critical Care Section, Medical Service, Tennessee Valley Healthcare System, Nashville Campus, Nashville, Tennessee, USA Deceased.

Purpose Of Review: Lung cancer remains the leading cause of cancer-related death in the United States, with poor overall 5-year survival. Early detection and diagnosis are key to survival as demonstrated in lung cancer screening trials. However, with increasing implementation of screening guidelines and use of computed tomography, there has been a sharp rise in the incidence of indeterminate pulmonary nodules (IPNs). Read More

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Subglottic and tracheal stenosis associated with coronavirus disease 2019.

J Laryngol Otol 2021 May 11:1-3. Epub 2021 May 11.

ENT - Head and Neck Department, Royal London Hospital, Barts NHS Healthcare Trust, London, UK.

Background: Coronavirus disease 2019 critical care patients endure prolonged periods of intubation. Late tracheostomy insertion, large endotracheal tubes and high cuff pressures increase their risk of subglottic and tracheal stenosis. This patient cohort also often appears to have co-morbidities associated with laryngotracheal stenosis, including high body mass index and laryngopharyngeal reflux. Read More

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A Large Intratemporal Facial Nerve Schwannoma Presenting as an Occluding External Auditory Canal Mass.

Ear Nose Throat J 2021 May 11:1455613211016706. Epub 2021 May 11.

Department of Otorhinolaryngology, 89681The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

Facial nerve schwannomas are rare, benign, slow-growing tumors that can occur in any segment of the facial nerve, although 71% of cases are intratemporal. Surgical resection can lead to facial nerve injury. Facial function recovery after reanimation is usually not better than House-Brackmann (HB) grade III. Read More

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Single institution experience in re-irradiation of biopsy-proven diffuse intrinsic pontine gliomas.

Childs Nerv Syst 2021 May 10. Epub 2021 May 10.

Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI, USA.

Objectives: Diffuse intrinsic pontine glioma (DIPG) is the leading cause of death from CNS tumors in children. Multiple clinical trials have failed to show any benefit from systemic therapy in DIPG, and radiation therapy (RT) alone remains the standard of care. Re-irradiation (rRT) for symptomatic relief is an option at disease progression. Read More

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