255,874 results match your criteria kv32 channels


ANTIHYPERTENSIVE AND CARDIOPROTECTIVE EFFECTS OF EPOXYEICOSATRIENOIC ACID ANALOGS AND SOLUBLE EPOXIDE HYDROLASE INHIBITORS (REVIEW).

Georgian Med News 2021 Mar(312):125-132

Tbilisi State Medical University, Departments of Pharmaceutical Technology and Medical Pharmacology, Georgia.

In the present article is considered antihypertensive and cardioprotective action of epoxieicosatrienoic acids (EETs) analogues and soluble epoxide hydrolase (sEH) inhibitors. Being epoxygenase products of arachidonic acid metabolism EETs provide a wide spectrum of biological activity in different organs implicated in the regulation of arterial pressure, including vascular endothelium (VE), heart and kidney. EETs are acting as autocrine or paracrine agents producing vasodilation, reduction in salt and fluid retention. Read More

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The "celebrity canary in the coal mine for the coronavirus": An examination of a theoretical model of celebrity illness disclosure effects.

Soc Sci Med 2021 Apr 28;279:113963. Epub 2021 Apr 28.

Murrow College of Communication, 208 Goertzen Hall, PO BOX 642530, Pullman, WA, 99164, USA. Electronic address:

Rationale: On March 11, 2020, actor Tom Hanks announced via social media that he had been diagnosed with COVID-19. Previous research has found celebrity illness disclosures to influence behavior, but during the uncertainty of a pandemic, the effects of such a disclosure were unclear.

Objective: To test the proposed Celebrity Illness Disclosure Effects (CIDE) model, demonstrating how an illness disclosure, communicated through mediated and interpersonal channels, may shape willingness to engage in prevention behaviors. Read More

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Comments on the evolution of TRPV6.

Ann Anat 2021 May 5:151753. Epub 2021 May 5.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, 66421 Homburg, Saar, Germany. Electronic address:

It is well known that not all biological findings derived from animals can be directly applied to humans. The TRPV6 protein may serve as an example which highlights these inter-species differences as an example of parallel evolutionary pathways. TRPV6 (and TRPV5) belong to a family of ion channels from the transient receptor potential group but are selectively permeable for Ca2+, in contrast to other members of the family. Read More

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Synthesis and BK channel-opening activity of 2-Amino-1,3-thiazole derivatives.

Bioorg Med Chem Lett 2021 May 5:128083. Epub 2021 May 5.

Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University, Shanghai 200444, China. Electronic address:

A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring. Read More

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Proton exit pathways surrounding the Oxygen Evolving Complex of Photosystem II.

Biochim Biophys Acta Bioenerg 2021 May 5:148446. Epub 2021 May 5.

Department of Chemistry, The Graduate Center, City University of New York, New York, NY 10016, United States; Department of Physics, City College of New York, New York 10031, United States; Department of Physics, The Graduate Center of the City University of New York, New York, NY 10016, United States. Electronic address:

Photosystem II allows water to be the primary electron source for the photosynthetic electron transfer chain. Water is oxidized to dioxygen at the Oxygen Evolving Complex (OEC), a MnCaO inorganic core embedded on the lumen side of PSII. Water-filled channels surrounding the OEC must bring in substrate water molecules, remove the substrate protons to the lumen, and may transport the product oxygen. Read More

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Dual role of miR-1 in the development and function of sinoatrial cells.

J Mol Cell Cardiol 2021 May 5. Epub 2021 May 5.

Department of Biosciences, Università degli Studi di Milano, Milan, Italy. Electronic address:

miR-1, the most abundant miRNA in the heart, modulates expression of several transcription factors and ion channels. Conditions affecting the heart rate, such as endurance training and cardiac diseases, show a concomitant miR-1 up- or down-regulation. Here, we investigated the role of miR-1 overexpression in the development and function of sinoatrial (SAN) cells using murine embryonic stem cells (mESC). Read More

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A Prototype Spatial-Spectral CT System for Material Decomposition with Energy-Integrating Detector.

Med Phys 2021 May 8. Epub 2021 May 8.

Johns Hopkins University, 720 Rutland Ave., Traylor Building 605, Baltimore, MD, 21205, USA.

Purpose: Spectral CT has great potential for a variety of clinical applications due to improved tissue and material discrimination over conventional single-energy CT. Many clinical and preclinical spectral CT systems have two spectral channels enabling dual-energy CT. Strategies include split-filtration, dual-layer detectors, photon counting detectors, and kVp-switching. Read More

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Exploring the oxygenase function of Form II Rubisco for production of glycolate from CO.

AMB Express 2021 May 8;11(1):65. Epub 2021 May 8.

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

The oxygenase activity of Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) converts ribulose-1,5-bisphosphate (RuBP) into 2-phosphoglycolate, which in turn channels into photorespiration, resulting in carbon and energy loss in higher plants. We observed that glycolate can be accumulated extracellularly when two genes encoding the glycolate dehydrogenase of cyanobacteria Synechocystis sp. PCC 6803 were inactivated. Read More

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Delayed KCNQ1/KCNE1 assembly on the cell surface helps I fulfill its function as a repolarization reserve in the heart.

J Physiol 2021 May 7. Epub 2021 May 7.

Department of Physiology & Biophysics, Virginia Commonwealth University, Richmond, VA, 23298, United States.

Key Points: In adult ventricular myocytes, the I channels are distributed on the surface sarcolemma, not t-tubules. In adult ventricular myocytes, KCNQ1 and KCNE1 have distinct cell surface and cytoplasmic pools. KCNQ1 and KCNE1 traffic from the endoplasmic reticulum to plasma membrane by separate routes, and assemble into I channels on the cell surface. Read More

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Therapeutic Antibodies Targeting Potassium Ion Channels.

Handb Exp Pharmacol 2021 May 8. Epub 2021 May 8.

TetraGenetics Inc, Arlington, MA, USA.

Monoclonal antibodies combine specificity and high affinity binding with excellent pharmacokinetic properties and are rapidly being developed for a wide range of drug targets including clinically important potassium ion channels. Nonetheless, while therapeutic antibodies come with great promise, K channels represent particularly difficult targets for biologics development for a variety of reasons that include their dynamic structures and relatively small extracellular loops, their high degree of sequence conservation (leading to immune tolerance), and their generally low-level expression in vivo. The process is made all the more difficult when large numbers of antibody candidates must be screened for a given target, or when lead candidates fail to cross-react with orthologous channels in animal disease models due to their highly selective binding properties. Read More

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Reproductive- and social-state plasticity of multiple sensory systems in a cichlid fish.

Integr Comp Biol 2021 May 7. Epub 2021 May 7.

Department of Biological Sciences, 202 Life Sciences Bldg., Louisiana State University, Baton Rouge, LA. 70803.

Intra- and inter-sexual communication is vital to the survival and reproductive success of animals. In species that cycle in and out of breeding or other physiological condition, sensory function can be modulated to optimize communication at crucial times. Little is known, however, about how widespread this sensory plasticity is across taxa, whether it occurs in multiple senses or both sexes within a species, and what potential modulatory substances and substrates are involved. Read More

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Fractional Coulomb blockade for quasi-particle tunneling between edge channels.

Sci Adv 2021 May 7;7(19). Epub 2021 May 7.

Solid State Physics Laboratory, Department of Physics, ETH Zurich, 8093 Zurich, Switzerland.

In the fractional quantum Hall effect, the elementary excitations are quasi-particles with fractional charges as predicted by theory and demonstrated by noise and interference experiments. We observe Coulomb blockade of fractional charges in the measured magneto-conductance of a 1.4-micron-wide quantum dot. Read More

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LncRNA SAMD12-AS1 promotes the progression of gastric cancer via DNMT1/p53 axis.

Arch Med Res 2021 May 4. Epub 2021 May 4.

Department of General Surgery, The No.967 Hospital of PLA Joint Logistics Support Force, Postgraduate Culture Base of Jinzhou Medical University, Dalian, China; Department of General Surgery, The No.967 Hospital of PLA Joint Logistics Support Force, Postgraduate Culture Base of Dalian Medical University, Dalian, China. Electronic address:

Background: Long noncoding RNAs (lncRNAs) are essential modulators of cancers initiation and progression via regulating gene expression and biological behaviors. LncRNA SAMD12-AS1 has been validated to promote the progression of several cancers, while its role in gastric cancer (GC) remains unclear. This study aims to explore the role of LncRNA SAMD12-AS1 in GC. Read More

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Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.

Mol Brain 2021 May 7;14(1):78. Epub 2021 May 7.

Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA.

Reconsolidation has been considered a process in which a consolidated memory is turned into a labile stage. Within the reconsolidation window, the labile memory can be either erased or strengthened. Manipulating acid-sensing ion channels (ASICs) in the amygdala via carbon dioxide (CO) inhalation enhances memory retrieval and its lability within the reconsolidation window. Read More

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Effects of thorium on bacterial, microalgal and micromeiofaunal community structures in a periphytic biofilm.

Ecotoxicol Environ Saf 2021 May 4;218:112276. Epub 2021 May 4.

Institut national de la recherche scientifique, 490 rue de la Couronne, G1K 9A9 Quebec City, QC, Canada. Electronic address:

Few ecotoxicity studies are available on thorium (Th) which hinders the ability to evaluate its ecotoxicological risk. Its release in the environment is often associated with the extraction of rare earth elements and uranium, as well as the field applications of phosphate fertilizers. This study investigates the effects of Th on microbial communities of periphytic biofilms. Read More

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CuSe nanowires shelled with NiFe layered double hydroxide nanosheets for overall water-splitting.

J Colloid Interface Sci 2021 Apr 21;599:370-380. Epub 2021 Apr 21.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science (Ministry of Education), State Key Laboratory Base of Eco-chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

It is imperative but challenging to develop non-noble metal-based bifunctional electrocatalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Our work reports a core-shell nanostructure that is constructed by the electrodeposition of ultrathin NiFe-LDH nanosheets (NiFe-LDHNS) on CuSe nanowires, which are obtained by selenizing Cu(OH) nanowires in situ grown on Cu foam. The obtained CuSe@NiFe-LDHNS electrocatalyst provides more exposed edges and catalytic active sites, thus exhibiting excellent OER and HER electrocatalytic performance in alkaline electrolytes. Read More

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Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum.

Cell Calcium 2021 Apr 30;97:102417. Epub 2021 Apr 30.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

Background: The roles of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and subfamily A, member 1 (TRPA1) in mechanisms of gastrointestinal motility are complex. This study aimed to clarify the effects of several TRPV1 and TRPA1 ligands on the electrical potentials generated by pacemaker cells in the mouse-isolated ileum.

Method: The pacemaker potentials of ileal segments of mice were recorded extracellularly using a 60-channel microelectrode array. Read More

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Use of automated patch clamp in cardiac safety assessment: Past, present and future perspectives.

J Pharmacol Toxicol Methods 2021 May 4:107072. Epub 2021 May 4.

North Stonington, CT, USA.

There is no doubt that automated patch clamp (APC) technology has revolutionized research in biomedical science. High throughput ion channel screening is now an integral part of the development and safety profiling of the majority of new chemical entities currently developed to address unmet medical needs. The increased throughput it provides has significantly improved the ability to overcome the time-consuming, low throughput bottlenecks resulting from the more conventional manual patch clamp method, considered the 'gold standard', for studying ion channel function and pharmacology. Read More

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Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress.

Toxicol Appl Pharmacol 2021 May 4:115558. Epub 2021 May 4.

Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.

Purpose: Studies argue in favor of hydrogen sulfide (HS) as the next potent therapeutic agent for neurodegenerative diseases. In present study, we investigated the effect of long term treatment with NaHS (as donor of HS) on induction and progress of the 6-hydroxydopamine (6-OHDA) -induced Parkinsonism in rat.

Methods: The 6-OHDA was injected into medial forebrain bundle of right hemisphere by stereotaxic surgery. Read More

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Molecular mechanism of apelin-13 regulation of colonic motility in rats.

Eur J Pharmacol 2021 May 4:174149. Epub 2021 May 4.

Department of Gastroenterology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, China. Electronic address:

Apelin is a novel neuropeptide identified as the endogenous ligand for the apelin receptor. Apelin and its receptor are widely distributed in the gastrointestinal tract. Studies have reported that apelin-13 is involved in modulating gastrointestinal motility; however, the evidence is insufficient and the relevant mechanism is still not fully clear. Read More

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Endothelial Transient Receptor Potential V4 Channels Mediate Lung Ischemia-Reperfusion Injury.

Ann Thorac Surg 2021 May 4. Epub 2021 May 4.

Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA. Electronic address:

Background: Lung ischemia-reperfusion injury (IRI), involving severe inflammation and edema, is a major cause of primary graft dysfunction following transplant. Activation of transient receptor potential vanilloid 4 (TRPV4) channels modulates vascular permeability. Thus, this study tests the hypothesis that endothelial TRPV4 channels mediate lung IRI. Read More

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Response of vegetation to submergence along Jingjiang Reach of the Yangtze River.

PLoS One 2021 7;16(5):e0251015. Epub 2021 May 7.

Department of Civil and Environmental Engineering, Tokyo Institute of Technology, Tokyo, Japan.

This work explores the changes in vegetation coverage and submergence time of floodplains along the middle and lower reaches of the Yangtze River (i.e., the Jingjiang River) and the relations between them. Read More

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Estimation of Apnea-Hypopnea Index using Deep Learning on 3D Craniofacial Scans.

IEEE J Biomed Health Inform 2021 May 7;PP. Epub 2021 May 7.

Obstructive sleep apnea (OSA) is characterized by decreased breathing events that occur through the night, with severity reported as the apnea-hypopnea index (AHI), which is associated with certain craniofacial features. In this study, we used data from 1366 patients collected as part of Stanford Technology Analytics and Genomics in Sleep (STAGES) across 11 US and Canadian sleep clinics and analyzed 3D craniofacial scans with the goal of predicting AHI, as measured using gold standard nocturnal polysomnography (PSG). First, the algorithm detects pre-specified landmarks on mesh objects and aligns scans in 3D space. Read More

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Upper Bounds on Device-Independent Quantum Key Distribution.

Phys Rev Lett 2021 Apr;126(16):160501

Institute of Informatics, National Quantum Information Centre, Faculty of Mathematics, Physics and Informatics, University of Gdańsk, 80-308 Gdańsk, Poland and International Centre for Theory of Quantum Technologies, University of Gdańsk, 80-952 Gdańsk, Poland.

Quantum key distribution (QKD) is a method that distributes a secret key to a sender and a receiver by the transmission of quantum particles (e.g., photons). Read More

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Exact Thermalization Dynamics in the "Rule 54" Quantum Cellular Automaton.

Phys Rev Lett 2021 Apr;126(16):160602

Max-Planck-Institut für Quantenoptik, Hans-Kopfermann-Straße 1, 85748 Garching, Germany.

We study the out-of-equilibrium dynamics of the quantum cellular automaton known as "Rule 54." For a class of low-entangled initial states, we provide an analytic description of the effect of the global evolution on finite subsystems in terms of simple quantum channels, which gives access to the full thermalization dynamics at the microscopic level. As an example, we provide analytic formulas for the evolution of local observables and Rényi entropies. Read More

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Na leak-current channel (NALCN) at the junction of motor and neuropsychiatric symptoms in Parkinson's disease.

J Neural Transm (Vienna) 2021 May 7. Epub 2021 May 7.

Departments of Psychiatry and Pharmacology, Toxicology and Neuroscience, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA.

Parkinson's disease (PD) is a debilitating movement disorder often accompanied by neuropsychiatric symptoms that stem from the loss of dopaminergic function in the basal ganglia and altered neurotransmission more generally. Akinesia, postural instability, tremors and frozen gait constitute the major motor disturbances, whereas neuropsychiatric symptoms include altered circadian rhythms, disordered sleep, depression, psychosis and cognitive impairment. Evidence is emerging that the motor and neuropsychiatric symptoms may share etiologic factors. Read More

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SynCells: A 60 × 60 μm Electronic Platform with Remote Actuation for Sensing Applications in Constrained Environments.

ACS Nano 2021 May 7. Epub 2021 May 7.

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Autonomous electronic microsystems smaller than the diameter of a human hair (<100 μm) are promising for sensing in confined spaces such as microfluidic channels or the human body. However, they are difficult to implement due to fabrication challenges and limited power budget. Here we present a 60 × 60 μm electronic microsystem platform, or SynCell, that overcomes these issues by leveraging the integration capabilities of two-dimensional material circuits and the low power consumption of passive germanium timers, memory-like chemical sensors, and magnetic pads. Read More

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To hum or not to hum: Neural transcriptome signature of male courtship vocalization in a teleost fish.

Genes Brain Behav 2021 May 7:e12740. Epub 2021 May 7.

Department of Neurobiology and Behavior, Cornell University, Ithaca, New York, United States.

For many animal species, vocal communication is a critical social behavior and often a necessary component of reproductive success. Additionally, vocalizations are often demanding motor acts. Wanting to know whether a specific molecular toolkit might be required for vocalization, we used RNA-sequencing to investigate neural gene expression underlying the performance of an extreme vocal behavior, the courtship hum of the plainfin midshipman fish (Porichthys notatus). Read More

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KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of VTA neurons by ethanol.

Alcohol Clin Exp Res 2021 May 7. Epub 2021 May 7.

Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, 60612.

Background: Alcohol excites neurons of the ventral tegmental area (VTA) and the release of dopamine from these neurons is a key event in ethanol reward and reinforcement. Many mechanisms for ethanol actions on neurons of the VTA have been proposed, but antagonists generally do not eliminate ethanol-induced excitation of VTA neurons. We have previously demonstrated that the ion channel KCNK13 plays an important role in ethanol excitation of mouse VTA neurons. Read More

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Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium.

Elife 2021 May 7;10. Epub 2021 May 7.

Plant and Microbial Biology, University of Zürich, Zürich, Switzerland.

In multicellular organisms, sexual reproduction requires the separation of the germline from the soma. In flowering plants, the female germline precursor differentiates as a single spore mother cell (SMC) as the ovule primordium forms. Here, we explored how organ growth contributes to SMC differentiation. Read More

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