172,813 results match your criteria late early


[Early and Late Toxicities and Socio-Medical Relevant Disorders after Oncological Treatment for Breast Cancer-Implications and Assessment of Rehabilitation Requirement].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):77-85. Epub 2021 Apr 15.

Frauenklinik, Universitätsklinikum, Würzburg.

Introduction: Reasonable to the improved prognosis of breast cancer (BC) long-term toxicities and side effects of oncological therapy gain more importance for work ability and social life of BC patients. Aim of this study was the analysis of occurence and differences of treatment-related side effects in relation to type of rehabilitation (so-called AHB vs. later rehabilitation) after therapy for BC. Read More

View Article and Full-Text PDF

Bioactivity-guided discovery of quality control markers in rhizomes of Curcuma wenyujin based on spectrum-effect relationship against human lung cancer cells.

Phytomedicine 2021 Mar 27;86:153559. Epub 2021 Mar 27.

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. Electronic address:

Background: Due to the diversity of the ingredients, the complexity of the mechanism of action, the uncertainty of the effective ingredients, coupled with the multiple species and multiple growing areas, the quality control (QC) of Traditional Chinese Medicines (TCMs) is challenging. Discovering and identifying effective compounds from the complex extracts of TCMs and then establishing a scientific QC method is the key to the holistic QC of TCMs.

Purpose: To develop an anti-lung-cancer-guided spectrum-effect relationship approach for the discovery of QC markers of the rhizome of Curcuma wenyujin (WEZ) and establish a bioactive compounds-based holistic QC method. Read More

View Article and Full-Text PDF

Doppler studies of placental function.

Placenta 2021 Apr 2;108:91-96. Epub 2021 Apr 2.

Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, And Center for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.

Placental-associated diseases account for most cases of adverse perinatal outcome in developing countries. Doppler evaluation has been incorporated as a predictive parameter at early pregnancy for high-risk placental disease, in the diagnosis and management of those fetuses with impaired intrauterine growth and for the evaluation of fetal wellbeing in those high-risk pregnancies. Uterine Doppler at second trimester predicts most instances of early-onset preeclampsia and intrauterine growth restriction. Read More

View Article and Full-Text PDF

Cost and clinical outcomes of postoperative intensive care unit versus general floor management in head and neck free flap reconstructive surgery patients.

Am J Otolaryngol 2021 Apr 12;42(5):103029. Epub 2021 Apr 12.

Department of Otolaryngology- Head and Neck Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address:

Purpose: To compare clinical, surgical, and cost outcomes in patients undergoing head and neck free-flap reconstructive surgery in the setting of postoperative intensive care unit (ICU) against general floor management.

Methods: Retrospective analysis of head and neck free-flap reconstructive surgery patients at a single tertiary academic medical center. Clinical data was obtained from medical records. Read More

View Article and Full-Text PDF

Parkinson's Disease and the Gut: Models of an Emerging Relationship.

Acta Biomater 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., 313 Snell Engineering, Boston, MA 02115, U.S.A.; Department of Biology, Northeastern University, 360 Huntington Ave., 313 Snell Engineering, Boston, MA 02115, U.S.A.. Electronic address:

Parkinson's disease (PD) is a common neurodegenerative disease characterized by a progressive loss of fine motor function that impacts 1-2 out of 1,000 people. PD occurs predominately late in life and lacks a definitive biomarker for early detection. Recent cross-disciplinary progress has implicated the gut as a potential origin of PD pathogenesis. Read More

View Article and Full-Text PDF

A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure.

J Hepatol 2021 Mar 29. Epub 2021 Mar 29.

Institute of Liver Studies, King's College Hospital, London, UK. Electronic address:

Background And Aims: Acetaminophen (APAP) induced acute liver failure (ALF) remains the commonest cause of ALF in the western world. Conventional prognostic models utilising markers of liver injury and organ failure to predict mortality lack sensitivity. We have previously demonstrated a microRNA signature that is associated with successful regeneration post-auxiliary liver transplant and recovery from APAP-ALF. Read More

View Article and Full-Text PDF

Cardiomyocyte heterogeneity during zebrafish development and regeneration.

Dev Biol 2021 Apr 12. Epub 2021 Apr 12.

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. Electronic address:

Contrary to adult mammals, zebrafish are able to regenerate their heart after cardiac injury. This regenerative response relies, in part, on the endogenous ability of cardiomyocytes (CMs) to dedifferentiate and proliferate to replenish the lost muscle. However, CM heterogeneity and population dynamics during development and regeneration require further investigation. Read More

View Article and Full-Text PDF

Identification of miRNA Associated with Reduced Survival after Whole-Thorax Lung Irradiation in Non-Human Primates.

Radiat Res 2021 Apr 15. Epub 2021 Apr 15.

ChromoLogic LLC, Monrovia, California 91016.

Thoracic exposure to ionizing radiation can lead to delayed injuries to the heart and lung that are serious and even life-threatening. These injuries are difficult to predict since they manifest over many weeks and months. To identify non-invasive, tissue-specific biomarkers for the early detection of late radiation injury, circulating microRNA (miRNA) levels were measured in non-human primates (NHP, Macaca mulatta) that received a single exposure of whole-thorax lung irradiation (WTLI) at a dose likely to result in 20% or 75% mortality within 180 days (9. Read More

View Article and Full-Text PDF

Impact of 13-valent pneumococcal conjugate vaccine on laboratory-confirmed pneumococcal meningitis and purulent meningitis among children ˂5 years in Cameroon, 2011-2018.

PLoS One 2021 15;16(4):e0250010. Epub 2021 Apr 15.

Pfizer Vaccines Medical Development & Medical/Scientific Affairs, New York, New York, United States of America.

Background: The 13-valent pneumococcal conjugate vaccine (PCV13) entered Cameroon's childhood national immunization programme (NIP) in July 2011 under a 3-dose schedule (6, 10, 14 weeks of age) without any catch-up. We described the impact of PCV13 onserotype distribution among pneumococcal meningitis cases over time.

Methods: We used laboratory-based sentinel surveillance data to identify meningitis cases among 2- to 59-month-old children with clinically-suspected bacterial meningitis (CSBM) admitted to hospitals in Yaoundé (August 2011-December 2018). Read More

View Article and Full-Text PDF

Differential expression of groEL-1, incB, pyk-F, tal, hctA and omcB genes during Chlamydia trachomatis developmental cycle.

PLoS One 2021 15;16(4):e0249358. Epub 2021 Apr 15.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.

Chlamydia trachomatis infects squamous and columnar epithelia at the mucosal surface. Research on gene expression patterns of C. trachomatis has predominantly focused on non-native host cells, with limited data on growth kinetics and gene expression of chlamydia in keratinocytes. Read More

View Article and Full-Text PDF

Mild periconceptional hyperglycemia: predictor of adverse fetomaternal outcomes in gestational diabetes?

Acta Diabetol 2021 Apr 15. Epub 2021 Apr 15.

Division of Endocrinology, Diabetes and Metabolism, Centro Hospitalar E Universitário Do Porto, Largo Professor Abel Salazar, 4099-001, Porto, Portugal.

Aim: To clarify whether mild first trimester hyperglycaemia (characteristic of early-onset GDM) is associated with higher incidence of congenital malformations and other adverse fetomaternal outcomes compared to women with second trimester hyperglycaemia (later-onset GDM).

Design And Methods: We analyzed the Portuguese National GDM database, containing data collected between 2011 and 2017. Two study groups were defined: Group 1-Women with GDM diagnosed during the first trimester (with fasting glycemia ≥ 92 and < 126 mg/dL); Group 2-Women with GDM diagnosed after the first 12 weeks of gestation, with either fasting glycemia or oral glucose tolerance test, according to the International Association of Pregnancy and Diabetes Study Group criteria. Read More

View Article and Full-Text PDF

Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation.

Mult Scler 2021 Apr 15:13524585211003479. Epub 2021 Apr 15.

Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany/ NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany/Einstein Center for Neurosciences, Berlin, Germany/Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Background: Cross-sectional studies suggest normal appearing white matter (NAWM) integrity loss may lead to cortical atrophy in late-stage relapsing-remitting multiple sclerosis (MS).

Objective: To investigate the relationship between NAWM integrity and cortical thickness from first clinical presentation longitudinally.

Methods: NAWM integrity and cortical thickness were assessed with 3T magnetic resonance imaging (MRI) in 102 patients with clinically isolated syndrome or early MS (33. Read More

View Article and Full-Text PDF

: the early modern psychiatry of transgender identification.

Hist Psychiatry 2021 Apr 15:957154X211006253. Epub 2021 Apr 15.

Maastricht University (external PhD programme), The Netherlands.

Herodotus's enigmatic Scythian and its Hippocratic interpretation interested many early modern authors. Its seeming dimension of transgender identification invited various medico-psychological and psychiatric reflections, culminating in nosologist de Sauvages' tentative 1731 term, . This article identifies pertinent discussions and what turn out to have been entangled, tentative psychologizations in late-seventeenth through mid-nineteenth-century mental medicine: of 'effeminacy of manners' ( such as observed in London's Beaux and mollies) and male homosexuality (); of the mental masculinity of some women (, ); of ubiquitous attributions of impotence to sorcery (); and lastly, of transfeminine persons encountered throughout the New World and increasingly beyond. Read More

View Article and Full-Text PDF

Pulse Oximetry Screening and Critical Congenital Heart Disease in the State of Oregon.

Clin Pediatr (Phila) 2021 Apr 15:99228211008704. Epub 2021 Apr 15.

Oregon Health and Science University, Portland, OR, USA.

Late diagnosis of critical congenital heart disease (CCHD) is associated with higher levels of morbidity and mortality in neonates. Nearly all states have passed laws mandating universal pulse oximetry screening (POxS) of newborns to improve early detection rates of CCHD. We performed a retrospective chart review of all transthoracic echocardiograms (TTEs) interpreted by our institution on patients between 0 and 30 days of life in the years 2010 (prior to POxS) and 2015 (after POxS). Read More

View Article and Full-Text PDF

Pressure ulcer prevention-Results of a multicentre cross-sectional survey on hospital infrastructures and processes in acute hospitals and accident and emergency departments.

J Eval Clin Pract 2021 Apr 14. Epub 2021 Apr 14.

Rudelsburgstraße 24, Berlin, Germany.

Aims And Objectives: Pressure ulcers (PUs) are a serious health problem. They can be considered as an indicator of the quality of health care and are associated with considerable cost increases for the health care system. The prevention of PUs is a major concern in hospital care. Read More

View Article and Full-Text PDF

Metachromatic Leukodystrophy: A Single-Centre Longitudinal Study Of 45 Patients.

J Inherit Metab Dis 2021 Apr 15. Epub 2021 Apr 15.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objective: To characterize the natural course of Metachromatic Leukodystrophy (MLD), explore intra/inter group differences, and identify biomarkers to monitor disease progression.

Methods: This is a longitudinal observational study. Genotype and characteristics at disease onset were recorded. Read More

View Article and Full-Text PDF

Unprecedented Migratory Bird Die-Off: A Citizen-Based Analysis on the Spatiotemporal Patterns of Mass Mortality Events in the Western United States.

Geohealth 2021 Apr 1;5(4):e2021GH000395. Epub 2021 Apr 1.

Department of Forest and Wildlife Ecology University of Wisconsin-Madison Madison WI USA.

Extensive, severe wildfires, and wildfire-induced smoke occurred across the western and central United States since August 2020. Wildfires resulting in the loss of habitats and emission of particulate matter and volatile organic compounds pose serious threatens to wildlife and human populations, especially for avian species, the respiratory system of which are sensitive to air pollutions. At the same time, the extreme weather (e. Read More

View Article and Full-Text PDF

Transitioning from university to postgraduate medical training: A narrative review of work readiness of medical graduates.

Health Sci Rep 2021 Jun 7;4(2):e270. Epub 2021 Apr 7.

Discipline of Rural and Remote Health, College of Medicine & Public Health Flinders University Bedford Park South Australia Australia.

Context: Work readiness is often described in terms of the clinical competence medical graduates bring to day 1 of internship. Despite being increasingly viewed as a key graduate outcome, work readiness has remained poorly defined.

Objective: This narrative review draws on the international literature to explore how different research methods provide differing insight into what constitutes work readiness of medical graduates. Read More

View Article and Full-Text PDF

Progressive Ataxia and Neurologic Regression in -Associated Bare Lymphocyte Syndrome.

Neurol Genet 2021 Jun 9;7(3):e586. Epub 2021 Apr 9.

Center for Genetics and Inherited Diseases (E.A., N.A.M.A.), and Faculty of Applied Medical Sciences (N.A.M.A.), Taibah University, Almadinah Almunwarah; Department of Adults Neurology (M.O.), National Neuroscience Institute, King Fahad Medical City; Section of Medical Genetics (M.A.O.E.), Childrens Specialist Hospital, King Fahad Medical City; Department of Medical Imaging in King Abdulaziz Medical City (M.A.), King Saud Ibn Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center; Pathology and Clinical Laboratory Medicine Administration (I.B.), King Fahad Medical City; Molecular Pathology (M.S.), Clinical Laboratory Medicine Administration, King Fahad Medical City, Riyadh, Saudi Arabia; Department of Laboratory Medicine (R.W.A.P.), Boston Childrens Hospital, MA; Section of Medical Genetics (A.A.), Childrens Specialist Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.

Objective: To identify the genetic cause of a late-onset immunodeficiency and subacute progressive neurodegenerative disease affecting cognition, motor, visual, and cerebellar systems in a patient with a family history of 2 younger siblings with an early-onset immunodeficiency disease.

Methods: Physical examinations, immunologic, brain MRI, whole-exome sequencing, and segregation studies were used to identify the genetic and neuroimmunologic etiology of disease in this family.

Results: We identified a homozygous loss-of-function (LOF) mutation (c. Read More

View Article and Full-Text PDF

Relationship Between Anterior Knee Laxity and General Joint Laxity During the Menstrual Cycle.

Orthop J Sports Med 2021 Mar 29;9(3):2325967121993045. Epub 2021 Mar 29.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.

Background: Anterior cruciate ligament (ACL) injury has been reported to have a higher incidence in women than in men.

Purpose/hypothesis: The purpose was to examine the relationship of anterior knee laxity (AKL), stiffness, and generalized joint laxity (GJL) with respect to the menstrual cycle. It was hypothesized that AKL and GJL would increase during the ovulation phase, when estrogen levels are high. Read More

View Article and Full-Text PDF

Age constraint for the Moreno Hill Formation (Zuni Basin) by CA-TIMS and LA-ICP-MS detrital zircon geochronology.

PeerJ 2021 9;9:e10948. Epub 2021 Mar 9.

Paleontology, North Carolina Museum of Natural Sciences, Raleigh, NC, USA.

The "mid-Cretaceous" (~125-80 Ma) was punctuated by major plate-tectonic upheavals resulting in widespread volcanism, mountain-building, eustatic sea-level changes, and climatic shifts that together had a profound impact on terrestrial biotic assemblages. Paleontological evidence suggests terrestrial ecosystems underwent a major restructuring during this interval, yet the pace and pattern are poorly constrained. Current impediments to piecing together the geologic and biological history of the "mid-Cretaceous" include a relative paucity of terrestrial outcrop stemming from this time interval, coupled with a historical understudy of fragmentary strata. Read More

View Article and Full-Text PDF

Impact of Esophagojejunal Reconstruction without Division of the Mesentery for Total Laparoscopic Total Gastrectomy.

J Gastric Cancer 2021 Mar 25;21(1):63-73. Epub 2021 Mar 25.

Department of Stomach Surgery, Asan Medical Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Purpose: This study aimed to compare the surgical outcomes of total laparoscopic total gastrectomy without mesentery division (LTG without MD) and conventional total laparoscopic total gastrectomy (CLTG), as well as evaluate the appropriate method for esophagojejunostomy (EJ) reconstruction after total laparoscopic total gastrectomy (TLTG).

Materials And Methods: We retrospectively analyzed data from 301 consecutive patients who underwent TLTG for upper or middle third gastric cancer between January 2016 and May 2019. After propensity score matching, 95 patients who underwent LTG without MD and 95 who underwent CLTG were assessed. Read More

View Article and Full-Text PDF

Untangling the Influence of Heat Stress on Crop Phenology, Seed Set, Seed Weight, and Germination in Field Pea ( L.).

Front Plant Sci 2021 29;12:635868. Epub 2021 Mar 29.

ICAR-Indian Institute of Pulses Research, Kanpur, India.

The apparent climatic extremes affect the growth and developmental process of cool-season grain legumes, especially the high-temperature stress. The present study aimed to investigate the impacts of high-temperature stress on crop phenology, seed set, and seed quality parameters, which are still uncertain in tropical environments. Therefore, a panel of 150 field pea genotypes, grouped as early ( = 88) and late ( = 62) maturing, were exposed to high-temperature environments following staggered sowing [normal sowing time or non-heat stress environment (NHSE); moderately late sowing (15 days after normal sowing) or heat stress environment-I (HSE-I); and very-late sowing (30 days after normal sowing) or HSE-II]. Read More

View Article and Full-Text PDF

Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland.

Nat Commun 2021 04 14;12(1):2239. Epub 2021 Apr 14.

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD, 20892, USA.

Enhancers are transcription factor platforms that synergize with promoters to control gene expression. Here, we investigate enhancers that activate gene expression several hundred-fold exclusively in the lactating mouse mammary gland. Using ChIP-seq for activating histone marks and transcription factors, we identify two candidate enhancers and one super-enhancer in the Csn1s2b locus. Read More

View Article and Full-Text PDF

TIM-3 drives temporal differences in restimulation-induced cell death sensitivity in effector CD8 T cells in conjunction with CEACAM1.

Cell Death Dis 2021 Apr 14;12(4):400. Epub 2021 Apr 14.

Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, 20817, USA.

Immune homeostasis depends upon effective clearance of pathogens while simultaneously preventing autoimmunity and immunopathology in the host. Restimulation-induced cell death (RICD) is one such mechanism where by activated T cells receive subsequent antigenic stimulation, reach a critical signal threshold through the T cell receptor (TCR), and commit to apoptosis. Many details of this process remain unclear, including the role of co-stimulatory and co-inhibitory proteins that influence the TCR signaling cascade. Read More

View Article and Full-Text PDF

Academic Research Consortium for High Bleeding Risk Definitions for Early, Late, and Very Late Bleeding Events.

Circ J 2021 Apr 14. Epub 2021 Apr 14.

Department of Cardiology, Kurashiki Central Hospital.

Background: The validity of the Academic Research Consortium for High Bleeding Risk (ARC-HBR) definitions of early (<1 year), late (1-4 years), and very late (>4 years) bleeding events is unknown.Methods and Results:This study was performed on patients (n=3,453) implanted with second-generation drug-eluting stents (DES) between 2010 and 2013. Data on all criteria of the ARC-HBR definition were collected retrospectively. Read More

View Article and Full-Text PDF

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.

Acta Neuropathol Commun 2021 Apr 14;9(1):70. Epub 2021 Apr 14.

Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 7HX, UK.

Huntington's disease (HD) is a late onset, inherited neurodegenerative disorder for which early pathogenic events remain poorly understood. Here we show that mutant exon 1 HTT proteins are recruited to a subset of cytoplasmic aggregates in the cell bodies of neurons in brain sections from presymptomatic HD, but not wild-type, mice. This occurred in a disease stage and polyglutamine-length dependent manner. Read More

View Article and Full-Text PDF

Role of caregiver factors in outpatient medical follow-up post-stroke: observational study in Singapore.

BMC Fam Pract 2021 Apr 14;22(1):74. Epub 2021 Apr 14.

Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #10-01, Singapore, 117549, Singapore.

Background: Outpatient medical follow-up post-stroke is not only crucial for secondary prevention but is also associated with a reduced risk of rehospitalization. However, being voluntary and non-urgent, it is potentially determined by both healthcare needs and the socio-demographic context of stroke survivor-caregiver dyads. Therefore, we aimed to examine the role of caregiver factors in outpatient medical follow-up (primary care (PC) and specialist outpatient care (SOC)) post-stroke. Read More

View Article and Full-Text PDF

Transcriptome architecture reveals genetic networks of bolting regulation in spinach.

BMC Plant Biol 2021 Apr 14;21(1):179. Epub 2021 Apr 14.

Department of Biotechnology, College of Agriculture, Isfahan University of Technology, Isfahan, Iran.

Background: Bolting refers to the early flowering stem production on agricultural and horticultural crops before harvesting. Indeed, bolting is an event induced by the coordinated effects of various environmental factors and endogenous genetic components, which cause a large reduction in the quality and productivity of vegetable crops like spinach. However, little is known about the signaling pathways and molecular functions involved in bolting mechanisms in spinach. Read More

View Article and Full-Text PDF