25,957 results match your criteria late-onset depression


Low prevalence of late-onset neutropenia following rituximab treatment in patients with pemphigus.

J Am Acad Dermatol 2020 May 22. Epub 2020 May 22.

Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.05.076DOI Listing

Occurrence of ventilator associated pneumonia using a tracheostomy tube with subglottic secretion drainage.

Minerva Anestesiol 2020 May 22. Epub 2020 May 22.

Anesthesia and Intensive Care Medicine, Policlinico di Sant'Orsola, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Background: Ventilator-associated pneumonia (VAP) is a significant cause of morbidity and mortality in critically ill patients who require mechanical ventilation (MV). Subglottic secretions above the endotracheal cuff are associated with bacteria colonization of lower respiratory tract, causing VAP. A preventive strategy to avoid subglottic secretion progression is the drainage with special tracheal tubes effective in preventing both early onset and late onset VAP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0375-9393.20.13989-0DOI Listing

Neonatal and young infant sepsis by Group B Streptococci and Escherichia coli: a single-center retrospective analysis in Germany-GBS screening implementation gaps and reduction in antibiotic resistance.

Eur J Pediatr 2020 May 23. Epub 2020 May 23.

Department of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität (TU) Dresden, Fetscherstraße 74, D-01307, Dresden, Germany.

The last nationwide surveillance study on neonatal and young infant sepsis due to Group B Streptococci (GBS) and Escherichia coli in Germany was conducted between 2009 and 2010. The aim of this study is to provide longitudinal epidemiological data on neonatal and young infant sepsis caused by GBS and E. coli to reevaluate existing data and to inform clinical decision-making. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-020-03659-8DOI Listing

Interleukin-6 as a Biomarker of Early-Onset Neonatal Sepsis.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Programa de Medicina, Facultad de Salud, Universidad Surcolombiana, Neiva, Huila, Colombia.

Objective:  The aim of this study is to determine the utility of C reactive protein (CRP) and interleukin (IL)-6 in the diagnosis of neonatal sepsis (NS) in a neonatal intensive care unit (NICU) in the south of Colombia.

Study Design:  A nonmatched case-control study was conducted. Convenience sampling was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1710010DOI Listing

Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia.

Glia 2020 May 23. Epub 2020 May 23.

Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Dystonin (Dst) is a causative gene for Dystonia musculorum (dt) mice, which is an inherited disorder exhibiting dystonia-like movement and ataxia with sensory degeneration. Dst is expressed in a variety of tissues, including the central nervous system and the peripheral nervous system (PNS), muscles, and skin. However, the Dst-expressing cell type(s) for dt phenotypes have not been well characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/glia.23843DOI Listing

Midlife Chronological and Endocrinological Transitions in Brain Metabolism: System Biology Basis for Increased Alzheimer's Risk in Female Brain.

Sci Rep 2020 May 22;10(1):8528. Epub 2020 May 22.

Center for Innovation in Brain Science and Department of Pharmacology, University of Arizona, Tucson, AZ, USA.

Decline in brain glucose metabolism is a hallmark of late-onset Alzheimer's disease (LOAD). Comprehensive understanding of the dynamic metabolic aging process in brain can provide insights into windows of opportunities to promote healthy brain aging. Chronological and endocrinological aging are associated with brain glucose hypometabolism and mitochondrial adaptations in female brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-65402-5DOI Listing

High Dietary Advanced Glycation End Products Impair Mitochondrial and Cognitive Function.

J Alzheimers Dis 2020 May 22. Epub 2020 May 22.

Department of Pharmacology and Toxicology and Higuchi Biosciences Center, University of Kansas, Lawrence, KS, USA.

Background: Advanced glycation end products (AGEs) are an important risk factor for the development of cognitive decline in aging and late-onset neurodegenerative diseases including Alzheimer's disease. However, whether and how dietary AGEs exacerbate cognitive impairment and brain mitochondrial dysfunction in the aging process remains largely unknown.

Objective: We investigated the direct effects of dietary AGEs on AGE adducts accumulation, mitochondrial function, and cognitive performance in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-191236DOI Listing

Sub-optimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena.

Eur Respir J 2020 May 22. Epub 2020 May 22.

Department of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada

Background: In clinical trials, the two anti-IL-5 monoclonal antibodies (mAbs, mepolizumab and reslizumab) that are approved to treat severe eosinophilic asthma, reduce exacerbations by approximately 50-60%.

Objective: To observe response to anti-IL-5 mAbs in real-life clinical setting, and to evaluate predictors of sub-optimal response.

Methods: In four Canadian academic centres, pre-defined clinical end-points in 250 carefully characterised moderate-to-severe asthmatics were collected prospectively to assess response to the two anti-IL-5 mAbs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00117-2020DOI Listing

Differential implications of persistent, remitted, and late-onset ADHD symptoms for substance abuse in women and men: A twin study from ages 11 to 24.

Drug Alcohol Depend 2020 Feb 27:107947. Epub 2020 Feb 27.

University of Minnesota, Twin Cities: Department of Psychology, 75 E. River Rd, Minneapolis, MN, 55455, United States.

Background: Persistence and emergence of ADHD in adulthood are associated with substance problems. We investigate differential implications of ADHD course for tobacco, alcohol, or marijuana problems by sex, then whether substance misuse results from ADHD or contributes to it, through a twin differences design.

Methods: A population-based cohort of 998 twins (61 % monozygotic; 52 % female), born in Minnesota from 1988 to 1994, was prospectively assessed from ages 11-24. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2020.107947DOI Listing
February 2020

Pulmonary hypertension in late-onset Methylmalonic Aciduria and Homocystinemia: a case report.

BMC Pediatr 2020 May 22;20(1):243. Epub 2020 May 22.

Department of Cardiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, Sichuan, China.

Background: Methylmalonic Aciduria and Homocystinemia, cobalamin C (cblC) is an inherited disease of vitamin B metabolism with a wide spectrum of clinical manifestations. cblC presenting with pulmonary hypertension (PH) as leading sympotom is rare and easily misdiagnosed because of limited awareness. Timely diagnosis is crucial by the relentless progression without appropriate treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-020-02130-9DOI Listing

Late-onset Pseudoxanthoma Elasticum Associated with a Hypomorphic ABCC6 Variant.

Am J Ophthalmol 2020 May 19. Epub 2020 May 19.

Genomics Laboratory, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK; Institute of Biomedical and Clinical Science, University of Exeter School of Medicine, Exeter, UK.

Purpose: To describe patients with late-onset Pseudoxanthoma elasticum (PXE) associated with a likely hypomorphic ABCC6 variant.

Design: Retrospective observational case series.

Methods: Clinical evaluation, multimodal retinal imaging, genetic testing and molecular modeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2020.05.009DOI Listing

Persistence of Inflammation After Uncomplicated Cataract Surgery: A 6-Month Laser Flare Photometry Analysis.

Adv Ther 2020 May 21. Epub 2020 May 21.

Ophthalmology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Purpose: To evaluate, by laser photometry, the persistency of anterior chamber flare after uneventful phacoemulsification in asymptomatic patients with no signs of inflammation on slit lamp examination.

Method: Seventy-five patients previously enrolled in a randomized clinical trial that evaluated inflammation after uneventful phacoemulsification in eyes treated with dexamethasone 0.1% ophthalmic suspension (group 1) or bromfenac 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12325-020-01383-1DOI Listing

Testosterone Levels Are Decreased and Associated with Disease Duration in Male Spinocerebellar Ataxia Type 2 Patients.

Cerebellum 2020 May 21. Epub 2020 May 21.

Center for the Investigation and Rehabilitation of Hereditary Ataxias (CIRAH), Holguin, Cuba.

Spinocerebellar ataxia type 2 (SCA2) is a progressive neurodegenerative disorder due to an unstable expansion of a CAG repeat in the ATXN2 gene. Despite clinical and experimental evidence indicating the relevance of the gonadotropic axis to the prognosis and therapeutics for several late-onset neurodegenerative disorders, its functioning and association with disease severity have not been previously explored in SCA2. To assess serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), and their clinical relevance in SCA2 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12311-020-01134-6DOI Listing

Global Approaches to the Prevention and Management of Delayed-onset Adverse Reactions with Hyaluronic Acid-based Fillers.

Plast Reconstr Surg Glob Open 2020 Apr 29;8(4):e2730. Epub 2020 Apr 29.

Batniji Facial Plastic Surgery, Newport Beach, Calif.

Background: Delayed-onset adverse reactions to hyaluronic acid (HA) fillers are uncommon but have received increased attention, particularly with regard to late-onset nodules. Globally, there is a need for comprehensive prevention and management strategies.

Methods: Experts with clinical practices in diverse regions of the world and extensive experience in managing complications related to HA fillers convened to propose and evaluate approaches to prevent delayed-onset adverse reactions after HA filler administration and manage late-onset nodules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GOX.0000000000002730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209845PMC

Biotinidase Deficiency: Prevalence, Impact And Management Strategies.

Pediatric Health Med Ther 2020 4;11:127-133. Epub 2020 May 4.

Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.

Biotinidase deficiency is an autosomal recessive inherited neurocutaneous disorder. Clinically untreated patients with BD can present with variable neurological and dermatological signs, such as seizures, hypotonia, feeding problems, developmental delay, hearing loss, optic atrophy ataxia, alopecia, and skin rash. Clinical findings of patients with partial BD reported in the literature show that it can occur from infancy to adulthood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/PHMT.S198656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211084PMC

Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel.

Clin Cosmet Investig Dermatol 2020 7;13:345-349. Epub 2020 May 7.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Over the past few decades, soft tissue augmentation is ever-increasing, specifically hyaluronic acid (HA)-based filler injections. As the number of these procedures have risen, so have the adverse reactions. Delayed-type inflammatory reactions (DIRs) secondary to tissue fillers are typically classified according to the time of appearance post-procedure and have various presentations including nodules, abscesses, edema, and discoloration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CCID.S247315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216297PMC

Missed induced bullous pemphigoid: when the anamnesis is the cure.

J Am Acad Dermatol 2020 May 18. Epub 2020 May 18.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.04.178DOI Listing

Robust Sampling of Defective Pathways in Alzheimer's Disease. Implications in Drug Repositioning.

Int J Mol Sci 2020 May 19;21(10). Epub 2020 May 19.

Battelle Center for Mathematical Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.

We present the analysis of the defective genetic pathways of the Late-Onset Alzheimer's Disease (LOAD) compared to the Mild Cognitive Impairment (MCI) and Healthy Controls (HC) using different sampling methodologies. These algorithms sample the uncertainty space that is intrinsic to any kind of highly underdetermined phenotype prediction problem, by looking for the minimum-scale signatures (header genes) corresponding to different random holdouts. The biological pathways can be identified performing posterior analysis of these signatures established via cross-validation holdouts and plugging the set of most frequently sampled genes into different ontological platforms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21103594DOI Listing

Induced pluripotent stem cells (iPSCs) as game-changing tools in the treatment of neurodegenerative disease: Mirage or reality?

J Cell Physiol 2020 May 21. Epub 2020 May 21.

Stem Cell and Regenerative Medicine Center, Tehran University of Medical Sciences, Tehran, Iran.

Based on investigations, there exist tight correlations between neurodegenerative diseases' incidence and progression and aberrant protein aggregreferates in nervous tissue. However, the pathology of these diseases is not well known, leading to an inability to find an appropriate therapeutic approach to delay occurrence or slow many neurodegenerative diseases' development. The accessibility of induced pluripotent stem cells (iPSCs) in mimicking the phenotypes of various late-onset neurodegenerative diseases presents a novel strategy for in vitro disease modeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.29800DOI Listing

Preterm infants harbour diverse populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.

Microb Genom 2020 May 21. Epub 2020 May 21.

Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.

spp. are frequently enriched in the gut microbiota of preterm neonates, and overgrowth is associated with necrotizing enterocolitis (NEC), nosocomial infections and late-onset sepsis. Little is known about the genomic and phenotypic characteristics of preterm-associated , as previous studies have focused on the recovery of antimicrobial-resistant isolates or culture-independent molecular analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/mgen.0.000377DOI Listing

[Late-onset migraine equivalent with prolonged aura and altered brain perfusion].

Rev Neurol 2020 Jun;70(11):430-432

Hospital Clínic de Barcelona, 08036 Barcelona, España.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.33588/rn.7011.2019333DOI Listing

Late-onset postsurgical hypoparathyroidism following parathyroidectomy for recurrent primary hyperparathyroidism: a case report and literature review.

Endocrine 2020 May 21. Epub 2020 May 21.

University Hospital of Pisa, Endocrine Unit 2, Pisa, Italy.

Purpose: Previously in 1987, a 21-year-old male was diagnosed with primary hyperparathyroidism (PHPT) when a right inferior parathyroid adenoma was removed. PHPT recurred after 3 and 6 years and on both occasions was cured by resection of parathyroid adenomas. At 52 years of age, the patient developed a late-onset hypoparathyroidism (HP), even though postsurgical HP typically occurs as a transient or permanent form soon after neck surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-020-02344-yDOI Listing

Analysis of clinical and laboratory characteristics and pathology of lupus nephritis-based on 710 renal biopsies in China.

Clin Rheumatol 2020 May 20. Epub 2020 May 20.

Department of Nephrology, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Medical School of Chinese PLA, the First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.

Objectives: This study aimed to analyse the clinical and laboratory characteristics of different pathologic classifications of lupus nephritis (LN) patients in terms of age at systemic lupus erythematosus (SLE) diagnosis and nephritis onset.

Method: Clinical, laboratory, and pathological data of 710 LN patients diagnosed by renal biopsy at our institution between 2000 and 2018 were retrospectively analysed. Patients were divided into the different pathological classification groups; childhood-, adult- and elderly-onset SLE groups and early- and late-onset LN groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10067-020-05115-2DOI Listing

Risk Factors for In-hospital Mortality After Transarterial Intervention After Postpancreatectomy Hemorrhage.

Cardiovasc Intervent Radiol 2020 May 20. Epub 2020 May 20.

Institute for Diagnostic and Interventional Radiology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

Purpose: Postpancreatectomy hemorrhage (PPH) is one of the leading causes of mortality after pancreatic resection. Late onset PPH is most often treated using a transarterial approach. The aim of this study was to analyze risk factors for in-hospital mortality after endovascular treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00270-020-02509-2DOI Listing

Amyloid accumulation in Down syndrome measured with amyloid load.

Alzheimers Dement (Amst) 2020 16;12(1):e12020. Epub 2020 Apr 16.

University of Wisconsin-Madison Waisman Center Madison Wisconsin.

Introduction: Individuals with Down syndrome (DS) show enhanced amyloid beta (Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid load ( ) was recently developed as an alternative to standardized uptake value ratios (SUVrs) to quantify Aβ burden with high sensitivity for detecting and tracking Aβ change.. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dad2.12020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233422PMC

Late-onset argininosuccinic aciduria associated with hyperammonemia triggered by influenza infection in an adolescent: A case report.

Mol Genet Metab Rep 2020 Sep 15;24:100605. Epub 2020 May 15.

Department of Pediatrics, Gunma University Graduate School of Medicine, Japan.

Hyperammonemia is a typical symptom of urea cycle disorders. While early-onset argininosuccinic aciduria (ASA) can often be detected by hyperammonemia, patients with late-onset ASA predominantly present with psychomotor retardation and mental disorders. However, in late-onset ASA that develops during early childhood, hyperammonemia can sometimes be caused by acute infections, stress, and reduced dietary intake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgmr.2020.100605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232106PMC
September 2020

An Unusual Presentation of Hemorrhagic Disease in an Infant: A Probable Case of Abetalipoproteinemia.

J Pediatr Hematol Oncol 2020 May 19. Epub 2020 May 19.

Departments of Child Health.

We report a probable case of abetalipoproteinemia in an infant who presented with unusual symptoms of late-onset vitamin K deficiency. Abetalipoproteinemia is a rare autosomal recessive disease caused by mutation of the microsomal triglyceride transfer protein gene, resulting in the absence of microsomal triglyceride transfer protein function in the small bowel. It is characterized by the absence of plasma apolipoprotein B-containing lipoproteins, fat malabsorption, hypocholesterolemia, retinitis pigmentosa, progressive neuropathy, myopathy, and acanthocytosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPH.0000000000001831DOI Listing

Endotracheal Surfactant Combined With Budesonide for Neonatal ARDS.

Front Pediatr 2020 5;8:210. Epub 2020 May 5.

Division of Neonatology, Department of Pediatrics, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Acute respiratory distress syndrome (ARDS) is a clinical condition characterized by acute diffuse inflammatory lung injury and severe hypoxemia. In 2017, the Montreux Consensus defined diagnostic criteria for ARDS in the neonatal period. The management of ARDS includes strict adherence to lung-protective ventilation strategies and therapeutic agents to improve gas exchange. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2020.00210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214613PMC

Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency.

Dis Model Mech 2020 May 19. Epub 2020 May 19.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

Human disorders of the post-squalene cholesterol biosynthesis pathway frequently result in skeletal abnormalities, yet our understanding of the mechanisms involved is limited. In a forward genetic approach, we have found that a late-onset skeletal mutant, named , is the result of a -acting regulatory mutation leading to loss of expression within prehypertrophic chondrocytes. Generated knockdown mutation resulted in lethality at larva stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.042549DOI Listing

Association between risk of preeclampsia and maternal plasma trimethylamine-N-oxide in second trimester and at the time of delivery.

BMC Pregnancy Childbirth 2020 May 19;20(1):302. Epub 2020 May 19.

Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.

Background: The data on the association between the microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) during pregnancy and risk of preeclampsia (PE) is limited.

Methods: We, therefore, conducted a prospective nested case control study during Sep 2017 to Dec 2018 to examine the association between plasma TMAO measured during pregnancy and the risk of PE. Total of 17 patients diagnosed with early onset PE (EOPE), 49 with late onset PE (LOPE) and 198 healthy controls were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12884-020-02997-7DOI Listing

Splenectomy for ABO-Incompatible Kidney Transplantation and Very Late-Onset Cytomegalovirus Disease.

Urol Int 2020 May 19:1-6. Epub 2020 May 19.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Introduction: Splenectomy had been previously performed in ABO-incompatible kidney transplantation to reduce the B cell pool. However, studies have shown that patients undergoing splenectomy may have a lifelong susceptibility to infection and mortality. Splenectomy may affect the incidence of cytomegalovirus (CMV) disease even at a very late stage after transplantation in ABO-incompatible recipients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000504862DOI Listing

Storage, Utilization and Disposal of Hematopoietic Stem Cell Products in Multiple Myeloma Patients.

Biol Blood Marrow Transplant 2020 May 16. Epub 2020 May 16.

Department of Hematology, Oncology and Rheumatology, Heidelberg University, Heidelberg, Germany.

High-dose chemotherapy (HD-CHT) and autologous blood stem-cell transplantation (ABSCT) represent the standard of care in multiple myeloma (MM) for transplant-eligible patients. Up to three HD-CHT/ABSCT treatments may be administered during the course of disease, including during late-onset relapse. Transplant centers routinely collect more than one peripheral blood stem cell (PBSC) graft. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2020.04.030DOI Listing

The diagnostic, prognostic and therapeutic potential of circulating microRNAs in ovarian cancer.

Int J Biochem Cell Biol 2020 May 16:105765. Epub 2020 May 16.

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK. Electronic address:

Ovarian cancer (OC) is often diagnosed at an advanced stage because of the late onset of symptoms, and this together with the lack of effective treatments, has meant it is associated with a very high mortality. The aberrant expression of MicroRNA (miRNA) contributes to the initiation and development of human tumors including OC. Several miRNAs are secreted by tumor cells and can be identified in body fluids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2020.105765DOI Listing

Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.

J Clin Invest 2020 May 19. Epub 2020 May 19.

Department of Neurology, Washington University School of Medicine, St. Louis, United States of America.

Dominant mutations in the HSP70 co-chaperone DNAJB6 cause a late onset muscle disease termed limb girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology. Disease mutations reside within the G/F domain of DNAJB6, but the molecular mechanisms underlying dysfunction are not well understood. Using yeast, cell culture, and mouse models of LGMDD1, we found that the toxicity associated with disease-associated DNAJB6 required its interaction with HSP70, and that abrogating this interaction genetically or with small molecules was protective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI136167DOI Listing

Late Onset Upper Eyelid and Brow Edema as a Long-Term Complication of Hyaluronic Acid Filler Injection.

Aesthet Surg J 2020 May 19. Epub 2020 May 19.

Oculoplastic Surgery Unit, Department of Ophthalmology, Shamir Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Late onset upper eyelid edema is an uncommonly recognized complication of hyaluronic acid (HA)-based filler injection to the supraorbital area.

Objectives: To report our experience in diagnosing and managing late onset upper eyelid edema.

Methods: Non-comparative, retrospective study of a series of 17 consecutive patients who presented with upper eyelid edema 6-24 months after uneventful HA filler injection in the supraorbital area. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/asj/sjaa126DOI Listing

Increased apolipoprotein E and decreased TNF-α in the cerebrospinal fluid of nondemented APOE-ε4 carriers.

Neuropsychopharmacol Rep 2020 May 19. Epub 2020 May 19.

Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Kodaira, Japan.

Aim: The ε4 allele of apolipoprotein E gene (APOE) is a well-known risk factor of late-onset Alzheimer's disease. However, little is known why this variant confers a risk for Alzheimer's disease. The aim of this study was to examine the influence of the APOE genotype on cerebrospinal fluid (CSF) protein levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/npr2.12110DOI Listing

A clinicopathological study of 8 patients with COVID-19 pneumonia and a late-onset exanthema.

J Eur Acad Dermatol Venereol 2020 May 19. Epub 2020 May 19.

Pathology department, Hospital Universitario de Torrejón, Torrejon de Ardoz, Madrid, Spain.

Our hospital diagnosed the two first non-imported COVID-19 cases in Spain on 26 February. Up to date, a total of 1177 COVID-19 patients have been hospitalized. Eight of them were referred for dermatological examination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16631DOI Listing

Advanced late-onset retinitis pigmentosa with dominant-acting D477G RPE65 mutation is responsive to oral synthetic retinoid therapy.

BMJ Open Ophthalmol 2020 5;5(1):e000462. Epub 2020 May 5.

Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland.

Objectives: No therapeutic interventions are currently available for autosomal dominant retinitis pigmentosa (adRP). An RPE65 Asp477Gly transition associates with late-onset adRP, reduced RPE65 enzymatic activity being one feature associated with this dominant variant. Our objective: to assess whether in a proof-of-concept study, oral synthetic 9 -retinyl acetate therapy improves vision in such advanced disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2020-000462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228561PMC

Theta-Burst Stimulation for Auditory-Verbal Hallucination in Very-Late-Onset Schizophrenia-Like Psychosis-A Functional Magnetic Resonance Imaging Case Study.

Front Psychiatry 2020 20;11:294. Epub 2020 Apr 20.

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Background: Treating very-late-onset (>60 years) schizophrenia-like psychosis (VLOSLP) is challenging. Age-related factors in elderly individuals (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2020.00294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212466PMC

Post Transplant Lymphoproliferative Disorder.

Indian J Hematol Blood Transfus 2020 Apr 17;36(2):229-237. Epub 2019 Sep 17.

1Department of Laboratory Science and Molecular Medicine, Army Hospital (Research and Referral), New Delhi, India.

Posttransplant lymphoproliferative disorder is an extremely fatal complication arising in transplant recipients as a side effect of immunosuppression. PTLDs are seen after both solid organ and hematopoietic stem cell transplants though the incidence is much higher in the former. Primary Epstein-Barr virus (EBV) infection or reactivation due to a state of immune dysregulation along with intensity of immunosuppression used are of paramount importance in pathogenesis of PTLD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12288-019-01182-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229077PMC

Resistome and virulome study on pathogenic Streptococcus agalactiae Guangzhou-SAG036.

Microb Pathog 2020 May 15:104258. Epub 2020 May 15.

Department of Civil and Environmental Engineering, University of Maryland, College Park, MD, 20742, USA.

Streptococcus agalactiae is considered as a leading case of bacterial infection among neonates. Although relative protection strategies have been performed in many high-income countries, resulting in a massive reduction in the occurrences of early-onset GBS disease, the late-onset disease has not affected. Here, the whole genome of S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micpath.2020.104258DOI Listing

Novel Biallelic CTSD Gene Variants Cause Late-Onset Ataxia and Retinitis Pigmentosa.

Mov Disord 2020 May 18. Epub 2020 May 18.

Department of Molecular Neurology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.28106DOI Listing

A late onset widespread skin rash in a previous Covid-19 infected patient: viral or multidrug effect?

J Eur Acad Dermatol Venereol 2020 May 18. Epub 2020 May 18.

Dermatology Unit "D. Innocenzi", Polo Pontino, Sapienza University of Rome, Rome, Italy.

in the end of 2019, a series of pneumonia cases emerged in China, with clinical presentations greatly resembling viral pneumonia, caused by Covid-19 o SARS-CoV-2. Currently, several clinicians described an increasingly cases of coronavirus-positive patients reporting skin problems, either in early stage of infection or as late onset manifestation. Recently, Dr. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16633DOI Listing

High Burden of Bloodstream Infections Associated with Antimicrobial Resistance and Mortality in the Neonatal Intensive Care Unit in Pune, India.

Clin Infect Dis 2020 May 18. Epub 2020 May 18.

Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Background: Antimicrobial resistance (AMR) is a growing threat to newborns in low and middle income countries (LMIC).

Methods: We performed a prospective cohort study in three tertiary Neonatal Intensive Care Units (NICUs) in Pune, India, to describe the epidemiology of neonatal bloodstream infections (BSI). All neonates admitted to the NICU were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciaa554DOI Listing

Differential diagnosis of vacuolar myopathies in the NGS era.

Brain Pathol 2020 May 17. Epub 2020 May 17.

Institute of Neuropathology, RWTH Aachen University, Aachen, Germany.

Altered autophagy accompanied by abnormal autophagic (rimmed) vacuoles detectable by light and electron microscopy is a common denominator of many familial and sporadic non-inflammatory muscle diseases. Even in the era of next generation sequencing (NGS), late-onset vacuolar myopathies remain a diagnostic challenge. We identified 32 adult vacuolar myopathy patients from 30 unrelated families, studied their clinical, histopathological and ultrastructural characteristics and performed genetic testing in index patients and relatives using Sanger sequencing and NGS including whole exome sequencing (WES). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12864DOI Listing

Generation of a human induced pluripotent stem cell line, BRCi004-A, derived from a patient with age-related macular degeneration.

Stem Cell Res 2020 Apr 21;45:101787. Epub 2020 Apr 21.

iPSC-based Drug discovery and Development Team, RIKEN BioResource Research Center, Kyoto, Japan; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. Electronic address:

Age-related macular degeneration (AMD) is a late-onset progressive blinding disease. We established human induced pluripotent stem cells (iPSCs) from an AMD patient. The generated iPSC line showed pluripotency markers and three-germ layer differentiation ability in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2020.101787DOI Listing

The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases.

Authors:
Ralph A Nixon

Biochim Biophys Acta Proteins Proteom 2020 May 13:140443. Epub 2020 May 13.

Center for Dementia Research, Nathan S. Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA; Departments of Psychiatry, New York University Langone Medical Center, 550 First Ave, New York, NY 10016, USA; Cell Biology, New York University Langone Medical Center, 550 First Ave, New York, NY 10016, USA; NYU Neuroscience Institute, New York University Langone Medical Center, 550 First Ave, New York, NY 10016, USA. Electronic address:

Lysosomes figure prominently in theories of aging as the proteolytic system most responsible for eliminating growing burdens of damaged proteins and organelles in aging neurons and other long lived cells. Newer evidence shows that diverse experimental measures known to extend lifespan in invertebrate aging models share the property of boosting lysosomal clearance of substrates through the autophagy pathway. Maintaining an optimal level of lysosome acidification is particularly crucial for these anti-aging effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbapap.2020.140443DOI Listing

Changing epidemiology and resistance patterns of pathogens causing neonatal bacteremia.

Eur J Clin Microbiol Infect Dis 2020 May 15. Epub 2020 May 15.

Department of Neonatology, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel.

To conduct a survey of the local prevalent bacteria and antibiotic resistance in a referral tertiary neonatal intensive care unit (NICU), in order to assess the efficacy of local antibiotic policies. We reviewed all positive blood and cerebrospinal fluid cultures obtained between January 2007 and December 2017 in the NICU of Schneider Children's Medical Center of Israel. Early and late-onset bacteremia were defined as episodes occurring within or after the first 3 calendar days of life respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10096-020-03921-9DOI Listing