888 results match your criteria ktx

Torque teno virus loads after kidney transplantation predict allograft rejection but not viral infection.

J Clin Virol 2021 Jul 25;140:104871. Epub 2021 May 25.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.

The main challenge of immunosuppressive therapy after solid organ transplantation is to create a new immunological balance that prevents organ rejection and does not promote opportunistic infection. Torque teno virus (TTV), a ubiquitous and non-pathogenic single-stranded DNA virus, has been proposed as a marker of functional immunity in immunocompromised patients. Here we investigate whether TTV loads predict the risk of common viral infection and allograft rejection in kidney transplantation recipients. Read More

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Colorectal Resection in Transplant Centers Benefits Kidney But Not Pancreas Transplant Recipients.

Int J Angiol 2021 Jun 13;30(2):139-147. Epub 2021 May 13.

Department of Surgery, Albany Medical Center, Albany, New York.

As graft and patient survival rates improve, transplant recipients are likely to undergo colorectal surgery in their lifetime. Current literature on the surgical outcomes of colorectal resection in kidney and pancreas transplant recipients is sparse. This investigation identifies areas of surgical risk for kidney, pancreas, and pancreas-kidney transplant recipients undergoing colorectal resection at transplant and teaching centers. Read More

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Kidney-Pancreas Transplant Recipients Experience Higher Risk of Complications Compared to the General Population after Undergoing Coronary Artery Bypass Grafting.

Int J Angiol 2021 Jun 3;30(2):107-116. Epub 2021 Feb 3.

Department of Surgery, University of Toledo College of Medicine, Toledo, Ohio.

This retrospective analysis aims to identify differences in surgical outcomes between pancreas and/or kidney transplant recipients compared with the general population undergoing coronary artery bypass grafting (CABG). Using Nationwide Inpatient Sample (NIS) data from 2005 to 2014, patients who underwent CABG were stratified by either no history of transplant, or history of pancreas and/or kidney transplant. Multivariate analysis was used to calculate odds ratio (OR) to evaluate in-hospital mortality, morbidity, length of stay (LOS), and total hospital charge in all centers. Read More

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Modification in induction immunosuppression regimens to safely perform kidney transplants amid the COVID-19 pandemic: A single-center retrospective study.

Clin Transplant 2021 May 20:e14365. Epub 2021 May 20.

Department of Transplant Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: The COVID-19 pandemic has negatively impacted organ donation and transplantation across the globe.

Methods: This study analyzed transplant outcomes during the pre-pandemic [PPE, 1/2019-2/2020] and pandemic era [PE, 3/2020-8/2020] based on changes in induction immunosuppression. During PPE, high immunological risk patients received 4-6 mg/kg, moderate risk 2-4 mg/kg, and low risk 1-2 mg/kg of ATG. Read More

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Vascular Access Perspectives in Patients After Kidney Transplantation.

Front Surg 2021 28;8:640986. Epub 2021 Apr 28.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.

More attention has been paid to the influence of arteriovenous fistula (AVF) on the cardiovascular system. In renal transplant recipients, some beneficial effect of an elective vascular access (VA) ligation was observed in patients with a high AVF flow. However, this strategy is not widely accepted and is in contradiction to the rule of vasculature preservation for possible future access. Read More

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The Changing Landscape of Pneumocystis Jiroveci Infection in Kidney Transplant Recipients: Single-Center Experience of Late-Onset Pneumocystis Pneumonia.

Transplant Proc 2021 May 4. Epub 2021 May 4.

Nephrology and Kidney Transplantation Clinic, Laiko Hospital, National and Kapodistrian University of Athens, Faculty of Medicine, Athens, Greece.

Background: Pneumocystis jiroveci pneumonia (PCP) is a life-threatening pulmonary infection after kidney transplantation (KTx). Its onset in the current era of modern immunosuppression and of routine use of universal PCP prophylaxis seems to differ from its onset in previous decades in terms of late onset with subtle clinical presentation, indicating a need for increased vigilance.

Methods: We retrospectively studied all KTx recipients from our center who underwent bronchoscopy and bronchoalveolar lavage (BAL) between 2009 and 2018. Read More

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Kidney transplant in patients with atypical hemolytic uremic syndrome in the anti-C5 era: single-center experience with tailored Eculizumab.

J Nephrol 2021 May 6. Epub 2021 May 6.

Kidney Transplant Unit, Center for HUS Prevention, Control and Management, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Rationale And Objective: Patients with atypical hemolytic uremic syndrome (aHUS) have long been considered ineligible for kidney transplantation (KTx) in several centers due to the high risk of disease recurrence, graft loss and life-threatening complications. The availability of Eculizumab (ECU) has now overcome this problem. However, the best approach towards timing, maintenance schedule, the possibility of discontinuation and patient monitoring has not yet been clearly established. Read More

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Real-world direct-acting antiviral treatment in kidney transplant and hemodialysis patients: the EpiTer-2 multicenter observational study.

Ann Gastroenterol 2021 5;34(3):438-446. Epub 2021 Feb 5.

Department of Infectious Diseases and Hepatology, Medical University of Białystok, Białystok (Tadeusz W. Łapiński, Robert Flisiak).

Background: Patients who undergo hemodialysis (HD) or kidney transplantation (KTx) previously had limited possibilities for treatment of hepatitis C virus (HCV) infection. Direct-acting antivirals (DAA) give these patients a chance of virus eradication and safe transplantation. The aim of this study was to evaluate the effectiveness and safety of DAA in KTx and HD patients in real-world settings. Read More

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February 2021

Causes of hypercalcemia in renal transplant recipients: persistent hyperparathyroidism and others.

Braz J Med Biol Res 2021 26;54(6):e10558. Epub 2021 Apr 26.

Divisão de Nefrologia, Departamento de Clinica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Hypercalcemia is common in patients after kidney transplantation (KTx) and is associated with persistent hyperparathyroidism in the majority of cases. This retrospective, single-center study evaluated the prevalence of hypercalcemia after KTx. KTx recipients were evaluated for 7 years after receiving kidneys from living or deceased donors. Read More

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Comparative analysis of kidney transplant costs related to recovery of renal function after the procedure.

J Bras Nefrol 2021 Apr 23. Epub 2021 Apr 23.

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Serviço de Transplante Renal, São Paulo, SP, Brasil.

Introduction: The number of kidney transplants (KTx) is increasing in Brazil and, consequently, the costs of this procedure increase the country's health budget. We retrospectively evaluated the data of kidney transplant procedures until hospital discharge, according to kidney function recovery after the procedure.

Methods: Retrospective analysis of the non-sensitized, 1st KTx from deceased donors performed between Jan/2010 to Dec/2017. Read More

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CD45RACD25CD127CD4 activated regulatory T cells are correlated with de novo donor-specific anti-HLA antibody formation after kidney transplantation in standard immunosuppression.

Int Immunopharmacol 2021 Apr 19;97:107661. Epub 2021 Apr 19.

Department of Transplant Surgery, Tokai University School of Medicine, Kanagawa, Japan.

Although de novo donor-specific anti-HLA antibodies (dnDSA) remain a barrier for human kidney transplantation (KTx), the role of regulatory T (Treg) cells in dnDSA formation remains unknown. To address this question, we evaluated Treg cell subsets in peripheral blood mononuclear cells in 15 healthy volunteers and 59 KTx recipients using flow cytometric analysis. The post-transplant CD25CD127CD4 Treg cells in KTx recipients were down-regulated compared with those of healthy volunteers (P < . Read More

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Posttransplant nephrotic syndrome resulting from NELL1-positive membranous nephropathy.

Am J Transplant 2021 Apr 18. Epub 2021 Apr 18.

Division of Nephrology, Department of Internal Medicine, University of Leipzig Medical Center, Leipzig, Germany.

Membranous nephropathy (MN) constitutes a major cause of nephrotic syndrome (NS) in adults. After kidney transplantation (KTx), both recurrent and de novo MN has been reported. In addition to PLA2R and THSD7A, recent identification of neural EGFL-like-1 protein, NELL1, as a potential disease antigen has enriched our understanding of MN pathogenesis. Read More

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A novel urine cell-free DNA preservation solution and its application in kidney transplantation.

Nephrology (Carlton) 2021 Apr 18. Epub 2021 Apr 18.

Biostatistics, R&D, AlloDx Biotech (Shanghai), Co., Ltd, Shanghai, China.

Aim: Urine cell-free DNA (cfDNA) is a new type of liquid biopsy biomarker used in tumours and allograft injury detection but is highly susceptible to degradation by the high nuclease activity of urine. This study presents a newly developed urine cfDNA preservation solution (AlloU), efficient for examining allograft injury in kidney transplant recipients (KTx).

Methods: We established urine-preserve solution called AlloU based on the response-surface methodology, with two commercial collection reagents (Streck and K2 EDTA preservation solution) included for analysis. Read More

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Incidence, Clinical Correlates, and Outcomes of Pulmonary Hypertension after Kidney Transplantation: Analysis of Linked U.S. Registry and Medicare Billing Claims.

Transplantation 2021 Apr 9. Epub 2021 Apr 9.

Saint Louis University, St. Louis, MO, USA University of Calgary, Calgary, AB, Canada University of Iowa, Iowa City, IA, USA Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA UT Health, San Antonio, TX, USA University of Wisconsin, Madison, WI, USA University of Chicago, Chicago, IL, USA Einstein Medical Center, Philadelphia, PA, USA Weill Cornell Medicine, New York, NY, USA Hennepin County Medical Center, Minneapolis, MN, USA University Virginia, Charlottesville, VA, USA.

Background: The incidence, risks, and outcomes associated with pulmonary hypertension (P-HTN) in the kidney transplant (KTx) population are not well described.

Methods: We linked U.S. Read More

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Pregnancies in kidney transplant recipients with complement gene variant-mediated thrombotic microangiopathy.

Clin Kidney J 2021 Apr 20;14(4):1255-1260. Epub 2020 Aug 20.

Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.

Background: Pregnancies in patients with complement gene variant-mediated thrombotic microangiopathy (cTMA) are challenging, and pregnancies in such patients after kidney transplantation (KTX) are even more so.

Methods: We identified nine pregnancies following KTX of three genetically high-risk cTMA patients enrolled in the Vienna thrombotic microangiopathy cohort. Preventive plasma therapy was used in three pregnancies, and one patient had ongoing eculizumab (ECU) therapy during two pregnancies. Read More

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Characteristics, management and outcomes of atypical haemolytic uraemic syndrome in kidney transplant patients: a retrospective national study.

Clin Kidney J 2021 Apr 13;14(4):1173-1180. Epub 2020 Aug 13.

RedInRen 16/009, RTYC ISCIII, Madrid, Spain.

Background: Kidney transplantation (KTx) is a strong trigger for the development of either recurrent or atypical haemolytic uraemic syndrome (aHUS). According to previous studies, eculizumab (ECU) is effective for prophylaxis and for treatment of recurrence.

Methods: We evaluated the experiences of Spanish patients with recurrent and aHUS associated with KTx, treated or not treated with ECU. Read More

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Immunomodulatory and protective effects of interleukin-4 on the neuropathological alterations induced by a potassium channel blocker.

J Neuroimmunol 2021 Jun 17;355:577549. Epub 2021 Mar 17.

USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP32, El Alia, Bab Ezzouar, 16111 Algiers, Algeria. Electronic address:

The pathophysiology of neurological diseases related to potassium-channel dysfunction such as epilepsy is increasingly linked to immune system modulation. However, there are limited reports of which interleukin-4 (IL-4) can act on the neuroinflammatory response after seizure. Hence, we evaluated the effect of IL-4 in murine model of neuroexcitotoxcity using kaliotoxin (KTx), a potassium-channel blocker. Read More

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Prophylactic antithrombotic management in adult and pediatric kidney transplantation: A systematic review and meta-analysis.

Pediatr Transplant 2021 Jun 7;25(4):e14021. Epub 2021 Apr 7.

Department of General Pediatrics and Haematology/Oncology, University Children's Hospital Tuebingen, Tuebingen, Germany.

Background: RGT is a major cause for early graft loss after KTx. Although evidence-based recommendations are lacking, aP is often used to prevent RGT. This systematic review aimed to determine the effectiveness and safety of aP in adult and pediatric KTx recipients. Read More

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[Kidney transplantation into the urological training in Colombia.]

Arch Esp Urol 2021 Apr;74(3):287-292

Unidad de Urología. Facultad de Medicina. Universidad Nacional de Colombia. Ciudad Universitaria. Bogotá. Colombia.

Kidney transplantation (KTx) is the best therapeutic modality for end stage renal disease. Currently in Colombia there are approximately 2800 patients waiting for KTx. Historically, urologists have beenin close contact with KTx, however in Colombia the interaction between urology and KT is scarce. Read More

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Herpes Zoster in Solid Organ Transplantation: Incidence and Risk Factors.

Front Immunol 2021 18;12:645718. Epub 2021 Mar 18.

Department of Internal Medicine-Nephrology and Transplantation, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands.

Background: Studies on herpes zoster (HZ) incidence in solid organ transplant (SOT) recipients report widely varying numbers. We investigated HZ incidence, severity, and risk factors in recipients of four different SOTs, with a follow-up time of 6-14 years.

Methods: Records of 1,033 transplant recipients after first heart (HTx: n = 211), lung (LuTx: n = 121), liver (LiTx: n = 258) and kidney (KTx: n = 443) transplantation between 2000 and 2014 were analyzed for VZV-PCR, clinical signs of HZ, and complications. Read More

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Organ integration in kidney transplant patients - Results of a KTx360° substudy.

J Psychosom Res 2021 Jun 25;145:110464. Epub 2021 Mar 25.

Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany; Project Kidney Transplantation 360° (NTx360°), Hannover Medical School, Hannover, Germany. Electronic address:

Objective: Organ transplantation is the treatment of choice for patients with end-stage organ disease. From early on, the psychological perspective on integrating the organ has been of interest. As quantitative studies on organ integration are scarce, we aimed at evaluating this aspect in a large sample of kidney transplant (KTx) recipients. Read More

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Comparison of erectile function in patients with end-stage renal disease receiving haemodialysis and kidney transplantation.

Andrologia 2021 Jul 2;53(6):e14068. Epub 2021 Apr 2.

Department of Nephrology, Çukurova University Faculty of Medicine, Adana, Turkey.

To investigate the frequency and risk factors of ED in haemodialysis patients (HDps) and kidney transplantation (KTx) recipients (KTxRs). HDps and KTxRs between the ages of 18-65 were compared in terms of ED. IEFF-15 (International Index of Erectile Function) score was used to evaluation of ED. Read More

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Blood Pressure Treatment in Kidney Transplant Recipients-Can We Improve?

Transplant Direct 2021 Apr 25;7(4):e688. Epub 2021 Mar 25.

Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, Oslo, Norway.

Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to identify the determinants of failure to achieve BP control. Read More

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The role of bariatric surgery on kidney transplantation: A systematic review and meta-analysis.

Can Urol Assoc J 2021 Mar 18. Epub 2021 Mar 18.

Division of General Surgery, McMaster University, Hamilton, ON, Canada.

Introduction: Obesity (body mass index [BMI] >35 kg/m) remains a relative contraindication for kidney transplant, while patients after kidney transplantation (KTX) are predisposed to obesity. The present study aims to investigate the role of bariatric surgery in improving transplant candidacy in patients prior to KTX, as well its safety and efficacy in KTX patients postoperatively.

Methods: A systematic search was conducted up to March 2020. Read More

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Predicting the outcome of COVID-19 infection in kidney transplant recipients.

BMC Nephrol 2021 03 19;22(1):100. Epub 2021 Mar 19.

Division of Nephrology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.

Background: We aimed to present the demographic characteristics, clinical presentation, and outcomes of our multicenter cohort of adult KTx recipients with COVID-19.

Methods: We conducted a multicenter, retrospective study using data of patients hospitalized for COVID-19 collected from 34 centers in Turkey. Demographic characteristics, clinical findings, laboratory parameters (hemogram, CRP, AST, ALT, LDH, and ferritin) at admission and follow-up, and treatment strategies were reviewed. Read More

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Time on previous renal replacement therapy is associated with worse outcomes of COVID-19 in a regional cohort of kidney transplant and dialysis patients.

Medicine (Baltimore) 2021 Mar;100(10):e24893

Department of Nephrology and Rheumatology.

Abstract: Chronic renal replacement therapy by either a kidney transplant (KTX) or hemodialysis (HD) predisposes patients to an increased risk for adverse outcomes of COVID-19. However, details on this interaction remain incomplete. To provide further characterization, we undertook a retrospective observational cohort analysis of the majority of the hemodialysis and renal transplant population affected by the first regional outbreak of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) in Germany. Read More

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Use of an electronic medication monitoring device to estimate medication adherence in kidney transplant patients.

Transl Behav Med 2021 Apr;11(3):842-851

Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hanover, Germany.

Electronic medication monitoring devices (EMD) have been used as a gold standard for assessing medication adherence. We used a wireless EMD (SimpleMed+), assessed its usability in patients after kidney transplantation (KTx), evaluated adherence, and analyzed concordance with other adherence measures. Fifty-five patients (53% female, mean age 46 years) at least 6 months after KTx agreed to use the EMD over a period of 8 weeks. Read More

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Norovirus Infections in Kidney Transplant Recipients.

Transplantation 2021 Mar 2. Epub 2021 Mar 2.

Department of Nephrology, Universitätsmedizin Essen, University Duisburg-Essen, Essen, Germany Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Essen, Germany Centre of Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany Institute for Virology, Universitätsmedizin Essen, University Duisburg-Essen, Essen, Germany.

Background: Norovirus (NoV) infection frequently progresses to chronic disease after kidney transplant (KTx). This study aims to assess potential risk factors helping to determine patients at risk of chronic NoV infection and to analyse the effect of NoV on allograft outcome. Additionally, we assessed the effectiveness of intravenous immunoglobulin (IVIg) therapy for chronic NoV infection. Read More

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Adherence to Pharmacotherapy and Lifestyle Recommendations Among Hemodialyzed Patients and Kidney Transplant Recipients.

J Ren Nutr 2021 Feb 25. Epub 2021 Feb 25.

Department of Internal Medicine and Transplant Nephrology, Medical University of Lodz, Poland. Electronic address:

Objective: Success in treatment with hemodialysis (HD) and kidney transplantation (KTx) requires good adherence. The objective of this study was to evaluate adherence to pharmacotherapy and health recommendations among HD and KTx patients using subjective and objective measures.

Methods: Two hundred thirty-nine enrolled patients, with 132 KTx (39F, 93M) and 107 HD (48F, 59M) completed a questionnaire regarding over-the-counter (OTC) medications and dietary supplements (DS), adherence to pharmacotherapy, lifestyle recommendations, and self-evaluation of knowledge on them. Read More

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February 2021

Change in Estimated GFR and Risk of Allograft Failure in Patients Diagnosed With Late Active Antibody-mediated Rejection Following Kidney Transplantation.

Transplantation 2021 Mar;105(3):648-659

Department of Medicine, University of Wisconsin, Madison, WI.

Background: There are challenges in designing adequate, well-controlled studies of patients with active antibody-mediated rejection (AMR) after kidney transplantation (KTx).

Methods: We assessed the functional relationship between change in estimated glomerular filtration rate (eGFR) following the diagnosis of AMR and the risk of subsequent death-censored graft failure using the joint modeling framework. We included recipients of solitary KTx between 1995 and 2013 at 4 transplant centers diagnosed with biopsy-proven active AMR at least 1 year post-KTx, who had a minimum of 3-year follow-up. Read More

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