2,824 results match your criteria ldh creatine

Biological markers and follow-up after discharge home of patients with COVID-19 pneumonia.

Emergencias 2021 Jun;33(3):174-180

Grupo "gestión del paciente sangrante" idiPaz-Hospital Universitario La Paz, Madrid, España. Universidad Rey Juan Carlos, Madrid, España.

Objectives: We aimed to analyze the clinical course of patients discharged from our emergency departament (ED) with pneumonia symptoms compatible with a diagnosis of COVID-19.

Material And Methods: We followed 102 patients discharged home with a diagnosis of pneumonia compatible with COVID19 between March 12 and 21, 2020, in our hospital in the southern part of the autonomous community of Madrid. Descriptive statistics (medians and interquartile ranges or frequencies, as appropriate) were compiled for the main variables. Read More

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Comparative evaluation of cardioprotective activity of and juice against isoprenaline-induced cardiotoxicity in rats.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

Objectives: Comparative evaluation of cardioprotective activity of and juice against isoprenaline induced cardiotoxicity in rats.

Methods: Rats (125-150 g) were orally administered (GA) and (FA) apple juice (3 mL/day, per oral) for 13 days. Myocardial injury was inducted on 14th and 15th day by the administration of Isoprenaline (85 mg/kg/day, subcutaneous). Read More

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Identification of a novel MICU1 nonsense variant causes myopathy with extrapyramidal signs in an Iranian consanguineous family.

Mol Cell Pediatr 2021 May 9;8(1). Epub 2021 May 9.

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Ca as a universal second messenger regulates basic biological functions including cell cycle, cell proliferation, cell differentiation, and cell death. Lack of the protein mitochondrial calcium uptake1 (MICU1), which has been regarded as a gatekeeper of Ca ions, leads to the abnormal mitochondrial Ca handling, excessive production of reactive oxygen species (ROS), and increased cell death. Mutations in MICU1 gene causes a very rare neuromuscular disease, myopathy with extrapyramidal signs (MPXPS), due to primary alterations in mitochondrial calcium signaling which demonstrates the key role of mitochondrial Ca uptake. Read More

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Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice.

Mediators Inflamm 2021 17;2021:6611085. Epub 2021 Apr 17.

Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Background: Interleukin-16 (IL-16) is an important inflammatory regulator and has been shown to have a powerful effect on the regulation of the inflammatory response. Cardiac inflammation has been reported to be closely related to doxorubicin- (DOX-) induced cardiac injury. In this study, the role of IL-16 in DOX-induced cardiac injury and the possible mechanisms were examined. Read More

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EQA/PT scheme to improve the equivalence of enzymatic results between mutual recognition laboratories in Beijing.

J Clin Lab Anal 2021 May 5:e23814. Epub 2021 May 5.

Department of Clinical Laboratory, Beijing Chao-Yang Hospital affiliated to Capital Medical University, Beijing, China.

Background: To utilize the external quality assessment (EQA)/proficiency testing (PT) scheme to evaluate the equivalence of different clinical enzymatic measuring systems in Beijing.

Methods: The Beijing Center for Clinical Laboratory (BCCL) distributed three investigation samples to mutual recognition clinical laboratories in Beijing including alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), creatine kinase (CK), and lactate dehydrogenase (LDH). These samples were derived from serum pools with values assigned by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) enzymatic reference measurement procedures (RMPs). Read More

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Moderate intensity cycling is better than running on recovery of eccentric exercise-induced muscle damage.

Phys Ther Sport 2021 Apr 21;50:65-73. Epub 2021 Apr 21.

Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objective: To compare the effects of moderate intensity running and cycling on markers of exercise-induced muscle damage in men.

Study Design: Randomized controlled trial.

Setting: Laboratory. Read More

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Post-Ischemic Treatment of Recombinant Human Secretory Leukocyte Protease Inhibitor (rhSLPI) Reduced Myocardial Ischemia/Reperfusion Injury.

Biomedicines 2021 Apr 13;9(4). Epub 2021 Apr 13.

Graduate Programs in Biomedical Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand.

Myocardial ischemia/reperfusion (I/R) injury is a major cause of mortality and morbidity worldwide. Among factors contributing to I/R injury, proteolytic enzymes could also cause cellular injury, expand the injured area and induce inflammation, which then lead to cardiac dysfunction. Therefore, protease inhibition seems to provide therapeutic benefits. Read More

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Epidemiological, clinical, and laboratory findings for patients of different age groups with confirmed coronavirus disease 2019 (COVID-19) in a hospital in Saudi Arabia.

PLoS One 2021 29;16(4):e0250955. Epub 2021 Apr 29.

Department of Internal Medicine, College of Medicine, University of Bisha, Bisha, Saudi Arabia.

Background: Although the coronavirus disease 2019 (COVID-19) pandemic continues to rage worldwide, clinical and laboratory studies of this disease have been limited in many countries. We investigated the epidemiologic, clinical, and laboratory findings of COVID-19 infected patients to identify the effective indicators correlated with the disease.

Methods: A retrospective study was conducted at King Abdullah Hospital in Bisha Province, Saudi Arabia, from March 20 to June 30, 2020. Read More

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Electrodiagnostic findings in patients with non-COVID-19- and COVID-19-related acute respiratory distress syndrome.

Acta Neurol Scand 2021 Apr 22. Epub 2021 Apr 22.

Traumatic Intensive Care Unit, Neuromuscolar Department - AOU Careggi, Florence, Italy.

Background: Critical illness polyneuropathy and myopathy (CIPNM) is a frequent neurological manifestation in patients with acute respiratory distress syndrome (ARDS) from coronavirus disease 2019 (COVID-19) infection. CIPNM diagnosis is usually limited to clinical evaluation. We compared patients with ARDS from COVID-19 and other aetiologies, in whom a neurophysiological evaluation for the detection of CIPNM was performed. Read More

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HOTAIR/miR-17-5p Axis is Involved in the Propofol-Mediated Cardioprotection Against Ischemia/Reperfusion Injury.

Clin Interv Aging 2021 15;16:621-632. Epub 2021 Apr 15.

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, People's Republic of China.

Background: Propofol (PPF) ameliorates ischemia/reperfusion (I/R) injury in multiple organs by reducing apoptosis and release of pro-inflammatory cytokines. This study aims to explore the mechanism of PPF in attenuating myocardial ischemia-reperfusion injury (MIRI).

Materials And Methods: Rat MIRI model was established, and PPF pre-treatment was performed 10 min before I/R. Read More

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polysaccharides inhibit ischemia/reperfusion-induced myocardial injury via the Nrf2 antioxidant pathway.

Toxicol Rep 2021 24;8:657-667. Epub 2021 Mar 24.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, China.

Oxidative stress is considered to be one of main pathophysiological mechanisms in myocardial ischemia/reperfusion (I/R) injury. polysaccharides (LBP), the main ingredient of , have potential antioxidant activity. We aimed to investigate the effects of LBP on myocardial I/R injury and explore the underlying mechanisms. Read More

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Study of the Mechanism of Action of Guanxin Shutong Capsules in the Treatment of Coronary Heart Disease Based on Metabolomics.

Front Pharmacol 2021 25;12:650438. Epub 2021 Mar 25.

College of Pharmacy, Tianjin Medical University, Tianjin, China.

: Guan-Xin-Shu-Tong capsule (GXSTC) is a traditional Chinese medicine (TCM) that has been used to treat coronary heart disease (CHD) for many years in China. However, the holistic mechanism of GXSTC against CHD is still unclear. Therefore, the purpose of this paper was to systematically explore the mechanism of action GXSTC in the treatment of CHD rats using a metabolomics strategy. Read More

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Rhabdomyolysis with myoglobin-induced acute kidney injury: A case series of four cases.

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):382-384

Renopath, Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India.

Rhabdomyolysis is a potentially life-threatening clinical syndrome characterized by the breakdown of skeletal muscle cells and release of creatine kinase (CK), lactate dehydrogenase (LDH), and myoglobin into the plasma and interstitial space. Rhabdomyolysis can occur due to a variety of causes and acute kidney injury (AKI) is one of its most dreaded complications occurring in 33%-50% patients. The main pathophysiology of renal injury is due to vasoconstriction, intraluminal casts, tubular obstruction, and direct myoglobin toxicity. Read More

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Sweroside Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1/Nrf2 Axis.

Front Cardiovasc Med 2021 19;8:650368. Epub 2021 Mar 19.

Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China.

Sweroside, a secoiridoid glucoside extracted from Hara, is reported to possess antioxidant and anti-inflammatory activities. However, whether sweroside has a protective effect on myocardial ischemia-reperfusion (IR) injury is yet to be elucidated. The present study aimed to confirm the cardioprotective effect of sweroside and to identify its underlying mechanism. Read More

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Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from , , and .

Pharm Biol 2021 Dec;59(1):391-400

Natural Product Research Team, Food Science R&D Center, KolmarBNH CO., LTD, Seoul, Republic of Korea.

Context: HemoHIM is an herbal preparation containing Nakai (Apiaceae), Makino (Umbelliferae), and Pallas (Paeoniaceae) developed for immune regulation. To date, studies on the antifatigue effects of HemoHIM have not been conducted.

Objective: The antifatigue effects of HemoHIM using models of citrinin and exercise-induced chronic fatigue syndrome were investigated. Read More

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December 2021

The Effect of Protein Supplementation versus Carbohydrate Supplementation on Muscle Damage Markers and Soreness Following a 15-km Road Race: A Double-Blind Randomized Controlled Trial.

Nutrients 2021 Mar 5;13(3). Epub 2021 Mar 5.

Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 XZ Nijmegen, The Netherlands.

We assessed whether a protein supplementation protocol could attenuate running-induced muscle soreness and other muscle damage markers compared to iso-caloric placebo supplementation. A double-blind randomized controlled trial was performed among 323 recreational runners (age 44 ± 11 years, 56% men) participating in a 15-km road race. Participants received milk protein or carbohydrate supplementation, for three consecutive days post-race. Read More

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Exogenous Transforming Growth Factor-β in Brain-Induced Symptoms of Central Fatigue and Suppressed Dopamine Production in Mice.

Int J Mol Sci 2021 Mar 4;22(5). Epub 2021 Mar 4.

Laboratory of Molecular Medicine, College of Korean Medicine, Daejeon University, Daejeon 34520, Korea.

Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is one of the most refractory diseases in humans and is characterized by severe central fatigue accompanied with various symptoms that affect daily life, such as impaired memory, depression, and somatic pain. However, the etiology and pathophysiological mechanisms of CFS remain unknown. To investigate the pathophysiological role of transforming growth factor (TGF)-β1, we injected a cytokine into the lateral ventricle of a C57BL/6 mouse. Read More

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Clinical Characteristics of Aortic Aneurysm in MIMIC-III.

Heart Surg Forum 2021 04 2;24(2):E351-E358. Epub 2021 Apr 2.

Department of Emergency Medicine, Changsha Central Hospital, University of South China, Hengyand, Hunan, China.

Background: Aortic aneurysm (AA) is an aortic disorder prone to sudden, life-threatening aortic dissection or rupture, with poor clinical outcomes. In this study, we aimed to analyze the clinical characteristics of AA in MIMIC-III to explore implications for management.

Methods: All patients with AA, including abdominal aortic aneurysm (AAA) and thoracic aortic aneurysm (TAA), in the MIMIC-III database were included. Read More

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Muscle Damage and Overreaching During Wildland Firefighter Critical Training.

J Occup Environ Med 2021 Apr;63(4):350-356

School of Integrative Physiology and Athletic Training, University of Montana, Missoula, Montana (Ms Christison, Mr Gurney, Mr Sol, Ms Williamson-Reisdorph, Ms Quindry, Dr Quindry, Dr Dumke); United States Department of Agriculture, Forest Service, National Technology and Development Program, Missoula, Montana (Mr Sol).

Objective: To document the effects of wildland firefighter (WLFF) critical training (CT) on physiologic markers of muscle damage and acute overreaching.

Methods: Eighteen male and three female WLFFs were studied during an 11-day CT. Upper-body (US), lower-body (LS) muscle soreness and body weight (BW) were collected daily. Read More

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Role of cardiac hypoxia in the pathogenesis of sudden death syndrome in broiler chickens - A metabolic and molecular study.

Acta Vet Hung 2021 Mar 19. Epub 2021 Mar 19.

3Poultry Diseases Research Center, School of Veterinary Medicine, Shiraz University, Shiraz, Islamic Republic of Iran.

Sudden death syndrome (SDS) is an economically important disorder in broiler chickens with unknown aetiology. The aim of the present study was to evaluate the metabolic and molecular alterations related to hypoxia in the myocardium of broiler chickens with SDS. Samples from the cardiac muscle of internal control broiler chickens (ICs) (n = 36) and chickens having died of SDS (n = 36) were obtained during the rearing period. Read More

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The traditional Chinese medicine formula Fufang-Zhenzhu-Tiaozhi protects myocardia from injury in diabetic minipigs with coronary heart disease.

Biomed Pharmacother 2021 May 5;137:111343. Epub 2021 Mar 5.

Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, China; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, China; Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chinese Medicine), China; Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University, Guangdong TCM Key Laboratory against Metabolic Diseases, China. Electronic address:

Background And Purpose: Diabetes mellitus (DM) is a major risk factor for coronary heart disease (CHD). Previous research has reported that the Fufang-Zhenzhu-Tiaozhi (FTZ) formula has obvious effects on the treatment of dyslipidemia and hyperglycemia. In the present study, we intended to establish a convenient DM-CHD model in minipigs and investigated the protective effect of FTZ against myocardial injury and its mechanism. Read More

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Predictive values of serum biochemical markers and apparent diffusion coefficient on delayed encephalopathy after acute carbon monoxide poisoning.

Turk Neurosurg 2020 Jul 16. Epub 2020 Jul 16.

Linzi District People's Hospital.

Aim: Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is a serious complication of carbon monoxide poisoning. This study aimed to explore the predictive values of serum biochemical markers and apparent diffusion coefficient (ADC) on DEACMP.

Material And Methods: Seventy-nine patients were divided into two groups based on the onset of DEACMP 60 days after with acute carbon monoxide poisoning. Read More

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Evaluation of seroprevalence and clinical and laboratory findings of patients admitted to health institutions in Gümüşhane with suspicion of Crimean-Congo hemorrhagic fever.

Turk J Med Sci 2021 Mar 23. Epub 2021 Mar 23.

Objective: To determine the seroprevalence and evaluate clinical findings and laboratory results of patients prediagnosed with Crimean-Congo hemorrhagic fever (CCHF) in Gümüşhane.

Methods: Included in the cross-sectional study were 362 patients (162 female, 200 male) between 0 and 94 years of age, who were followed up after receiving a preliminary diagnosis of CCHF between January 2011 and December 2019. Anamnesis, age, sex, clinical findings, laboratory results, epidemiological and clinical evaluations, severity criteria, risk factor reviews, and a comparison of the suspected negative cases with positive cases were analyzed retrospectively. Read More

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Cardioprotective Effects of Mebudipine in a Rat Model of Doxorubicin-Induced Heart Failure.

Iran J Med Sci 2021 Mar;46(2):136-143

Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Mebudipine, a dihydropyridine calcium-channel blocker (CCB), shows greater time- and voltage-dependent inhibitory effects than nifedipine. Its significant negative chronotropic effects without having considerable negative inotropic properties may make it a suitable candidate for the pharmacotherapy of heart failure (HF). This study aimed to investigate the possible beneficial action of mebudipine in a rat model of HF. Read More

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Cardioprotective Effect of Quercetin and Sitagliptin in Doxorubicin-Induced Cardiac Toxicity in Rats.

Tavga Ahmed Aziz

Cancer Manag Res 2021 12;13:2349-2357. Epub 2021 Mar 12.

Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Sulaimani City, Iraq.

Objective: A previous study revealed a pronounced protective effect of combining quercetin (QC) with sitagliptin (STN) in testicular tissue. Accordingly, this study was designed to evaluate the cardioprotective effects of QC and STN each alone or in combination in doxorubicin (DOX)-induced cardiotoxicity in the rats.

Methodology: Thirty male adult Wistar rats were divided into five groups: the first group (control) treated with sodium chloride, the second group treated with DOX (3 mg/kg I. Read More

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[Cardiac presentations in severe and critical coronavirus disease 2019].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Feb;33(2):229-232

Department of Infectious Disease, the Eighth People's Hospital of Guangzhou, Guangzhou 510000, Guangdong, China. Corresponding author: Lei Chunliang, Email:

Objective: To investigate the cardiac presentations and the possible influencing factors of severe and critical coronavirus disease 2019 (COVID-19).

Methods: A retrospective study was conducted. Patients with severe and critical COVID-19 admitted to the Eighth People's Hospital of Guangzhou from January 21st to February 24th 2020 were enrolled. Read More

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February 2021

[Analysis of high-risk factors and clinical characteristics of sepsis-related liver injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Feb;33(2):186-191

Department of General Intensive Care Unit, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310052, Zhejiang, China.

Objective: To analyze the risk factors and clinical characteristics of liver injury in patients with sepsis and to provide a reference for early recognition, early diagnosis, early intervention, and improve the survival rate of patients.

Methods: The clinical data of sepsis patients admitted to the department of general intensive care unit (ICU) of the Second Affiliated Hospital of Zhejiang University School of Medicine from July 2014 to October 2020 were retrospectively analyzed. According to the occurrence of acute liver injury, patients with sepsis were divided into the liver injury group and the non-liver injury group, and the differences of demographic data, history, history of primary diseases, laboratory indicators on the first time of admission, treatments, the severity of the disease and other indicators were compared and analyzed. Read More

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February 2021

Proteomics analysis as an approach to understand the formation of pale, soft, and exudative (PSE) pork.

Meat Sci 2021 Jul 22;177:108353. Epub 2020 Oct 22.

College of Food Science and Pharmaceutics, Xinjiang Agricultural University, Xinjiang, China. Electronic address:

We investigated ten pale, soft, and exudative (PSE), and ten normal meat samples from pig carcasses. The meat quality at 0, 5, 12, and 24 h post-mortem and the key enzyme activities at 0 and 24 h post-mortem were determined. We selected three PSE and three normal samples for proteomics analysis at 0 h and 24 h post-mortem. Read More

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Coronavirus disease 2019: a comprehensive review and meta-analysis on cardiovascular biomarkers.

Curr Opin Cardiol 2021 May;36(3):367-373

Select Laboratory Partners, Greensboro, North Carolina.

Purpose Of Review: Preventive cardiology has an important role to play in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The SARS-CoV-2 pandemic has been observed to have a greater mortality impact on subgroups of people in the population who are deemed to be at higher medical disease risk. Individuals with cardiovascular disorders are one such COVID-19-associated high-mortality risk group. Read More

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Brazilin prevents against myocardial ischemia-reperfusion injury through the modulation of Nrf2 via the PKC signaling pathway.

Ann Transl Med 2021 Feb;9(4):312

Department of Cardiology, the First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Brazilin, a major ingredient of ., possesses multiple pharmaceutical activities, although whether or not brazilin exerts any protective effect on myocardial ischemia-reperfusion injury (MIRI) has not yet been reported. The present study determined the cardioprotective effects of brazilin, and elucidated the role of nuclear factor E2-associated factor 2 (Nrf2) in this process. Read More

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February 2021