Antioxid Redox Signal 2021 Jul 30. Epub 2021 Jul 30.
University of Vermont College of Medicine, 12352, Burlington, Vermont, United States;
Significance: Numerous abnormalities in T cells have been described in patients with systemic lupus erythematosus (SLE), including lymphopenia, DNA demethylation, expression of endogenous retroviruses, increased cell death, enlarged mitochondria, production of reactive oxygen species (ROS), and the appearance of CD4-CD8- T cells. We propose a model in which accelerated homeostatic proliferation of T cells promotes an epigenetic and metabolic program leading to this cluster of abnormalities. Recent Advances: Growing knowledge of the innate immune disorders in SLE has included increased mitochondrial size and ROS production that induces oligomerization of mitochondrial antiviral-signaling (MAVS) protein and type I Interferon production, as well as DNA demethylation, upregulation of inflammatory genes, and expression of certain endogenous retroviruses in SLE peripheral blood mononuclear cells (PBMC). Read More