Microb Drug Resist 2021 Apr 9. Epub 2021 Apr 9.
Department of Clinical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
A clinically isolated pan-resistant strain (ST11), KPN142 was subjected to whole-genome sequencing. Genomic sequence of KPN142 showed that limited antibiotic resistances (β-lactams , sulfonamides [ and ], bacitracin , tetracycline , aminoglycosides [, , , , and ], and chloramphenicol ) were mediated by enzymes, and efflux pumps contributed most to pan resistance. Five types of multidrug resistance efflux pump families were identified, including the resistance nodulation division superfamily (AcrAB-TolC, AcrD, MdtABC, and KexD), the ATP-binding cascade superfamily (MacAB), the small multidrug resistance family (KpnEF), the multidrug and toxic compound extrusion family (KdeA), and the major facilitator superfamily (EmrAB). Read More