9,612 results match your criteria leading channel

Liddle Syndrome due to a Novel c.1713 Deletion in the Epithelial Sodium Channel β-Subunit in a Normotensive Adolescent.

AACE Clin Case Rep 2021 Jan-Feb;7(1):65-68. Epub 2020 Dec 28.

College of Medicine, California Northstate University, Elk Grove, California.

Objective: Liddle syndrome (LS) is a rare autosomal dominant condition secondary to a gain-of-function mutation affecting the epithelial sodium channels (ENaCs) in the distal nephron. It presents with early-onset hypertension, hypokalemia, and metabolic alkalosis in the face of hyporeninemia and hypoaldosteronism. We report a novel mutation affecting the ENaCs in a normotensive adolescent with LS. Read More

View Article and Full-Text PDF
December 2020

A numerical study of arsenic contamination at the Bagnoli bay seabed by a semi-anthropogenic source. Analysis of current regime.

Sci Total Environ 2021 Apr 5;782:146811. Epub 2021 Apr 5.

Italian Institute of Geophysics and Vulcanology (INGV), Italy; CNR-IRISS, Naples, Italy. Electronic address:

Bagnoli Coroglio is an urban district of the City of Naples (South Italy), which fronts the Tyrrhenian Sea for nearly 3 km. It is part of the Campi Flegrei caldera, one of the most explosive volcanic areas in Europe. The need for redeveloping the site after the intense industrial activities of the twentieth century has prompted a remarkable research effort to investigate the pollution's degree, nature, and extent at both the land and seafloor. Read More

View Article and Full-Text PDF

One-step phosphorization preparation of gradient-P-doped CdS/CoP hybrid nanorods having multiple channel charge separation for photocatalytic reduction of water.

J Colloid Interface Sci 2021 Mar 31;596:431-441. Epub 2021 Mar 31.

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua 321004, China. Electronic address:

The separation and transfer of photogenerated charge carriers are the crucial process in photocatalysis, and the realization of multiple charge separation and transfer routes in a single catalyst structure is very promising to achieve high-efficiency catalytic performance. We herein report a simple strategy to synthesize CdS/CoP hybrid nanorods (HNRs) via a one-step phosphorization treatment of the CdS/Co(OH) precursors, in which the gradient-P-doped-CdS NRs and CoP cocatalyst can be synchronously obtained (denoted as gP-CdS/CoP HNRs). The gradient P doping gradually reduced the band gap of CdS as well as elevated Fermi level with doping concentration up, resulting in the formation of a built-in electric field in the CdS NRs. Read More

View Article and Full-Text PDF

Recent advances in the pathophysiology of PIEZO1-related hereditary xerocytosis.

Am J Hematol 2021 Apr 13. Epub 2021 Apr 13.

UR4666 HEMATIM, Université Picardie Jules Verne, Amiens, France.

Hereditary xerocytosis is a rare red blood cell disease related to gain-of-function mutations in the FAM38A gene, encoding PIEZO1, in 90% of cases. PIEZO1 is a broadly expressed mechano-transducer that plays a major role in many cell systems and tissues that respond to mechanical stress. In erythrocytes, PIEZO1 adapts the intracellular ionic content and cell hydration status to the mechanical constraints induced by the environment. Read More

View Article and Full-Text PDF

Hypertension in Kidney Transplant Recipients: Where Are We Today?

Curr Hypertens Rep 2021 Apr 13;23(4):21. Epub 2021 Apr 13.

Department of Nephrology, Hospital Universitario de Badajoz, and Cardiovascular Risk Chair, University of Salamanca School of Medicine, Salamanca, Spain.

Purpose Of Review: Cardiovascular disease is the leading cause of death and allograft loss among kidney transplant recipients, and hypertension is an independent risk factor for cardiovascular morbidity of this patient population. The etiology of hypertension is multifactorial, including pre-transplant volume overload, post-transplant recipient and donor-associated variables, and transplant-specific causes (immunosuppressive medications, allograft dysfunction and surgical complications such as transplant artery stenosis).

Recent Findings: No randomized controlled trials have assessed the optimal blood pressure targets and explored the best antihypertensive regimen for kidney transplant recipients. Read More

View Article and Full-Text PDF

Extracellular cap domain is an essential component of the TRPV1 gating mechanism.

Nat Commun 2021 04 12;12(1):2154. Epub 2021 Apr 12.

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.

Transient receptor potential (TRP) channels are polymodal molecular sensors involved in numerous physiological processes and implicated in a variety of human diseases. Several structures of the founding member of the TRP channel family, TRPV1, are available, all of which were determined for the protein missing the N- and C-termini and the extracellular S5-P-loop. Here, we present structures of the full-length thirteen-lined ground squirrel TRPV1 solved by cryo-EM. Read More

View Article and Full-Text PDF

Stress-Related Brain Neuroinflammation Impact in Depression: Role of the Corticotropin-Releasing Hormone System and P2X7 Receptor.

Neuroimmunomodulation 2021 Apr 12:1-9. Epub 2021 Apr 12.

Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina.

Depression and other psychiatric stress-related disorders are leading causes of disability worldwide. Up to date, treatments of mood disorders have limited success, most likely due to the multifactorial etiology of these conditions. Alterations in inflammatory processes have been identified as possible pathophysiological mechanisms in psychiatric conditions. Read More

View Article and Full-Text PDF

A Heart Failure-Associated Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel.

Front Physiol 2021 22;12:661429. Epub 2021 Mar 22.

Department of Physiology and Cell Biology, Frick Center for Heart Failure and Arrhythmias, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States.

Na1.5, encoded by the gene , is the predominant voltage-gated sodium channel expressed in the heart. It initiates the cardiac action potential and thus is crucial for normal heart rhythm and function. Read More

View Article and Full-Text PDF

Channelopathies in fragile X syndrome.

Nat Rev Neurosci 2021 Apr 7. Epub 2021 Apr 7.

Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA.

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the leading monogenic cause of autism. The condition stems from loss of fragile X mental retardation protein (FMRP), which regulates a wide range of ion channels via translational control, protein-protein interactions and second messenger pathways. Rapidly increasing evidence demonstrates that loss of FMRP leads to numerous ion channel dysfunctions (that is, channelopathies), which in turn contribute significantly to FXS pathophysiology. Read More

View Article and Full-Text PDF

TRPV1 channels as a newly identified target for vitamin D.

Channels (Austin) 2021 Dec;15(1):360-374

Department of Pharmacology and the Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.

Vitamin D is known to elicit many biological effects in diverse tissue types and is thought to act almost exclusively upon its canonical receptor within the nucleus, leading to gene transcriptional changes and the subsequent cellular response. However, not all the observed effects of vitamin D can be attributed to this sole mechanism, and other cellular targets likely exist but remain to be identified. Our recent discovery that vitamin D is a partial agonist of the Transient Receptor Potential Vanilloid family 1 (TRPV1) channel may provide new insights as to how this important vitamin exerts its biological effects either independently or in addition to the nuclear vitamin D receptor. Read More

View Article and Full-Text PDF
December 2021

MCOLN1 gene therapy corrects neurologic dysfunction in the mouse model of mucolipidosis IV.

Hum Mol Genet 2021 Apr 5. Epub 2021 Apr 5.

Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital Research Institute/Harvard Medical School, 185 Cambridge St., Boston, 02114 MA.

Mucolipidosis IV (MLIV) is an orphan disease leading to debilitating psychomotor deficits and vision loss. It is caused by loss-of-function mutations in the MCOLN1 gene that encodes the lysosomal transient receptor potential channel mucolipin1, or TRPML1. With no existing therapy, the unmet need in this disease is very high. Read More

View Article and Full-Text PDF

Direct phase modulation via optical injection: theoretical study.

Opt Express 2021 Mar;29(6):9574-9588

Direct phase modulation via optical injection is a newly developed method for coding the phase of a gain-switched laser, which meets high requirements placed on transmitters for quantum key distribution: compactness, low losses, compatibility with CMOS technologies, and the absence of undesirable effects leading to the side-channel information leakage. Despite the successful implementation and good prospects for the further development of this system, there is still a lack of theoretical investigations of this scheme in the literature. Here, for the first time, we perform its theoretical analysis. Read More

View Article and Full-Text PDF

Reactive Oxygen Species Regulate Endoplasmic Reticulum Stress and ER-Mitochondrial Ca Crosstalk to Promote Programmed Necrosis of Rat Nucleus Pulposus Cells under Compression.

Oxid Med Cell Longev 2021 16;2021:8810698. Epub 2021 Mar 16.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Programmed necrosis of nucleus pulposus (NP) cells caused by excessive compression is a crucial factor in the etiopathogenesis of intervertebral disc degeneration (IVDD). The endoplasmic reticulum (ER) and mitochondria are crucial regulators of the cell death signaling pathway, and their involvement in IVDD has been reported. However, the specific role of ER stress (ERS) and ER-mitochondria interaction in compression-induced programmed necrosis of NP cells remains unknown. Read More

View Article and Full-Text PDF

Decreased 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice.

Hypertension 2021 Apr 5:HYPERTENSIONAHA12016458. Epub 2021 Apr 5.

Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (Y.W., R.Y., Y.L.).

Chronic nicotine exposure significantly increases hypertensive risk in smokers, but the underlying mechanisms are poorly understood. In the kidneys, 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) catalyzes the conversion from active into inactive glucocorticoids and plays a pivotal role in the regulation of blood pressure. We hypothesized that nicotine-induced blood pressure elevation is in part mediated by change in renal 11β-HSD2 leading to higher MR (mineralocorticoid receptor) occupancy. Read More

View Article and Full-Text PDF

Liquid-Liquid Flows with Non-Newtonian Dispersed Phase in a T-Junction Microchannel.

Micromachines (Basel) 2021 Mar 22;12(3). Epub 2021 Mar 22.

Kutateladze Insitute of Thermophysics SB RAS, 630090 Novosibirsk, Russia.

Immiscible liquid-liquid flows in microchannels are used extensively in various chemical and biological lab-on-a-chip systems when it is very important to predict the expected flow pattern for a variety of fluids and channel geometries. Commonly, biological and other complex liquids express non-Newtonian properties in a dispersed phase. Features and behavior of such systems are not clear to date. Read More

View Article and Full-Text PDF

Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing.

Cells 2021 Mar 16;10(3). Epub 2021 Mar 16.

Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg Bad Krozingen, and Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.

The mechanical environment of cardiac cells changes continuously and undergoes major alterations during diseases. Most cardiac diseases, including atrial fibrillation, are accompanied by fibrosis which can impair both electrical and mechanical function of the heart. A key characteristic of fibrotic tissue is excessive accumulation of extracellular matrix, leading to increased tissue stiffness. Read More

View Article and Full-Text PDF

Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression.

Int J Mol Sci 2021 Mar 30;22(7). Epub 2021 Mar 30.

Laboratory of Animal Cell Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi 464-8601, Japan.

Aldosterone excess is a cardiovascular risk factor. Aldosterone can directly stimulate an electrical remodeling of cardiomyocytes leading to cardiac arrhythmia and hypertrophy. L-type and T-type voltage-gated calcium (Ca) channels expression are increased by aldosterone in cardiomyocytes. Read More

View Article and Full-Text PDF

Evaluation of Beta-Catenin Subcellular Localization and Water Channel Protein AQP1 Expression as Predictive Markers of Chemo-Resistance in Ovarian High-Grade Serous Carcinoma: Comparative Study between Preoperative Peritoneal Biopsies and Surgical Samples.

Diagnostics (Basel) 2021 Mar 5;11(3). Epub 2021 Mar 5.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, 00168 Roma, Italy.

Mutations of the β-catenin gene (CTNNB1), leading to aberrant immunohistochemical expression of β-catenin, represent a key mechanism of WNT/β-catenin pathway alteration in ovarian cancer. Aquaporin 1 (AQP1), as component of transmembrane-water-channel family proteins, has been documented in different human tumors and, recently, also in ovarian carcinoma. Only few studies have investigated the pathogenetic and prognostic role of β-catenin and AQP1 in ovarian carcinoma. Read More

View Article and Full-Text PDF

Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita 5650871, Osaka, Japan.

The voltage-gated proton channel, Hv1, also termed VSOP, was discovered in 2006. It has long been suggested that proton transport through voltage-gated proton channels regulate reactive oxygen species (ROS) production in phagocytes by counteracting the charge imbalance caused by the activation of NADPH oxidase. Discovery of Hv1/VSOP not only confirmed this process in phagocytes, but also led to the elucidation of novel functions in phagocytes. Read More

View Article and Full-Text PDF

Bluetooth Low Energy Interference Awareness Scheme and Improved Channel Selection Algorithm for Connection Robustness.

Sensors (Basel) 2021 Mar 24;21(7). Epub 2021 Mar 24.

M-Group, DistriNet, Department of Computer Science, KU Leuven Bruges Campus, 8200 Bruges, Belgium.

Bluetooth Low Energy (BLE) is a popular wireless communication protocol heavily used in Internet of Things applications. Nowadays, robustness is considered a key requirement in wireless communication. However, radio interference from various sources may affect the performance of BLE devices, leading to channel congestion. Read More

View Article and Full-Text PDF

Refining Genotypes and Phenotypes in -Related Neurological Disorders.

Int J Mol Sci 2021 Mar 10;22(6). Epub 2021 Mar 10.

Division of Paediatric Epileptology, Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Pathogenic variants in , encoding for the voltage-gated potassium channel K1.2, have been identified as the cause for an evolving spectrum of neurological disorders. Affected individuals show early-onset developmental and epileptic encephalopathy, intellectual disability, and movement disorders resulting from cerebellar dysfunction. Read More

View Article and Full-Text PDF

Stomach 3D Reconstruction Using Virtual Chromoendoscopic Images.

IEEE J Transl Eng Health Med 2021 24;9:1700211. Epub 2021 Feb 24.

Department of Internal MedicineTsujinaka Hospital KashiwanohaKashiwa277-0871Japan.

Gastric endoscopy is a golden standard in the clinical process that enables medical practitioners to diagnose various lesions inside a patient's stomach. If a lesion is found, a success in identifying the location of the found lesion relative to the global view of the stomach will lead to better decision making for the next clinical treatment. Our previous research showed that the lesion localization could be achieved by reconstructing the whole stomach shape from chromoendoscopic indigo carmine (IC) dye-sprayed images using a structure-from-motion (SfM) pipeline. Read More

View Article and Full-Text PDF
February 2021

High data rate communications in vivo using ultrasound.

IEEE Trans Biomed Eng 2021 Apr 1;PP. Epub 2021 Apr 1.

The emergence of in-body medical devices has provided a means of capturing physiological or diagnostic information and streaming this information outside of the body. Currently, electromagnetic-based communications make up the bulk of in-body medical device communication protocols. Traditional electromagnetic-based solutions are limited in their data rates and available power. Read More

View Article and Full-Text PDF

TRPC5 in cardiovascular diseases.

Rev Cardiovasc Med 2021 Mar;22(1):127-135

Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, P. R. China.

Cardiovascular diseases (CVD), especially acute myocardial infarction, are the leading cause of death, morbidity and disability across the world, affecting millions of people each year. Atherosclerosis (AS) is the major cause of CVD, and is a chronic inflammation involving different cell types and various molecular mechanisms. Ca dynamics of endothelial cells (ECs) and smooth muscle cells (SMCs) exert a significant influence on many aspects of CVD. Read More

View Article and Full-Text PDF

Structure of Gcn1 bound to stalled and colliding 80S ribosomes.

Proc Natl Acad Sci U S A 2021 Apr;118(14)

Institute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany;

The Gcn pathway is conserved in all eukaryotes, including mammals such as humans, where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential effector protein for the kinase Gcn2, which in turn is activated by stalled ribosomes, leading to phosphorylation of eIF2 and a subsequent global repression of translation. The fine-tuning of this adaptive response is performed by the Rbg2/Gir2 complex, a negative regulator of Gcn2. Read More

View Article and Full-Text PDF

Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes.

J Biol Chem 2021 Mar 28:100606. Epub 2021 Mar 28.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. Electronic address:

In addition to maintaining cellular ER Ca stores, store-operated Ca entry (SOCE) regulates several Ca-sensitive cellular enzymes, including certain adenylyl cyclases (ADCYs), enzymes that synthesize the secondary messenger cAMP. Ca, acting with calmodulin (CaM), can also increase the activity of PDE1-family phosphodiesterases (PDEs), which cleave the phosphodiester bond of cAMP. Surprisingly, SOCE regulated cAMP signaling has not been studied in cells expressing both Ca-sensitive enzymes. Read More

View Article and Full-Text PDF

VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release.

Cell Mol Immunol 2021 Mar 30. Epub 2021 Mar 30.

Department of Infectious Diseases, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.

Mitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS-mediated innate immune response. The regulation of mtDNA release upon mitostress remains uncharacterized. Here, we identified mitochondria-associated vaccinia virus-related kinase 2 (VRK2) as a key regulator of this process. Read More

View Article and Full-Text PDF

Transcriptional regulation of intermolecular Ca signaling in hibernating ground squirrel cardiomyocytes: The myocardin-junctophilin axis.

Proc Natl Acad Sci U S A 2021 Apr;118(14)

State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China;

The contraction of heart cells is controlled by the intermolecular signaling between L-type Ca channels (LCCs) and ryanodine receptors (RyRs), and the nanodistance between them depends on the interaction between junctophilin-2 (JPH2) in the sarcoplasmic reticulum (SR) and caveolin-3 (CAV3) in the transversal tubule (TT). In heart failure, decreased expression of JPH2 compromises LCC-RyR communication leading to deficient blood-pumping power. In the present study, we found that JPH2 and CAV3 transcription was concurrently regulated by serum response factor (SRF) and myocardin. Read More

View Article and Full-Text PDF

Role of TRPM7 kinase in cancer.

Cell Calcium 2021 Mar 22;96:102400. Epub 2021 Mar 22.

Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada; Department of Pharmacology, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada. Electronic address:

Cancer is the second leading cause of death worldwide and accounted for an estimated 9.6 million deaths, or 1 in 6 deaths, in 2018. Despite recent advances in cancer prevention, diagnosis, and treatment strategies, the burden of this disease continues to grow with each year, with dire physical, emotional, and economic consequences for all levels of society. Read More

View Article and Full-Text PDF

Analysis of differential expression of hypoxia-inducible microRNA-210 gene targets in mild and severe preeclamptic patients.

Noncoding RNA Res 2021 Mar 9;6(1):51-57. Epub 2021 Mar 9.

Department of Obstetrics and Gynecology, Salmaniya Medical Complex, Manama, Bahrain.

Preeclampsia (PE) is a multi-system disorder that is specific to human pregnancy. Inadequate oxygenation of uterus and placenta is considered as one of the leading causes for the disease. MicroRNA-210(miR-210) is one of the prime molecules that has emerged in response to hypoxia. Read More

View Article and Full-Text PDF