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Exploring the changes of brain immune microenvironment in Alzheimer's disease based on PANDA algorithm combined with blood brain barrier injury-related genes.

Biochem Biophys Res Commun 2021 Apr 14;557:159-165. Epub 2021 Apr 14.

College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave., Shanghai, 201306, PR China. Electronic address:

Studies have shown that the specific entry of peripheral cells into the brain parenchyma caused by BBB injury and the imbalance of the immune microenvironment in the brain are closely related to the pathogenesis of Alzheimer's disease (AD). Because of the difficulty of obtaining data inside the brain, it is urgent to find out the relationship between the peripheral and intracerebral data and their influence on the development of AD by machine learning methods. However, in the actual algorithm design, it is still a challenge to extract relevant information from a variety of data to establish a complete and accurate regulatory network. Read More

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Neutral and Threatening Distracter Word Stimuli are Unnecessarily Stored in Working Memory but Do Not Differ in Their Degree of Working Memory Storage.

Biol Psychol 2021 Apr 14:108091. Epub 2021 Apr 14.

Department of Psychology, University of Wisconsin - Milwaukee, United States. Electronic address:

Evidence suggests that threatening stimuli induce attentional biases compared to neutral stimuli, leading to subsequent storage in working memory. The current study examined how threatening versus neutral word distracters influence attention, and how this affects the unnecessary storage of these task-irrelevant stimuli in working memory. We measured the N2pc and contralateral delay activity (CDA), two event-related potentials (ERPs) that index attentional selection and the number of items maintained in WM, respectively, as participants completed a lateralized change detection task using word stimuli. Read More

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"What did you do this weekend?" Relationships between weekend activities, recovery experiences, and changes in work-related well-being.

Appl Psychol Health Well Being 2021 Apr 17. Epub 2021 Apr 17.

Univ. Grenoble Alpes, SENS, Grenoble, France.

Recovery refers to the process of replenishing resources that occurs when employees distance themselves from their work, leading to improvements in work-related well-being indicators (WRWB), such as burnout and vigor. Research has shown that weekend activities are related to changes in WRWB and that recovery experiences could mediate these relationships. This study aimed to examine the indirect relationships of recovery activities on changes in burnout and vigor, through weekend recovery experiences. Read More

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Back to the future: optimised microwell culture of individual human preimplantation stage embryos.

J Assist Reprod Genet 2021 Apr 16. Epub 2021 Apr 16.

Altravita IVF Clinic, Moscow, Russia.

Although in vitro culture of human embryos is a crucial step in assisted reproduction, the lack of focused research hampers worldwide standardisation and consistent outcomes. Only 1.2% of research papers published in five leading journals in human reproduction in 2019 focused on in vitro culture conditions, creating the impression that the optimisation process has approached its limits. Read More

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Implementation conditions leading to the scale-up of an innovation involving the optimal use of antipsychotics in long-term care centers: The Optimizing Practices, use, Care and Services-Antipsychotics (OPUS-AP) program.

Res Social Adm Pharm 2021 Apr 12. Epub 2021 Apr 12.

University of Sherbrooke, Canada; Research Center on Aging of CIUSSS de L'Estrie-CHUS, Canada. Electronic address:

Background: Antipsychotics are often used for the first-line management of behavioral and psychological symptoms of dementia despite their limited efficacy and the risk of serious adverse drug events, compounded with disregard for guidelines recommending prioritizing non-pharmacological interventions. Some innovative interventions promote the deprescription of antipsychotics in long term care (LTC) settings.

Objective: The objective of this article is to present the conditions leading to the scale-up of an innovative program on the appropriate use of antipsychotics in LTC centers. Read More

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Smoothing the transition of adolescents with CF from pediatric to adult care: Pre-transfer needs.

Arch Pediatr 2021 Apr 13. Epub 2021 Apr 13.

Filière muco CFTR 165, Hospices Civils de Lyon, chemin du Grand-Revoyet, 69310 Pierre-Bénite, France; Unité Transversale en Éducation Thérapeutique du Patient, University Grenoble-Alpes ThEMAS TIMC-IMAG (UMR CNRS 5525), Communaute d'Universités et Établissements Université Grenoble Alpes, 38400 Saint-Martin-d'Hères, France; CRCM pédiatrique UTEP, filière muco CFTR, Communaute d'Universités et Établissements Université Grenoble Alpes, CHU Grenoble Alpes UTEP BP 217, 38043 Grenoble, France.

Introduction: In France, the cystic fibrosis (CF) care pathway is performed in 45 CF centers, the life expectancy of patients has steadily increased, but to date there are no national recommendations for the transition from pediatric to adult care. The transition to an adult CF center still raises questions about the relevance of its organizational arrangements. The "SAFETIM need" study aimed to identify the organizational needs both of patients and of parents before the transfer to an adult CF center. Read More

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Fabrication and characterization of photo-responsive metal-organic framework membrane for gas sensing using planar optical waveguide sensor.

Anal Chim Acta 2021 May 13;1158:338385. Epub 2021 Mar 13.

College of Chemistry, Xinjiang University, Urumqi, 830046, PR China.

A facile, novel fabrication approach using UV light irradiation was proposed to fabricate a photo-responsive metal-organic framework (PR-MOF-1, [Zn-(bdc)-(dpNDI)], where bdc = benzene-1,4-dicarboxylic acid; dpNDI = N,N'-di(4-pyridyl)-1,4,5,8-naphthalenetetracarboxy diimide) membrane. The morphology of the PR-MOF-1 framework evolved from a honeycomb porous structure to a densified ladder-layered structure after 60 min of UV-light illumination. The as-grown film was optically transparent and exhibited a greater sensing response to ethylenediamine (EDA) gas in the presence of interfering substances such as ammonia and dimethylamine as well as benzene, toluene, xylene, and styrene gases, as measured using an asymmetric planar optical waveguide gas sensor. Read More

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A novel miniaturized homogeneous label-free electrochemical biosensing platform combining integrated microelectrode and functional nucleic acids.

Anal Chim Acta 2021 May 17;1158:338415. Epub 2021 Mar 17.

Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education of China, Xi'an, 710061, China. Electronic address:

A miniaturized platform combining integrated microelectrode (IME) and functional nucleic acids was developed for homogeneous label-free electrochemical biosensing. IME was constructed with a carbon fiber microelectrode and a platinum wire in a θ type glass tube as a two-electrode system for electrochemical monitoring at microliter level. A newly reported G-triplex/methylene blue (G3/MB) complex was used as the signal generator in the homogeneous label-free electrochemical biosensor. Read More

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Appetite, oral health and weight loss in community-dwelling older men: an observational study from the Concord Health and Ageing in Men Project (CHAMP).

BMC Geriatr 2021 Apr 16;21(1):255. Epub 2021 Apr 16.

Centre for Education and Research on Ageing, Concord Clinical School, The University of Sydney, and the Ageing and Alzheimer's Institute, Concord Repatriation General Hospital, Sydney Local Health District, Concord, NSW, Australia.

Background: Unintended weight loss and the reduction in appetite are common phenomenon among older people. Reduced appetite has been linked to medication related reductions in saliva production, reduced taste ability and poor oral health. Poor appetite can result in reduced nutrient intake ensuing weight loss. Read More

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Efficacy and safety of fremanezumab in patients with migraine and inadequate response to prior preventive treatment: subgroup analyses by country of a randomized, placebo-controlled trial.

J Headache Pain 2021 Apr 16;22(1):26. Epub 2021 Apr 16.

Department of Neurology, Charité Universitätsmedizin, Charitépl. 1, 10117, Berlin, Germany.

Background: The FOCUS study evaluated the efficacy of migraine preventive medications across different countries within the same patient population, particularly for patients with difficult-to-treat migraine. These prespecified subgroup analyses evaluated efficacy by country in the FOCUS study of fremanezumab in adults with episodic migraine or chronic migraine and documented inadequate response to 2 to 4 migraine preventive medication classes.

Methods: Overall, 838 participants were enrolled in the FOCUS study, a randomized, double-blind, placebo-controlled, parallel-group, phase 3b study performed at 104 sites. Read More

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Early postnatal allergic airway inflammation induces dystrophic microglia leading to excitatory postsynaptic surplus and autism-like behavior.

Brain Behav Immun 2021 Apr 13. Epub 2021 Apr 13.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Translational Neuroscience Center, Graduate School of Medicine, and School of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Ookawa, Fukuoka 831-8501, Japan; Department of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, 2-6-11 Yakuin, Chuo-ku, Fukuoka 810-0022, Japan. Electronic address:

Microglia play key roles in synaptic pruning, which primarily occurs from the postnatal period to adolescence. Synaptic pruning is essential for normal brain development and its impairment is implicated in neuropsychiatric developmental diseases such as autism spectrum disorders (ASD). Recent epidemiological surveys reported a strong link between ASD and atopic/allergic diseases. Read More

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Self-amplifying mRNA-Based Vaccine Technology and Its Mode of Action.

Curr Top Microbiol Immunol 2021 Apr 17. Epub 2021 Apr 17.

GSK, 14200 Shady Grove Road, Rockville, MD, 20850, USA.

Self-amplifying mRNAs derived from the genomes of positive-strand RNA viruses have recently come into focus as a promising technology platform for vaccine development. Non-virally delivered self-amplifying mRNA vaccines have the potential to be highly versatile, potent, streamlined, scalable, and inexpensive. By amplifying their genome and the antigen encoding mRNA in the host cell, the self-amplifying mRNA mimics a viral infection, resulting in sustained levels of the target protein combined with self-adjuvanting innate immune responses, ultimately leading to potent and long-lasting antigen-specific humoral and cellular immune responses. Read More

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Feasibility and Preliminary Efficacy of a Community-Based Addiction Rehabilitation Electronic System in Substance Use Disorder: Pilot Randomized Controlled Trial.

JMIR Mhealth Uhealth 2021 Apr 16;9(4):e21087. Epub 2021 Apr 16.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Drug use disorder has high potential for relapse and imposes an enormous burden on public health in China. Since the promulgation of the Anti-drug law in 2008, community-based rehabilitation has become the primary approach to treat drug addiction. However, multiple problems occurred in the implementation process, leading to a low detoxification rate in the community. Read More

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Restricted Channel Migration in 2D Multilayer ReS.

ACS Appl Mater Interfaces 2021 Apr 16. Epub 2021 Apr 16.

Department of Applied Physics, Sookmyung Women's University, Seoul 04310, Republic of Korea.

When thickness-dependent carrier mobility is coupled with Thomas-Fermi screening and interlayer resistance effects in two-dimensional (2D) multilayer materials, a conducting channel migrates from the bottom surface to the top surface under electrostatic bias conditions. However, various factors including (i) insufficient carrier density, (ii) atomically thin material thickness, and (iii) numerous oxide traps/defects considerably limit our deep understanding of the carrier transport mechanism in 2D multilayer materials. Herein, we report the restricted conducting channel migration in 2D multilayer ReS after a constant voltage stress of gate dielectrics is applied. Read More

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The relationship between air pollutants and maternal socioeconomic factors on preterm birth in California urban counties.

J Expo Sci Environ Epidemiol 2021 Apr 15. Epub 2021 Apr 15.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.

Background: Preterm birth is the leading cause of perinatal morbidity and mortality in the U.S. and disparities among racial and ethnic groups persist. Read More

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Simulation study on the indirect effect of sulfate on the summer climate over the eastern China monsoon region.

Sci Rep 2021 Apr 15;11(1):8295. Epub 2021 Apr 15.

Liaoning Weather Modification Office, Shenyang, 110166, China.

In this study, we designed a sensitivity test using the half number concentration of sulfate in the nucleation calculation process to study the aerosol-cloud interaction (ACI) of sulfate on clouds, precipitation, and monsoon intensity in the summer over the eastern China monsoon region (ECMR) with the National Center for Atmospheric Research Community Atmosphere Model version 5. Numerical experiments show that the ACI of sulfate led to an approximately 30% and 34% increase in the cloud condensation nuclei and cloud droplet number concentrations, respectively. Cloud droplet effective radius below 850 hPa decreased by approximately 4% in the southern ECMR, while the total liquid water path increased by 11%. Read More

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Gamma radiation synthesis of a novel amphiphilic terpolymer hydrogel pH-responsive based chitosan for colon cancer drug delivery.

Carbohydr Polym 2021 Jul 24;263:117975. Epub 2021 Mar 24.

Radiation Research of Polymer Chemistry Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, P.O. Box 8029, Egypt.

Particularly, chitosan (Cs) loaded with drug cannot pass through the colonic region, often leading in the bursting drug release in the stomach due to its solubility in gastric contents. The novelty of the current article is to solve this limitation by performing gamma irradiation cross-linking of Cs with two anionic polymers of (acrylic acid)-co-(2-acrylamido-2-methylpropane-sulfonic acid) (AAc/AMPS) to give amphiphilic hydrogel. The shifted in the characteristic FTIR peaks of Cs in the (Cs/AAc/AMPS) confirm the exits of inter-molecular interactions that make Cs and (AAc/AMPS) are miscible. Read More

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Stimulus valence, episodic memory, and the priming of brain activation profiles in borderline personality disorder.

Psychol Med 2021 Apr 16:1-11. Epub 2021 Apr 16.

Department of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, USA.

Background: Borderline personality disorder (BPD) is characterized by instability in affective regulation that can result in a loss of cognitive control. Triggers may be neuronal responses to emotionally valenced context and/or stimuli. 'Neuronal priming' indexes the familiarity of stimuli, and may capture the obligatory effects of affective valence on the brain's processing system, and how such valence mediates responses to the repeated presentation of stimuli. Read More

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Ratiometric fluorescent detection of silver nanoparticles in aqueous samples using peptide-based fluorogenic probes with aggregation-induced emission characteristics.

J Hazard Mater 2021 Jun 13;411:125041. Epub 2021 Jan 13.

Department of Chemistry and Chemical Engineering, Inha University, Incheon 402-751, South Korea. Electronic address:

The quantification of silver nanoparticles and Ag contamination in the aquatic ecosystem has attracted considerable interest. Benzoimidazolyl-cyanovinylene (1) was synthesized as an aggregation-induced emission fluorophore, and a fluorescent peptidyl probe (2 and 3) bearing this fluorophore was developed. The fluorescent peptidyl probes coordinated with Ag selectively among various metal ions, leading to a ratiometric response to Ag in pure aqueous solutions. Read More

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Characteristics Associated With Functional Changes During Systemic Cancer Treatments: A Systematic Review Focused on Older Adults.

J Natl Compr Canc Netw 2021 Apr 15:1-8. Epub 2021 Apr 15.

2Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

Background: Maintaining functional status is important to older adults with cancer, but data are limited on how systemic treatments affect functional status. We systematically reviewed changes in functional status during systemic cancer treatments and identified characteristics associated with functional decline and improvement.

Methods: We searched PubMed, Embase, Web of Science, and Cochrane Register of Controlled Trials for articles examining characteristics associated with functional changes in older adults during systemic cancer treatment published in English between database inception and January 11, 2019 (PROSPERO CRD42019123125). Read More

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Effect of East Asian atmospheric particulate matter deposition on bacterial activity and community structure in the oligotrophic Northwest Pacific.

Environ Pollut 2021 Apr 5;283:117088. Epub 2021 Apr 5.

College of Marine Life Sciences, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, 266003, China; Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.

Large amounts of anthropogenic East Asian (EA) particulate matters (PM), containing inorganic nutrients and organic matter, are deposited in the oligotrophic Northwest Pacific Ocean. However, the effects of such deposition on marine microbes remain unclear. In this study, the effect of EA PM deposition on marine bacteria was assessed by five on-board microcosm experiments, conducted in oligotrophic basins of the South China Sea. Read More

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Non-Surgical Interventions for Lumbar Spinal Stenosis Leading To Neurogenic Claudication: A Clinical practice guideline.

J Pain 2021 Apr 12. Epub 2021 Apr 12.

Health Systems Management, Rush University, Chicago, Illinois, USA; Director of Research, American Hip Institute. Electronic address:

Lumbar spinal stenosis (LSS) causing neurogenic claudication (NC) is increasingly common with an aging population and can be associated with significant symptoms and functional limitations. We developed this guideline to present the evidence and provide clinical recommendations on non-surgical management of patients with LSS causing NC. Using the GRADE approach, a multidisciplinary guidelines panel based recommendations on evidence from a systematic review of randomized controlled trials and systematic reviews published through June 2019, or expert consensus. Read More

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Assessment of West Nile Virus Lineage 2 Dynamics in Greece and Future Implications.

Vector Borne Zoonotic Dis 2021 Apr 15. Epub 2021 Apr 15.

Department of Microbiology and Immunology, Georgetown University, Washington, District of Columbia, USA.

The emergence of West Nile Virus lineage 2 (WNV-2) has contributed to multiple major human outbreaks in Greece since 2010. Studies to date investigating biological and environmental factors that contribute to West Nile Virus (WNV) transmission have resulted in complex statistical models. We sought to examine open publicly available data to ascertain if a predictive risk assessment could be employed for WNV-2 in Greece. Read More

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Free-Radical Generation from Bulk Nanobubbles in Aqueous Electrolyte Solutions: ESR Spin-Trap Observation of Microbubble-Treated Water.

Langmuir 2021 Apr 15. Epub 2021 Apr 15.

New Industry Creation Hatchery Center, Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan.

Microbubbles are very fine bubbles that shrink and collapse underwater within several minutes, leading to the generation of free radicals. Electron spin resonance spectroscopy (ESR) confirmed the generation of hydroxyl radicals under strongly acidic conditions. The drastic environmental change caused by the collapse of the microbubbles may trigger radical generation via the dispersion of the elevated chemical potential that had accumulated around the gas-water interface. Read More

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How resilient is reading to letter rotations? A parafoveal preview investigation.

J Exp Psychol Learn Mem Cogn 2021 Apr 15. Epub 2021 Apr 15.

Departamento de Metodologia and ERI-Lectura.

Skilled readers have developed a certain amount of tolerance to variations in the visual form of words (e.g., CAPTCHAs, handwritten text, etc. Read More

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Advancing Evidence-Based Practice Through Implementation Science: Critical Contributions of Doctor of Nursing Practice- and Doctor of Philosophy-Prepared Nurses.

Worldviews Evid Based Nurs 2021 Apr;18(2):93-101

College of Nursing, Helene Fuld Health Trust National Institute for EBP, The Ohio State University, Columbus, OH, USA.

Purpose: Describe the evolution of implementation science and the roles and potential collaborations of doctorally prepared nurses to advance implementation science in practice settings.

Methods: Review of academic preparation and areas of expertise for doctorally prepared nurses as it relates to implementation science and evidence-based practice (EBP).

Findings: There have been substantial gains in the number of academic programs in healthcare that include content on EBP, resulting in healthcare teams that are motivated to align practices with best evidence. Read More

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A novel PSEN2 p.Ser175Phe variant in a family with Alzheimer's disease.

Neurol Sci 2021 Apr 15. Epub 2021 Apr 15.

Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Alzheimer's disease (AD) can be either sporadic or familial, and familial forms of AD accounts for only 5% of the cases. So far, autosomal dominantly inherited mutations in "Presenilin 1" (PSEN1), "Presenilin 2" (PSEN2), and "Amyloid precursor protein" (APP) genes were associated with familial AD. Amid the others, pathogenic mutations in the PSEN2 gene are less common. Read More

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Intermittent two-drug antiretroviral therapies maintain long-term viral suppression in real life in highly experienced HIV-infected patients.

J Antimicrob Chemother 2021 Apr 14. Epub 2021 Apr 14.

Sorbonne University, Infectious Diseases Department, Pitié-Salpêtrière Hospital, AP-HP, Pierre Louis Epidemiology and Public Health Institute (iPLESP), INSERM 1136, Paris, France.

Objectives: To assess in real life whether two-drug regimens (2-DRs) given 4-5 days a week in virally suppressed patients can maintain viral suppression over 48 and 96 weeks.

Methods: This observational single-centre study enrolled all patients who initiated an intermittent 2-DR between 01/01/2016 and 30/06/2019. The primary outcome was the rate of virological failure (VF), defined as confirmed plasma viral load (pVL) ≥50 copies/mL or single pVL ≥50 copies/mL followed by ART change at week 48 (W48) and W96. Read More

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Interactions between serum FSH, inhibin B and antral follicle count in the decline of serum AMH during the menstrual cycle in late reproductive age.

Endocrinol Diabetes Metab 2021 Apr 8;4(2):e00172. Epub 2020 Aug 8.

Department of Academic Family Medicine College of Medicine University of Saskatchewan Saskatchewan Canada.

Objective: To investigate the hormonal interrelationships during the menstrual cycle in women of late reproductive age with suppressed serum AMH and antral follicle count (AFC).

Methods: Serum hormones (AMH, FSH, LH, estradiol, progesterone, inhibin A, inhibin B), AFC (2-10 mm) and AMH/AFC ratio (an estimate of AMH/follicle) were assessed every 2-3 days across the menstrual cycle in 26 healthy ovulatory women aged 18-50 years.

Results: An 11-fold fall in AMH/AFC was observed in women aged ≥45 years compared to those 18-45 years ( < . Read More

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NAFLD-Associated HCC: Progress and Opportunities.

J Hepatocell Carcinoma 2021 8;8:223-239. Epub 2021 Apr 8.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Due to an increase in the obesity-associated metabolic syndrome of epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of hepatocellular carcinoma (HCC) in western countries. This presents added challenges, as NAFLD-associated HCC tends to present at an advanced stage in older patients with co-morbidities. Their prognosis is generally poor with the benefits of standard therapies less certain. Read More

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