34,885 results match your criteria laryngeal cancer

Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review.

J Int Med Res 2021 May;49(5):3000605211014784

Unit of Otorhinolaryngology, University Luigi Vanvitelli, Napoli, Italy.

This current report describes a rare clinical case of neuroendocrine carcinoma (NEC) of the larynx with associated Lambert-Eaton myasthenic paraneoplastic syndrome (LEMS). A 68-year-old male patient presented with severe dysphonia and dysphagia. He underwent a total laryngectomy and the excised lesion was extremely large. Read More

View Article and Full-Text PDF

Revised Korean Cough Guidelines, 2020: Recommendations and Summary statements.

Tuberc Respir Dis (Seoul) 2021 May 13. Epub 2021 May 13.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Cough is the most common respiratory symptom that can result from various causes, and is a major clinical problem that reduces patients' quality of life. Thus, clinical guidelines for the treatment of cough were established in 2014 by the cough guideline committee under the Korean Academy of Tuberculosis and Respiratory Diseases. From October 2018 to July 2020, the cough guidelines were revised by the members of the committee based on the first guidelines. Read More

View Article and Full-Text PDF

Intrathoracic vs Cervical Anastomosis After Totally or Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer: A Randomized Clinical Trial.

JAMA Surg 2021 May 12. Epub 2021 May 12.

Department of Surgery, Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Transthoracic minimally invasive esophagectomy (MIE) is increasingly performed as part of curative multimodality treatment. There appears to be no robust evidence on the preferred location of the anastomosis after transthoracic MIE.

Objective: To compare an intrathoracic with a cervical anastomosis in a randomized clinical trial. Read More

View Article and Full-Text PDF

Supracricoid laryngectomy: the impact of senescence on swallowing safety.

Einstein (Sao Paulo) 2021 10;19:eAO5715. Epub 2021 May 10.

Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro, RJ, Brazil.

Objective: To investigate the association between aging and the functional aspects of swallowing (laryngeal penetration and laryngotracheal aspiration) in individuals who underwent supracricoid laryngectomy in the late period and without complaints.

Methods: A total of 70 patients, 56 (80%) aged >60 years and 14 (20%) <60 years, under outpatient follow-up, after cancer treatment and with no complaints of swallowing, performed functional evaluation using the swallowing videofluoroscopy. Image classification was performed using the penetration-aspiration scale developed by Rosenbek. Read More

View Article and Full-Text PDF

Glottic Malignant Fibrous Histiocytoma: A Case Report and Literature Review.

Case Rep Oncol 2021 Jan-Apr;14(1):641-646. Epub 2021 Mar 31.

Hazm Mebaireek General Hospital (HMGH), Hamad Medical Corporation (HMC), Doha, Qatar.

Pleomorphic sarcoma of the larynx is a rare variant of laryngeal cancer. We present the case of a 59-year-old male patient who has been smoking for 40 years. He presented with signs and symptoms of an obstructive glottic mass. Read More

View Article and Full-Text PDF

Post-Surgery Subcutaneous Seeding of Laryngeal Squamous Cell Carcinoma: A Rare Case.

Case Rep Oncol 2021 Jan-Apr;14(1):568-572. Epub 2021 Mar 22.

Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Laryngeal squamous cell carcinoma (LSCC) is the most common malignant head and neck cancer, with a 40% recurrence rate in the first 3 years after radical treatment. Recurrence of LSCC mostly comprises lymphogenous metastasis, hematogenic metastasis, and locoregional recurrence, while LSCC seeding is rarest: there are only 4 cases reported in PubMed, and none of them is one of subcutaneous seeding. We report a case with post-surgery subcutaneous seeding of LSCC. Read More

View Article and Full-Text PDF

Role and mechanism of action of circular RNA and laryngeal cancer.

Pathol Res Pract 2021 Apr 30;223:153460. Epub 2021 Apr 30.

Clinical Laboratory, Linyi Central Hospital, Linyi, 276400 Shandong, China. Electronic address:

Laryngeal squamous cell carcinoma (LSCC), is the second most common malignant cancer of the head and neck after oral cavity cancer. Laryngeal cancer is associated with huge socio-economic burden worldwide. Studies have widely explored the role of non-coding RNAs, especially microRNAs and long non-coding RNAs in pathogenesis of laryngeal cancer. Read More

View Article and Full-Text PDF

Management of Early Glottic Cancer Treated by CO2 Laser According to Surgical-Margin Status: A Systematic Review of the Literature.

Int Arch Otorhinolaryngol 2021 Apr 24;25(2):e301-e308. Epub 2020 Sep 24.

Department of Biomedicine, Neuroscience and Advanced Diagnostics, ENT Clinic, University of Palermo, Palermo, Italy.

 Transoral laser microsurgery (TLM) is the treatment of choice for Tis-T2 squamous cell glottic carcinomas due to its advantages compared with open surgery and radiotherapy. However, the CO laser beam causes changes and damage on the specimens, making the histological assessment of resection margins, the gold standard for confirming radical tumor resection, sometimes difficult.  To assess the different ways to manage patients depending on the status of the histopathological margin according to recent studies to detect the most commonly shared therapeutic strategy. Read More

View Article and Full-Text PDF

APE1 facilitates PD-L1-mediated progression of laryngeal and hypopharyngeal squamous cell carcinoma.

Int Immunopharmacol 2021 May 6;97:107675. Epub 2021 May 6.

Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Electronic address:

Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HSCC) seriously affect the life quality of patients. Nowadays, immunotherapy is widely used in the treatment of cancer. Tumor-infiltrating lymphocytes (TILs), programmed cell death 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) play key roles in the immunotherapy of cancer. Read More

View Article and Full-Text PDF

Asymptomatic swallowing disorders may be present in individuals with laryngeal and hypopharyngeal cancer treated with chemo-radiotherapy.

Eur Arch Otorhinolaryngol 2021 May 7. Epub 2021 May 7.

Department of Otolaryngology, Hospital Universitario Central de Asturias (HUCA), Avenida de Roma, s/n, 33011, Oviedo, Spain.

Purpose: Patients with advanced laryngeal and hypopharyngeal cancer are often treated with chemo-radiotherapy to avoid total laryngectomy. Subclinical swallowing disorders could be present in these patients even though patients do not complain of any symptoms. We sought to evaluate the impact of chemoradiation on swallowing and quality of life. Read More

View Article and Full-Text PDF

Management of patients with bilateral recurrent laryngeal nerve paralysis following esophagectomy.

Thorac Cancer 2021 May 6. Epub 2021 May 6.

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: Recurrent laryngeal nerve paralysis (RLNP) is a common complication after esophagectomy which can cause severe pulmonary complications. However, bilateral RLNP has been rarely reported in esophagectomy patients. The objective of our study is to investigate the clinical significance of patients who had bilateral RLNP following esophagectomy. Read More

View Article and Full-Text PDF

Bioinformatics analysis of laryngeal squamous cell carcinoma: seeking key candidate genes and pathways.

PeerJ 2021 14;9:e11259. Epub 2021 Apr 14.

Department of Otolaryngology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Background: Laryngeal squamous cell carcinoma (LSCC) is the second most aggressive head and neck squamous cell carcinoma. Although much work has been done to optimize its treatment, patients with LSCC still have poor prognosis. Therefore, figuring out differentially expressed genes (DEGs) contained in the progression of LSCC and employing them as potential therapeutic targets or biomarkers for LSCC is extremely meaningful. Read More

View Article and Full-Text PDF

Significance of site-specific radiation dose and technique for success of implant-based prosthetic rehabilitation in irradiated head and neck cancer patients-A cohort study.

Clin Implant Dent Relat Res 2021 May 4. Epub 2021 May 4.

Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.

Background: Radiotherapy aggravates implant-based prosthetic rehabilitation in patients with head and neck cancer.

Purpose: To evaluate the impact of radiation dose at implant and parotid gland site for prosthetic rehabilitation.

Material And Methods: The retrospective study includes 121 irradiated head and neck cancer patients with 751 inserted implants. Read More

View Article and Full-Text PDF

I seed implantation brachytherapy for glottic carcinoma: an experimental and clinical study.

Am J Cancer Res 2021 15;11(4):1321-1334. Epub 2021 Apr 15.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.

I seed implantation brachytherapy (ISIB) is the preferred treatment for prostate cancer. Is ISIB technically suitable for glottic carcinoma (GC)? This question has not been answered in the literature; thus, the present study was carried out to evaluate the feasibility and effect of ISIB on GC in animal and clinical studies. An animal model of Tu-212 cell laryngeal carcinoma xenografts (n = 20 animals) underwent ISIB treatments [experimental group (EG) using 0. Read More

View Article and Full-Text PDF

Efficacy and safety of lacosamide in the treatment of status epilepticus in a patient with comorbidities.

Acta Biomed 2021 Apr 30;92(S1):e2021090. Epub 2021 Apr 30.

UOC Neurologia, Department of Systems Medicine, University of Tor Vergata.

Efficacy, safety and tolerability of lacosamide in the treatment of status epilepticus are well described. However, other evidence of its pharmacologic profile in elderly patients with other comorbidities seems warranted. We describe the case of an 80 year-old woman with an history of arterial hypertension, ischemic cardiomyopathy, COPD, CKD, previous laryngeal cancer, a stoma positioning for diverticular disease and previous surgery for a left frontal meningioma. Read More

View Article and Full-Text PDF

Study on the relationship between preoperative platelet parameters and laryngeal squamous cell carcinoma.

Minerva Surg 2021 May 4. Epub 2021 May 4.

Department of Head and Neck Cancer, Oncology Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China -

View Article and Full-Text PDF

A novel surgical approach for hypopharyngeal carcinoma resection via the paraglottic space.

BMC Surg 2021 May 3;21(1):230. Epub 2021 May 3.

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, NHC Key Laboratory of Otorhinolaryngology (Shandong University), 107 Wenhua Xilu, Jinan, 250012, Shandong, China.

Background: Conservative surgery has proven advantageous in controlling hypopharyngeal squamous cell carcinoma (HSCC) and preserving speech and swallowing function in carefully selected patients, typically with early T-stages diseases. A variety of modified surgical procedures or techniques have been proposed.

Methods: In this study, we present a novel surgical approach for hypopharyngeal carcinoma resection utilizing the paraglottic space. Read More

View Article and Full-Text PDF

Review of recent treatment trends of laryngeal cancer in Poland: a population-based study.

BMJ Open 2021 Apr 30;11(4):e045308. Epub 2021 Apr 30.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Warszawa, Poland.

Objectives: To investigate the utilisation of different treatment modalities for patients with laryngeal cancer (LC) during last decade in Poland.

Setting: Retrospective population-based study.

Participants: Patients with LC treated between January 2009 and December 2018. Read More

View Article and Full-Text PDF

[Radiotherapy for patients with early-stage glottic squamous cell carcinoma of the larynx: Interest of hypofractionation?]

Cancer Radiother 2021 Apr 27. Epub 2021 Apr 27.

Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59000 Lille, France. Electronic address:

Hypofractionated radiotherapy of early-stage squamous cell carcinoma of the glottic larynx is a promising treatment option. This can be divided into radiotherapy with moderate hypofractionation (up to 2.5Gy per fraction), more intense hypofractionation (between 2. Read More

View Article and Full-Text PDF

Clinical significance of tumor-stroma ratio in head and neck cancer: a systematic review and meta-analysis.

BMC Cancer 2021 Apr 30;21(1):480. Epub 2021 Apr 30.

Institute of Biomedicine, Pathology, University of Turku and Turku University Hospital, Turku, Finland.

Background: The clinical significance of tumor-stroma ratio (TSR) has been examined in many tumors. Here we systematically reviewed all studies that evaluated TSR in head and neck cancer.

Methods: Four databases (Scopus, Medline, PubMed and Web of Science) were searched using the term tumo(u)r-stroma ratio. Read More

View Article and Full-Text PDF

[A clinical observation of laryngeal ossifying fibromyxoid tumor].

Vestn Otorinolaringol 2021 ;86(2):82-84

Voronezh regional pathoanatomical bureau, Voronezh, Russia.

A rare observation of ossifying fibromyxoid tumor of the larynx in a 23-year-old young man is presented. Surgical intervention, performed in two stages, provided a positive result. With dynamic observation of this patient for three years, continued growth and tumor recurrence were not observed. Read More

View Article and Full-Text PDF

Outline of The Pmda's Review For Sakigake Designation Products Boron Neutron Capture Therapy For Head and Neck Carcinoma.

Oncologist 2021 Apr 29. Epub 2021 Apr 29.

Center for Regulatory Science, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan.

The Ministry of Health, Labour and Welfare approved a drug called Borofalan ( B), a treatment system, and a dose calculation program for boron neutron capture therapy (BNCT) in March 2020. The application pertaining to the products submitted to the Pharmaceuticals and Medical Devices Agency was supported by a Japanese open-label uncontrolled trial (Study 002) in patients with unresectable locally recurrent head and neck squamous cell carcinoma after chemoradiotherapy or radiotherapy, or in those with unresectable locally advanced or locally recurrent (LA/LR) head and neck non-squamous cell carcinoma. The drug was administered as a single intravenous dose using infusion rates of 200 mg/kg/h for the first two hours after the start of administration and 100 mg/kg/h during irradiation. Read More

View Article and Full-Text PDF

Tumor-Infiltrating Lymphocytes in the Tumor Microenvironment of Laryngeal Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.

Biomedicines 2021 Apr 28;9(5). Epub 2021 Apr 28.

Coordinator of the International Head and Neck Scientific Group, 35125 Padua, Italy.

The presence of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment has been demonstrated to be of prognostic value in various cancers. In this systematic review and meta-analysis, we investigated the prognostic value of TIL in laryngeal squamous cell carcinoma (LSCC). We performed a systematic search in PubMed for publications that investigated the prognostic value of TIL in LSCC. Read More

View Article and Full-Text PDF

Optimal Management of the Unilateral Recurrent Laryngeal Nerve Involvement in Patients with Thyroid Cancer.

Cancers (Basel) 2021 Apr 28;13(9). Epub 2021 Apr 28.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto 860-8555, Japan.

We aimed to determine the optimal management of recurrent laryngeal nerve (RLN) involvement in thyroid cancer. We enrolled 80 patients with unilateral RLN involvement in thyroid cancer between 2000 and 2016. Eleven patients with preoperatively functional vocal folds (VFs) underwent sharp tumor resection to preserve the RLN (shaving group). Read More

View Article and Full-Text PDF

Assessing Various Control Samples for Microarray Gene Expression Profiling of Laryngeal Squamous Cell Carcinoma.

Biomolecules 2021 Apr 16;11(4). Epub 2021 Apr 16.

Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.

Selection of optimal control samples is crucial in expression profiling tumor samples. To address this issue, we performed microarray expression profiling of control samples routinely used in head and neck squamous cell carcinoma studies: human bronchial and tracheal epithelial cells, squamous cells obtained by laser uvulopalatoplasty and tumor surgical margins. We compared the results using multidimensional scaling and hierarchical clustering versus tumor samples and laryngeal squamous cell carcinoma cell lines. Read More

View Article and Full-Text PDF

Immune Cell Infiltrates and Neutrophil-to-Lymphocyte Ratio in Relation to Response to Chemotherapy and Prognosis in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas.

Cancers (Basel) 2021 Apr 25;13(9). Epub 2021 Apr 25.

Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain.

Our goal was to assess the correlation of immune parameters with the response to induction chemotherapy (ICT) in head and neck squamous cell carcinoma (HNSCC) patients. Pretreatment biopsies from 64 patients with HNSCC that received ICT were assessed for PD-L1 protein expression and density of CD8+ and FOXP3+ tumor infiltrating lymphocytes (TIL). In addition, the neutrophil-to-lymphocyte ratio (NLR) was calculated from pretreatment whole blood counts. Read More

View Article and Full-Text PDF

Current Intraoperative Imaging Techniques to Improve Surgical Resection of Laryngeal Cancer: A Systematic Review.

Cancers (Basel) 2021 Apr 15;13(8). Epub 2021 Apr 15.

Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands.

Laryngeal cancer is a prevalent head and neck malignancy, with poor prognosis and low survival rates for patients with advanced disease. Treatment consists of unimodal therapy through surgery or radiotherapy in early staged tumors, while advanced stage tumors are generally treated with multimodal chemoradiotherapy or (total) laryngectomy followed by radiotherapy. Still, the recurrence rate for advanced laryngeal cancer is between 25 and 50%. Read More

View Article and Full-Text PDF

Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas.

Cancers (Basel) 2021 Apr 15;13(8). Epub 2021 Apr 15.

Laboratório de Interações Celulares, Instituto de Ciências Biomédicas, Prédio de Ciências da Saúde-Cidade Universitária, Universidade Federal do Rio de Janeiro-UFRJ, Ilha do Fundão, A. Carlos Chagas, 373-bloco F, sala 26, Rio de Janeiro 21941-902, Brazil.

Head and neck squamous cell carcinomas (HNSCC) are among the most common and lethal tumors worldwide, occurring mostly in oral cavity, pharynx, and larynx tissues. The squamous epithelia homeostasis is supported by the extracellular matrix (ECM), and alterations in this compartment are crucial for cancer development and progression. Laminin is a fundamental component of ECM, where it represents one of the main components of basement membrane (BM), and data supporting its contribution to HNSCC genesis and progression has been vastly explored in oral cavity squamous cell carcinoma. Read More

View Article and Full-Text PDF

Influence of Recurrent Laryngeal Nerve Transient Unilateral Palsy on Objective Voice Parameters and on Voice Handicap Index after Total Thyroidectomy (Including Thyroid Carcinoma).

Int J Environ Res Public Health 2021 Apr 18;18(8). Epub 2021 Apr 18.

Department of Otorhinolaryngology and Maxillofacial Surgery, Military University Hospital, 16902 Prague, Czech Republic.

Total thyroidectomy (TT) is one of the most common surgical endocrine surgeries. Voice impairment after TT can occur not only in patients with recurrent laryngeal nerve (RLN) transient paralysis, but also in cases of normal vocal cord mobility. To compare voice limits using a speech range profile (SRP) in patients before and 14 days after TT and to investigate the influence of the early results of voice quality after TT on the personal lives of patients. Read More

View Article and Full-Text PDF