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Enhancing stress reactivity and wellbeing in early schizophrenia: A randomized controlled trial of Integrated Coping Awareness Therapy (I-CAT).

Schizophr Res 2021 Jul 28;235:91-101. Epub 2021 Jul 28.

Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, United States of America; School of Behavioural and Health Sciences, Australian Catholic University, Australia.

Individuals with schizophrenia spectrum disorders (SSD) are at heightened risk for exposure to stressful life events which can lead to increased sensitivity to stress and a dysregulated stress response, which are in turn associated with poor long-term functioning. Stress reactivity is thus a promising treatment target in the early stages of SSD. Integrated-Coping Awareness Therapy (I-CAT) is a manualized intervention integrating mindfulness and positive psychology to target a dysregulated stress response in SSD. Read More

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The effect of timing of enteral nutrition support on feeding outcomes and dysphagia in patients with head and neck cancer undergoing radiotherapy or chemoradiotherapy: A systematic review.

Clin Nutr ESPEN 2021 Aug 3;44:96-104. Epub 2021 Jun 3.

School of Human Movement and Nutrition Sciences, University of Queensland, Queensland, Australia. Electronic address:

Background & Aims: Patients with head and neck cancer (HNC) often require enteral nutrition (EN). This systematic review reports the effect of EN timing in patients with HNC undergoing curative-intent and definitive or adjuvant radiotherapy or chemoradiotherapy on tube feeding duration, tube-related complications and dysphagia.

Methods: Randomised controlled trials (RCTs) published between January 2015-April 2020 were obtained from Medline, CINAHL and Embase. Read More

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Intraoperative overlay of optic radiation tractography during anteromesial temporal resection: a prospective validation study.

J Neurosurg 2021 Jul 30:1-10. Epub 2021 Jul 30.

1Department of Clinical and Experimental Epilepsy, University College London and Epilepsy Society MRI Unit, London.

Objective: Anteromesial temporal lobe resection (ATLR) results in long-term seizure freedom in patients with drug-resistant focal mesial temporal lobe epilepsy (MTLE). There is significant anatomical variation in the anterior projection of the optic radiation (OR), known as Meyer's loop, between individuals and between hemispheres in the same individual. Damage to the OR results in contralateral superior temporal quadrantanopia that may preclude driving in 33%-66% of patients who achieve seizure freedom. Read More

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Effect of root surface charge on the absorption and accumulation of Cu(II) by different japonica and indica rice varieties under acidic conditions.

Ecotoxicol Environ Saf 2021 Jul 27;223:112547. Epub 2021 Jul 27.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, P.O. Box 821, Nanjing, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Excessive amounts of copper (Cu) in soils causes toxic effects on plants. In this study, 58 rice cultivars were classified into tolerant, moderately tolerant, and susceptible types for Cu(II) toxicity based on 50% germination (LC). Nine japonica rice varieties (three each from the tolerant, moderately tolerant, and susceptible groups) and six indica rice varieties (three from the moderately tolerant and susceptible groups) were selected for the hydroponics experiments. Read More

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Large-scale true-time-delay remote beamforming with EO frequency combs and multicore fiber.

Opt Lett 2021 Aug;46(15):3793-3796

Optical true-time-delay (OTTD) beamforming is a promising solution to support the ultra-broadband radio access network. However, large-scale antenna arrays set at remote radio units require the OTTD counterpart to have corresponding larger-scale channel numbers. Here, we demonstrate an OTTD remote beamforming network with a record 287 channel number using electro-optic frequency combs and multicore fiber. Read More

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Study of aerosol optical properties at two urban areas in the north of Vietnam with the implication for biomass burning impacts.

Environ Sci Pollut Res Int 2021 Jul 30. Epub 2021 Jul 30.

Graduate Institute of Applied Geology, National Central University, Taoyuan, 32000, Taiwan.

The spatiotemporal distribution and characterization of aerosol optical properties in the north of Vietnam were investigated extensively using the long-term measurements obtained from Moderate Resolution Imaging Spectroradiometer (MODIS) (from 2010 to 2019) and two Aerosol Robotic Network (AERONET) stations (Nghia Do, Hanoi City, from 2010 to 2019 and Son La from 2012 to 2019) located in fast-developing urban areas. This study also analyzed the tendency of AOD over different wavelengths as well as the influences of meteorological parameters and boundary layer height (BLH) on AOD and Ångström exponent (AE). The annual mean AOD at Nghia Do and Son La stations were 0. Read More

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Downscaling a Human Well-Being Index for Environmental Management and Environmental Justice Applications in Puerto Rico.

Appl Geogr 2020 Jul;123:1-14

U.S. Environmental Protection Agency, Gulf Ecosystems Measurement and Modeling Division, 1 Sabine Island Drive, Gulf Breeze, FL 32561.

Human well-being is often an overarching goal in environmental decision-making, yet assessments are often limited to economic, health, or ecological endpoints that are more tangible to measure. Composite indices provide a comprehensive approach to measuring well-being in terms of multi-dimensional components, such as living standards, health, education, safety, and culture. For example, the Human Well-Being Index (HWBI) framework, initially developed for the U. Read More

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Food insecurity and mental health of women during COVID-19: Evidence from a developing country.

PLoS One 2021 29;16(7):e0255392. Epub 2021 Jul 29.

Centre for Development Economics and Sustainability, Department of Economics, Monash University, Melbourne, Australia.

Background: This study examines the association between food insecurity and mental health of women during the COVID-19 pandemic in a resource poor setting.

Materials And Methods: Data were collected at two time-points (wave 1 and 2) from 2402 women, one per household, participating in a larger study during extended COVID-19 lockdown in the rural areas of the southwest region of Bangladesh. The primary outcome of the analyses is the association between food insecurity, measured using the Food Insecurity Experience Scale (FIES), and stress level, measured using the Perceived Stress Scale (PSS), for women during the lockdown. Read More

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Effectiveness of smartphone application-based self-management interventions in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.

J Adv Nurs 2021 Jul 29. Epub 2021 Jul 29.

School of Nursing, Sun Yat-sen University, Guangzhou, Guangdong, China.

Aims: To synthesize evidences on smartphone application-based intervention and determine its effectiveness on glycaemic control, self-management behaviours, psychological well-being, quality of life and cardiometabolic risk factors.

Design: A systematic review and meta-analysis of randomized controlled trials (RCTs).

Data Sources: Major English and Chinese electronic databases were searched from January 2008 to January 2021, including PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, Google Scholar, China National Knowledge Infrastructure (CNKI), Wanfang and Sinomed. Read More

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Habitat prediction modelling for vulture conservation in Gangetic-Thar-Deccan region of India.

Environ Monit Assess 2021 Jul 29;193(8):532. Epub 2021 Jul 29.

IIFM, Bhopal, India, 462003.

Ecologically and economically important obligate scavengers like vultures are under threat of extinction in the old world. Several resident and migratory vulture sites and individuals are hosted by the Gangetic-Thar-Deccan region of India with varied landscapes. The landscape is under threat from anthropogenic activities and climate change impacting the habitat. Read More

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Cardiac remodeling in fetuses conceived by ARTs: fresh versus frozen embryo transfer.

Hum Reprod 2021 Jul 27. Epub 2021 Jul 27.

BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Universitat de Barcelona, Barcelona, Spain.

Study Question: Do fetuses from frozen embryo transfer (FET) present signs of cardiac remodeling and suboptimal function similar to those observed in fetuses from fresh embryo transfer (ET)?

Summary Answer: Fetuses from both fresh ET and FET present signs of fetal cardiac remodeling and suboptimal function, with more pronounced changes after fresh ET as compared to FET.

What Is Known Already: Our group and others have previously demonstrated that fetuses and children conceived by ARTs present cardiac remodeling and suboptimal function. These fetuses show dilated atria, more globular and thicker ventricles, reduced longitudinal motion, and impaired relaxation. Read More

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Hyaluronic Acid Hydrogel Microspheres for Slow Release Stem Cell Delivery.

ACS Biomater Sci Eng 2021 Jul 29. Epub 2021 Jul 29.

Likarda LLC, 10330 Hickman Mills Drive, Suite B, Kansas City, Missouri 64137, United States.

Cell therapies are hampered by a lack of available delivery systems, resulting in inconsistent outcomes in animal studies and human clinical trials. Hydrogel encapsulants offer a broad range of tunable characteristics in the design of cell delivery vehicles. The focus of the hydrogel field has been on durable encapsulants that provide long-term paracrine function of the cells. Read More

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Holmium laser enucleation of the prostate: A truly size-independent method?

Low Urin Tract Symptoms 2021 Jul 28. Epub 2021 Jul 28.

Department of Urology, University Hospital, LMU Munich, Munich, Germany.

Objectives: To evaluate the impact of prostate size on functional outcomes and perioperative morbidity, we analyzed patients undergoing holmium laser enucleation of the prostate (HoLEP) for lower urinary tract symptoms (LUTS). As LUTS secondary to benign prostatic obstruction (BPO) are a chronic progressive disease, prevalence and prostate size increase with age. HoLEP is a size-independent method for surgical treatment of LUTS/BPO and can be offered in medication-refractory patients with durable long-term results and reduced perioperative morbidity. Read More

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Warfarin Treatment Is Associated to Increased Internal Carotid Artery Calcification.

Front Neurol 2021 12;12:696244. Epub 2021 Jul 12.

Neurology, Neurocenter, Helsinki University Hospital, Helsinki, Finland.

Long-term treatment with the vitamin K antagonist warfarin is widely used for the prevention of venous thrombosis and thromboembolism. However, vitamin K antagonists may promote arterial calcification, a phenomenon that has been previously studied in coronary and peripheral arteries, but not in extracranial carotid arteries. In this observational cohort study, we investigated whether warfarin treatment is associated with calcification of atherosclerotic carotid arteries. Read More

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Debating the embolization of a large aberrant systemic artery for pulmonary sequestration using an Amplatzer duct occluder: a case report and literature review.

Cardiol Young 2021 Jul 29:1-6. Epub 2021 Jul 29.

Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan610041, China.

Here, we report two rare cases of pulmonary sequestration that were fed by large systemic arteries and embolized with a large Amplatzer duct occluder and their 3-year follow-up, and we discuss the efficacy and safety of the embolization of a large aberrant systemic artery to pulmonary sequestration using an Amplatzer duct occluder. A 9-year-old boy complained of chest pain for 1 month, and a 6-year-old boy initially complained of recurrent cough for 3 months. A series of examinations was launched to evaluate any possible malformation or abnormalities in the patients. Read More

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Contemporary Review on Craniectomy and Cranioplasty; Part 1: Decompressive Craniectomy.

J Craniofac Surg 2021 Jul 27. Epub 2021 Jul 27.

Applied Medical Sciences Department, Luminus Technical University College, Amman, Jordan Consultant Clinical Scientist (Reconstructive Science), London, UK.

Abstract: This paper aims to review clinical benefits of decompressive craniectomy (DC) in both adult and paediatric populations; its indications and factors contributing to its postoperative success. The Glasgow Outcome Scale and the Modified Rankin Scale are the most commonly used scales to assess the long-term outcome in patients post DC. In adult traumatic brain injury patients, 2 randomized clinical trials were carried out; DECRA (Decompressive Craniectomy in Diffuse Traumatic Brain Injury) and RESCUEicp (Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of inter cranial pressure) employing collectively 555 patients. Read More

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Risdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls.

N Engl J Med 2021 Jul;385(5):427-435

From the Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston (B.T.D.); the Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (R.M., G.B.), and the Center of Translational and Experimental Myology, IRCCS Istituto Giannina Gaslini, Genoa (C.B.) - both in Italy; the Department of Developmental Neurology, Medical University of Gdańsk, Gdańsk, Poland (M.M.-B.); the Paediatric Gait Analysis Service of New South Wales, the Children's Hospital at Westmead and the University of Sydney, Sydney (K.R.); the Department of Pediatrics, Peking University First Hospital, Beijing (H.X.), and Children's Hospital of Fudan University, Shanghai (Y.W.) - both in China; the Department of Neurology, Faculdade de Medicina, Universidade de São Paulo, São Paulo (E.Z.); the Dubowitz Neuromuscular Centre, National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, and Great Ormond Street Hospital for Children NHS Foundation Trust, London (G.B.), Roche Products, Welwyn Garden City (M.E.-K.), and the Muscular Dystrophy UK Oxford Neuromuscular Centre, the Department of Paediatrics, University of Oxford, Oxford (L.S.) - all in the United Kingdom; Russian Children Neuromuscular Center, Veltischev Clinical Pediatric Research Institute, Pirogov Russian National Research Medical University, Moscow (D.V.); Pharma Development, Safety (M.G.), Product Development Medical Affairs - Neuroscience and Rare Disease (K.G., P.F.), and Pharma Development Neurology (R.S.S.), F. Hoffmann-La Roche, and Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel (O.K., H.K.) - both in Basel, Switzerland; the Division of Child Neurology, Centre de Références des Maladies Neuromusculaires, the Department of Pediatrics, University Hospital Liege, University of Liege, Liege, Belgium (L.S.); and I-Motion, Institut de Myologie, Assistance Publique Hôpitaux de Paris, Hôpital Armand Trousseau, Paris (L.S.).

Background: Type 1 spinal muscular atrophy (SMA) is a progressive neuromuscular disease characterized by an onset at 6 months of age or younger, an inability to sit without support, and deficient levels of survival of motor neuron (SMN) protein. Risdiplam is an orally administered small molecule that modifies pre-messenger RNA splicing and increases levels of functional SMN protein in blood.

Methods: We conducted an open-label study of risdiplam in infants with type 1 SMA who were 1 to 7 months of age at enrollment. Read More

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Combination of ablation and embolization for intermediate-sized liver metastases from colorectal cancer: what can we learn from treating primary liver cancer?

Diagn Interv Radiol 2021 Jul 28. Epub 2021 Jul 28.

Interventional Oncology Service, University College Hospital, London, UK;Centre for Medical Imaging, University College London, London, UK.

Colorectal cancer liver metastases (CRLMs) are common. Treating CRLMs with thermal ablation can prolong survival, but compared to lesions smaller than 3 cm, local control rates and overall survival are relatively worse with larger, intermediate (3-5 cm) lesions. Local recurrence rates range between 1. Read More

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Ultra-low-dose radiation treatment for early-stage ocular adnexal MALT lymphoma.

Eur J Ophthalmol 2021 Jul 28:11206721211035622. Epub 2021 Jul 28.

Department of Internal Medicine, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.

Purpose: To investigate the long-term outcomes of ultra-low-dose (4 Gy) radiation treatment (RT) in patients with early-stage ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma.

Methods: This retrospective case series includes eight patients with ocular adnexal MALT lymphoma who received ultra-low-dose RT at a single tertiary referral center between March 2016 and February 2018. Response to treatment and the time taken to respond were analyzed. Read More

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Microfabricated disk technology: rapid scale up in midbrain organoid generation.

Methods 2021 Jul 24. Epub 2021 Jul 24.

Early Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, Quebec, H3A 2B4, Canada. Electronic address:

By providing a three-dimensional in vitro culture system with key features of the substantia nigra region in the brain, 3D neuronal organoids derived from human induced pluripotent stem cells (iPSCs) provide living neuronal tissue resembling the midbrain region of the brain. However, a major limitation of conventional brain organoid culture is that it is often labor-intensive, requiring highly specialized personnel for moderate throughput. Additionally, the methods published for long-term cultures require time-consuming maintenance to generate brain organoids in large numbers. Read More

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Thulium laser vapo-enucleation treatment for prostates >100 cc following urinary retention.

Urologia 2021 Jul 27:3915603211016325. Epub 2021 Jul 27.

University Hospitals of Leicester NHS Trust, Leicester, UK.

Introduction: Practical advantages of Thulium in the endoscopic treatment of BPH include its technical versatility, precision and safety, offering reduced need for haemostasis and risk of injury. Evidence has shown Holmium laser to be effective in the treatment of chronic retention, however no studies address the use of Thulium laser for larger prostates after urinary retention.

Objectives: We have selected this group in our retrospective analysis on the efficacy of Thulium laser vapo-enucleation for men with both urinary retention and large prostate volumes greater than 100 cc. Read More

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Temporal Expression Pattern of Hemoxygenase-1 Expression and Its Association with Vasospasm and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.

Neurocrit Care 2021 Jul 26. Epub 2021 Jul 26.

Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Red blood cell-induced cerebral inflammation and toxicity has been shown to be attenuated by induction of the heme-catalyzing enzyme, hemoxygenase-1 (HO-1), in animal models of subarachnoid hemorrhage (SAH). Although inflammatory mechanisms leading to secondary neuronal injury in SAH are becoming increasingly well understood, markers of cerebral inflammation have so far not been implemented in clinical prediction models of SAH.

Methods: In this biomarker observational study, HO-1 messenger ribonucleic acid (mRNA) expression levels were determined in cerebrospinal fluid (CSF) and blood of 66 patients with aneurysmal SAH on days 1, 7, and 14 after the SAH event. Read More

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Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy.

Sci Rep 2021 Jul 26;11(1):15171. Epub 2021 Jul 26.

Multidisciplinary Department of Medical, Surgical and Dental Specialities, Università Della Campania Luigi Vanvitelli, Napoli, Italy.

The purpose of this study is to evaluate the safety and efficacy of two novel heavy dyes for macular surgery: DoubledyneTM and TwinTM. One eye from each of 144 patients undergoing surgery for macular hole or macular pucker was included in the study. The eyes were randomly divided into two groups according to the dye used during surgery. Read More

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γδ T cells cultured with artificial antigen-presenting cells and IL-2 show long-term proliferation and enhanced effector functions compared with γδ T cells cultured with only IL-2 after stimulation with zoledronic acid.

Cytotherapy 2021 Jul 24. Epub 2021 Jul 24.

Department of Microbiology, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea; Catholic Hematopoietic Stem Cell Bank, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background Aims: Immunotherapeutic approaches using γδ T cells have emerged as the function of γδ T cells in tumor surveillance and clearance has been discovered. In vitro expansion methods of γ9δ2 T cells have been based on phosphoantigens and cytokines, but expansion methods using feeder cells to generate larger numbers of γδ T cells have also been studied recently. However, there are no studies that directly compare γδ T cells cultured with phosphoantigens with those cultured with feeder cells. Read More

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The impact of a needs-oriented dental prophylaxis program on bacteremia after toothbrushing and systemic inflammation in children, adolescents, and young adults with chronic kidney disease.

Pediatr Nephrol 2021 Jul 23. Epub 2021 Jul 23.

Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: Chronic kidney disease (CKD) still leads to high mortality rates, mainly due to cardiovascular disease. One important influencing factor is persisting low-grade chronic inflammation partly maintained by gingivitis that favors transient bacteremia during daily activities such as toothbrushing.

Methods: To examine whether intensive dental prophylaxis can restore oral health, reduce the prevalence of bacteremia and degree of systemic inflammation indicated by CRP levels, we conducted this pilot study examining 30 CKD patients aged 6-26 years, 15 receiving intensive prophylaxis (IP), 15 receiving treatment as usual (TAU) serving as control group. Read More

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Pre-procedural ATI score (age-thrombus burden-index of microcirculatory resistance) predicts long-term clinical outcomes in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Oxford Heart Centre, NIHR Biomedical Research Centre, Oxford University Hospitals, Oxford, UK; Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Electronic address:

Background: The ATI (Age-Thrombus burden-Index of Microvascular Resistance [IMR]) score was developed to predict suboptimal myocardial reperfusion in patients with ST-Elevation Myocardial Infarction (STEMI). When applied in the early phases of revascularization (e.g. Read More

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Impact of Nutritional Assessment on Long-Term Outcomes in Patients with Carotid Artery Stenting.

Int J Clin Pract 2021 Jul 26:e14637. Epub 2021 Jul 26.

Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.

Background And Aims: Malnutrition is associated with poor clinical outcomes in many diseases. The Controlling Nutritional Status (CONUT) is an objective index used for evaluating nutritional status of hospitalized patients. The aim of this study was to investigate the relationship between malnutrition assessed by CONUT score and the prognosis in patients undergoing carotid artery stenting (CAS). Read More

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Tailored or adapted interventions for adults with chronic obstructive pulmonary disease and at least one other long-term condition: a mixed methods review.

Cochrane Database Syst Rev 2021 Jul 26;7:CD013384. Epub 2021 Jul 26.

Physiotherapy, Alfred Health, Melbourne, Australia.

Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterised by shortness of breath, cough and recurrent exacerbations. People with COPD often live with one or more co-existing long-term health conditions (comorbidities). People with more severe COPD often have a higher number of comorbidities, putting them at greater risk of morbidity and mortality. Read More

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A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization.

Lab Chip 2021 Jul 26. Epub 2021 Jul 26.

Université Paris-Saclay, CNRS, Centre de Nanosciences et Nanotechnologies C2N, UMR9001, Palaiseau 91120, France.

We have developed and tested a novel microfluidic device for blood oxygenation, which exhibits a large surface area of gas exchange and can support long-term sustainable endothelialization of blood microcapillaries, enhancing its hemocompatibility for clinical applications. The architecture of the parallel stacking of the trilayers is based on a central injection for blood and a lateral injection/output for gas which allows significant reduction in shear stress, promoting sustainable endothelialization since cells can be maintained viable for up to 2 weeks after initial seeding in the blood microchannel network. The circular design of curved blood capillaries allows covering a maximal surface area at 4 inch wafer scale, producing high oxygen uptake and carbon dioxide release in each single unit. Read More

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Exploring the Role of Web-Based Interventions in the Self-management of Dementia: Systematic Review and Narrative Synthesis.

J Med Internet Res 2021 Jul 26;23(7):e26551. Epub 2021 Jul 26.

Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Background: The increasing prevalence of dementia has promoted a move toward equipping people with the skills required for greater self-management of the condition to enable a better quality of life. Self-management encompasses numerous skills, such as goal setting and decision making, which aim to improve an individual's physical and mental well-being when they live with long-term health conditions. Effective self-management may lead to increased well-being and quality of life. Read More

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