39,967 results match your criteria lead concentrations

Changes in nutrient balance, methane emissions, physiologic biomarkers and production performance in goats fed different forage-to-concentrate ratios during lactation.

J Anim Sci 2021 Apr 13. Epub 2021 Apr 13.

Department of Animal Sciences, Division of Nutritional Sciences, University of Illinois, Urbana, USA.

The objective was to determine the effect forage to concentrate (F:C) ratio and stage of lactation on methane emissions, digestibility, nutrient balance, lactation performance, and metabolic responses in lactating goats. Twenty Murciano-Granadina dairy goats were used in an experiment divided into three periods: early (30 d), mid (100 d) and late (170 d) lactation. All goats were fed a diet with 35:65 F:C (FCL) during early-lactation. Read More

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Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells.

Mol Neurobiol 2021 Apr 13. Epub 2021 Apr 13.

Brain Research Laboratory, Department of Emergency Medicine, Emory University School of Medicine, Whitehead Biomedical Research Building, Room 655A, Atlanta, GA, 30322, USA.

A substantial literature supports the notion that cancer is a metabolic disease. Mitochondria are sexually dimorphic, and progesterone (P4) plays a key regulatory role in mitochondrial functions. We investigated the effect of P4 on mitochondrial functions in three human glioblastoma multiforme (GBM) cell lines. Read More

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Omnipresent distribution of herbicides and their transformation products in all water body types of an agricultural landscape in the North German Lowland.

Environ Sci Pollut Res Int 2021 Apr 13. Epub 2021 Apr 13.

Institute of Natural Resource Conservation, Christian-Albrechts University Kiel, Olshausenstr. 75, 24118, Kiel, Germany.

The research of the environmental fate of pesticides has demonstrated that applied compounds are altered in their molecular structure over time and are distributed within the environment. To assess the risk for contamination by transformation products (TP) of the herbicides flufenacet and metazachlor, the following four water body types were sampled in a small-scale catchment of 50 km in 2015/2016: tile drainage water, stream water, shallow groundwater, and drinking water of private wells. The TP were omnipresent in every type of water body, more frequently and in concentrations up to 10 times higher than their parent compounds. Read More

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High glucose promotes the aging of human dental pulp cells through Wnt/beta-catenin signaling.

Dent Med Probl 2021 Jan-Mar;58(1):39-46

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Iran.

Background: Diabetes is one of the most common metabolic diseases that disrupt the functioning of different body organs, including oral tissue. Some diabetic complications remain even after the control of the hyperglycemic condition. The adverse effect of hyperglycemia on the pulp structure and function has been shown previously. Read More

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Colchicine for the treatment of COVID-19 patients: efficacy, safety, and model informed dosage regimens.

Xenobiotica 2021 Apr 12:1-14. Epub 2021 Apr 12.

Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Colchicine is widely investigated for cardioprotection of COVID-19 patients since it can prevent the phenomenon of 'cytokine storm' and may reduce the complications arising from COVID-19. Despite the potentially beneficial effects of colchicine, there is no consensus on the appropriate dosage regimen and numerous schemes are currently used.In this study, simulations were performed to identify the ability of dosage regimens to attain plasma levels in CVOID-19 patients, known to be generally safe and efficacious. Read More

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In vivo assessment of a delayed release formulation of larazotide acetate indicated for celiac disease using a porcine model.

PLoS One 2021 12;16(4):e0249179. Epub 2021 Apr 12.

Comparative Medicine Institute, North Carolina State University, Raleigh, NC, United States of America.

There is no FDA approved therapy for the treatment of celiac disease (CeD), aside from avoidance of dietary gluten. Larazotide acetate (LA) is a first in class oral peptide developed as a tight junction regulator, which is a lead candidate for management of CeD. A delayed release formulation was tested in vitro and predicted release in the mid duodenum and jejunum, the target site of CeD. Read More

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The impact of artisanal gold mining, ore processing and mineralization on water quality in Marmato, Colombia.

Environ Geochem Health 2021 Apr 11. Epub 2021 Apr 11.

Gran Colombia Gold Corp., Medellín, Colombia.

Marmato, Colombia, has been an important centre of gold mining since before the first Spanish colonizers arrived in 1536. The Marmato deposit is hosted in a dacite and andesite porphyry stock as sheeted sulphide-rich veinlet systems. The district is currently experiencing a surge in both major mining projects and artisanal mining, driven by sustained high gold prices. Read More

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Bioaccumulation of heavy metals in Stachys inflata and Scariola orientalis affected by particulate matters of a cement factory in central Iran.

Environ Sci Pollut Res Int 2021 Apr 12. Epub 2021 Apr 12.

Department of Natural Resources, Isfahan University of Technology, Isfahan, 84156-83111, Iran.

Industrial activities can affect accumulation of pollutants (e.g., heavy metals (HMs)) by plants and influence their entrance to the food chain. Read More

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The Role of Mitochondrial Impairment and Oxidative Stress in the Pathogenesis of Lithium-Induced Reproductive Toxicity in Male Mice.

Front Vet Sci 2021 24;8:603262. Epub 2021 Mar 24.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Lithium (Li) is prescribed against a wide range of neurological disorders. Besides its excellent therapeutic properties, there are several adverse effects associated with Li. The impact of Li on renal function and diabetes insipidus is the most common adverse effect of this drug. Read More

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