Epilepsy Res 2021 Apr 20;174:106644. Epub 2021 Apr 20.
Inserm, Biochemistry and Molecular Biology Laboratory, HMNO, CBP, CHRU Lille & EA 7364 - RADEME, North France University Lille, 2, Bld Prof Jules Leclercq, 59037, Lille, France. Electronic address:
Introduction: DL-3-hydroxy-3-phenylpentanamide (HEPP) and DL-3-hydroxy-3-(4'chlorophenyl)-pentanamide (Cl-HEPP) are phenyl-alcohol-amides that are metabotropic GABAB receptor (MGBR) antagonists and protective against absence seizures. This study aims to further characterize the anticonvulsant profile of these drugs.
Methods: HEPP and Cl-HEPP were evaluated in various standardized acute seizure and toxic tests in female Swiss-OF1 mice. Read More