Pain 2021 Apr 5. Epub 2021 Apr 5.
Summit Spine and Joint Center, Lawrenceville, GA, United States Department of Anesthesiology, Augusta University, Augusta, GA, United States Department of Anesthesiology, University of Utah, Salt Lake City, UT, United States Department of Surgery, Kern Medical Center, Bakersfield, CA, United States.
Abstract: Recent randomized controlled trials comparing the efficacy between intraoperative methadone and other opioids on postoperative outcomes have been limited by their small sample sizes and conflicting results. We performed a meta-analysis on randomized controlled trials which investigated outcomes between methadone and an opioid control group. Primary outcome data included postoperative opioid consumption, number of patients who received postoperative opioids, time to first analgesic, and pain scores. Read More