5,992 results match your criteria lamotrigine

Lamotrigine for Treating Anger in Veterans With Posttraumatic Stress Disorder.

Clin Neuropharmacol 2021 Sep-Oct 01;44(5):184-185

Phoenix VA Health Care System, Phoenix, AZ.

Abstract: Lamotrigine is an antiepileptic drug that was Food and Drug Administration approved in 2003 for use in the maintenance treatment of bipolar I disorder to delay the time to recurrence of new mood episodes. The mechanism by which lamotrigine achieves its therapeutic effect in the treatment of bipolar disorder is unknown. Here, we report on 2 Veterans with combat-related posttraumatic stress disorder (PTSD) endorsing significant anger, aggression, and agitation, who were treated with selective serotonin reuptake inhibitors, but whose residual symptoms of anger and aggression were ultimately successfully managed with lamotrigine augmentation. Read More

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September 2021

Drugs for patients with epilepsy and excessive daytime sleepiness.

Epilepsy Behav 2021 Sep 14;124:108311. Epub 2021 Sep 14.

Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.

Excessive daytime sleepiness (EDS) and attentional deficits are often observed in people with epilepsy. They may be the consequence of seizures and subclinical discharges as well as of comorbid conditions as obstructive sleep apnea/hypopnea syndrome (OSAS), attention deficit hyperactivity disorder (ADHD), or other less frequent disorders. Excessive daytime sleepiness may also be caused or worsened by antiseizure medications (ASMs). Read More

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September 2021

Assessment of a wide array of organic micropollutants of emerging concern in wastewater treatment plants in Greece: Occurrence, removals, mass loading and potential risks.

Sci Total Environ 2021 Aug 24;802:149860. Epub 2021 Aug 24.

Department of Chemistry, Aristotle University of Thessaloniki, GR 54124 Thessaloniki, Greece; Centre for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Thessaloniki, 10th km Thessaloniki-Thermi Rd, GR 57001, Greece. Electronic address:

Exploring the contamination profile of multi-class emerging contaminants (ECs) in wastewater is highly desirable. To this end, the occurrence, removal, mass loading and risks associated with a large panel of pharmaceuticals and personal care products, illicit drugs, perfluorinated compounds and organophosphate flame retardants in two wastewater treatment plants (WWTPs) in the region of Thessaloniki (Greece) after a survey is illustrated. Influent and effluent wastewaters were submitted to solid phase extraction on Oasis HLB cartridges, followed by ultra-high-performance liquid chromatography Orbitrap high-resolution mass spectrometry (UHPLC-Orbitrap MS). Read More

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Lamotrigine in the maintenance treatment of bipolar disorder.

Cochrane Database Syst Rev 2021 Sep 15;9:CD013575. Epub 2021 Sep 15.

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background: Bipolar disorder is a chronic mental disorder with repetitive mania/hypomania as well as depressive episodes, which eventually results in marked impairment in overall functioning and health-related quality of life.  A worldwide prevalence rate of 2.4% has been reported. Read More

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September 2021

Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center.

Toxicol Rep 2021 30;8:1592-1598. Epub 2021 Aug 30.

Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

Lamotrigine and levetiracetam are widely used second-generation anti-epileptic drugs. Existing literature indicates that overdose of either drug is typically benign, but neurologic and cardiac toxicity can occur in some cases. In this retrospective study, we analyzed a large dataset of serum/plasma drug levels for lamotrigine and levetiracetam. Read More

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Visual snow syndrome and its relationship with migraine.

Neurologia 2021 Sep 11. Epub 2021 Sep 11.

Servicio de Neurología, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, España.

Introduction: Visual snow syndrome (VSS) is a central nervous system disorder that consists of the constant perception of small black and white dots throughout the entire visual field.

Development: VSS can present from infancy to old age, with greater prevalence in the young population, and shows no difference between sexes. The diagnostic criteria include the presence of visual snow and such other visual phenomena as palinopsia, photophobia, nyctalopia, and other persistent visual phenomena. Read More

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September 2021

A LC-MS strategy to determine lamotrigine by Q-Q-trap tandem mass spectrometry coupled with triple stage fragmentation to enhance sensitivity and selectivity.

Anal Methods 2021 Sep 10. Epub 2021 Sep 10.

School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, PR China.

A high-performance liquid chromatography tandem mass spectrometry cubed (HPLC/MS) method was developed and validated to quantify lamotrigine in human plasma with carbamazepine as an internal standard. The HPLC/MS/MS system is composed of a Shimadzu UFLC XR high-performance liquid chromatograph coupled with a hybrid linear ion trap triple quadrupole mass spectrometer. Following simple protein precipitation with methanol, the separation of lamotrigine and carbamazepine was performed on an Agilent Poroshell 120 SB-C18 column (4. Read More

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September 2021

Surveillance of drug overdose and identification of its risk factors by a multivariate analysis using the Japanese Adverse Drug Event Report database.

Asian J Psychiatr 2021 Sep 2;65:102826. Epub 2021 Sep 2.

School of Pharmacy, Aichi Gakuin University, Nagoya, Japan.

Background: Limited information is currently available on drug overdose in Japan. Therefore, the present study examined drug overdose using the Japanese Adverse Drug Event Report (JADER) database.

Methods: The records of drug overdose in patients were extracted from the JADER database. Read More

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September 2021

Treatment outcomes in drug resistant juvenile myoclonic epilepsy: Valproate resistance may not be the end of the road.

Seizure 2021 Sep 1;92:112-117. Epub 2021 Sep 1.

Department of Neurology, Avitis Institute of Medical Sciences, Kerala, India.

Objective: To determine treatment responses to various antiseizure medicines (ASMs) in patients with drug resistant juvenile myoclonic epilepsy (DRJME) METHODS: We reviewed records of all JME patients attending epilepsy clinics at 5 centers during a 5-year period. We used International Consensus Criteria to diagnose JME and International League Against Epilepsy Criteria to define drug resistance and sustained seizure freedom. We only used broad spectrum medicines which included valproate, lamotrigine, topiramate, levetiracetam, clobazam, phenobarbitone, clonazepam, and zonisamide. Read More

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September 2021

Pharmaceuticals in edible crops irrigated with reclaimed wastewater: Evidence from a large survey in Israel.

J Hazard Mater 2021 08 25;416:126184. Epub 2021 May 25.

Department of Soil and Water Sciences, Institute of Environmental Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 7610001, Israel. Electronic address:

Pharmaceuticals and other contaminants of emerging concern (CECs) are continuously introduced into the agroecosystem via reclaimed wastewater irrigation, a common agricultural practice in water-scarce regions. Although reclaimed wastewater irrigated crops are sold and consumed, only limited information is available on the occurrence of pharmaceuticals and other CECs in edible produce. Here, we report data on CECs in irrigation water, soils, and crops collected from 445 commercial fields irrigated with reclaimed wastewater in Israel. Read More

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Genetics and antiepileptic-mood stabilizer treatment response in bipolar disorder: what do we know?

Pharmacogenomics 2021 Sep 6. Epub 2021 Sep 6.

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN 55905, USA.

Antiepileptic-mood stabilizers (AED-MS) are often used to treat bipolar disorder (BD). Similar to other mood disorder medications, AED-MS treatment response varies between patients. Identification of biomarkers associated with treatment response may ultimately help with the delivery of individualized treatment and lead to improved treatment efficacy. Read More

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September 2021

Clonic seizures, continuous spikes-and-waves during slow sleep, choreoathetosis and response to sulthiame in a child with FRRS1L encephalopathy.

Brain Dev 2021 Sep 2. Epub 2021 Sep 2.

Paediatric Neurology Unit, Hospital Tunku Azizah Kuala Lumpur, Malaysia.

Background: Ferric chelate reductase 1 like (FRRS1L) encephalopathy is a rare cause of developmental and epileptic encephalopathy. Only a few cases have been reported thus far and seizures tend to be drug refractory. We report an additional case to highlight the good seizure response to sulthiame. Read More

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September 2021

Levetiracetam, lamotrigine and carbamazepine: which monotherapy during pregnancy?

Neurol Sci 2021 Sep 1. Epub 2021 Sep 1.

Epilepsy Centre, Department of System Medicine, Policlinico Tor Vergata, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.

Objective: Epilepsy treatment during pregnancy is still challenging. The study is aimed at comparing the efficacy and safety of carbamazepine (CBZ), lamotrigine (LTG) and levetiracetam (LEV) monotherapies during pregnancy in women with focal (FE) or generalized (GE) epilepsy.

Methods: A multicentre retrospective study was conducted to evaluate seizures frequency and seizure freedom (SF) rate during 3 months before pregnancy, each trimester of gestation and post-partum period in women on monotherapy with CBZ, LTG and LEV. Read More

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September 2021

Effects of Maternal Exposure to Lamotrigine during Pregnancy on Gonadal Toxicity in Fetus Rats.

Galen Med J 2020 3;9:e1557. Epub 2020 Oct 3.

Department of Obstetrics and Gynecology, Islamic Azad University, Tehran Medical Sciences, Tehran, Iran.

Background: Lamotrigine is one of the newest antiepileptic drugs that is used as one of the most common treatments in pregnancy. Since the investigation of the teratogenic effects of lamotrigine is very limited and there is no report of its teratogenic effects on fetal gonads, we aimed to investigate the teratogenic effects of lamotrigine on embryonic gonads.

Materials And Methods: This study was performed on nine female Wistar female rats (8 weeks, weighing 180-200 mg). Read More

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October 2020

Association of Optimal Lamotrigine Serum Levels and Therapeutic Efficacy in Mood Disorders: A Systematic Review.

J Clin Psychopharmacol 2021 Aug 26. Epub 2021 Aug 26.

From the Department of Psychiatry and Deaddiction, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India Department of Psychiatry and Psychology, Mayo Clinic Mayo Medical Libraries, Mayo Clinic College of Medicine, Rochester, MN.

Purpose: The aim of the study was to appraise the current evidence on the optimal serum level for lamotrigine (LAM) in the treatment of mood disorders (major depressive disorder, bipolar disorder).

Methods: Major databases were searched for randomized controlled trials, open-label trials, and observational studies reporting serum LAM levels in adult patients treated with LAM for mood disorders.

Results: A total of 814 abstracts were screened and 24 articles were selected for full-text review. Read More

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DRESS is a Mess: A Case of Cross Reactivity Between Lacosamide and Lamotrigine.

S D Med 2021 Jul;74(7):324-328

Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Drug reaction with eosinophilia with systemic symptoms (DRESS) syndrome is a rare drug reaction often presenting with both cutaneous manifestations and potentially life-threatening internal organ involvement. The precise incidence of DRESS is still unclear as it is easily missed due to its highly variable clinical presentation. However, with an expected mortality rate of approximately 10 percent, it is important for clinicians to be familiar with pharmacologic etiologies commonly implicated in the pathogenesis. Read More

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The Relationship Between Valproate and Lamotrigine/Levetiracetam Use and Prognosis in Patients With Epilepsy and Heart Failure: A Danish Register-Based Study.

J Card Fail 2021 Aug 24. Epub 2021 Aug 24.

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Objective: To compare the hazard for all-cause mortality and mortality due to heart failure (HF) between valproate (VPA) and levetiracetam (LEV)/lamotrigine (LTG) users in patients aged ≥ 65 with comorbidities of epilepsy and HF.

Methods: This was a cohort study using Danish registers during the period from January 1996 to July 2018. The study population included new users of LTG, LEV or VPA. Read More

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Changes in antiepileptic drug prescriptions over a decade in childbearing women in Lombardy region, Italy.

Br J Clin Pharmacol 2021 Aug 24. Epub 2021 Aug 24.

Laboratory for Mother and Child Health, Department of Public Health, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Aims: To describe the antiepileptic drug (AED) prescription pattern in pregnant women and women of childbearing age in the 2010-2019 period in the Lombardy region, Italy.

Methods: The Lombardy region administrative healthcare databases (2010-2019) were analysed. AEDs were classified as drugs belonging to the N03A subgroup of the Anatomical Therapeutic Chemical Classification System. Read More

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UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers.

Xenobiotica 2021 Sep 3:1-9. Epub 2021 Sep 3.

Central Institute for Experimental Animals, Kawasaki, Japan.

Lamotrigine is a phenyltriazine anticonvulsant used to treat epilepsy and bipolar disorder, with species-dependent metabolic profiles. In this study, we investigated the metabolism of lamotrigine in chimeric NOG-TKm30 mice transplanted with human hepatocytes (humanised-liver mice).Substantial lamotrigine N2-glucuronidation activities were observed in the liver microsomes from humanised-liver mice, humans, marmosets, and rabbits, compared to those from monkeys, minipigs, guinea pigs, rats, and mice. Read More

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September 2021

Micellar buccal film for safe and effective control of seizures: Preparation, in vitro characterization, ex vivo permeation studies and in vivo assessment.

Eur J Pharm Sci 2021 Nov 18;166:105978. Epub 2021 Aug 18.

Pharmacology Department, Medical Research Division, National Research Centre, Dokki, Cairo, 12622 Egypt.

The current research article focused on formulating an easily applied, water-based buccal film loaded with the antiepileptic drug, lamotrigine (LTG). The designed film can be comfortably administered by epileptic patients to ensure a controllable therapeutic efficacy against seizures. The solubility of LTG in water was significantly improved by micellar solubilization. Read More

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November 2021

Effectiveness of multiple-dose activated charcoal in lamotrigine poisoning: a case series.

Clin Toxicol (Phila) 2021 Aug 18:1-3. Epub 2021 Aug 18.

Clinical Toxicology Center, Saitama Medical University Hospital, Saitama, Japan.

Introduction: Lamotrigine toxicity can cause coma, seizures, and intraventricular conduction disturbances, and treatment options include good supportive care. We report two cases of lamotrigine poisoning in which multiple-dose activated charcoal may have shortened the elimination half-life of lamotrigine.

Case 1: A 21-year-old woman ingested 15. Read More

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Periodic Catatonia: Long-term Treatment With Lamotrigine: A Case Report.

J Psychiatr Pract 2021 Jul 28;27(4):322-325. Epub 2021 Jul 28.

Periodic catatonia is a rare form of catatonia, characterized by episodes occurring in a cyclic pattern with clinical features of combined stupor and excitement, with intervals of remission. Although periodic catatonia is not common, it is an urgent condition, requiring hospitalization for evaluation and treatment. The management of periodic catatonia is quite challenging, mainly because of the unknown pathophysiological mechanisms involved in the onset of this clinical entity, which are less clear than in other forms of catatonia. Read More

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Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury.

Injury 2021 Aug 8. Epub 2021 Aug 8.

Department of Neurosurgery, İstinye University, Faculty of Medicine, Istanbul, Turkey. Electronic address:

Introduction: Lamotrigine, an anticonvulsant drug with inhibition properties of multi-ion channels, has been shown to be able to attenuates secondary neuronal damage by influencing different pathways. The aim of this study was to look into whether lamotrigine treatment could protect the spinal cord from experimental spinal cord ischemia-reperfusion injury.

Materials And Methods: Thirty-two rats, eight rats per group, were randomly assigned to the sham group in which only laparotomy was performed, and to the ischemia, methylprednisolone and lamotrigine groups, where the infrarenal aorta was clamped for thirty minutes to induce spinal cord ischemia-reperfusion injury. Read More

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Effectiveness of crocin of saffron (Crocus sativus L.) against chemotherapy-induced peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial.

J Ethnopharmacol 2021 Aug 11;281:114511. Epub 2021 Aug 11.

School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Ethnopharmacological Relevance: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the complications vexes patients treated with anti-cancer agents. Saffron has been demonstrated to attenuate symptoms of peripheral neuropathy in animal models. Also, there is a published clinical trial that investigated the pain relieving effect of saffron following nationally accepted rules and concluded that saffron was successful in alleviating pain symptoms in patients suffering from fibromyalgia. Read More

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Prevention of Steroid-Induced Neuropsychiatric Complications With Neuroleptic Drugs: A Review.

Am J Hosp Palliat Care 2021 Aug 13:10499091211034771. Epub 2021 Aug 13.

Johns Hopkins Palliative Care Program, the Department of Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Corticosteroids are used for a multitude of indications in palliative patients. In this narrative review, we aim to review literature on the treatment and prevention of neuropsychiatric complications of steroids. For prevention, only lamotrigine had a positive effect in a small number of studies. Read More

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Evaluation of the interference of lamotrigine on the analysis of synthetic cannabinoids in urine by the immunoassay method.

Scand J Clin Lab Invest 2021 Aug 11:1-8. Epub 2021 Aug 11.

Department of Biochemistry, ToksiLab Toxicology Laboratory, İstanbul, Turkey.

We aimed to evaluate the interference of lamotrigine (LMG) on the synthetic cannabinoids metabolite-K2/1 (SCm/K1) urine test by Homogeneous Enzyme Immunoassay (Immune-SCm/K1). This study consists of two parts: case-control and interference effect research. In the case-control study, two groups using LMG and a non-use of LMG were formed, all of them non-SC users. Read More

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Oro-mucosal midazolam maleate: Use and effectiveness in adults with epilepsy in the UK.

Epilepsy Behav 2021 Aug 6;123:108242. Epub 2021 Aug 6.

University of Sheffield, United Kingdom.

Background: Oro-mucosal midazolam maleate (OMM) with suitable training to family and carers is being increasingly recognized as the treatment of choice to mitigate the development of status epilepticus in non-hospital community settings. There are no studies to describe the use, effectiveness, and suitable dosing of OMM in adults with epilepsy in community settings.

Purpose: To describe the use, effectiveness, and dosing of OMM in the emergency treatment of epileptic seizures in community settings. Read More

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Manic Episode Induced by Lamotrigine in Rapid Cycling Bipolar Disorder.

Cureus 2021 Jul 5;13(7):e16184. Epub 2021 Jul 5.

Psychiatry, University Hospital Center of Sao Joao, Oporto, PRT.

Bipolar disorder is characterized by persistent and/or recurrent mood changes between depressive and manic poles. Rapid cycling is a frequent, although underrecognized, condition in bipolar disorder, and it is known to worsen the prognosis of the disease. With regard to the treatment of bipolar depression, there is a shortage of evidence-supported treatment choices, and the literature on the subject includes few references to cases of manic switch induced by lamotrigine. Read More

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False-positive drug test results in patients taking psychotropic drugs. A literature review.

Psychiatr Pol 2021 Apr 30;55(2):435-446. Epub 2021 Apr 30.

Uniwersytet Medyczny w Lublinie, I Klinika Psychiatrii, Psychoterapii i Wczesnej Interwencji.

Introduction: The study reviews the literature on false-positive drug test results in patients taking psychotropic medications.

Method: A narrative review of available literature in English and Polish was conducted by searching MEDLINE/PubMed and Google Scholar databases using the search phrase ‛falsepositive drug test' and names of selected registered antidepressant, antipsychotic and mood stabilizing medications as well as pharmaceuticals used in the treatment of ADHD. Review articles, case reports and original papers from years 1990-2019 were analyzed. Read More

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