Crit Care Med 2021 Apr 5. Epub 2021 Apr 5.
1 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 2 Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. 3 Department of Medicine, Division of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 4Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. 5 Department of Anesthesiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY.
Objectives: In patients with coronavirus disease 2019-associated acute respiratory distress syndrome, sedatives and opioids are commonly administered which may lead to increased vulnerability to neurologic dysfunction. We tested the hypothesis that patients with coronavirus disease 2019-associated acute respiratory distress syndrome are at higher risk of in-hospital mortality due to prolonged coma compared with other patients with acute respiratory distress syndrome matched for disease severity.
Design: Propensity-matched cohort study. Read More