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New tree-ring data from Canadian boreal and hemi-boreal forests provide insight for improving the climate sensitivity of terrestrial biosphere models.

Sci Total Environ 2022 Aug 15:158062. Epub 2022 Aug 15.

Department of Biology, University of Western Ontario, London, Ontario, Canada; Nicholas School of the Environment, Duke University, Durham, NC, USA; Environmental & Climate Sciences Department, Brookhaven National Laboratory, Upton, NY, USA.

Understanding boreal/hemi-boreal forest growth sensitivity to seasonal variations in temperature and water availability provides important basis for projecting the potential impacts of climate change on the productivity of these ecosystems. Our best available information currently comes from a limited number of field experiments and terrestrial biosphere model (TBM) simulations of varying predictive accuracy. Here, we assessed the sensitivity of annual boreal/hemi-boreal forest growth in Canada to yearly fluctuations in seasonal climate variables using a large tree-ring dataset and compared this to the climate sensitivity of annual net primary productivity (NPP) estimates obtained from fourteen TBMs. Read More

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A high-resolution nutrient emission inventory for hotspot identification in the Yangtze River Basin.

J Environ Manage 2022 Aug 15;321:115847. Epub 2022 Aug 15.

College of Environmental Sciences and Engineering, State Environmental Protection Key Laboratory of All Material Fluxes in River Ecosystems, Peking University, Beijing, 100871, China. Electronic address:

A high-resolution nutrient emission inventory can provide reliable and accurate identification of priority control areas, which is crucial for efficient decisions on water quality restoration. However, the inventories widely used in large-scale modeling are usually based on provincial inputs, which induce the challenges of lacking localized parameters and missing localized characteristic when provincial scale inputs are converted to finer scales with the down-scale methods. Based on elaborate investigations and statistical data at the county scale with multi-scale data conversion, the China Emission Inventory of Nutrients (CEIN) was developed with a spatial resolution of a 0. Read More

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Factors Associated With Image-Guided Radiation Therapy Image Rejection in a Multisite Institution.

JCO Oncol Pract 2022 Aug 18:OP2100622. Epub 2022 Aug 18.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Nonclinical factors and cognitive biases have been shown to significantly affect clinical decision making. In this study, we aimed to identify clinical and environmental factors that might influence the decision to approve or reject image-guided radiation therapy (IGRT) images in a large multisite institution.

Methods: We identified all IGRT image approval and rejection decisions recorded within an electronic imaging system from July 1, 2016, to June 30, 2018. Read More

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Stress and Anxiety Reduction Effects of a Reiki Program During the COVID-19 Pandemic Among Employees in Lima, Peru.

Holist Nurs Pract 2022 Sep-Oct 01;36(5):E48-E56

Faculty of Psychology, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Evidence has been found of how the coronavirus disease-2019 (COVID-19) pandemic has increased stress and anxiety indicators. Against this background, the present research aims to determine the effect of a distance Reiki intervention program on stress and anxiety during the period of isolation due to COVID-19 among people working in the city of Lima, Peru. The related hypothesis was that distance Reiki would generate a reduction in stress and anxiety levels. Read More

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Association between gut microbiota and depressive symptoms: A cross-sectional population-based study in South Korea.

Psychosom Med 2022 Jul 18. Epub 2022 Jul 18.

Department of Biochemistry, Ewha Womans University College of Medicine, Seoul, Republic of Korea.

Objective: To investigate the association between gut microbiota and depressive symptoms in a large population cohort of Korean adults.

Methods: Overall, 1,238 participants were included in the study. Participants were categorized into depressed or non-depressed groups, based on the depressive symptoms reported on the Center for Epidemiologic Studies Rating Scale for Depression, with a cut-off score of 16, and their fecal microbiota was profiled using 16S ribosomal RNA gene sequencing. Read More

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Lotus Leaf-Inspired Breathable Membrane with Structured Microbeads and Nanofibers.

ACS Appl Mater Interfaces 2022 Aug 18. Epub 2022 Aug 18.

Department of Biomedical Engineering, City University of Hong Kong, Hong Kong S.A.R 999077, China.

Electrospinning is a feasible technology to fabricate nanomaterials. However, the preparation of nanomaterials with controllable structures of microbeads and fine nanofibers is still a challenge, which hinders widespread applications of electrospun products. Herein, inspired by the micro/nanostructures of lotus leaves, we constructed a structured electrospun membrane with excellent comprehensive properties. Read More

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Adaptation and construct validity evaluation of a tablet-based, short neuropsychological test battery for use with adolescents and young adults living with HIV in Thailand.

Neuropsychology 2022 Aug 18. Epub 2022 Aug 18.

Research Institute for Health Sciences.

Objective: Deficits in neurocognitive functioning are common among adolescents and young adults (AYA) with perinatally acquired HIV (PHIV). Limitations of traditional neuropsychological tests hinder assessment of neurocognition in low- and middle-income countries where most AYA with PHIV reside. Computerized testing could make assessment of neurocognition more accessible in these countries. Read More

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Recent Advances on the Metal-Organic Frameworks-Based Biosensing Methods for Cancer Biomarkers Detection.

Crit Rev Anal Chem 2022 Aug 18:1-17. Epub 2022 Aug 18.

Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.

Sensitive and selective detection of cancer biomarkers is crucial for early diagnosis and treatment of cancer, one of the most dangerous diseases in the world. Metal-organic frameworks (MOFs), a class of hybrid porous materials fabricated through the assembly of metal ions/clusters and organic ligands, have attracted increasing attention in the sensing of cancer biomarkers, due to the advantages of adjustable size, high porosity, large surface area and ease of modification. MOFs have been utilized to not only fabricate active sensing interfaces but also arouse a variety of measurable signals. Read More

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Genomic investigation of the Chinese alligator reveals wild-extinct genetic diversity and genomic consequences of their continuous decline.

Mol Ecol Resour 2022 Aug 18. Epub 2022 Aug 18.

MOE Key Laboratory of Biosystems Homeostasis & Protection, State Conservation Centre for Gene Resources of Endangered Wildlife, College of Life Sciences, Zhejiang University, Hangzhou, China.

Critically endangered species are usually restricted to small and isolated populations. High inbreeding without gene flow among populations further aggravates their threatened condition and reduces the likelihood of their long-term survival. Chinese alligator (Alligator sinensis) is one of the most endangered crocodiles in the world and has experienced a continuous decline over the past ca. Read More

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Tissue-Specific CRISPR-Cas9 Screening in Drosophila.

Methods Mol Biol 2022 ;2540:157-176

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany.

Over the last century research in Drosophila has resulted in many fundamental contributions to our understanding of the biology of multicellular organisms. Many of these breakthroughs have been based on the identification of novel gene functions in large-scale genetic screens. However, conventional forward-genetic screens have been limited by the random nature of mutagenesis and difficulties in mapping causal mutations, while reverse-genetic RNAi screens suffer from incomplete knockdown of gene expression. Read More

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January 2022

Single-Cell Transcriptional Profiling and Gene Regulatory Network Modeling in Tg2576 Mice Reveal Gender-Dependent Molecular Features Preceding Alzheimer-Like Pathologies.

Mol Neurobiol 2022 Aug 18. Epub 2022 Aug 18.

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7 avenue des Hauts Fourneaux, L-4362, Esch-sur-Alzette, Luxembourg.

Alzheimer's disease (AD) onset and progression is influenced by a complex interplay of several environmental and genetic factors, one of them gender. Pronounced gender differences have been observed both in the relative risk of developing AD and in clinical disease manifestations. A molecular level understanding of these gender disparities is still missing, but could provide important clues on cellular mechanisms modulating the disease and reveal new targets for gender-oriented disease-modifying precision therapies. Read More

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A Comprehensive Comparison of Different Nodal Subclassification Methods in Surgically Resected Non-Small-Cell Lung Cancer Patients.

Ann Surg Oncol 2022 Aug 18. Epub 2022 Aug 18.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Introduction: The revision of the N descriptor in non-small-cell lung cancer has been widely discussed in the past few years. Many different subclassification methods based on number or location of lymph nodes have been proposed for better distinguishing different N patients. This study aimed to systematically collect them and provide a comprehensive comparison among different subclassification methods in a large cohort. Read More

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Duckweed: a potential phytosensor for heavy metals.

Plant Cell Rep 2022 Aug 18. Epub 2022 Aug 18.

Department of Food Science, University of Tennessee, 102 Food Safety and Processing Building 2600 River Dr., Knoxville, TN, 37996, USA.

Globally, heavy metal (HM) contamination is one of the primary causes of environmental pollution leading to decreased quality of life for those affected. In particular, HM contamination in groundwater poses a serious risk to human health and the potential for destabilization of aquatic ecosystems. At present, strategies to remove HM contamination from wastewater are inefficient, costly, laborious, and often the removal poses as much risk to the environment as the initial contamination. Read More

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Extraordinary Nonlinear Optical Interaction from Strained Nanostructures in van der Waals CuInPS.

ACS Nano 2022 Aug 18. Epub 2022 Aug 18.

School of Engineering, College of Engineering and Computer Science, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.

Local strain engineering and structural modification of 2D materials furnish benevolent control over their optoelectronic properties and provide an exciting approach to tune light-matter interaction in layered materials. Application of strain at the nanoscale is typically obtained through permanently deformed nanostructures such as nanowrinkles, which yield large band gap modulation, photoluminescence enhancement, and surface potential. Ultrathin transition metal dichalcogenides (TMDs) have been greatly analyzed for such purposes. Read More

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Identifying low-quality patterns in accidents reports from textual data.

Int J Occup Saf Ergon 2022 Aug 18:1-27. Epub 2022 Aug 18.

Companhia Hidrelétrica do São Francisco (CHESF), Brazil.

Accident investigation reports provide useful knowledge to support companies to propose preventive and mitigative measures. However, the information presented in accident reports databases is normally large, complex, filled out with errors, missing and/or redundant data. In this paper, we propose text mining and natural language processing techniques to investigate low-quality accident reports. Read More

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Distribution and Genomic Variation of Thermophilic Cyanobacteria in Diverse Microbial Mats at the Upper Temperature Limits of Photosynthesis.

mSystems 2022 Aug 18:e0031722. Epub 2022 Aug 18.

Department of Plant and Microbial Biology, University of Minnesotagrid.17635.36, St. Paul, Minnesota, USA.

Thermophilic cyanobacteria have been extensively studied in Yellowstone National Park (YNP) hot springs, particularly during decades of work on the thick laminated mats of Octopus and Mushroom springs. However, focused studies of cyanobacteria outside these two hot springs have been lacking, especially regarding how physical and chemical parameters along with community morphology influence the genomic makeup of these organisms. Here, we used a metagenomic approach to examine cyanobacteria existing at the upper temperature limit of photosynthesis. Read More

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Tools in the Era of Multidrug Resistance in Bacteria: Applications for New Antimicrobial Peptides Discovery.

Curr Pharm Des 2022 Aug 17. Epub 2022 Aug 17.

Department of Sciences, University of Basilicata - Potenza (Italy) - Via dell'Ateneo Lucano 10,85100, Potenza, Italy.

Antimicrobial peptides (AMPs) are small molecules belonging to innate immunity that act against bacteria, fungi, and viruses. With the spread of bacterial strains resistant to current antibiotics, the scientific community is deeply committed to the identification and study of new molecules with putative antimicrobial activity. In this context, AMPs represent a promising alternative to overcome this problem. Read More

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From Phosphate Fluoride to Fluorophosphate: Design of Novel Ultraviolet/Deep-Ultraviolet Nonlinear Optical Materials for BePOF with Optical Property Enhancement.

ACS Appl Mater Interfaces 2022 Aug 18. Epub 2022 Aug 18.

Research Center for Crystal Materials; CAS Key Laboratory of Functional Materials and Devices for Special Environments, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Science, 40-1 South Beijing Road, Urumqi 830011, China.

Fluorine-containing compounds have stimulated the exploration of ultraviolet/deep-ultraviolet nonlinear optical (NLO) materials. Alkali/alkaline-earth metal phosphates are one of the important potential systems as NLO materials, while the common small birefringence limits the phase-matching (PM) ability in the ultraviolet/deep-ultraviolet region. Herein, by applying a "fluorination synergy-induced enhancement of optical property" strategy, novel structures of phosphate fluoride/fluorophosphate in BePOF with good thermodynamic/dynamic stability and promising NLO-related properties are discovered via performing crystal structure prediction combined with first-principles calculations. Read More

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A survey on road hazardous material transportation accidents in Iran.

Int J Inj Contr Saf Promot 2022 Aug 18:1-9. Epub 2022 Aug 18.

Fereshteh Taheri, Occupational Health Research Center, Iran University of Medical Sciences, Tehran, Iran.

Hazardous material road transportation is one of the most challenging procedures performed by large trucks and trailers. In this study, after examining and analyzing road hazardous material transportation accidents, occurred over 5 years in Iran, the contributing factors of road hazardous material transportation accidents were determined. Subsequently, the introduced factors were prioritized using fault tree analysis and the Dempster-Shafer evidence theory. Read More

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[Application of anterior serratus branch of thoracodorsal vessel in repairing chest wall defect].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Aug;36(8):1021-1025

Department of Oncology Plastic Surgery, Hunan Province Cancer Hospital, Changsha Hunan, 410008, P. R. China.

Objective: To investigate the application of anterior serratus branch of thoracodorsal vessel in repairing chest wall defect.

Methods: Between October 2018 and March 2021, bilateral free lower abdominal flaps were used to repair large-area complex defects after chest wall tumor surgery in 23 patients. The patients were all female; the age ranged from 23 to 71 years, with an average age of 48. Read More

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[Study on bone microstructure and pathology of type L2 and L3 osteonecrosis of the femoral head specimens classified by China-Japan Friendship Hospital classification based on "three-columns structure"].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Aug;36(8):1003-1010

Department of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing Jiangsu, 210001, P. R. China.

Objective: To analyze the similarities and differences of bone microstructure and apoptosis phenotype of lateral column, middle column, and medial column in type L2 and L3 osteonecrosis of the femoral head (ONFH) specimens classified by China-Japan Friendship Hospital (CJFH) classification, so as to carry out a quantitative study of ONFH "three-columns structure theory" and to provide research support for the treatment of ONFH by rotational osteotomy through the base of femoral neck.

Methods: Discarded femoral head specimens from 16 patients (16 hips) with CJFH type L2 and L3 ONFH undergone total hip arthroplasty between April 2020 and February 2021 were selected as the research objects. First, the "three-column structure" of the femoral head was three-dimensionally segmented by Micro-CT, and the bone volume to total volume (BV/TV), bone surface area to bone volume ratio (BS/BV), trabecular spacing/separation (Tb. Read More

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Au-Decorated graphene as a sensing platform for O adsorption and desorption kinetics.

Nanoscale 2022 Aug 18. Epub 2022 Aug 18.

Quantum Solid-State Physics, Department of Physics and Astronomy, KU Leuven, Leuven, Belgium.

The adsorption and desorption kinetics of molecules is of significant fundamental and applied interest. In this paper, we present a new method to quantify the energy barriers for the adsorption and desorption of gas molecules on few-atom clusters, by exploiting reaction induced changes of the doping level of a graphene substrate. The method is illustrated for oxygen adsorption on Au clusters. Read More

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Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a murine critical size defect.

J Orthop Translat 2022 Sep 4;36:64-74. Epub 2022 Aug 4.

Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.

Background: A critical size bone defect is a clinical scenario in which bone is lost or excised due to trauma, infection, tumor, or other causes, and cannot completely heal spontaneously. The most common treatment for this condition is autologous bone grafting to the defect site. However, autologous bone graft is often insufficient in quantity or quality for transplantation to these large defects. Read More

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September 2022

Disrupted intra- and inter-network connectivity in unilateral acute tinnitus with hearing loss.

Front Aging Neurosci 2022 1;14:833437. Epub 2022 Aug 1.

Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.

Purpose: Currently, the underlying neurophysiological mechanism of acute tinnitus is still poorly understood. This study aimed to explore differences in brain functional connectivity (FC) within and between resting-state networks (RSNs) in acute tinnitus patients with hearing loss (ATHL). Furthermore, it also evaluated the correlations between FC alterations and clinical characteristics. Read More

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Effectiveness of aerobic and resistance training on the motor symptoms in Parkinson's disease: Systematic review and network meta-analysis.

Front Aging Neurosci 2022 1;14:935176. Epub 2022 Aug 1.

Sports Rehabilitation Research Center, China Institute of Sport Science, Beijing, China.

Background/objectives: Aerobic and resistance training are common complementary therapies to improve motor symptoms in people with Parkinson's disease (PD), and there is still a lack of advice on which intensity and period of aerobic or resistance training is more appropriate for people with PD. Therefore, a network meta-analysis was conducted to assess the comparative efficacy of aerobic and resistance training of different intensities and cycles on motor symptoms in patients with Parkinson's disease.

Methods: Based on several biomedical databases, a search strategy system was conducted to retrieve randomized controlled trials (RCTs) without language restrictions. Read More

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Opportunities and challenges of targeting c-Met in the treatment of digestive tumors.

Front Oncol 2022 1;12:923260. Epub 2022 Aug 1.

Department of General Surgery, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin, China.

At present, a large number of studies have demonstrated that c-Met generally exerts a crucial function of promoting tumor cells proliferation and differentiation in digestive system tumors. c-Met also mediates tumor progression and drug resistance by signaling interactions with other oncogenic molecules and then activating downstream pathways. Therefore, c-Met is a promising target for the treatment of digestive system tumors. Read More

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Event-Based Atmospheric Precipitation Uncovers Significant Even and Odd Hg Isotope Anomalies Associated with the Circumpolar Vortex.

Environ Sci Technol 2022 Aug 17. Epub 2022 Aug 17.

Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, Guizhou 550002, People's Republic of China.

The determination of the mass-independent fractionation of even Hg isotopes (even-MIF, ΔHg) in atmospheric samples adds another intriguing feature to the Hg isotope system. Despite our lack of sufficient experimental verification and the momentary absence of a valid mechanism to explain its occurrence, even-MIF could be instrumental in understanding the cycle and deposition of atmospheric Hg. In contrast to slightly positive ΔHg values (<0. Read More

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Recommendations for quantifying and reducing uncertainty in climate projections of species distributions.

Glob Chang Biol 2022 Aug 5. Epub 2022 Aug 5.

Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, Washington, USA.

Projecting the future distributions of commercially and ecologically important species has become a critical approach for ecosystem managers to strategically anticipate change, but large uncertainties in projections limit climate adaptation planning. Although distribution projections are primarily used to understand the scope of potential change-rather than accurately predict specific outcomes-it is nonetheless essential to understand where and why projections can give implausible results and to identify which processes contribute to uncertainty. Here, we use a series of simulated species distributions, an ensemble of 252 species distribution models, and an ensemble of three regional ocean climate projections, to isolate the influences of uncertainty from earth system model spread and from ecological modeling. Read More

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Vaccine development against Schmallenberg virus: from classical inactivated to modified-live to scaffold particle vaccines.

One Health Outlook 2022 Aug 17;4(1):13. Epub 2022 Aug 17.

Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald - Insel Riems, Germany.

Background: Subsequent to its first detection in 2011, the insect-transmitted bunyavirus Schmallenberg virus (SBV; genus Orthobunyavirus) caused a large-scale epizootic of fetal malformation in the European ruminant population. By now, SBV established an enzootic status in Central Europe with regular wave-like re-emergence, which has prompted intensive research efforts in order to elucidate the pathogenesis and to develop countermeasures. Since different orthobunyaviruses share a very similar structural organization, SBV has become an important model virus to study orthobunyaviruses in general and for the development of vaccines. Read More

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Diagnostic accuracy for colorectal cancer of a quantitative faecal immunochemical test in symptomatic primary care patients: a study protocol.

Diagn Progn Res 2022 Aug 18;6(1):16. Epub 2022 Aug 18.

Department of Medical Sciences, Örebro University, Örebro, Sweden.

Background: There is increasing evidence supporting the use of faecal immunochemical tests (FIT) in patients reporting symptoms associated with colorectal cancer (CRC), but most studies until now have focused on selected subjects already referred for investigation. We therefore set out to determine the accuracy and predictive values of FIT in a primary care population.

Method: A prospective, multicentre, single-gated comparative diagnostic study on quantitative FIT in patients aged 40 years and above presenting in primary care with symptoms associated with CRC will be conducted. Read More

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