1,704 results match your criteria large caliber

Hemorrhagic cerebral proliferative angiopathy in two pediatric patients: case reports.

Childs Nerv Syst 2021 May 6. Epub 2021 May 6.

Division of Interventional Neuroradiology, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.

Cerebral proliferative angiopathy (CPA) is an infrequent vascular malformation. It is composed of a nidus, arterial feeders, and venous drainage. Some special features differentiate it from the common arteriovenous malformations (AVM). Read More

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Low incidence of milk fistula with continued breastfeeding following radiologic and surgical interventions on the lactating breast.

Breast Dis 2021 Apr 22. Epub 2021 Apr 22.

Current institution: Surgical Oncology, Ridley-Tree Cancer Center, Sansum Clinic, Santa Barbara, CA, USA.

Background: Milk fistula is a potential complication of radiologic and surgical procedures on the lactating breast, though its incidence is unknown. Some postulate that larger defects and/or closer proximity to the nipple increase the risk of fistula.

Objective: This study aimed to estimate the incidence of milk fistula and characterize risk factors in patients who continued breastfeeding after surgical or radiological procedures. Read More

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[Prehospital treatment of tension pneumothorax in children-which decisions do we make? : Results of a survey among German emergency physicians].

Anaesthesist 2021 Apr 23. Epub 2021 Apr 23.

Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

Background: The preclinical treatment of a traumatic or spontaneous tension pneumothorax remains a particular challenge in pediatric patients. Currently recommended interventions for decompression are either finger thoracostomy or needle decompression. Due to the tiny intercostal spaces, finger thoracostomy may not be feasible in small children and surgical preparation may be necessary. Read More

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Performance assessment of intravenous catheters for massive transfusion: A pragmatic in vitro study.

Transfusion 2021 Apr 13. Epub 2021 Apr 13.

Veterens Affairs Portland Health Care System, Portland, Oregon, USA.

Background: Rapid infusion of warmed blood products is the cornerstone of trauma resuscitation and treatment of surgical and obstetric massive hemorrhage. Integral to optimizing this delivery is selection of an intravenous (IV) catheter and use of a rapid infusion device (RID). We investigated which IV catheter and RID system enabled the greatest infusion rate of blood products and the governing catheter characteristics. Read More

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The Small 14-French (Fr) Percutaneous Catheter vs. Large (28-32Fr) Open Chest Tube for Traumatic Hemothorax (P-CAT): A Multi-center Randomized Clinical Trial.

J Trauma Acute Care Surg 2021 Mar 16. Epub 2021 Mar 16.

Division of Acute Care Surgery, Department of Surgery, University of Arizona, Tucson, Arizona Division of Acute Care Surgery, Department of Surgery, University of Nebraska, Omaha, Nebraska Division of Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin Division of Acute Care Surgery, Department of Surgery, Loma Linda University, Loma Linda, California Department of Surgery, New York Medical College, Valhalla, New York.

Introduction: The traditional treatment of traumatic hemothorax (HTX) has been an insertion of a large-bore 36-40 French (FR) chest tube (CT). Our previous single-center randomized controlled trial (RCT) had shown that 14Fr percutaneous catheters (PCs) (pigtail) were equally as effective as CTs. We performed a multi-center RCT, hypothesizing that PCs are as equally effective as CTs in the management of patients with traumatic HTX. Read More

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Reweighting non-equilibrium steady-state dynamics along collective variables.

J Chem Phys 2021 Apr;154(13):134105

Max Planck Institute for Polymer Research, 55128 Mainz, Germany.

Computer simulations generate microscopic trajectories of complex systems at a single thermodynamic state point. We recently introduced a Maximum Caliber (MaxCal) approach for dynamical reweighting. Our approach mapped these trajectories to a Markovian description on the configurational coordinates and reweighted path probabilities as a function of external forces. Read More

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X-Linked Hypohidrotic Ectodermal Dysplasia in Crossbred Beef Cattle Due to a Large Deletion in .

Animals (Basel) 2021 Mar 2;11(3). Epub 2021 Mar 2.

Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.

X-linked hypohidrotic ectodermal dysplasia-1 (ECTD1) in people results in a spectrum of abnormalities, most importantly hypotrichosis, anodontia/oligodontia, and absent or defective ectodermally derived glands. Five Red Angus-Simmental calves born over a 6-year period demonstrated severe hypotrichosis and were diagnosed as affected with ECTD1-like syndrome. Two died of severe pneumonia within a week of birth. Read More

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A technique to facilitate the cannulation of the foramen ovale for balloon compression.

Br J Neurosurg 2021 Mar 30:1-4. Epub 2021 Mar 30.

Department of Neurosurgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Percutaneous balloon compression is a safe and effective treatment for trigeminal neuralgia. Current technique consists of penetrating the foramen ovale using a sharp 14G needle with a stylet. Difficulty of cannulation of the foramen ovale, failures of cannulation and major neurovascular complications of the procedure, although rare, may be due to the relatively large caliber of this needle and its sharp tip. Read More

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Combined percutaneous and transurethral cystoscopy for large urethral foreign bodies: A case report and literature review.

Urol Case Rep 2021 Jul 4;37:101625. Epub 2021 Mar 4.

Department of Urology, Hamad Medical Corporation, Doha, Qatar.

Since early reports in the literature, cases with urethral foreign bodies have been extremely variable and interestingly challenging. Various presentations have been reported, including self-insertion for sexual pleasure, assaults, trauma, and foreign bodies migration. Management by endoscopic surgery is usually a preferred option for small foreign bodies. Read More

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Alternative Access for Mechanical Circulatory Support.

Interv Cardiol Clin 2021 Apr 13;10(2):257-268. Epub 2021 Feb 13.

Department of Internal Medicine, Division of Cardiology, University of Washington Medical Center, 1959 Northeast Pacific Street, Seattle, WA 98195-6171, USA. Electronic address:

Femoral arterial access is the default strategy for large-bore interventional procedures, including temporary mechanical circulatory support implantation and structural heart therapies, based on superior outcomes and operator ease. In addition to patient size and comorbidities, vessel tortuosity, significant calcification, and diminutive vessel caliber all may make iliofemoral access prohibitively high risk or impossible. Given the increase of large-bore transcatheter procedures, bleeding avoidance strategies are essential and thus novel mechanisms for large-bore access have evolved. Read More

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An Anatomical Guide to the Terminal Facial Artery: Lumen Diameter and Associated Anatomy Relevant to Dermatologic Procedures.

Dermatol Surg 2021 Mar 9. Epub 2021 Mar 9.

Medical College of Georgia at Augusta University, Augusta, Georgia; Department of Dermatology, Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.

Background: Dermal filler injection in the vicinity of the terminal facial artery (FA) can lead to vascular compromise with devastating consequences, including tissue necrosis, blindness, and stroke.

Objective: The purpose of this study was to examine lumen diameter and other anatomical features of the terminal FA relevant to dermal filler injection.

Materials And Methods: Eighteen embalmed adult cadavers were dissected along the distribution of the terminal FA. Read More

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Endoscopic Removal of a Press-Through Pack from the Anal Canal.

Case Rep Gastroenterol 2021 Jan-Apr;15(1):137-141. Epub 2021 Feb 3.

Department of Gastroenterology, St. Luke's International Hospital, Tokyo, Japan.

The incidence of press-through pack (PTP) ingestion has been increasing. In many cases, the ingested PTP is lodged in the esophagus. Here, we report a case of endoscopic removal of a PTP from the anal canal. Read More

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February 2021

Impact of drug formulations on kinetics and toxicity in a preclinical model of paclitaxel-induced neuropathy.

J Peripher Nerv Syst 2021 Mar 8. Epub 2021 Mar 8.

Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Peripheral neuropathy is a common side effect of paclitaxel. Clinical studies suggest that different paclitaxel formulations influence the severity and time course of paclitaxel-induced peripheral neuropathy. We compared two paclitaxel formulations, nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and Cremophor EL paclitaxel (CreEL-paclitaxel), for their toxicity, distribution, and clearance in the peripheral nervous system. Read More

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Environmental Exposures in Singapore Schools: An Ecological Study.

Int J Environ Res Public Health 2021 02 14;18(4). Epub 2021 Feb 14.

UC Berkeley School of Public Health, Berkeley, CA 94704, USA.

Global climate change is a clear and present danger to our environment, but the impacts of climate change on human health are less known. People in Asian countries are more susceptible to the negative impacts of climate change and the subsequent environmental exposures because of the high population density, rapid urbanization, and natural geography of the region. The objective of this multidisciplinary collaborative ecological study was to explore the impact of environmental exposures such as temperature (°C), noise (db), humidity (%rh), air conditioning exposure time (hours), and distance traveled to school (km) on the comfort and academic success of school children in Singapore. Read More

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February 2021

Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation.

Genesis 2021 Apr 2;59(4):e23416. Epub 2021 Mar 2.

Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.

Embryonic vascular development is achieved through the complex arrays of differentiation, proliferation, migration and mutual interaction of different cell types, and visualization as well as purification of unique cell populations are fundamental in studying its detailed mechanisms using in vivo experimental models. We previously demonstrated that Tmem100 was a novel endothelial gene encoding a small transmembrane protein, and that Tmem100 null mice showed embryonic lethality due to severe impairment of vascular formation. In the present study, we generated an EGFP reporter mouse line using a 216 kb genomic region containing mouse Tmem100 gene. Read More

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The Refractory Period Matters: Unifying Mechanisms of Macroscopic Brain Waves.

Neural Comput 2021 Feb 22:1-19. Epub 2021 Feb 22.

Laufer Center for Physical and Quantitative Biology, Department of Physics and Astronomy, and Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, U.S.A.

The relationship between complex brain oscillations and the dynamics of individual neurons is poorly understood. Here we utilize maximum caliber, a dynamical inference principle, to build a minimal yet general model of the collective (mean field) dynamics of large populations of neurons. In agreement with previous experimental observations, we describe a simple, testable mechanism, involving only a single type of neuron, by which many of these complex oscillatory patterns may emerge. Read More

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February 2021

Balloon anchoring to traverse the sigmoid sinus for delivery of large-caliber venous stents: A technical note.

Interv Neuroradiol 2021 Feb 17:1591019921996885. Epub 2021 Feb 17.

Department of Neurosurgery, 38654Kansai Rosai Hospital, Amagaski, Japan.

Background: In the reconstruction of the superior sagittal sinus or transverse sinus, it is desirable to place a large-diameter guiding catheter into the transverse sinus to introduce the stent delivery system smoothly. The utility of an anchoring technique with a percutaneous transluminal angioplasty (PTA) balloon for navigating an 8 F guiding catheter into the transverse sinus is demonstrated. Two dural arteriovenous fistula (dAVF) cases (Cognard type II a +b, Borden type II) that underwent sinus stenting are presented. Read More

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February 2021

Vascular Tissue Engineering: Polymers and Methodologies for Small Caliber Vascular Grafts.

Front Cardiovasc Med 2020 11;7:592361. Epub 2021 Jan 11.

Hematology and Stem Cell Laboratory, Faculty of Pharmacy, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil.

Cardiovascular disease is the most common cause of death in the world. In severe cases, replacement or revascularization using vascular grafts are the treatment options. While several synthetic vascular grafts are clinically used with common approval for medium to large-caliber vessels, autologous vascular grafts are the only options clinically approved for small-caliber revascularizations. Read More

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January 2021

Sex steroids and markers of micro- and macrovascular damage among women and men from the general population.

Eur J Prev Cardiol 2021 Jan 12. Epub 2021 Jan 12.

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Aims: The contribution of sex hormones to micro- and macrovascular damage might differ among women and men. In particular, little is known about the association between sex hormones and small vessel disease. Therefore, we examined the association of total oestradiol, total testosterone, free-androgen index (FAI), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and androstenedione levels with micro- and macrovascular diseases. Read More

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January 2021

Extending the Reach of Craniofacial Free Flaps Using the Descending Branch of the Lateral Circumflex Femoral Vessels.

Plast Reconstr Surg 2021 Feb;147(2):260e-264e

From the Department of Plastic Surgery, Texas Children's Hospital; the Division of Plastic Surgery, Children's of Alabama, University of Alabama at Birmingham; Craniofacial and Pediatric Plastic Surgery, Dell Children's Medical Center of Central Texas, and the Department of Surgery and Perioperative Care, Dell Medical School, University of Texas at Austin.

Summary: Craniofacial free tissue transfer is sometimes complicated by insufficient pedicle length and/or paucity of recipient vessels. A saphenous vein graft can be used to reach the high-flow, large-caliber vessels of the neck, but because of the vein's taper and thick wall, there is often a mismatch. Following the principle of like-for-like, the authors prefer the descending branch of the lateral circumflex femoral vessels to achieve a more anatomical pedicle extension for free tissue transfer in complex craniofacial reconstruction. Read More

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February 2021

Combined Spinal-Epidural Anaesthesia for Caesarean Delivery in Takayasu's Arteritis: A Viable Alternative.

Cureus 2021 Jan 3;13(1):e12459. Epub 2021 Jan 3.

Anaesthesiology, Tata Main Hospital, Jamshedpur, IND.

Takayasu's arteritis (TA), also known as "pulseless disease", is a nonspecific inflammatory arteritis of large and medium caliber arteries of unknown aetiology with a predilection for young women of childbearing age. Although the evolution of the disease is not affected during pregnancy, it can result in uncontrolled hypertension, multiple organ dysfunction, and stenosis that hinder regional blood flow. Associated pregnancy, therefore, poses an increased risk to the mother and foetus due to the many cardiovascular complications that can occur in the course of the disease, making anaesthesia for caesarean delivery especially challenging to the anaesthesiologist. Read More

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January 2021

Immunocytochemical and ultrastructural organization of the taste thalamus of the tree shrew (Tupaia belangeri).

J Comp Neurol 2021 Jan 18. Epub 2021 Jan 18.

Department of Psychology, University of Virginia, Charlottesville, Virginia, USA.

Ventroposterior medialis parvocellularis (VPMP) nucleus of the primate thalamus receives direct input from the nucleus of the solitary tract, whereas the homologous thalamic structure in the rodent does not. To reveal whether the synaptic circuitries in these nuclei lend evidence for conservation of design principles in the taste thalamus across species or across sensory thalamus in general, we characterized the ultrastructural and molecular properties of the VPMP in a close relative of primates, the tree shrew (Tupaia belangeri), and compared these to known properties of the taste thalamus in rodent, and the visual thalamus in mammals. Electron microscopy analysis to categorize the synaptic inputs in the VPMP revealed that the largest-size terminals contained many vesicles and formed large synaptic zones with thick postsynaptic density on multiple, medium-caliber dendrite segments. Read More

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January 2021

Variations of the Anatomy and Bony Landmarks of Deep Circumflex Iliac Artery in a Select Kenyan Population.

Craniomaxillofac Trauma Reconstr 2020 Dec 10;13(4):300-304. Epub 2020 Sep 10.

Department of Human Physiology, University of Nairobi, Nairobi, Kenya.

Background: The deep circumflex iliac artery (DCIA) is a large caliber artery which branches laterally from the external iliac artery (EIA), directly opposite the origin of the inferior epigastric artery (IEA). Population variations have been reported in its origin, length, and branching patterns. These may alter its relationship to palpable surgical landmarks such as the anterior superior iliac spine (ASIS) and the pubic tubercle (PT) which are used to locate the artery preoperatively, thus predisposing it iatrogenic injury. Read More

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December 2020

Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription.

J Biol Chem 2020 12;295(51):17632-17645

Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan; Graduate School of Medical Sciences, Nara Medical University, Kashihara, Nara, Japan. Electronic address:

Thoracic great vessels such as the aorta and subclavian arteries are formed through dynamic remodeling of embryonic pharyngeal arch arteries (PAAs). Previous work has shown that loss of a basic helix-loop-helix transcription factor Hey1 in mice causes abnormal fourth PAA development and lethal great vessel anomalies resembling congenital malformations in humans. However, how Hey1 mediates vascular formation remains unclear. Read More

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December 2020

Congenital cutaneous neurofibromas in neurofibromatosis type 1: Clinicopathological features in early infancy.

J Dtsch Dermatol Ges 2021 Jan 14;19(1):73-80. Epub 2021 Jan 14.

Dermatology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Background And Objective: Clinicopathological features of cutaneous neurofibromas presenting as large irregularly shaped congenital café-au-lait macules (CALM) in Neurofibromatosis type 1 (NF1) patients have not been well characterized. We aimed to analyze the histopathological findings of large "atypical" CALM in children with NF1.

Patients And Methods: In this retrospective observational study we analyzed histopathological and immunostaining features of 21 biopsy specimens from 18 large hyperpigmented macules with irregular borders with or without hypertrichosis present during the first months of life in NF1 diagnosed children. Read More

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January 2021

Ultrasound-Assisted Intraosseous Injection of Platelet-Rich Plasma for a Patient With Tibial Plateau Subchondral Bone Marrow Lesion: A Case Presentation and Technical Illustration.

Cureus 2020 Dec 26;12(12):e12312. Epub 2020 Dec 26.

Regenerative Medicine, Shen-Shen Regenerative Medicine Clinic, Taipei, TWN.

The subchondral bone marrow lesion (BML) has been found to have a significant correlation with pain in osteoarthritis patients. The intraosseous injection with orthobiologics such as platelet-rich plasma (PRP) or bone marrow aspirate concentrate has shown a promising therapeutic effect on BML-related pain. Traditionally, the intraosseous injection was performed with a large caliber trocar to break into the subchondral bone under fluoroscopy guidance and the patient was usually sedated prior to the procedure. Read More

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December 2020

Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy.

Cell 2021 Feb 4;184(3):759-774.e18. Epub 2021 Jan 4.

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

To investigate circuit mechanisms underlying locomotor behavior, we used serial-section electron microscopy (EM) to acquire a synapse-resolution dataset containing the ventral nerve cord (VNC) of an adult female Drosophila melanogaster. To generate this dataset, we developed GridTape, a technology that combines automated serial-section collection with automated high-throughput transmission EM. Using this dataset, we studied neuronal networks that control leg and wing movements by reconstructing all 507 motor neurons that control the limbs. Read More

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February 2021

Non-Invasive Predictors of Esophageal Varices with a High Risk of Bleeding in Pediatric Cirrhotic Patients.

J Pediatr Gastroenterol Nutr 2020 Dec 30;Publish Ahead of Print. Epub 2020 Dec 30.

Pediatric Gastroenterology Group, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Medical School of Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objectives: To evaluate non-invasive predictive factors of varices with a high risk of bleeding in pediatric cirrhotic patients.

Methods: This retrospective, cross-sectional study included data from 158 children with cirrhosis, a median age of 5.38 years (IQ: 2. Read More

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December 2020

Thiel-embalmed porcine placenta: A valid and reusable microsurgical practice model.

Ann Chir Plast Esthet 2021 Apr 30;66(2):115-125. Epub 2020 Dec 30.

Division de chirurgie plastique et reconstrictive, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada. Electronic address:

Background: Simulation models are increasingly important for skill acquisition during microsurgery training. Prosthetics, living and non-living biological models have been proposed in the literature in the optics of recreating real-life scenarios in a controlled environment. This study aims to validate and prove the reusability of a novel non-living biological model: the porcine placenta. Read More

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[Fibromuscular dysplasia and its neurological manifestations].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(11):116-123

Research Center of Neurology, Moscow, Russia.

The authors present the current data on the classification, epidemiology, etiology, neurological manifestations, prognosis, diagnosis, and treatment of patients with fibromuscular dysplasia (FMD). The review is based on the selection of publications by searching PubMed for keywords from the first sources until March 2019. FMD is a segmental non-atherosclerotic and non-inflammatory disease of large- and medium-caliber arteries leading to their stenosis. Read More

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December 2020