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Systemic Optimization and Validation of Normal and Reversed-Phase Eco-Friendly Chromatographic Methods for Simultaneous Determination of Paracetamol and Phenylephrine Hydrochloride in the Presence of Paracetamol Impurities.

J AOAC Int 2021 Sep 14. Epub 2021 Sep 14.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El-Aini 11562-Cairo-Egypt.

Background: Chromatographic behavior of different substances in normal and reversed phases is an interesting area in the scientific community.

Objective: The work aimed to optimize and validate chromatographic separation methods for simultaneous determination of paracetamol (PAR) and phenylephrine HCl (PHE) in presence of PAR impurities namely, P-Aminophenol (PAP), P-Nitrophenol (PNP), Acetanilide (ACT) and P-Chloroacetanilide (CAC) with further quantification of these toxic impurities.

Methods: Thin layer chromatography based on normal phase separation was carried out on aluminum sheet of silica gel 60 F254 using ethanol:chloroform:ammonia as a developing system, followed by densitometric measurements. Read More

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September 2021

Rapid Detection of SARS-CoV-2 Antigens and Antibodies Using OFET Biosensors Based on a Soft and Stretchable Semiconducting Polymer.

ACS Biomater Sci Eng 2021 Sep 14. Epub 2021 Sep 14.

Leibniz Institute of Polymer Research Dresden e.V., Hohe Straße 6, Dresden 01069, Germany.

In the midst of the COVID-19 pandemic, adaptive solutions are needed to allow us to make fast decisions and take effective sanitation measures, e.g., the fast screening of large groups (employees, passengers, pupils, etc. Read More

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September 2021

Effect of adhesive application method on repair bond strength of composite.

Restor Dent Endod 2021 Aug 4;46(3):e32. Epub 2021 Jun 4.

Department of Conservative Dentistry, Graduate School, Dankook University College of Dentistry, Cheonan, Korea.

Objectives: This study aimed to evaluate the effect of the application method of universal adhesives on the shear bond strength (SBS) of repaired composites, applied with different thicknesses.

Materials And Methods: The 84 specimens (Filtek Z350 XT) were prepared, stored in distilled water for a week and thermocycled (5,000 cycles, 5°C to 55°C). They were roughened using 400-grit sandpapers and etched with phosphoric acid. Read More

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Fully Convolutional Network and Visual Saliency-Based Automatic Optic Disc Detection in Retinal Fundus Images.

J Healthc Eng 2021 31;2021:3561134. Epub 2021 Aug 31.

School of Information and Control Engineering, Shenyang Jianzhu University, Shenyang 110168, China.

We present in this paper a novel optic disc detection method based on a fully convolutional network and visual saliency in retinal fundus images. Firstly, we employ the morphological reconstruction-based object detection method to locate the optic disc region roughly. According to the location result, a 400 × 400 image patch that covers the whole optic disc is obtained by cropping the original retinal fundus image. Read More

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Sensitive, High-Speed, and Broadband Perovskite Photodetectors with Built-In TiO Metalenses.

Small 2021 Sep 12:e2102694. Epub 2021 Sep 12.

Laboratory for Advanced Interfacial Materials and Devices, Research Centre for Smart Wearable Technology, Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong SAR, China.

Monolithic integration of nanostructured metalenses with broadband light transmission and good charge transport can simultaneously enhance the sensitivity, speed, and efficiency of photodetectors. The realization of built-in broadband metalenses in perovskite photodetectors, however, has been largely challenged by the limited choice of materials and the difficulty in nanofabrication. Here a new type of broadband-transmitting built-in TiO metalens (meta-TiO ) is devised, which is readily fabricated by one-step and lithograph-free glancing angle deposition. Read More

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September 2021

Crack Suppression in Conductive Film by Amyloid-Like Protein Aggregation toward Flexible Device.

Adv Mater 2021 Sep 12:e2104187. Epub 2021 Sep 12.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, China.

A fatal weakness in flexible electronics is the mechanical fracture that occurs during repetitive fatigue deformation; thus, controlling the crack development of the conductive layer is of prime importance and has remained a great challenge until now. Herein, this issue is tackled by utilizing an amyloid/polysaccharide molecular composite as an interfacial binder. Sodium alginate (SA) can take part in amyloid-like aggregation of the lysozyme, leading to the facile synthesis of a 2D protein/saccharide hybrid nanofilm over an ultralarge area (e. Read More

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September 2021

Single-layer Inverted Internal Limiting Membrane Flap Versus Conventional Peel for Small- or Medium-sized Full-thickness Macular Holes.

Am J Ophthalmol 2021 Sep 9. Epub 2021 Sep 9.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Purpose: To compare the outcomes of using an internal limiting membrane (ILM) flap and the conventional ILM peel technique for small- or medium-sized full-thickness macular hole (FTMH) repair.

Design: Retrospective, interventional case series.

Methods: Eyes with an FTMH ≤ 400 µm that underwent vitrectomy with either a single-layer inverted ILM flap (flap group, 55 eyes) or an ILM peel (peel group, 62 eyes) were enrolled. Read More

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September 2021

Evaluation of some aspects in supervised cell type identification for single-cell RNA-seq: classifier, feature selection, and reference construction.

Genome Biol 2021 09 9;22(1):264. Epub 2021 Sep 9.

Department of Computer Science, Emory University, 400 Dowman Drive, Atlanta, GA, 30322, USA.

Background: Cell type identification is one of the most important questions in single-cell RNA sequencing (scRNA-seq) data analysis. With the accumulation of public scRNA-seq data, supervised cell type identification methods have gained increasing popularity due to better accuracy, robustness, and computational performance. Despite all the advantages, the performance of the supervised methods relies heavily on several key factors: feature selection, prediction method, and, most importantly, choice of the reference dataset. Read More

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September 2021

Work Hardening of Heat-Treated AlSi10Mg Alloy Manufactured by Selective Laser Melting: Effects of Layer Thickness and Hatch Spacing.

Materials (Basel) 2021 Aug 28;14(17). Epub 2021 Aug 28.

Department of Engineering and Architecture, University of Parma, Via G. Usberti, 181/A, 43124 Parma, Italy.

The present study analyzed the microstructure and the mechanical properties of AlSi10Mg SLMed bars (10 × 10 × 300 mm) and billets (10 × 100 × 300 mm) before and after the direct aging at 200 °C for 4 h and the T6 heat treatment. The discussed results are compared to those obtained by the AlSi10Mg samples manufactured with the same geometry but using different process parameters (layer thickness higher than 40 μm and a hatch spacing lower than 100 μm) and also through the Quality Index (QI). These work conditions allow the obtaining of a microstructural variation and different tensile properties in as-built top samples. Read More

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Photonic Lift-off Process to Fabricate Ultrathin Flexible Solar Cells.

ACS Appl Mater Interfaces 2021 Sep 9. Epub 2021 Sep 9.

McKetta Department of Chemical Engineering and Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712, United States.

A microsecond time-scale photonic lift-off (PLO) process was used to fabricate mechanically flexible photovoltaic devices (PVs) with a total thickness of less than 20 μm. PLO is a rapid, scalable photothermal technique for processing extremely thin, mechanically flexible electronic and optoelectronic devices. PLO is also compatible with large-area devices, roll-to-roll processing, and substrates with low temperature compatibility. Read More

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September 2021

First-Principles Study of Hydrogen Storage of Sc-Modified Semiconductor Covalent Organic Framework-1.

ACS Omega 2021 Aug 20;6(34):21985-21993. Epub 2021 Aug 20.

Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, People's Republic of China.

At present, the development of new carbon-based nanoporous materials with semiconductor properties and high hydrogen storage capacity has become a research hotspot in the field of hydrogen storage and hydrogen supply. Here, we pioneered the study of the hydrogen storage capacity of a scandium (Sc) atom-modified semiconductor covalent organic framework-1 (COF-1) layer. It was found that the hydrogen storage capacity of the COF-1 structure was significantly enhanced after the modification of the Sc atom. Read More

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Skimmed breast milk for treatment of hypertriglyceridemia in an infant with congenital nephrotic syndrome.

Nutr Clin Pract 2021 Sep 6. Epub 2021 Sep 6.

Division of Pediatric Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.

Congenital nephrotic syndrome (CNS) is a complex condition that requires multidisciplinary care. Hyperlipidemia is a characteristic feature with elevation of serum cholesterol and triglycerides. Little evidence is available to guide treatment of dyslipidemia in infants with CNS. Read More

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September 2021

Electroactive Nanogel Formation by Reactive Layer-by-Layer Assembly of Polyester and Branched Polyethylenimine via Aza-Michael Addition.

Langmuir 2021 Sep 3. Epub 2021 Sep 3.

Department of Chemistry, Izmir Institute of Technology, Izmir, 35430, Turkey.

We here demonstrate the utilization of reactive layer-by-layer (rLBL) assembly to form a nanogel coating made of branched polyethylenimine (BPEI) and alkyne containing polyester (PE) on a gold surface. The rLBL is generated by the rapid aza-Michael addition reaction of the alkyne group of PE and the -NH groups of BPEI by yielding a homogeneous gel coating on the gold substrate. The thickness profile of the nanogel revealed that a 400 nm thick coating is formed by six multilayers of rLBL, and it exhibits 50 nm roughness over 8 μm distance. Read More

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September 2021

Preparation of hexagonal nanoporous AlO/TiO/TiN as a novel photodetector with high efficiency.

Sci Rep 2021 Sep 2;11(1):17572. Epub 2021 Sep 2.

Nanophotonics and Applications (NPA) Lab, Physics Department, Faculty of Science, Beni-Suef University, Beni Suef, 62514, Egypt.

The unique optical properties of metal nitrides enhance many photoelectrical applications. In this work, a novel photodetector based on TiO/TiN nanotubes was deposited on a porous aluminum oxide template (PAOT) for light power intensity and wavelength detection. The PAOT was fabricated by the Ni-imprinting technique through a two-step anodization method. Read More

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September 2021

High optoelectronic performance of a local-back-gate ReS/ReSe heterojunction phototransistor with hafnium oxide dielectric.

Nanoscale 2021 Sep 2;13(34):14435-14441. Epub 2021 Sep 2.

State Key Laboratory of ASIC and System, Shanghai Institute of Intelligent Electronics & Systems, School of Microelectronics, Fudan University, Shanghai 200433, China.

A high optoelectronic performance ReS/ReSe van der Waals (vdW) heterojunction phototransistor utilizing thin hafnium oxide (HfO) as a local-back-gate dielectric layer was prepared and studied. The heterojunction-based phototransistor exhibits a superior electrical performance with a large rectification ratio of ∼10. Furthermore, unlike diode-like heterojunction devices, the innovative introduction of a local-back-gate in this phototransistor provides an outstanding gate-tunable capability with an ultra-low off-state current of 433 fA and a high on/off current ratio of over 10. Read More

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September 2021

High-Q ultrasensitive integrated photonic sensors based on slot-ring resonator on a 3C-SiC-on-insulator platform.

Opt Lett 2021 Sep;46(17):4316-4319

We demonstrate, to the best of our knowledge, the first high- silicon carbide (SiC) integrated photonic sensor based on slot-ring resonators on a 3C-SiC-on-insulator (SiCOI) platform. We experimentally demonstrate an intrinsic of 17,400 at around 1310 nm wavelength for a slot-ring resonator with 40 µm radius with water cladding. By applying different concentrations of a sodium chloride (NaCl) solution that covers the devices, measured bulk sensitivities of 264-300 nm/RIU (refractive index unit) are achieved in the slot-ring resonator with a 400-450 nm rail width and a 100-200 nm slot width. Read More

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September 2021

Sulfur-Rich Polymers Based Cathode with Epoxy/Ally Dual-Sulfur-Fixing Mechanism for High Stability Lithium-Sulfur Battery.

ACS Nano 2021 Sep 1. Epub 2021 Sep 1.

State Key Laboratory of Fine Chemicals, Department of Polymer Science & Materials, Liaoning Province Engineering Research Centre of High Performance Resins. Dalian University of Technology, Dalian, 116024, China.

Lithium-sulfur (Li-S) batteries have attracted a great deal of attention for the next-generation energy storage devices due to their inherently high theoretical energy density, high natural abundance, and low cost. However, the dissolution of polysulfides in electrolytes and their undesirable shuttle behavior lead to poor cycling performance, which obstructs practical application. Herein, we report a dual-sulfur-fixing mechanism of epoxy/allyl compound/sulfur system to prepare poly(sulfur-random-4-vinyl-1,2-epoxycyclohexane) (SVE) copolymers as powerful cathode materials. Read More

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September 2021

Exploiting Free-Standing p-CuO/n-TiO Nanochannels as a Flexible Gas Sensor with High Sensitivity for HS at Room Temperature.

ACS Sens 2021 Aug 31. Epub 2021 Aug 31.

College of Sciences, Northeastern University, Shenyang 110819, China.

Hydrogen sulfide (HS) is an extremely hazardous gas and is harmful to human health and the environment. Here, we developed a flexible HS gas-sensing device operated at room temperature (25 °C) based on CuO nanoparticles coated with free-standing TiO-nanochannel membranes that were prepared by simple electrochemical anodization. Benefiting from the modulated conductivity of the CuO/TiO p-n heterojunction and a unique nanochannel architecture, the traditional thermal energy was innovatively replaced with UV irradiation (λ = 365 nm) to provide the required energy for triggering the sensing reactions of HS. Read More

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A Soft Variable-Area Electrical-Double-Layer Energy Harvester.

Adv Mater 2021 Aug 31:e2103142. Epub 2021 Aug 31.

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.

The technological promise of soft devices-wearable electronics, implantables, soft robotics, sensors-has accelerated the demand for deformable energy sources. Devices that can convert mechanical energy to electrical energy can enable self-powered, tetherless, and sustainable devices. This work presents a completely soft and stretchable (>400% strain) energy harvester based on variable-area electrical-double-layer (EDL) capacitors (≈40 µF cm ). Read More

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Is the atmospheric boundary layer altitude or the strong thermal inversions that control the vertical extent of aerosols?

Sci Total Environ 2021 Aug 19;802:149758. Epub 2021 Aug 19.

National Atmospheric Research Laboratory (NARL), Gadanki, India. Electronic address:

It is well known that the atmospheric boundary layer (ABL) plays a significant role in controlling the variability of atmospheric constituents such as aerosols and trace-gases. Hence, significant diurnal and seasonal variation in these will be observed as the ABL altitude does. However, on several occasions, high aerosol concentration in the lidar measurements is observed even above the ABL altitude. Read More

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Automated Grapevine Cultivar Identification via Leaf Imaging and Deep Convolutional Neural Networks: A Proof-of-Concept Study Employing Primary Iranian Varieties.

Plants (Basel) 2021 Aug 8;10(8). Epub 2021 Aug 8.

Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, Limassol CY-3603, Cyprus.

Extending over millennia, grapevine cultivation encompasses several thousand cultivars. Cultivar (cultivated variety) identification is traditionally dealt by ampelography, requiring repeated observations by experts along the growth cycle of fruiting plants. For on-time evaluations, molecular genetics have been successfully performed, though in many instances, they are limited by the lack of referable data or the cost element. Read More

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Technology CAD (TCAD) Simulations of MgSi/Si Heterojunction Photodetector Based on the Thickness Effect.

Sensors (Basel) 2021 Aug 18;21(16). Epub 2021 Aug 18.

The College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China.

Research on infrared detectors has been widely reported in the literature. For infrared detectors, PbS, InGaAs, PbSe, InSb, and HgxCd1-xTe materials are the most widely used and have been explored for photodetection applications. However, these are toxic and harmful substances which are not conducive to the sustainable development of infrared detectors and are not eco-friendly. Read More

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The Ultraviolet Index Is Well Estimated by the Terrestrial Irradiance at 310 nm.

Sensors (Basel) 2021 Aug 17;21(16). Epub 2021 Aug 17.

Hackensack Meridian Center for Discovery and Innovation, 111 Ideation Way, Nutley, NJ 07110, USA.

Ultraviolet (UV) exposure significantly contributes to non-melanoma skin cancer. In the context of health, UV exposure is the product of time and the UV Index (UVI), a weighted sum of the irradiance over all wavelengths from = 250 to 400 nm. In our analysis of the United States Environmental Protection Agency's UV-Net database of over 400,000 spectral irradiance measurements taken over several years, we found that the UVI is well estimated by 77 . Read More

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Optimization of α-FeO Nanopillars Diameters for Photoelectrochemical Enhancement of α-FeO-TiO Heterojunction.

Herme G Baldovi

Nanomaterials (Basel) 2021 Aug 7;11(8). Epub 2021 Aug 7.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.

Global warming is pushing the world to seek to green energy sources and hydrogen is a good candidate to substitute fossil fuels in the short term. In future, it is expected that production of hydrogen will be carried out through photo-electrocatalysis. In this way, suitable electrodes that acts as photoanode absorbing the incident light are needed to catalyse water splitting reaction. Read More

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Evolution of Structural and Magnetic Properties of Fe-Co Wire-like Nanochains Caused by Annealing Atmosphere.

Materials (Basel) 2021 Aug 23;14(16). Epub 2021 Aug 23.

Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warsaw, Poland.

Thermal treatment is a post-synthesis treatment that aims to improve the crystallinity and interrelated physical properties of as-prepared materials. This process may also cause some unwanted changes in materials like their oxidation or contamination. In this work, we present the post-synthesis annealing treatments of the amorphous FeCo ( = 0. Read More

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Application of Amorphous Zirconium-Yttrium-Aluminum-Magnesium-Oxide Thin Film with a High Relative Dielectric Constant Prepared by Spin-Coating.

Membranes (Basel) 2021 Aug 10;11(8). Epub 2021 Aug 10.

State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China.

Amorphous metal oxide has been a popular choice for thin film material in recent years due to its high uniformity. The dielectric layer is one of the core materials of the thin film transistor (TFT), and it affects the ability of charges storage in TFT. There is a conflict between a high relative dielectric constant and a wide band gap, so we solved this problem by using multiple metals to increase the entropy of the system. Read More

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Electrospun liquid crystal elastomer microfiber actuator.

Sci Robot 2021 Aug;6(57)

Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093, USA.

Fibers capable of generating axial contraction are commonly seen in nature and engineering applications. Despite the broad applications of fiber actuators, it is still very challenging to fabricate fiber actuators with combined large actuation strain, fast response speed, and high power density. Here, we report the fabrication of a liquid crystal elastomer (LCE) microfiber actuators using a facile electrospinning technique. Read More

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Constructing a High-Energy and Durable Single-Crystal NCM811 Cathode for All-Solid-State Batteries by a Surface Engineering Strategy.

ACS Appl Mater Interfaces 2021 Sep 25;13(35):41669-41679. Epub 2021 Aug 25.

State Key Laboratory for Physical Chemistry of Solid Surfaces, and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China.

Single-crystal LiNiCoMnO (S-NCM811) with an electrochemomechanically compliant microstructure has attracted great attention in all-solid-state batteries (ASSBs) for its superior electrochemical performance compared to the polycrystalline counterpart. However, the undesired side reactions on the cathode/solid-state electrolyte (SSE) interface causes inferior capacity and rate capability than lithium-ion batteries, limiting the practical application of S-NCM811 in the ASSB technology. Herein, it shows that S-NCM811 delivers a high capacity (205 mAh g, 0. Read More

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September 2021

Porous Ion Gel: A Versatile Ionotronic Sensory Platform for High-Performance, Wearable Ionoskins with Electrical and Optical Dual Output.

ACS Nano 2021 Aug 24. Epub 2021 Aug 24.

Department of Chemical Engineering, University of Seoul, Seoul 02504, Republic of Korea.

The development of elastic ionic conductors offers opportunities to fabricate key wearable ionic components such as ionoskins that can perceive mechanical deformation. However, there is still plenty of room to overcome the trade-off between sensitivity and detectable range of previous systems and impart additional functionality. Here, we propose porous ion gels for high-performance, functional ionic sensory platforms. Read More

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Biology and pathology of the uterine microenvironment and its natural killer cells.

Cell Mol Immunol 2021 Sep 23;18(9):2101-2113. Epub 2021 Aug 23.

Department of Obstetrics & Gynaecology, University of Cambridge, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK.

Tissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity. Determining how immune cells inhabit, housekeep, and defend gut, lung, brain, liver, uterus, and other organs helps revealing the intimate details of tissue physiology and may offer new therapeutic targets to treat pathologies. Read More

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September 2021