82,922 results match your criteria late cohort


Iron status in late pregnancy is inversely associated with birth weight in Colombia.

Public Health Nutr 2021 Apr 16:1-29. Epub 2021 Apr 16.

ALZAK Foundation, Cartagena, Colombia.

Objective: Gestational Anaemia (GA) is common in developing countries. This study assessed the relationship of late GA and negative perinatal outcomes in participants recruited in a reference maternity unit of the Caribbean region of Colombia.

Design: Prospective analytical birth cohort study. Read More

View Article and Full-Text PDF

Role of Hyperbaric Oxygenation Plus Hypofractionated Stereotactic Radiotherapy in Recurrent High-Grade Glioma.

Front Oncol 2021 30;11:643469. Epub 2021 Mar 30.

Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.

Background: The presence of hypoxic cells in high-grade glioma (HGG) is one of major reasons for failure of local tumour control with radiotherapy (RT). The use of hyperbaric oxygen therapy (HBO) could help to overcome the problem of oxygen deficiency in poorly oxygenated regions of the tumour. We propose an innovative approach to improve the efficacy of hypofractionated stereotactic radiotherapy (HSRT) after HBO (HBO-RT) for the treatment of recurrent HGG (rHGG) and herein report the results of an analysis. Read More

View Article and Full-Text PDF

Clinical characteristics, risk factors and outcome of severe Norovirus infection in kidney transplant patients: a case-control study.

BMC Infect Dis 2021 Apr 15;21(1):351. Epub 2021 Apr 15.

INSERM U944, "Cellular Biology of Viral Interactions" Team, Université de Paris, Paris, France.

Background: Human Norovirus (HuNoV) has recently been identified as a major cause of diarrhea among kidney transplant recipients (KTR). Data regarding risk factors associated with the occurrence of HuNoV infection, and its long-term impact on kidney function are lacking.

Methods: We conducted a retrospective case-control study including all KTR with a diagnosis of HuNoV diarrhea. Read More

View Article and Full-Text PDF

Neonatal outcomes and risk of neonatal sepsis in an expectantly managed cohort of late preterm prelabor rupture of membranes.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 1;261:1-6. Epub 2021 Apr 1.

Obstetrics and Gynecology, University of Milano-Bicocca, FMBBM Monza, Carate Hospital, Lecco Hospital, Italy.

Objective: Expectant management in patients with prelabor preterm rupture of membranes between between 34 and 36 weeks (late preterm pPROM or LpPROM) has been shown to decrease the burden of prematurity, when compared to immediate delivery. As the severity of prematurity depends on gestational age (GA) at PROM, and PROM to delivery interval, we first investigated how such variables affect neonatal outcomes (NO). Second, we assessed the risk of neonatal sepsis. Read More

View Article and Full-Text PDF

Large-Scale Screening of Lipase Acid Deficiency in at Risk Population.

Clin Chim Acta 2021 Apr 12. Epub 2021 Apr 12.

Normandie Univ, UNIROUEN, INSERM U1245, CHU Rouen, Department of Metabolic Biochemistry, 76000 Rouen, France. Electronic address:

Background: Lysosomal acid lipase deficiency (LALD, OMIM#278000) is a rare lysosomal disorder with an autosomal recessive inheritance. The main clinical manifestations are related to a progressive accumulation of cholesteryl esters, triglycerides or both within the lysosome in different organs such as the liver, spleen, and cardiovascular system. A wide range of clinical severity is associated with LALD including a severe very rare antenatal/neonatal/infantile phenotype named Wolman disease and a late-onset form named cholesteryl ester storage disease (CESD). Read More

View Article and Full-Text PDF

Effect of Implementation of HEART Chest Pain Protocol on Emergency Department Disposition, Testing and Cost.

West J Emerg Med 2021 Feb 4;22(2):308-318. Epub 2021 Feb 4.

Naval Medical Center Portsmouth, Department of Emergency Department, Portsmouth, Virginia.

Background: Symptoms concerning for acute coronary syndromes (ACS) such as chest pain and dyspnea are some of the most common reasons for presenting to an emergency department (ED). The HEART score (history, electrocardiogram, age, risk factors and troponin) was developed and has been externally validated in an emergency setting to determine which patients with chest pain are at increased risk for poor outcomes. Our hospital adopted a HEART score-based protocol in late 2015 to facilitate the management and disposition of these patients. Read More

View Article and Full-Text PDF
February 2021

Maternal Late-Pregnancy Serum Unmetabolized Folic Acid Concentrations Are Not Associated with Infant Allergic Disease: A Prospective Cohort Study.

J Nutr 2021 Apr 13. Epub 2021 Apr 13.

School of Medicine, The University of Western Australia, Crawley, Australia.

Background: The increase in childhood allergic disease in recent decades has coincided with increased folic acid intakes during pregnancy. Circulating unmetabolized folic acid (UMFA) has been proposed as a biomarker of excessive folic acid intake.

Objective: We aimed to determine if late-pregnancy serum UMFA and total folate concentrations were associated with allergic disease risk in the offspring at 1 y of age in a population at high risk of allergy. Read More

View Article and Full-Text PDF

A different kind of battle: the effects of NICU admission on military parent mental health.

J Perinatol 2021 Apr 13. Epub 2021 Apr 13.

Uniformed Services University of Health Sciences, Bethesda, MD, USA.

Objective: To determine the incidence of mental health symptoms in military families after prolonged NICU admission.

Study Design: Prospective cohort study of military-affiliated NICU parents participating in serial electronic surveys, which included validated screening tools for acute stress (ASD), post-traumatic stress (PTSD), and depression disorders.

Results: Among 106 military parents surveyed after NICU admission, 24. Read More

View Article and Full-Text PDF

Molecular analysis of phenotypic interactions of asthma.

Cytokine 2021 Apr 10:155524. Epub 2021 Apr 10.

Servicio de Alergia e Inmunología Clínica, Hospital General de México, "Dr. Eduardo Liceaga", 06720 Mexico City, Mexico. Electronic address:

Introduction: Asthma is a heterogeneous disease characterized by multiples respiratory symptoms; this is a polygenic entity that involves a complex interaction of environmental factors and inherent to the individual. To understand the development of asthma, some phenotypes have been proposed.

Objective: This work's purpose was to explore different molecules related to asthma development and to define each phenotype's specific characteristics. Read More

View Article and Full-Text PDF

Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease.

Psychol Med 2021 Apr 14:1-10. Epub 2021 Apr 14.

IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France.

Background: Cynical hostility (CH), a specific dimension of hostility that consists of a mistrust of others, has been suggested as a high-risk trait for dementia. However, the influence of CH on the incidence of Alzheimer's disease (AD) remains poorly understood. This study investigated whether late-life CH is associated with AD risk and structural neuroimaging markers of AD. Read More

View Article and Full-Text PDF

Chronic bronchitis in the 50-year follow-up of the European cohorts of the Seven Countries Study: prevalence, mortality and association with cardiovascular diseases.

Respir Med 2021 Apr 2;181:106385. Epub 2021 Apr 2.

Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.

Objectives: To study prevalence of chronic bronchitis (CB) in residential populations and its relationship with mortality in a 50-year follow-up.

Material And Methods: In the late 1950's-early 1960's, 7047 men aged 40-59 years were enrolled in 10 European cohorts of the Seven Countries Study (in Finland, the Netherlands, Italy, Serbia and Greece). After baseline examination, follow-up for mortality was extended during 50 years (45 year in the Serbian cohorts). Read More

View Article and Full-Text PDF

Fetal Heart Rate Decelerations in Women with Sleep-Disordered Breathing.

Reprod Sci 2021 Apr 13. Epub 2021 Apr 13.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Emerging literature has shown that women with sleep-disordered breathing (SDB) have increased risk for gestational hypertension/preeclampsia and gestational diabetes. Case reports suggest an association between maternal apnea and fetal heart rate deceleration but data are lacking on how maternal sleep impacts fetal health. Since decelerations may be associated with adverse outcomes, we sought to determine whether fetal heart rate decelerations were associated with SDB. Read More

View Article and Full-Text PDF

Mechanical unloading by miniature axial flow pumps in late cardiac allograft failure due to acute rejection.

J Artif Organs 2021 Apr 12. Epub 2021 Apr 12.

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Allograft failure secondary to rejection commonly requires a multimodal treatment, ultimately including mechanical circulatory support. A few case reports have demonstrated the use of Impella-devices due to its assumed favorable safety profile in this fragile cohort. However, this treatment option does not play a role in choice of anti-rejective therapy in clinical routine up to date. Read More

View Article and Full-Text PDF

Maternal diet, depression and antidepressant treatment in pregnancy and across the first 12 months postpartum in the MPEWS pregnancy cohort study: Perinatal diet, depression and antidepressant use.

J Affect Disord 2021 Mar 31;288:74-82. Epub 2021 Mar 31.

College of Science, Health, Education and Engineering, Murdoch University, Murdoch, Australia.

Background: There is increasing interest in the association between perinatal depression and diet including whether diet may have an impact on depressive symptoms and equally whether depression influences diet. Furthermore, whether pharmacological treatment of depression with antidepressant medication also may influence diet.

Methods: We examine diet, perinatal depression, and antidepressant use in 442 women recruited in early pregnancy and followed until 12 months postpartum as part of the Mercy Pregnancy Emotional Wellbeing Study. Read More

View Article and Full-Text PDF

Permanent endoscopic gallbladder stenting versus removal of gallbladder drainage, Long-term outcomes after management of acute cholecystitis in high-risk surgical patients for cholecystectomy: Multi-center retrospective cohort study.

J Hepatobiliary Pancreat Sci 2021 Apr 12. Epub 2021 Apr 12.

First Department of Internal Medicine, Gifu University Hospital, Gifu, Japan.

Endoscopic transpapillary gallbladder drainage (EGBD) has been reported as an effective gallbladder drainage treatment option for acute cholecystitis in high-risk surgical patients. However, the long-term outcomes such as cholecystitis' recurrence rate after placement of EGB stenting (EGBS) have not been well studied yet.

Aims: The aim of the present study was to compare the long-term outcome of EGBS and removal of gallbladder drainage after percutaneous transhepatic gallbladder drainage (PTGBD) or endoscopic nasogallbladder drainage (ENGBD) for acute cholecystitis in high-risk surgical patients and clarify the usefulness of long-term placement of EGBS. Read More

View Article and Full-Text PDF

Evolution of surgical management for phaeochromocytoma over a 17-year period: an Australian perspective.

ANZ J Surg 2021 Apr 12. Epub 2021 Apr 12.

Department of General Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Background: Minimally invasive adrenalectomy and advances in anaesthetic techniques have transformed surgery for phaeochromocytoma. This 17-year review describes the evolution of phaeochromocytoma care in our unit.

Methods: We performed a retrospective cohort review of all patients who underwent adrenalectomy for phaeochromocytoma from 2000 to 2016. Read More

View Article and Full-Text PDF

Detection of Renal Insufficiency in a Cohort of Patients With Beta-thalassemia Major Using Cystatin-C.

J Pediatr Hematol Oncol 2021 Apr 9. Epub 2021 Apr 9.

Departments of Pediatrics Clinical and Chemical Pathology, Cairo University, Cairo, Egypt.

With increased life expectancy among patients with beta-thalassemia major (β-TM) renal insufficiency has been frequently noted because of the persistence of anemia, iron overload and some drug side effects. Serum creatinine becomes elevated in late stage of kidney affection. Cystatin-C is more sensitive biomarker for kidney dysfunction. Read More

View Article and Full-Text PDF

Early Start of Anti-Dementia Medication Delays Transition to 24-Hour Care in Alzheimer's Disease Patients: A Finnish Nationwide Cohort Study.

J Alzheimers Dis 2021 Apr 3. Epub 2021 Apr 3.

Department of Industrial Engineering and Management, School of Science, Aalto University, Espoo, Finland.

Background: Dementia is one of the strongest predictors of admission to a 24-hour care facility among older people, and 24-hour care is the major cost of Alzheimer's disease (AD).

Objective: The aim of this study was to evaluate the association of early start of anti-dementia medication and other predisposing factors with 2-year risk of transition to 24-hour care in the nationwide cohort of Finnish AD patients.

Methods: This was a retrospective, non-interventional study based on individual-level data from Finnish national health and social care registers. Read More

View Article and Full-Text PDF

Acquisition of Developmental Milestones in Hypomyelination With Atrophy of the Basal Ganglia and Cerebellum and Other TUBB4A-Related Leukoencephalopathy.

J Child Neurol 2021 Apr 12:883073821000977. Epub 2021 Apr 12.

Division of Neurology, 6567Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Mutations in are associated with a spectrum of neurologic disorders categorized as -related leukoencephalopathy. Affected children can present with global developmental delay or normal early development, followed by a variable loss of skills over time. Further research is needed to characterize the factors associated with the divergent developmental trajectories in this rare monogenic disorder because this phenotypic spectrum is not fully explained by genotype alone. Read More

View Article and Full-Text PDF

The Evolving Immunotherapy Landscape and the Epidemiology, Diagnosis, and Management of Cardiotoxicity: Primer.

JACC CardioOncol 2021 Mar 12;3(1):35-47. Epub 2021 Jan 12.

Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Immune checkpoint inhibitors (ICIs) are newer therapies being applied to an increasing number of patients with cancer. Data suggest that up to 36% of cancer patients may be eligible for immunotherapy and, in late 2019, there were more than 3,362 clinical trials initiated to evaluate the effectiveness of immunotherapy, either as single agents or in combination with other immunotherapy, targeted therapies, or traditional cytotoxic or radiation therapy. With the combination of both immune and non-immune treatment approaches, the complexity in making the diagnosis of cardiotoxicity related to an ICI will increase substantially. Read More

View Article and Full-Text PDF

Muscle damage in response to a single bout of high intensity concentric exercise in patients with Pompe disease.

Ann Transl Med 2021 Mar;9(5):389

Department of Neurology, Medical School, University of Pécs, Pécs, Hungary.

Background: In Pompe disease, resistance exercise could be an effective treatment to delay motor function impairment, however, the acute effects of this exercise modality are unclear.

Methods: In a prospective cohort study, we compared responses to a single bout of resistance exercise by serum markers of muscle damage and quantitative muscle magnetic resonance imaging (MRI) in patients (n=12) and age- and gender-matched healthy controls (n=12). Participants performed 50 maximal effort concentric knee flexions on a dynamometer. Read More

View Article and Full-Text PDF

Pregnancies in kidney transplant recipients with complement gene variant-mediated thrombotic microangiopathy.

Clin Kidney J 2021 Apr 20;14(4):1255-1260. Epub 2020 Aug 20.

Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.

Background: Pregnancies in patients with complement gene variant-mediated thrombotic microangiopathy (cTMA) are challenging, and pregnancies in such patients after kidney transplantation (KTX) are even more so.

Methods: We identified nine pregnancies following KTX of three genetically high-risk cTMA patients enrolled in the Vienna thrombotic microangiopathy cohort. Preventive plasma therapy was used in three pregnancies, and one patient had ongoing eculizumab (ECU) therapy during two pregnancies. Read More

View Article and Full-Text PDF

Clinical impact of the heart team on the outcomes of surgical aortic valve replacement among octogenarians.

J Thorac Cardiovasc Surg 2021 Mar 11. Epub 2021 Mar 11.

Department of Cardiac Surgery, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:

Objectives: The effectiveness of a multidisciplinary heart team in the management of patients with severe symptomatic aortic stenosis is unknown. This study evaluated the impact of a heart team on the outcomes of surgical aortic valve replacement in octogenarians.

Methods: Between May 2007 and January 2016, 528 patients aged 80 years or more were referred to our institutional heart team for a transcatheter aortic valve replacement. Read More

View Article and Full-Text PDF

Too little, too late?: Can an integrated empathy-building intervention shift gero-attitudes for undergraduates in an online course?

Gerontol Geriatr Educ 2021 Apr 11:1-17. Epub 2021 Apr 11.

The University of North Carolina, Greensboro, North carolina, USA.

By 2050, 22.1% of the United States population will be 65 years or older, increasing the demand for well-trained, enthusiastic professionals to serve them. At the same time, later life is frequently pathologized, and there continues to be a preference for youth by those who are yet to be old as well as older adults themselves. Read More

View Article and Full-Text PDF

Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity.

Radiother Oncol 2021 Apr 7. Epub 2021 Apr 7.

Strahlentherapie Speyer, Germany. Electronic address:

Aim: To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi).

Materials And Methods: Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased urinary stream. Read More

View Article and Full-Text PDF

Impact of induction strategy change on first-year rejection in pediatric heart transplantation at a single center - from postoperative basiliximab to either postoperative anti-thymocyte globulin or preoperative basiliximab.

Clin Transplant 2021 Apr 10:e14314. Epub 2021 Apr 10.

Children's of Alabama Heart Transplant Program, Alabama, USA.

Background: Our pediatric heart transplant center transitioned from post-bypass basiliximab (BAS) induction to either anti-thymocyte globulin (ATG) or pre-bypass BAS. The purpose of this study was to compare first-year rejection rates before and after this change.

Methods: A single center retrospective analysis was conducted of pediatric heart transplant recipients from 2010-2019. Read More

View Article and Full-Text PDF

A long-term follow-up study of minimally invasive Ivor Lewis esophagectomy with linear stapled anastomosis.

Surg Endosc 2021 Apr 9. Epub 2021 Apr 9.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Minimally invasive esophagectomy (MIE) is increasingly performed to expect lower complication rate compared to open esophagectomy. Studies of minimally invasive Ivor Lewis esophagectomy (MIILE) with circular staplers have reported better outcomes compared to MIE with cervical anastomosis, but frequent anastomotic complications have also been reported. MIILE with linear staplers is a promising alternative, but the long-term functional and oncological outcomes are uncertain. Read More

View Article and Full-Text PDF

Diagnostic value of culture results from aqueous tap versus vitreous tap in cases of bacterial endophthalmitis.

Br J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and Biomedical Research Centre, Institute of Ophthalmology, UCL, London, UK

Objective: To investigate the concordance between aqueous and vitreous tap culture results among different types of bacterial endophthalmitis.

Methods And Analysis: This retrospective cohort analysis included all cases diagnosed with endophthalmitis at Moorfields Eye Hospital between January 2008 and March 2020. Aqueous and vitreous samples obtained simultaneously at presentation. Read More

View Article and Full-Text PDF

A prospective study investigating the efficacy and toxicity of definitive ChemoRadiation and ImmunOtherapy (CRIO) in locally and/or regionally advanced unresectable cutaneous squamous cell carcinoma.

Radiat Oncol 2021 Apr 9;16(1):69. Epub 2021 Apr 9.

Department of Medical Oncology, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, QLD, Australia.

Background: Patients with unresectable advanced cutaneous squamous cell carcinoma (cSCC) are generally treated with palliative intent. Immune checkpoint blockade has significant activity in the palliative setting in patients with recurrent or metastatic cSCC. This single arm phase 2 prospective study aims to investigate the combination of curative intent chemoradiation and durvalumab (anti-PD-L1 checkpoint inhibitor) for this patient cohort. Read More

View Article and Full-Text PDF

The influence of maternal body mass index on interobserver variability of fetal ultrasound biometry and amniotic fluid assessment in late pregnancy.

Ultrasound Obstet Gynecol 2021 Apr 9. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Maternal Fetal Medicine, USA.

Objectives: Determine interobserver reproducibility of fetal ultrasound biometry and amniotic fluid assessment in the third trimester according to BMI categories.

Methods: Prospective cohort of women with singleton gestations beyond 34 weeks, recruited into 4 groups according to BMI categories: normal, overweight, obese and morbid obese. Multiple pregnancies, diabetes, growth and fetal abnormalities were excluded. Read More

View Article and Full-Text PDF