3,918 results match your criteria layer aims

Retinal microvasculature and optic disc alterations in non-pathological high myopia with optical coherence tomography angiography.

Graefes Arch Clin Exp Ophthalmol 2021 May 7. Epub 2021 May 7.

Department of Ophthalmology, Health Sciences University, Antalya Training and Research Hospital, Antalya, Turkey.

Purpose: This study aims to investigate the early characteristics of retinochoroidal and peripapillary perfusion in non-pathological high myopia (HM) without retinopathy and compare them to the age- and sex-matched healthy subjects using optical coherence tomography angiography (OCTA).

Methods: This prospective, cross-sectional study included 35 eyes of 35 patients in the non-pathological HM group (axial length (AL) ≥ 26 mm) and 35 eyes of 35 subjects in the control group. OCT and OCTA were used for the assessment of vessel density, foveal avascular zone, subfoveal choroidal thickness, choriocapillaris flow area, retinal nerve fiber layer thickness, and optic nerve head measurements. Read More

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Multi-level aspect based sentiment classification of Twitter data: using hybrid approach in deep learning.

PeerJ Comput Sci 2021 13;7:e433. Epub 2021 Apr 13.

Department of Computer Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Social media is a vital source to produce textual data, further utilized in various research fields. It has been considered an essential foundation for organizations to get valuable data to assess the users' thoughts and opinions on a specific topic. Text classification is a procedure to assign tags to predefined classes automatically based on their contents. Read More

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Repurposing Vorinostat for the Treatment of Disorders Affecting Brain.

Neuromolecular Med 2021 May 4. Epub 2021 May 4.

Applied Biology Division, CSIR- Indian Institute of Chemical Technology, Tarnaka, Uppal Road, Hyderabad, 500007, Telangana, India.

Based on the findings in recent years, we summarize the therapeutic potential of vorinostat (VOR), the first approved histone deacetylase (HDAC) inhibitor, in disorders of brain, and strategies to improve drug efficacy and reduce side effects. Scientific evidences provide a strong case for the therapeutic utility of VOR in various disorders affecting brain, including stroke, Alzheimer's disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, X-linked adrenoleukodystrophy, epilepsy, Niemann-Pick type C disease, and neuropsychiatric disorders. Further elucidation of the neuroprotective and neurorestorative properties of VOR using proper clinical study designs could provide momentum towards its clinical application. Read More

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Triggerable Super Absorbent Polymers for Coating Debonding Applications.

Polymers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Research Unit of Advanced, Composite, Nano-Materials and Nanotechnology, School of Chemical Engineering, National Technical University of Athens, 9 Heroon Polytechniou St., Zographos, GR-15773 Athens, Greece.

This study aims to examine how core-shell super absorbent polymers (SAPs) can be effective in relation to recycling processes by using them as triggerable materials in coating binders. Super absorbent polymers are partially cross-linked, three-dimensional polymer networks that can absorb and retain water. Coatings based on an acrylic binder, including SAPs, were applied onto plastic substrates of acrylonitrile-butadiene-styrene/polycarbonate. Read More

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Submandibular gland degloving: A minimally invasive function-preserving surgical approach for benign diseases.

Head Neck 2021 May 4. Epub 2021 May 4.

Otolaryngology Division, Azienda Ospedaliero Universitaria, Sassari, Italy.

In the Video S1, a modified technique for submandibular gland resection in benign disease is shown. The main plane of dissection is below the fascia and immediately superficial to the fibrous capsule of the gland. The video shows the surgical steps and the structures that become evident along the procedure and illustrates some tips and tricks. Read More

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Carbonic Anhydrases II, IX, and XII in Reflux Esophagitis.

Dig Dis Sci 2021 Apr 30. Epub 2021 Apr 30.

Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014, Oulu, Finland.

Background: The pathogenesis of gastroesophageal reflux disease (GERD) has not been resolved in detail. Esophageal epithelial cells provide resistance to acidic reflux via several mechanisms, many of which involve buffering acid with bicarbonate and transporting protons. Carbonic anhydrases (CAs) are enzymes that control the acid-base balance by catalyzing the reversible hydration of carbon dioxide to produce bicarbonate and hydrogen ions. Read More

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Improved response of human gingival fibroblasts to titanium coated with micro-/nano-structured tantalum.

Int J Implant Dent 2021 May 3;7(1):36. Epub 2021 May 3.

Department of Dental Implantology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.

Objectives: This study aims to evaluate the ability of tantalum-coated titanium to improve human gingival fibroblasts' adhesion, viability, proliferation, migration performance, and the potential molecular mechanisms.

Materials And Methods: Titanium plates were divided into two groups: (1) no coating (Ti, control), (2) Tantalum-coated titanium (Ta-coated Ti). All samples were characterized by scanning electronic microscopy, surface roughness, and hydrophilicity. Read More

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Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment.

Sci Total Environ 2021 Apr 27;785:147365. Epub 2021 Apr 27.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China. Electronic address:

Plastics are widely used in many fields due to their stable physical and chemical properties, and their global production and usage increase significantly every year, which leads to the accumulation of microplastics in the entire ecosystem. Numerous studies have shown that microplastics (MPs) have harmful effects on living organisms. This review aims to provide a comprehensive conclusion of the current knowledge of the impacts of MPs on the stability of the gut microenvironment, especially on the gut barrier. Read More

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Recent trends in natural polysaccharide based bioinks for multiscale 3D printing in tissue regeneration: A review.

Int J Biol Macromol 2021 Apr 29. Epub 2021 Apr 29.

Tissue Engineering Laboratory, PSG Institute of Advanced studies, Coimbatore 641004, Tamil Nadu, India. Electronic address:

Biofabrication by three-dimensional (3D) printing has been an attractive technology in harnessing the possibility to print anatomical shaped native tissues with controlled architecture and resolution. 3D printing offers the possibility to reproduce complex microarchitecture of native tissues by printing live cells in a layer by layer deposition to provide a biomimetic structural environment for tissue formation and host tissue integration. Plant based biomaterials derived from green and sustainable sources have represented to emulate native physicochemical and biological cues in order to direct specific cellular response and formation of new tissues through biomolecular recognition patterns. Read More

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Plasma miR-26a-5p is a biomarker for retinal neurodegeneration of early diabetic retinopathy.

Eye (Lond) 2021 Apr 30. Epub 2021 Apr 30.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.

Purpose: Retinal neurodegeneration is an early pathological change in diabetic retinopathy (DR). Early-stage retinal neurodegeneration is usually asymptomatic. This study aims to identify circulating microRNAs (miRNAs) as sensitive biomarkers for early retinal neurodegeneration. Read More

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The impact of chronic alcohol overuse on cardiac function and prognosis: layer-specific longitudinal strain and mid-term outcome analysis.

Kardiol Pol 2021 Apr 29. Epub 2021 Apr 29.

Background: The exact effects of alcohol drinking on cardiac function are not clear.

Aims: The determine the relationship between consumed amount of alcohol, myocardial injury, and prognosis.

Methods: Myocardial function and cardiac outcomes were examined in subjects with chronic alcoholism by classical and strain echocardiographic parameters, including global (GLS) and layer-specific longitudinal strain of the endocardial (GLSendo) and epicardial (GLSepi) layer. Read More

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Experimental study of ultrastructural mechanisms and kinetics of tegumental secretion in cestodes parasitizing fish (Cestoda: Diphyllobothriidea).

J Fish Dis 2021 Apr 29. Epub 2021 Apr 29.

Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Sciences, Ulan-Ude, Russia.

The structural response and plasticity of the cestode tegument in response to the influence of the host organism is not yet well understood. The main aims of our in vitro study were to analyse the ultrastructural mechanisms and kinetics of tegumental secretion in two cestode species, Dibothriocephalus dendriticus and Ligula interrupta, in response to the influence of fish host blood serum. The incubation of plerocercoids in the culture medium, which contained fish host blood serum, resulted in an increased number of secretory products on the tegumental surface. Read More

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GLAUDIA: A predicative system for glaucoma diagnosis in mass scanning.

Health Informatics J 2021 Apr-Jun;27(2):14604582211009276

Columbus State University, USA.

Glaucoma is a serious eye disease characterized by dysfunction and loss of retinal ganglion cells (RGCs) which can eventually lead to loss of vision. Robust mass screening may help to extend the symptom-free life for the affected patients. The retinal optic nerve fiber layer can be assessed using optical coherence tomography, scanning laser polarimetry (SLP), and Heidelberg Retina Tomography (HRT) scanning methods which, unfortunately, are expensive methods and hence, a novel automated glaucoma diagnosis system is needed. Read More

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Residual wide-kernel deep convolutional auto-encoder for intelligent rotating machinery fault diagnosis with limited samples.

Neural Netw 2021 Apr 9;141:133-144. Epub 2021 Apr 9.

Department of Mechnical Engineering, Politecnico di Milano, Milan, Italy. Electronic address:

This paper deals with the development of a novel deep learning framework to achieve highly accurate rotating machinery fault diagnosis using residual wide-kernel deep convolutional auto-encoder. Unlike most existing methods, in which the input data is processed by fast Fourier transform (FFT) and wavelet transform, this paper aims to learn important features from limited raw vibration signals. Firstly, the wide-kernel convolutional layer is introduced in the convolutional auto-encoder that can ensure the model can learn effective features from the data without any signal processing. Read More

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Dual-Functionality Evaluation of a Novel Collagen Crosslinking Resin.

Y Wang Y Liu H Liu S Li

J Dent Res 2021 Apr 24:220345211007428. Epub 2021 Apr 24.

University of Missouri-Kansas City School of Dentistry, Kansas City, MO, USA.

Current adhesives bond to dentin via a micro-interlocking mechanism within the hybrid layer. Besides such mechanical retention, bonding to dentin would benefit from additional chemical interaction between collagen and resin. This study aims to synthesize a novel light-curable collagen crosslinker methacrylate (MA) functionalized grapeseed extract (GSE) and to assess MAGSE's ability to crosslink dentin collagen in a clinically relevant setting as well as its role in light-cure as a resin. Read More

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Home Energy Efficiency and Subjective Health in Greater London.

J Urban Health 2021 Apr 23. Epub 2021 Apr 23.

UCL Institute for Environmental Design and Engineering, London, UK.

The UK has introduced legislation that requires net-zero greenhouse gas emissions to be achieved by 2050. Improving the energy efficiency of homes is a key objective to help reach this target, and the UK government's Clean Growth Strategy aims to get many homes up to an Energy Performance Certificate (EPC) Band of C by 2035. The relationship between home energy-efficiency and occupant health and wellbeing remains an area of ongoing research. Read More

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Short and Robust Anti-Infective Lipopeptides Engineered Based on the Minimal Antimicrobial Peptide KR12 of Human LL-37.

ACS Infect Dis 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska 68198-5900, United States.

This study aims to push the frontier of the engineering of human cathelicidin LL-37, a critical antimicrobial innate immune peptide that wards off invading pathogens. By sequential truncation of the smallest antibacterial peptide (KR12) of LL-37 and conjugation with fatty acids, with varying chain lengths, a library of lipopeptides is generated. These peptides are subjected to antibacterial activity and hemolytic assays. Read More

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Monte Carlo determination of a nanoDot OSLD response using quality index for diagnostic kilovoltage X-ray beams.

Fujio Araki

Phys Med 2021 Apr 19;84:101-108. Epub 2021 Apr 19.

Department of Health Sciences, Faculty of Life Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto 862-0976, Japan. Electronic address:

Purpose: This study aims to investigate the energy response of an optically stimulated luminescent dosimeter known as nanoDot for diagnostic kilovoltage X-ray beams via Monte Carlo calculations.

Methods: The nanoDot response is calculated as a function of X-ray beam quality in free air and on a water phantom surface using Monte Carlo simulations. The X-ray fluence spectra are classified using the quality index (QI), which is defined as the ratio of the effective energy to the maximum energy of the photons. Read More

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[Significance of the intact of the fascia propria in protection of pelvic plexus during total mesorectal excision].

P Chi X J Wang

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Apr;24(4):297-300

Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China.

Total mesorectal excision (TME) is the gold standard of surgical treatment for mid and low rectal cancer. It aims to improve the oncological outcomes as well as preserve anal sphincter, sexual and urinary function. Compared with sympathetic nerve injury alone, pelvic plexus and neurovascular bundle (NVB) injury has significant effect on postoperative sexual dysfunction, especially erectile function. Read More

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Determination of the refractive index and wavelength dependent optical properties of few-layer CrCl within the Fresnel formalism.

J Microsc 2021 Apr 17. Epub 2021 Apr 17.

Dipartimento di Scienze Fisiche e Chimiche (DSFC), Università degli Studi dell'Aquila.

Based on previous report on the optical microscopy contrast of mechanically exfoliated few layer CrCl transferred on 285 nm and 270 nm SiO on Si(100), we focus on the experimental determination of an effective mean complex refractive index via a fitting analysis based on the Fresnel equations formalism. Accordingly, the layer and wavelength dependent absorbance and reflectance are calculated. Layer and wavelength dependent optical contrast curves are then evaluated demonstrating that the contrast is significantly high only around well-defined wavelength bands. Read More

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Peaks ofcircumpapillary retinal nerve fibre layer and associations in healthy eyes: the Beijing Eye Study 2011.

Br J Ophthalmol 2021 Apr 15. Epub 2021 Apr 15.

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.

Aims: To investigate the distribution and associations of the circumpapillary retinal nerve fibre layer thickness (RNFLT) profile, characterised as peak height and peak position, in healthy eyes.

Methods: 667 healthy participants (294 male) were randomly selected from the Beijing Eye Study 2011. RNFLT was measured at 768 points at 3. Read More

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Exploring the role of macular thickness as a potential early biomarker of neurodegeneration in acute schizophrenia.

Int Ophthalmol 2021 Apr 15. Epub 2021 Apr 15.

Department of Psychiatry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (SBV) Deemed To Be University, Puducherry, India.

Objective: The retina has been investigated as a gateway to assess the neurodegenerative changes in the brain. Schizophrenia is also conceptualized as a neurodegenerative disorder like Alzheimer's and Parkinson's disease. The current literature suggests reduced retinal nerve fibre layer (RNFL) thickness and macular thickness (MT), as a marker of neurodegeneration, in patient suffering from chronic schizophrenia. Read More

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Silver Sulfadiazine's Effect on Keratin-19 Expression as Stem Cell Marker in Burn Wound Healing.

Biomedicine (Taipei) 2020 5;10(2):5-11. Epub 2020 Jun 5.

Department of Histology, Faculty of Medicine Universitas Indonesia, Jln. Salemba Raya No. 6 Jakarta, 10430, Jakarta, Indonesia.

Background: Burn wounds are one of the causes of cutaneous injury that involve both epidermal and dermal layers of skin. Silver sulfadiazine (SSD) has been widely used to treat burn wounds, however recent studies have found the treatment to have some drawbacks, such as cellular toxicity effects. Cutaneous wound regeneration is known to start from the basal layer of the epidermal epithelial cells, which are enriched with highly proliferative cells. Read More

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Rapid Estimation of Entire Brain Strain Using Deep Learning Models.

IEEE Trans Biomed Eng 2021 Apr 14;PP. Epub 2021 Apr 14.

Objective: Many recent studies have suggested that brain deformation resulting from a head impact is linked to the corresponding clinical outcome, such as mild traumatic brain injury (mTBI). Even though several finite element (FE) head models have been developed and validated to calculate brain deformation based on impact kinematics, the clinical application of these FE head models is limited due to the time-consuming nature of FE simulations. This work aims to accelerate the process of brain deformation calculation and thus improve the potential for clinical applications. Read More

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Dataset on the effect of flavonoids on the stabilization of the resin-dentin interface.

Data Brief 2021 Apr 19;35:106984. Epub 2021 Mar 19.

Grupo de Investigaciones Básicas y Aplicadas en Odontología, Departamento de Salud Oral, Facultad de Odontología, Universidad Nacional de Colombia, Bogotá, Colombia.

Data in this article are associated with our research article "Effect of Myricetin on Odontoblast-like Cells and its Potential to Preserve Resin-Dentin Bonds." Both a poor infiltration of resin monomers into the demineralized dentin matrix and hydrolytic degradation of the adhesive could lead to the instability of the resin-dentin interface. The degradation of collagen is caused by matrix metalloproteinases (MMP) and cysteine cathepsins. Read More

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Comparative Evaluation of Short Fiber-reinforced Composite Resin Thickness on Fracture Resistance of Class II Composite Restoration: An Study.

J Contemp Dent Pract 2020 Nov 1;21(11):1201-1204. Epub 2020 Nov 1.

Department of Conservative Dentistry, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.

Aim: This study aims to evaluate the difference in fracture resistance of the short fiber-reinforced composite (SFRC) thickness as intermediate layer of class II composite restoration.

Materials And Methods: Thirty human maxillary premolars were selected and divided into three groups. In groups I, II, and III, class II cavities were prepared. Read More

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November 2020

Endophytic fungus Diaporthe caatingaensis MT192326 from Buchanania axillaris: An indicator to produce biocontrol agents in plant protection.

Environ Res 2021 Apr 17;197:111147. Epub 2021 Apr 17.

Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Erode District, Tamil Nadu, India.

The study aims at the Isolation, screening and antibacterial evaluation of Camptothecin (CPT) and its derivatives, an anticancer molecule from endophytic fungus Diaporthe caatingaensis MT192326 of the medicinal plant, Buchanania axillaris. Plant parts were collected from Sathyamangalam Tiger Reserve forest, Tamil Nadu. The fungus was isolated using DEKM07 medium was used as the screening medium for the presence of CPT. Read More

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Strong link between coronavirus count and bad air: a case study of India.

Environ Dev Sustain 2021 Apr 3:1-14. Epub 2021 Apr 3.

Department of Physics, HNB Garhwal University, Srinagar, Garhwal, Uttarakhand India.

The present study aims to highlight the contrast relationship between COVID-19 (Coronavirus Disease-2019) infections and air pollutants for the Indian region. The COVID-19 data (cumulative, confirmed cases and deaths), air pollutants (PM, PM, NO and SO) and meteorological data (temperature and relative humidity) were collected from January 2020 to August 2020 for all 28 states and the union territory of India during the pandemic. Now, to understand the relationship between air pollutant concentration, meteorological factor, and COVID-19 cases, the nonparametric Spearman's and Kendall's rank correlation were used. Read More

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Evaluation of the retinal nerve fiber layer with optic coherence tomography in patients with alcohol use disorder.

J Fr Ophtalmol 2021 Apr 8. Epub 2021 Apr 8.

Hitit university, Erol Olçok training and research hospital, department of psychiatry, 019030 Corum, Turkey.

Objective: This study aims to evaluate the retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) among patients with alcohol and tobacco use disorder.

Methods: This study included 29 patients and 29 age and gender-matched healthy participants without alcohol dependency. The patients underwent full ophthalmologic examination including visual acuity, intraocular pressure, anterior segment and fundus examinations, and RNFL measurements taken with spectral-domain OCT. Read More

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Quantitative risk assessment of storm surge using GIS techniques and open data: A case study of Daya Bay Zone, China.

J Environ Manage 2021 Jul 8;289:112514. Epub 2021 Apr 8.

Hubei Key Laboratory of Marine Geological Resources/College of Marine Science and Technology, China University of Geosciences, Wuhan, 430074, China. Electronic address:

Storm surge is a natural disaster, often causing economic damage and loss of human life in the coastal communities. In recent decades, with more people attracted to coastal areas, the potential economic losses resulted from storm surges are increasing. Therefore, it is important to make risk assessments to identify areas at risk and design risk reduction strategies. Read More

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