439,433 results match your criteria late

Long term evolution of Fast Ripples during epileptogenesis.

J Neural Eng 2021 Apr 13. Epub 2021 Apr 13.

Universite de Rennes 1, Campus Beaulieu, Rennes, Bretagne, 35065, FRANCE.

Objective: Fast Ripples (FRs) have received considerable attention in the last decade since they represent an electrophysiological biomarker of the Epileptogenic Zone (EZ). However, the real dynamics underlying the occurrence, amplitude, and time-frequency content of FRs generation during epileptogenesis are still not well understood. This work aims at characterizing and explaining the evolution of these features. Read More

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Matairesinol, an active constituent of HC9 polyherbal formulation, exhibits HDAC8 inhibitory and anticancer activity.

Biophys Chem 2021 Apr 2;273:106588. Epub 2021 Apr 2.

Cancer Research Lab., Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed to be University, Pune-Satara Road, Pune 411043, Maharashtra, India. Electronic address:

Histone deacetylase 8 (HDAC8) has emerged as a promising drug target for cancer therapeutics development. HDAC8 has been reported to regulate cancer cell proliferation, invasion and promote metastasis through modulation of cell cycle associated proteins. Of late, phytocompounds have been demonstrated to exhibit anticancer and anti-HDAC8 activity. Read More

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Chronic bronchitis in the 50-year follow-up of the European cohorts of the Seven Countries Study: prevalence, mortality and association with cardiovascular diseases.

Respir Med 2021 Apr 2;181:106385. Epub 2021 Apr 2.

Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.

Objectives: To study prevalence of chronic bronchitis (CB) in residential populations and its relationship with mortality in a 50-year follow-up.

Material And Methods: In the late 1950's-early 1960's, 7047 men aged 40-59 years were enrolled in 10 European cohorts of the Seven Countries Study (in Finland, the Netherlands, Italy, Serbia and Greece). After baseline examination, follow-up for mortality was extended during 50 years (45 year in the Serbian cohorts). Read More

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Nighttime warming alleviates the incidence of juniper forest growth decline on the Tibetan Plateau.

Sci Total Environ 2021 Apr 6;782:146924. Epub 2021 Apr 6.

State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing, China.

Recent warming over the Tibetan Plateau (TP) is approximately twice the global-mean surface temperature increase and poses a threat to the healthy growth of forests. Although many studies have focused on whether recent climate warming has caused forest growth decline on the TP, it remains unclear how asymmetric warming, that is faster increasing nighttime temperature than daytime, impacts forest growth decline. We explored this question by using a ring-width index series from 1489 juniper trees (Juniperus prezwalskii and J. Read More

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An Evaluation of Pediatric Secondary Overtriage in the Pennsylvania Trauma System.

J Surg Res 2021 Apr 10;264:368-374. Epub 2021 Apr 10.

Trauma and Acute Care Surgery, Penn Medicine Lancaster General Health, Lancaster, Pennsylvania.

Background: We sought to determine the secondary overtriage rate of pediatric trauma patients admitted to pediatric trauma centers. We hypothesized that pediatric secondary overtriage (POT) would constitute a large percentage of admissions to PTC.

Materials And Methods: The Pennsylvania Trauma Outcome Study database was retrospectively queried from 2003 to 2017 for pediatric (age ≤ 18 y) trauma patients transferred to accredited pediatric trauma centers in Pennsylvania (n = 6). Read More

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Gender-specific prevalence and influencing factors of depression in elderly in rural China: A cross-sectional study.

J Affect Disord 2021 Apr 2;288:99-106. Epub 2021 Apr 2.

Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China; Department of Social Medicine and Health Administration, School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address:

Background: With an aging population, late-life depression has been a major health problem in rural China. This study aims to explore the gender-specific prevalence of geriatric depression in rural Tianjin, its influencing factors, and to provide a scientific basis for the prevention and intervention of depression in the elderly.

Methods: A cross-sectional study of 4,933 elderly individuals in rural Tianjin was conducted using the cluster sampling method. Read More

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Postoperative changes in vertical ground reaction forces, walking barefoot and with ankle-foot orthoses in children with Cerebral Palsy.

Clin Biomech (Bristol, Avon) 2021 Mar 23;84:105336. Epub 2021 Mar 23.

Faculty of Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway; Division of Orthopaedic Surgery, Department of Research, Oslo University Hospital, Oslo, Norway.

Background: Children with cerebral palsy often have problems to support the body centre of mass, seen as increased ratio between excessive vertical ground reaction forces during weight acceptance and decreased forces below bodyweight in late stance. We aimed to examine whether increasing ankle range of motion through surgery and restraining motion with ankle-foot orthoses postoperatively would have impact on the vertical ground reaction force in weight acceptance and late stance.

Methods: Ground reaction forces were recorded from 24 children with bilateral and 32 children with unilateral cerebral palsy, each measured walking barefoot before and after triceps surae lengthening. Read More

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Outcomes of endoscopic submucosal dissection for early esophageal and gastric cardia adenocarcinomas.

Clin Res Hepatol Gastroenterol 2021 Apr 10:101700. Epub 2021 Apr 10.

Department of Gastroenterology and Digestive Oncology, Cochin Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Université de Paris, France. Electronic address:

Objectives: Adenocarcinomas of the esophagus and of the gastric cardia are regarded as a same clinical entity in oncology. For endoscopic resection however, endoscopic mucosal resection is recommended for esophageal adenocarcinoma, while endoscopic submucosal dissection (ESD) is advocated for gastric adenocarcinomas. Our aim was to compare the outcomes of ESD in both types of esophagogastric junction adenocarcinomas. Read More

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Palliation of malignant esophageal obstruction using an anti-migration self-expandable metal stent: results of a prospective multicenter study.

Clin Res Hepatol Gastroenterol 2021 Apr 10:101683. Epub 2021 Apr 10.

Department of Gastroenterology, General Hospital, Sanremo (IM), Italy.

Background: Self-expanding metal stents (SEMS) placement is primarily indicated to palliate dysphagia for patients with expected short-term survival. We aimed to assess the migration rate and other stent-related adverse events (AEs) of a fully covered SEMS with an anti-migration system (FCSEMS-AMS) for palliation of malignant dysphagia.

Methods: This is a prospective study including patients with inoperable esophageal cancer that received a FCSEMS-AMS (Taewoong, Niti-S Beta), in five tertiary-care endoscopic centers from January 2014 to February 2016. Read More

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Long Term Outcomes of Dose Escalated Pelvic Lymph Node Intensity Modulated Radiation Therapy (IMRT) with A Simultaneous Hypofractionated Boost to the Prostate For Very High Risk Adenocarcinoma of the Prostate, a Prospective Phase II Clinical Trial.

Pract Radiat Oncol 2021 Apr 10. Epub 2021 Apr 10.

Froedtert and the Medical College of Wisconsin Department of Radiation Oncology.

Purpose/objectives: There remains limited data as to the feasibility, safety and efficacy of higher doses of elective radiation therapy (RT) to the pelvic lymph nodes in men with high risk prostate cancer. We conducted a phase II study to evaluate moderate dose escalation to the pelvic lymph nodes using a simultaneous integrated boost (SIB) to the prostate.

Materials/methods: Patients were eligible with biopsy proven adenocarcinoma of the prostate, a calculated lymph node (LN) risk of at least 25%, Karnofsky Performance Scale ≥ 70, and no evidence of M1 disease. Read More

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Clinico-pathological and transcriptomic analysis of radiation-induced lung injury in non-human primates.

Int J Radiat Oncol Biol Phys 2021 Apr 10. Epub 2021 Apr 10.

Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA. Electronic address:

Purpose: Radiation-induced lung injury (RILI) is a progressive condition, with an early phase, radiation pneumonitis (RP), and a late phase, lung fibrosis (LF). RILI may occur after partial-body ionizing radiation exposures or by internal radioisotope exposure, with wide individual variability in timing and extent of lung injury. This study aims to provide new insights into the pathogenesis and progression of RILI in the non-human primate (NHP) rhesus macaque model. Read More

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The past, present and future of the tree of life.

Curr Biol 2021 Apr;31(7):R314-R321

Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University, Halifax, NS, Canada; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada. Electronic address:

The advent of comparative genomics in the late 1990s led to the discovery of extensive lateral gene transfer in prokaryotes. The resulting debate over whether life as a whole is best represented as a tree or a network has since given way to a general consensus in which trees and networks co-exist rather than stand in opposition. Embracing this consensus allows us to move beyond the question of which is true or false. Read More

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Inclusion and Diversity in Oncofertility Care.

J Adolesc Young Adult Oncol 2021 Apr 13. Epub 2021 Apr 13.

Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Oncofertility Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma.

Pathol Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Upper tract urothelial carcinoma (UTUC) is a rare tumor with an incidence that varies greatly between Eastern and Western countries. Transaldolase 1 (TALDO1) is a rate-limiting enzyme of the pentose phosphate pathway. In humans, aberrant TALDO1 activity has been implicated in various autoimmune diseases and malignancies; however, the function of TALDO1 in UTUC has not been previously investigated. Read More

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Changes in nutrient balance, methane emissions, physiologic biomarkers and production performance in goats fed different forage-to-concentrate ratios during lactation.

J Anim Sci 2021 Apr 13. Epub 2021 Apr 13.

Department of Animal Sciences, Division of Nutritional Sciences, University of Illinois, Urbana, USA.

The objective was to determine the effect forage to concentrate (F:C) ratio and stage of lactation on methane emissions, digestibility, nutrient balance, lactation performance, and metabolic responses in lactating goats. Twenty Murciano-Granadina dairy goats were used in an experiment divided into three periods: early (30 d), mid (100 d) and late (170 d) lactation. All goats were fed a diet with 35:65 F:C (FCL) during early-lactation. Read More

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Shifting osteogenesis in vascular calcification.

JCI Insight 2021 Apr 13. Epub 2021 Apr 13.

Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, United States of America.

Transitions between cell fates commonly occur in development and disease. However, reversing an unwanted cell transition in order to treat disease remains an unexplored area. Here, we report a successful process of guiding ill-fated transitions toward normalization in vascular calcification. Read More

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Can extended upper pole ureterectomy prevent ureteral stump syndrome after proximal approach for duplex kidneys?

Int Braz J Urol 2021 Jul-Aug;47(4):821-826

Unidade de Urologia Pediátrica, Divisão de Urologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo - FMUSP, SP, Brasil.

Introduction: Symptomatic duplex kidneys usually present with recurrent urinary tract infection due to ureteral obstruction (megaureter, ureterocele or ectopic ureter) and/or vesicoureteral reflux. Upper-pole nephrectomy is a widely accepted procedure to correct symptomatic duplex systems with poor functioning moieties, also known as upper or proximal approach. The distal ureteral stump syndrome (DUSS) can be a late complication of this approach. Read More

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Tailored Synthesis of Skeletally Diverse Stemona Alkaloids through Chemoselective Dyotropic Rearrangements of β-Lactones.

Angew Chem Int Ed Engl 2021 Apr 13. Epub 2021 Apr 13.

Tsinghua University, Department of Chemistry, CHINA.

Collective synthesis of skeletally diverse Stemona alkaloids has been achieved, featuring tailored dyotropic rearrangements of b -lactones as key elements. Specifically, three typical 5/7/5 tricyclic skeletons associated with stemoamide, tuberostemospiroline and parvistemonine were first accessed through chemoselective alkyl-, hydrogen-, and aryl-migration dyotropic rearrangements of b -lactones, respectively. With rational manipulations of substrate structures and reaction conditions, these dyotropic rearrangements proceeded with excellent efficiency, good chemoselectivity and high stereospecificity. Read More

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Current Management of Age-Related Macular Degeneration.

Adv Exp Med Biol 2021 ;1256:295-314

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Age-related macular degeneration (AMD) remains a leading cause of blindness worldwide. The assessment and management of patients with this condition has evolved in the last decades. In this chapter, current standards for diagnosis, follow-up, and treatment of patients with AMD are reviewed and summarized. Read More

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January 2021

Innate Immunity in Age-Related Macular Degeneration.

Adv Exp Med Biol 2021 ;1256:121-141

Section on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Multiple lines of investigation have demonstrated that inflammation plays significant roles in etiology of age-related macular degeneration (AMD). Although interventional trials in AMD therapy targeting inflammatory pathways have been conducted, they have not yet been successful and a detailed understanding as to why some have failed is still elusive. One limitation is the relative dearth of information on how immune cells interact with retinal cells to generate AMD phenotypes at each disease stage. Read More

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January 2021

Age-Related Macular Degeneration: Epidemiology and Clinical Aspects.

Adv Exp Med Biol 2021 ;1256:1-31

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Age-related macular degeneration (AMD) is a degenerative disease of the human retina affecting individuals over the age of 55 years. This heterogeneous condition arises from a complex interplay between age, genetics, and environmental factors including smoking and diet. It is the leading cause of blindness in industrialized countries. Read More

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January 2021

Fetal Heart Rate Decelerations in Women with Sleep-Disordered Breathing.

Reprod Sci 2021 Apr 13. Epub 2021 Apr 13.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Emerging literature has shown that women with sleep-disordered breathing (SDB) have increased risk for gestational hypertension/preeclampsia and gestational diabetes. Case reports suggest an association between maternal apnea and fetal heart rate deceleration but data are lacking on how maternal sleep impacts fetal health. Since decelerations may be associated with adverse outcomes, we sought to determine whether fetal heart rate decelerations were associated with SDB. Read More

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Myocardial strain features by 2D-STE during the course of fulminant myocarditis: Correlation with characteristics by CMR and clinical implications.

Medicine (Baltimore) 2021 Apr;100(15):e25050

Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.

Abstract: Myocardial strain analysis by 2D speckle tracking echocardiography could determine the left ventricular function. Our purpose is to investigate the global longitudinal strain (GLS) changes during the course of fulminant myocarditis (FM) and evaluate their correlation with cardiac magnetic resonance (CMR).Patients with clinical diagnosis of FM from June 30, 2017 to June 30, 2019 were screened prospectively. Read More

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Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane, promoting fitness upon envelope stress.

Elife 2021 Apr 13;10. Epub 2021 Apr 13.

Laboratory of Microbiology and Molecular Genetics, CNRS, Toulouse, France.

Integral outer membrane proteins (OMPs) are crucial for the maintenance of the proteobacterial envelope permeability barrier to some antibiotics and detergents. In Enterobacteria, envelope stress caused by unfolded OM proteins (OMPs) activates the sigmaE (σ) transcriptional response. σ upregulates OMP-biogenesis factors, including the b-barrel assembly machinery (BAM) that catalyzes OMP folding. Read More

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Age at Migration and Cognitive Health Among Chinese Older Immigrants in the United States.

J Aging Health 2021 Apr 13:8982643211006612. Epub 2021 Apr 13.

43354Rutgers Institute for Health, Health Care Policy and Aging Research, The State University of New Jersey, New Brunswick, NJ, USA.

This study addressed two questions: (1) Is age at migration associated with cognitive function among Chinese older immigrants? and (2) what personal and environmental factors confound the above relationship? Data were derived from the Population Study of Chinese Elderly ( = 2957). Quantile and linear regressions were used to examine the associations between age at migration and Mini-Mental State Examination (MMSE) and global cognitive function, respectively. Migration in late middle age (50-64) or late adulthood (65 or older) was associated with lower MMSE scores. Read More

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Dithiocarbamate Complexes as Single Source Precursors to Nanoscale Binary, Ternary and Quaternary Metal Sulfides.

Chem Rev 2021 Apr 13. Epub 2021 Apr 13.

Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, U.K.

Nanodimensional metal sulfides are a developing class of low-cost materials with potential applications in areas as wide-ranging as energy storage, electrocatalysis, and imaging. An attractive synthetic strategy, which allows careful control over stoichiometry, is the single source precursor (SSP) approach in which well-defined molecular species containing preformed metal-sulfur bonds are heated to decomposition, either in the vapor or solution phase, resulting in facile loss of organics and formation of nanodimensional metal sulfides. By careful control of the precursor, the decomposition environment and addition of surfactants, this approach affords a range of nanocrystalline materials from a library of precursors. Read More

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Long-term outcomes of self-expanding versus balloon-expandable transcatheter aortic valves: Insights from the OBSERVANT study.

Catheter Cardiovasc Interv 2021 Apr 13. Epub 2021 Apr 13.

Division of Cardiology, A.O.U. Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy.

Objectives: To compare clinical outcomes of balloon-expandable (BE) and self-expanding (SE) transcatheter aortic valves (TAVs) up to 5 years.

Background: To date, no robust, comparative data of BE and SE TAVs at long-term are available.

Methods: We considered a total of 1,440 patients enrolled in the multicenter OBSERVANT study and undergoing transfemoral transcatheter aortic valve implantation (TF-TAVI) with either supra-annular SE (n = 830, 57. Read More

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Diversity-Oriented Synthesis of Aliphatic Fluorides via Reductive C(sp3)-C(sp3) Cross-Coupling Fluoroalkylation.

Angew Chem Int Ed Engl 2021 Apr 13. Epub 2021 Apr 13.

University of Science and Technology of China, Chemistry, 96 Jinzhai Road, 230026, Hefei, CHINA.

Monofluorinated alkyl compounds are of great importance in pharmaceuticals, agrochemicals and materials. Herein, we describe a direct nickel-catalyzed monofluoromethylation of unactivated alkyl halides using a low cost industrial raw material, bromofluoromethane, by demonstrating a general and efficient reductive cross-coupling of two alkyl halides. Results with 1-bromo-1-fluoroalkane also demonstrate the viability of monofluoroalkylation, which further established the first example of reductive C(sp3)-C(sp3) cross-coupling fluoroalkylation. Read More

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Infantile leukemia-What factors determine its distinct biological nature? Clinicopathological study of 78 cases.

Int J Lab Hematol 2021 Apr 13. Epub 2021 Apr 13.

Department of Pathology, Duke University Medical Center, Durham, NC, USA.

Introduction: Infantile leukemia encompasses a heterogeneous group which needs stratifying for treatment selection.

Methods: We collected 78 cases of infantile leukemia and retrospectively analyzed their clinicopathological data.

Results: Infantile leukemia featured a ratio of acute myeloid leukemia (AML) to B-lymphoblastic leukemia (B-ALL) of 1:2, with a better survival for AML than B-ALL (median survival 36 vs 24 months). Read More

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Total Synthesis of Anti-Cancer Meroterpenoids Dysideanone B and Dysiherbol A and Structural Reassignment of Dysiherbol A.

Angew Chem Int Ed Engl 2021 Apr 12. Epub 2021 Apr 12.

Nankai University, State Key Laboratory of Medicinal Chemical Biology, 38 Tongyan Rd, 300350, Tianjin, CHINA.

The first total synthesis of marine anti-cancer meroterpenoids dysideanone B and dysiherbol A have been accomplished in a divergent way. The synthetic route features: 1) a site and stereoselective α -position alkylation of Wieland-Miescher ketone derivative with a bulky benzyl bromide to join the terpene and aromatic moieties together and set the stage for subsequent cyclization reactions; 2) an intramolecular radical cyclization to construct the 6/6/6/6-tetracycle of dysideanone B and an intramolecular Heck reaction to forge the 6/6/5/6-fused core structure of dysiherbol A, respectively. A late-stage introduction of the ethoxy group in dysideanone B reveals that this group might come from the solvent ethanol. Read More

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