73,648 results match your criteria lead morbidity


Challenges in replicating secondary analysis of electronic health records data with multiple computable phenotypes: A case study on methicillin-resistant Staphylococcus aureus bacteremia infections.

Int J Med Inform 2021 Jul 16;153:104531. Epub 2021 Jul 16.

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:

Background: Replication of prediction modeling using electronic health records (EHR) is challenging because of the necessity to compute phenotypes including study cohort, outcomes, and covariates. However, some phenotypes may not be easily replicated across EHR data sources due to a variety of reasons such as the lack of gold standard definitions and documentation variations across systems, which may lead to measurement error and potential bias. Methicillin-resistant Staphylococcus aureus (MRSA) infections are responsible for high mortality worldwide. Read More

View Article and Full-Text PDF

Preanalytic and analytic factors affecting the measurement of haemoglobin concentration: impact on global estimates of anaemia prevalence.

BMJ Glob Health 2021 Jul;6(7)

Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

The accuracy of haemoglobin concentration measurements is crucial for deriving global anaemia prevalence estimates and monitoring anaemia reduction strategies. In this analysis, we examined and quantified the factors affecting preanalytic and analytic variation in haemoglobin concentrations. Using cross-sectional data from three field studies (in children, pregnant and nonpregnant women), we examined the difference in haemoglobin concentration between venous-drawn and capillary-drawn blood measured by HemoCue (ie, preanalytic) and modelled how the bias observed may affect anaemia prevalence estimates in population surveys and anaemia public health severity classification across countries. Read More

View Article and Full-Text PDF

External Applicability of the COMPASS and VOYAGER-PAD Trials on Patients with Symptomatic Lower Extremity Artery Disease in France: The COPART Registry.

Eur J Vasc Endovasc Surg 2021 Jul 28. Epub 2021 Jul 28.

Department of Vascular Medicine, Toulouse University Hospital, Toulouse, France; UMR 1031 INSERM, StromaLab, Toulouse III - Paul Sabatier University, Toulouse, France.

Objective: The aim of this study was to examine the external applicability of the COMPASS and the VOYAGER-PAD trials in patients with lower extremity artery disease (LEAD) in the real world.

Methods: This was a multicentre retrospective analysis of prospectively collected COPART data, a French multicentre registry of patients hospitalised for symptomatic LEAD. The proportion of patients eligible for the combination of rivaroxaban 2. Read More

View Article and Full-Text PDF

Development and Application of an interactive Physiologically Based Pharmacokinetic (iPBPK) Model to Predict Oxytetracycline Tissue Distribution and Withdrawal Intervals in Market-Age Sheep and Goats.

Toxicol Sci 2021 Jul 30. Epub 2021 Jul 30.

Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506.

Oxytetracycline (OTC) is a widely used antibiotic in food-producing animals. Extralabel use of OTC is common and may lead to violative residues in edible tissues. It is important to have a quantitative tool to predict scientifically-based withdrawal intervals (WDIs) after extralabel use in food animals to ensure human food safety. Read More

View Article and Full-Text PDF

From late fatherhood to prenatal screening of monogenic disorders: evidence and ethical concerns.

Hum Reprod Update 2021 Jul 30. Epub 2021 Jul 30.

Competence Centre on Health Technologies, Tartu, Estonia.

Background: With the help of ART, an advanced parental age is not considered to be a serious obstacle for reproduction anymore. However, significant health risks for future offspring hide behind the success of reproductive medicine for the treatment of reduced fertility associated with late parenthood. Although an advanced maternal age is a well-known risk factor for poor reproductive outcomes, understanding the impact of an advanced paternal age on offspring is yet to be elucidated. Read More

View Article and Full-Text PDF

The health literacy disparity in adolescents with sickle cell disease.

J Spec Pediatr Nurs 2021 Jul 29:e12353. Epub 2021 Jul 29.

Louise Herrington School of Nursing, Baylor University, Dallas, Texas, USA.

Purpose: There are over 100,000 individuals with sickle cell disease (SCD) in the United States, most of whom are Black, poor, and publically insured. In combination with a chronic illness, these demographics lead to significant barriers to healthcare for patients with SCD, leaving them exceptionally vulnerable within the healthcare system. This unique vulnerability is especially notable when transitioning adolescents with SCD from pediatric to adult care, as this is a significant time of morbidity and mortality for these patients. Read More

View Article and Full-Text PDF

Factors Affecting Willingness to Use Indoor Residual Spraying Among Pregnant Women Attending Antenatal Care in Hyperendemic State of West Africa: A Random Survey.

J Med Entomol 2021 Jul 30. Epub 2021 Jul 30.

Oyo State College of Health Science and Technology, Ibadan, Nigeria.

This study assessed the perception of pregnant women on indoor residual spraying (IRS), documented acceptability, and factors that significantly dictate willingness to use IRS among the pregnant women attending antenatal clinic in Ibadan Nigeria. A structured questionnaire was used to obtain relevant information from 500 pregnant women. Descriptive and principal component analysis (PCA) were done at 5% level of significance. Read More

View Article and Full-Text PDF

Atypical Burkholderia Cepacia Resistance to Ceftazidime/Avibactam and Co-trimoxazole: A Case of Open Wound Contamination and Persistent Bacteremia.

Cureus 2021 Jun 22;13(6):e15836. Epub 2021 Jun 22.

Internal Medicine, Central Hospital, Benin City, NGA.

Wound contamination and subsequent colonization by microbes can significantly impair tissue repair and lead to the development of chronic non-healing ulcers. Atypical and bacterial species are common in cases of soil contamination of open wounds leading to a complex infection that is both difficult to diagnose and treat. Despite much research on the involvement of atypical organisms, including and , in antibiotic resistance, there is no consensus on the timeline from contamination to infection and on an algorithm for early diagnosis and management. Read More

View Article and Full-Text PDF

The effects of genetic drift and genomic selection on differentiation and local adaptation of the introduced populations of in southern Russia.

PeerJ 2021 21;9:e11776. Epub 2021 Jul 21.

Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov University, Moscow, Russian Federation.

Background: Asian tiger mosquito is an arbovirus vector that has spread from its native habitation areal in Southeast Asia throughout North and South Americas, Europe, and Africa. was first detected in the Southern Federal District of the Russian Federation in the subtropical town of Sochi in 2011. In subsequent years, this species has been described in the continental areas with more severe climate and lower winter temperatures. Read More

View Article and Full-Text PDF

Current Practices in Missing Data Handling for Interrupted Time Series Studies Performed on Individual-Level Data: A Scoping Review in Health Research.

Clin Epidemiol 2021 23;13:603-613. Epub 2021 Jul 23.

Research Department of Primary Care and Population Health, University College London (UCL), London, UK.

Objective: Missing data can produce biased estimates in interrupted time series (ITS) analyses. We reviewed recent ITS investigations on health topics for determining 1) the data management strategies and statistical analysis performed, 2) how often missing data were considered and, if so, how they were evaluated, reported and handled.

Study Design And Setting: This was a scoping review following standard recommendations from the PRISMA Extension for Scoping Reviews. Read More

View Article and Full-Text PDF

A bioimpedance-based monitor for real-time detection and identification of secondary brain injury.

Sci Rep 2021 Jul 29;11(1):15454. Epub 2021 Jul 29.

Thayer School of Engineering, Dartmouth College, HB 8000, 14 Engineering Dr., Hanover, NH, 03755, USA.

Secondary brain injury impacts patient prognosis and can lead to long-term morbidity and mortality in cases of trauma. Continuous monitoring of secondary injury in acute clinical settings is primarily limited to intracranial pressure (ICP); however, ICP is unable to identify essential underlying etiologies of injury needed to guide treatment (e.g. Read More

View Article and Full-Text PDF

Study protocol for a randomised controlled trial evaluating the clinical effect of antibiotic prophylaxis in children with recurrent respiratory tract infections: the Approach study.

BMJ Open 2021 Jul 29;11(7):e044505. Epub 2021 Jul 29.

Department of Paediatric Infectious Diseases and Immunology, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands

Introduction: Respiratory tract infections (RTIs) affect children all over the world and are associated with significant morbidity and mortality. In particular, recurrent RTIs cause a high burden of disease and lead to frequent doctor visits. Children with recurrent RTIs generally have no significant alterations or deficits in systemic immunity. Read More

View Article and Full-Text PDF

Relationships of beverage consumption and actigraphy-assessed sleep parameters among urban-dwelling youth from Mexico.

Public Health Nutr 2021 Jul 30:1-24. Epub 2021 Jul 30.

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Objective: To examine whether usual beverage intake was associated with sleep timing, duration, and fragmentation among adolescents.

Design: Usual beverage intake was assessed with a food frequency questionnaire. Outcomes included sleep duration, midpoint (median of bed and wake times), and fragmentation, assessed with 7-day actigraphy. Read More

View Article and Full-Text PDF

Hyperemesis gravidarum and vitamin K deficiency: a systematic review.

Br J Nutr 2021 Jul 30:1-31. Epub 2021 Jul 30.

Amsterdam University Medical Centers, University of Amsterdam, department of Obstetrics and Gynaecology, Amsterdam Reproduction & Development research institute, Meibergdreef 9, Amsterdam, the Netherlands.

Hyperemesis gravidarum (HG), severe nausea and vomiting in pregnancy, can lead to vitamin deficiencies. Little is known about HG-related vitamin K deficiency. We aim to summarize available evidence on the occurrence of HG-related vitamin K deficiency and corresponding maternal and neonatal complications. Read More

View Article and Full-Text PDF

Directional deep brain stimulation of the posteromedial hypothalamus for refractory intermittent explosive disorder: a case series using a novel neurostimulation device and intraoperative microdialysis.

World Neurosurg 2021 Jul 26. Epub 2021 Jul 26.

Division of Neuroscience, Sírio-Libanês Hospital, São Paulo, Brazil; LIM 23, Institute of Psychiatry, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil.

Background: Intermittent Explosive Disorder (IED) is a psychiatric disorder characterized by recurrent outbursts of aggressive behaviour. Deep brain stimulation (DBS) in the posteromedial nucleus of the hypothalamus (pHyp) is an alternative therapy for extreme cases and shows promising results. Intraoperative microdialysis can help elucidate the neurobiological mechanism of pHyp-DBS. Read More

View Article and Full-Text PDF

Accurate influenza forecasts using type-specific incidence data for small geographic units.

PLoS Comput Biol 2021 Jul 29;17(7):e1009230. Epub 2021 Jul 29.

Infectious Disease Group, Predictive Science Inc., San Diego, California, United States.

Influenza incidence forecasting is used to facilitate better health system planning and could potentially be used to allow at-risk individuals to modify their behavior during a severe seasonal influenza epidemic or a novel respiratory pandemic. For example, the US Centers for Disease Control and Prevention (CDC) runs an annual competition to forecast influenza-like illness (ILI) at the regional and national levels in the US, based on a standard discretized incidence scale. Here, we use a suite of forecasting models to analyze type-specific incidence at the smaller spatial scale of clusters of nearby counties. Read More

View Article and Full-Text PDF

Pulmonary Hypertension in the child with Bronchopulmonary Dysplasia.

Pediatr Pulmonol 2021 Jul 29. Epub 2021 Jul 29.

Pediatric Allergy, Immunology, and Pulmonary Medicine, t University Medical Center, Nashville, TN.

Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of prematurity resulting from complex interactions of perinatal factors that often lead to prolonged respiratory support and increased pulmonary morbidity. There is also growing appreciation for the dysmorphic pulmonary bed characterized by vascular growth arrest and remodeling, resulting in pulmonary vascular disease (PVD) and its most severe form, pulmonary hypertension (PH) in children with BPD. In this review, we comprehensively discuss the pathophysiology of PH in children with BPD, evaluate the current recommendations for screening and diagnosis of pulmonary hypertension, discern associated comorbid conditions, and outline the current treatment options. Read More

View Article and Full-Text PDF

The role of grit and resilience in children with reading disorder: a longitudinal cohort study.

Ann Dyslexia 2021 Jul 29. Epub 2021 Jul 29.

Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave, San Francisco, CA, 94143, USA.

Prior studies have suggested that grit and resilience predict both academic and career success. However, these qualities have not been examined in children with reading disorder (RD). We therefore investigated whether grit and resilience were associated with anxiety, depression, academic performance, and quality of life (QOL) in these students. Read More

View Article and Full-Text PDF

Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.

Clin Transl Med 2021 Jul;11(7):e410

State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Liver fibrosis and fibrosis-related hepatocarcinogenesis are a rising cause for morbidity and death worldwide. Although transforming growth factor-β (TGF-β) is a critical mediator of chronic liver fibrosis, targeting TGF-β isoforms and receptors lead to unacceptable side effect. This study was designed to explore the antifibrotic effect of Compound kushen injection (CKI), an approved traditional Chinese medicine formula, via a therapeutic strategy of rebalancing TGF-β/Smad7 signaling. Read More

View Article and Full-Text PDF

Training general practitioners in the ABC 5As method of delivering stop-smoking advice: a pragmatic, two-arm cluster randomised controlled trial.

ERJ Open Res 2021 Jul 26;7(3). Epub 2021 Jul 26.

Institute of General Practice (Ifam), Centre for Health and Society (chs), Addiction Research and Clinical Epidemiology Unit, Medical Faculty of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

This study assessed the effectiveness of a 3.5-h training session for general practitioners (GPs) in providing brief stop-smoking advice and compared two methods of giving advice - ABC 5As - on the rates of delivery of such advice and of recommendations of evidence-based smoking cessation treatment during routine consultations. A pragmatic, two-arm cluster randomised controlled trial was carried out including a pre-/post-design for the analyses of the primary outcome in 52 GP practices in Germany. Read More

View Article and Full-Text PDF

Long Non-Coding RNAs in Diagnosis, Treatment, Prognosis, and Progression of Glioma: A State-of-the-Art Review.

Front Oncol 2021 12;11:712786. Epub 2021 Jul 12.

Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Glioma is the most common malignant central nervous system tumor with significant mortality and morbidity. Despite considerable advances, the exact molecular pathways involved in tumor progression are not fully elucidated, and patients commonly face a poor prognosis. Long non-coding RNAs (lncRNAs) have recently drawn extra attention for their potential roles in different types of cancer as well as non-malignant diseases. Read More

View Article and Full-Text PDF

Diagnostic Value of High-Resolution Computed Tomography Scan in COVID-19: Do We Need to Think Outside the Box?

Cureus 2021 Jun 23;13(6):e15849. Epub 2021 Jun 23.

Radiology, Sargoda Medical College, Sargoda, PAK.

Background and objective The ambiguous nature and high infectivity of the coronavirus disease 2019 (COVID-19) have caused soaring morbidity and mortality worldwide. Real-time polymerase chain reaction (RT-PCR) is preferred for detecting COVID-19. However, its poor sensitivity and the emerging use of high-resolution CT (HRCT) scan for disease severity make the use of RT-PCR quite obsolete. Read More

View Article and Full-Text PDF

Prevalence of positive factor V Leiden and prothrombin mutations in samples tested for thrombophilia in Saudi Arabia.

Am J Blood Res 2021 15;11(3):255-260. Epub 2021 Jun 15.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre (KFSH&RC) Riyadh, Saudi Arabia.

Venous thromboembolism (VTE) is a multifactorial disease that results from the interaction of both inherited and acquired risk factors. The complications of these risk factors often lead to significant morbidity and mortality. There are many inherited thrombophilia risk factors, such as factor V Leiden (FVL) and prothrombin gene mutation (PT). Read More

View Article and Full-Text PDF

Coping with dyspareunia, the importance of inter and intrapersonal context on women's sexual distress: a population-based study.

Reprod Health 2021 Jul 28;18(1):161. Epub 2021 Jul 28.

Department of Reproductive Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Recently known as the genito-pelvic pain/penetration disorder (GPPPD), Dyspareunia is considered a negative factor affecting a couple's sexual health. This paper analyzes pain in Dyspareunia cases and determines protective factors causing lower levels of sexual distress among patients.

Methods: In a population-based cross-sectional study conducted in 2017, the cluster quota sampling technique was adopted to randomly select 590 Iranian married women aged 18-70 years from 30 health centers. Read More

View Article and Full-Text PDF

Exposure to Neurointervention During Neurology Training.

Stroke 2021 Jul 29:STROKEAHA121036026. Epub 2021 Jul 29.

Department of Neurology and Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (A.P.J.).

There is an urgent need to include a dedicated neurointerventional rotation in the curriculum of neurology residency and vascular neurology fellowship based on the paradigm shift in recent years of stroke workflow. The recent changes coupled with growing body of evidence about lack of neurointerventional exposure in current curriculum makes it imperative for us to restructure the training for future neurologists. The exposure will prepare the neurology house-staff for the contemporary management of cerebrovascular diseases and will lead to high quality, patient-centric care. Read More

View Article and Full-Text PDF

Impact of scaling up prenatal nutrition interventions on human capital outcomes in low- and middle-income countries: a modeling analysis.

Am J Clin Nutr 2021 Jul 28. Epub 2021 Jul 28.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: Prenatal nutrition interventions can lead to improved birth outcomes, which in turn are associated with better education and human capital outcomes later in life.

Objective: We estimated the impact of scaling up iron-folic acid (IFA), calcium, multiple micronutrient (MMS), and balanced energy protein (BEP) supplementation for pregnant women, on human capital outcomes in low- and middle-income countries (LMIC).

Methods: We used mathematical modeling with proportional reductions in adverse birth outcomes to estimate the potential gains in school years and lifetime income due to scaling up each prenatal nutrition intervention. Read More

View Article and Full-Text PDF

A Novel Small Molecule Inhibits Hepatitis C Virus Propagation in Cell Culture.

Microbiol Spectr 2021 Jul 28:e0043921. Epub 2021 Jul 28.

Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.

Hepatitis C virus (HCV) can cause acute and chronic infection that is associated with considerable liver-related morbidity and mortality. In recent years, there has been a shift in the treatment paradigm with the discovery and approval of agents that target specific proteins vital for viral replication. We employed a cell culture-adapted strain of HCV and human hepatoma-derived cells lines to test the effects of our novel small-molecule compound (AO13) on HCV. Read More

View Article and Full-Text PDF

The Effect of Good Enough Sex (GES) Model-Based Sexual Counseling Intervention on the Body Image in Women Surviving Breast Cancer: A Randomized Clinical Trial.

Asian Pac J Cancer Prev 2021 Jul 1;22(7):2303-2310. Epub 2021 Jul 1.

Department of Reproductive Health Midwifery, School of Nursing & Midwifery, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Women undergoing breast cancer treatment experience a number of changes, including loss or deformity of one or both breasts, surgical wounds, skin changes, and weight gain. These changes are very closely related to physical appearance and body image and often lead to reduced mental health, marital quality and psychological stress.  Objective: This study aimed to determine the effect of Good Enough Sex (GES) model-based counseling intervention on the body image in women surviving breast cancer. Read More

View Article and Full-Text PDF

Frailty in Parkinson's disease: A systematic review and meta-analysis.

Clin Park Relat Disord 2021 25;4:100095. Epub 2021 May 25.

Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Introduction: Frailty and Parkinson's disease (PD) are common conditions that increase with age. Independently, frailty and PD lead to increased morbidity and mortality for patients. Few studies report on frailty in patients with PD. Read More

View Article and Full-Text PDF

Pediatric Skull Base Tumors: A Management Challenge.

J Pediatr Neurosci 2021 Jan-Mar;16(1):35-43. Epub 2021 Jun 25.

Division of Neurosurgery, Department of Surgery and Anatomy, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Context: Skull base tumors are varied in children and are particularly challenging to pediatric neurosurgeons, with few papers in the literature describing the evolution, complications, and outcome. The authors evaluated long-term outcomes in children submitted to skull base tumor surgery and performed a literature review.

Aims: The aim of this study was to analyze surgical results, complications, and outcomes, on comparison with previous publications. Read More

View Article and Full-Text PDF