Cancers (Basel) 2021 Apr 15;13(8). Epub 2021 Apr 15.
Laboratório de Interações Celulares, Instituto de Ciências Biomédicas, Prédio de Ciências da Saúde-Cidade Universitária, Universidade Federal do Rio de Janeiro-UFRJ, Ilha do Fundão, A. Carlos Chagas, 373-bloco F, sala 26, Rio de Janeiro 21941-902, Brazil.
Head and neck squamous cell carcinomas (HNSCC) are among the most common and lethal tumors worldwide, occurring mostly in oral cavity, pharynx, and larynx tissues. The squamous epithelia homeostasis is supported by the extracellular matrix (ECM), and alterations in this compartment are crucial for cancer development and progression. Laminin is a fundamental component of ECM, where it represents one of the main components of basement membrane (BM), and data supporting its contribution to HNSCC genesis and progression has been vastly explored in oral cavity squamous cell carcinoma. Read More