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Chronic encapsulated expanding hematomas after stereotactic radiosurgery for intracranial arteriovenous malformations.

J Neurosurg 2021 Jul 30:1-11. Epub 2021 Jul 30.

Departments of1Neurological Surgery and.

Objective: Cerebral arteriovenous malformations (AVMs) are rare cerebral vascular lesions that are associated with high morbidity and mortality from hemorrhage; however, stereotactic radiosurgery (SRS) is a well-validated treatment modality. Few reports have delineated a subgroup of patients who develop delayed chronic encapsulated expanding hematomas (CEEHs) despite angiographic evidence of AVM obliteration following radiosurgery. In this report, the authors performed a retrospective review of more than 1000 radiosurgically treated intracranial AVM cases to delineate the incidence and management of this rare entity. Read More

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Toward a transitional care from childhood and adolescence to adulthood in surgical neurooncology? A lesson from the Necker-Enfants Malades and the Sainte-Anne Hospitals collaboration.

J Neurosurg Pediatr 2021 Jul 30:1-7. Epub 2021 Jul 30.

1Service de Neurochirurgie, GHU Paris-Hôpital Sainte-Anne, Paris.

Objective: Transitional care in surgical neurooncology is poorly studied. However, this period is pivotal, since it allows the patient to be empowered in his or her disease management. Here, the authors describe the experience of the Necker-Enfants Malades and the Sainte-Anne Hospital collaboration. Read More

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Undergraduate student nurses' experiences of their community placements.

Nurse Educ Today 2021 Jul 9;106:105054. Epub 2021 Jul 9.

School of Nursing and Midwifery, National University of Ireland Galway. Electronic address:

Background: Community nursing placements play an increasingly important part in the undergraduate nursing students learning experience as a greater proportion of health care delivery is set to migrate to community care settings. Therefore, nursing education programmes and health services must ensure that student nurses are exposed to high quality community placements that provide suitable learning experiences for students to acquire the skills and knowledge required for the health service of the future.

Objectives: This qualitative evidence synthesis examines undergraduate nursing students' experiences of community nursing placements from 1996 to date. Read More

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Narrative arcs and shaping influences in long-term medication adherence.

Soc Sci Med 2021 Jul 24;285:114264. Epub 2021 Jul 24.

Department of Marketing, University of Tennessee, 321 Stokely Management Center, 916 Volunteer Boulevard, Knoxville, TN, 37996-0530, USA. Electronic address:

Long-term adherence to medications is not well understood and poses a significant challenge for many chronically ill persons. Past research provides insights on adherence in short durations such as a day or several weeks, even though chronically ill patients are required to take medications for periods as long as a lifetime. To fill this important knowledge gap, we study the temporal unfolding of prolonged medication-taking experiences among thirty adults, mostly African American, with chronic hypertension in the U. Read More

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Experienced critical incidents affecting lead-times in the stroke care chain for low-priority patients - A qualitative study with critical incident technique.

Int Emerg Nurs 2021 Jul 27;58:101040. Epub 2021 Jul 27.

Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden; Sahlgrenska Universitetssjukhuset, Gothenburg, Sweden; Chalmers University of Technology, Gothenburg, Sweden.

Background: The time elapsing from the alarm being raised to arrival at the stroke unit is crucial for patients suffering a conceivable stroke. More knowledge is needed about critical incidents-both favourable and unfavourable-affecting the lead time in the care chain.

Aim: To explore favourable and unfavourable critical incidents (CIs), affecting lead times in the care chain from the alerted ambulance to the stroke unit, as experienced by nurses, for low-priority patients suffering a conceivable acute stroke. Read More

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Updated knowledge and practical implementations of stress echocardiography in ischemic and non-ischemic cardiac diseases: an expert consensus of the Working Group of Echocardiography of the Hellenic Society of Cardiology.

Hellenic J Cardiol 2021 Jul 27. Epub 2021 Jul 27.

Metropolitan Hospital Center, Piraeus, Greece; Hamersmith University Hospital, London, UK.

Stress echocardiography (SE) is a well-established and valid technique, widely-used for the diagnostic evaluation of patients with ischemic and non-ischemic cardiac diseases. This statement of the Echocardiography Working Group of the Hellenic Society of Cardiology summarizes the consensus of the writing group regarding the applications of SE, based on the expertise of their members and on a critical review of current medical literature. The main objectives of the consensus document include a comprehensive review of SE methodology and training, focusing on the preparation, the protocols used and the analysis of the SE images and an updated, evidence-based knowledge about SE applications on ischemic and non-ischemic heart diseases, such as in cardiomyopathies, heart failure and valvular heart disease. Read More

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Robot-assisted exploration of somatic nerves in the pelvis and transection of the sacrospinous ligament for Alcock canal syndrome.

J Minim Invasive Gynecol 2021 Jul 27. Epub 2021 Jul 27.

Department of Obstetrics and Gynecology, Kurashiki Medical Center, Okayama, Japan. Electronic address:

Objective: Some articles have reported the surgical management of Alcock canal syndrome (ACS) using transperineal [1], transgluteal [2], or conventional laparoscopic approach [3, 4]. In 2015, Rey and Oderda reported the first robotic neurolysis of the pudendum, providing the advantages of robot-assisted surgery: magnified and 3-dimensional vision and greater precision of movements [5]. However, to our knowledge, there have been no reports of the use of a robotic platform for the treatment of ACS in the field of gynecology. Read More

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Identification and characteristics of a novel aminoglycoside phosphotransferase, APH(3')-IId, from an MDR clinical isolate of Brucella intermedia.

J Antimicrob Chemother 2021 Jul 30. Epub 2021 Jul 30.

Key Laboratory of Medical Genetics of Zhejiang Province, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Objectives: To describe a novel chromosomal aminoglycoside phosphotransferase named APH(3')-IId identified in an MDR Brucella intermedia ZJ499 isolate from a cancer patient.

Methods: Species identity was determined by PCR and MALDI-TOF MS analysis. WGS was performed to determine the genetic elements conferring antimicrobial resistance. Read More

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Patient delay and associated factors among tuberculosis patients in Gamo zone public health facilities, Southern Ethiopia: An institution-based cross-sectional study.

PLoS One 2021 30;16(7):e0255327. Epub 2021 Jul 30.

Departments of Public Health, Mizan Tepi University, Mizan Aman, Ethiopia.

Background: Delayed tuberculosis diagnosis and treatment increase morbidity, mortality, expenditure, and transmission in the community. Early diagnosis and initiation of treatment are essential for effective TB control. Therefore, the main objective of this study was to assess the magnitude and factors associated with patient delay among tuberculosis patients in Gamo Zone, Southern Ethiopia. Read More

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T cell homeostatic proliferation promotes a redox state that drives metabolic and epigenetic upregulation of inflammatory pathways in lupus.

Antioxid Redox Signal 2021 Jul 30. Epub 2021 Jul 30.

University of Vermont College of Medicine, 12352, Burlington, Vermont, United States;

Significance: Numerous abnormalities in T cells have been described in patients with systemic lupus erythematosus (SLE), including lymphopenia, DNA demethylation, expression of endogenous retroviruses, increased cell death, enlarged mitochondria, production of reactive oxygen species (ROS), and the appearance of CD4-CD8- T cells. We propose a model in which accelerated homeostatic proliferation of T cells promotes an epigenetic and metabolic program leading to this cluster of abnormalities. Recent Advances: Growing knowledge of the innate immune disorders in SLE has included increased mitochondrial size and ROS production that induces oligomerization of mitochondrial antiviral-signaling (MAVS) protein and type I Interferon production, as well as DNA demethylation, upregulation of inflammatory genes, and expression of certain endogenous retroviruses in SLE peripheral blood mononuclear cells (PBMC). Read More

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Anti-GAD associated post-infectious cerebellitis after COVID-19 infection.

Neurol Sci 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

The coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread rapidly all over the world. Besides severe pneumonia, it causes multisystemic disease, including neurological findings. Here, we present a patient with anti-glutamic acid decarboxylase (anti-GAD) antibody-associated cerebellitis developed after COVID-19 infection. Read More

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Public Perceptions of Physician Attire and Professionalism in the US.

JAMA Netw Open 2021 Jul 1;4(7):e2117779. Epub 2021 Jul 1.

Department of Plastic & Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: In recent years, casual physician attire (fleece jackets and softshell jackets) has become increasingly popular, but to our knowledge, public perceptions of these garments have not been studied. Furthermore, gender biases may result in differing expectations and perceptions of female and male physicians and may be associated with patient rapport and trust building.

Objective: To characterize public perceptions of casual physician attire and implicit gender biases in public assessment of physicians' professional attire. Read More

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The Fast Health Interoperability Resources (FIHR) Standard: Systematic Literature Review of Implementations, Applications, Challenges and Opportunities.

JMIR Med Inform 2021 Jul 30;9(7):e21929. Epub 2021 Jul 30.

Department of Computer Engineering, Faculty of Computer Science, Universitas Sriwijaya, Palembang, Indonesia.

Background: Information technology has shifted paper-based documentation in the health care sector into a digital form, in which patient information is transferred electronically from one place to another. However, there remain challenges and issues to resolve in this domain owing to the lack of proper standards, the growth of new technologies (mobile devices, tablets, ubiquitous computing), and health care providers who are reluctant to share patient information. Therefore, a solid systematic literature review was performed to understand the use of this new technology in the health care sector. Read More

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The impact of an electronic hospital system on therapeutic drug monitoring.

J Clin Pharm Ther 2021 Jul 30. Epub 2021 Jul 30.

QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.

What Is Known And Objective: Australian hospitals have undergone a transformation with both a review and expansion of traditional roles of healthcare professionals and the implementation of an ieMR. The implementation of an ieMR brings large scale organizational change within the health system especially for staff with direct patient contact. This is changing the future of healthcare and the roles of healthcare professionals. Read More

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Long non‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p.

Oncol Rep 2021 Sep 30;46(3). Epub 2021 Jul 30.

Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

A prevalent type of bone tumor, osteosarcoma (OS) is prone to pulmonary metastasis, which results in a high relapse risk and poor prognosis for patients. The progression of OS is significantly associated with the expression of long non‑coding (lnc)RNA H19. To the best of our knowledge, however, the exact molecular mechanism of this lncRNA has not been fully investigated. Read More

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September 2021

What is the relations between dysgeusia and alterations of the nutritional status? A metanarrative analysis of integrative review.

Acta Biomed 2021 Jul 29;92(S2):e2021023. Epub 2021 Jul 29.

Università degli Studi di Pavia.

Background And Aim: Dysgeusia is  an altered or damaged tasting perception of a multifactorial etiology, from polypharmacy, infections to chemotherapy and radiotherapy. Approximately 5% of the population suffer from a diminished taste sensation, which unfortunately remains underestimated by the affected person, creating the conditions for a dramatic underestimation of the incidence of the symptom. The aim of this study is to summarize the evidences present in literature on the relations between Dysgeusia and alterations of the nutritional status Methods: an integrative review with metanarrative analysis of the articles included was carried out in August 2020. Read More

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The safety of care focused on patient identity: an observational study.

Acta Biomed 2021 Jul 29;92(S2):e2021038. Epub 2021 Jul 29.

Università degli Studi di Parma.

Background And Aim: Healthcare organizations, in order to reduce errors and extend the number of safe practices, are looking for possible solutions to enhance the clients' health quality care and trying to spread the culture of safety healthcare. Although in the literature the field of research "patient safety" is very debated, there are few empirical studies that investigate about the strategies undertaken by nursing students for the patients identification process during their care pathway. The aim of this study is to investigate the knowledge of the Ministerial Recommendation No. Read More

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Take a picture! The role of visual methods in understanding psychiatric patient's everyday life.

Acta Biomed 2021 Jul 29;92(S2):e2021028. Epub 2021 Jul 29.


Background And Aim: Understanding the patient's experience of mental illness can foster better support for this population and greater partnership with healthcare professionals. This study aims to explore the application of visual methods in the psychiatric field and, in particular, the experience of people suffering from psychotic disorders because it is still an open question that has not been only partially empirically examined.

Methods: This qualitative study was conducted using two visual methods (auto-photography and photo-elicitation) associated with the narrative that emerged from an unstructured interview, in a clinical setting of adult Mental Health in Italy, between October 2019 and February 2020. Read More

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Educating "Helping" Professional Students to "Help" Trans People Navigate Their Health Care Needs: A Review of Recent Literature.

Justin E Lerner

J Homosex 2021 Jul 30:1-30. Epub 2021 Jul 30.

School of Social Work, University of Washington, Seattle, Washington, USA.

In the 2015 United States Trans Survey, trans people overwhelmingly indicated that training health-care providers about trans health is an urgent policy priority within the US. This literature review examines the types of educational training interventions health professional schools have developed from 2015-2020 focused on trans health. This review revealed that the fields of medicine and interprofessional education have created the majority of interventions, which tend to increase students' knowledge, comfort, and confidence working with trans patients. Read More

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Complete resolution of chylothorax with ibrutinib in chronic lymphocytic leukemia: a case report.

Ann Palliat Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Chylothorax is an infrequent pleural effusion often caused by traumatic or nontraumatic injury to the thoracic duct. Nontraumatic chylothorax caused by chronic lymphocytic leukemia (CLL) is rarely reported. Previous experience has implied that the main factor affecting the treatment of chylothorax is whether the anti-cancer treatment is effective. Read More

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A narrative review: has regionalization truly achieved its intended goal in the surgical management of pancreatic cancer?

Chin Clin Oncol 2021 Jul 30. Epub 2021 Jul 30.

Department of General Surgery, Division of Surgical Oncology, The Ohio State University College of Medicine, Columbus, OH, USA.

Objective: The purpose of this narrative review is to present the data to date on the volume-outcome association in pancreas cancer surgery and describe the prevalence of and barriers to regionalized pancreas cancer care in western health systems.

Background: Numerous studies have demonstrated an association between increasing hospital or surgeon volume and improved patient morbidity and mortality in patients undergoing surgery for pancreas cancer. However, since the initial promotion of minimum volume standards, regionalization has remained difficult to establish. Read More

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Is N-terminal pro-brain type natriuretic peptide a useful marker in newborns with heart defects?

Adv Clin Exp Med 2021 Jul 30. Epub 2021 Jul 30.

Department of Neonate and Infant Pathology, Medical University of Lublin, Poland.

Background: Heart diseases are currently a significant cause of morbidity and mortality in newborns. The existing diagnostic methods are often not sufficient or, in many cases, cannot be used. Great advances have been achieved in medical knowledge concerning biomarkers for the diagnosis of circulatory system disorders in adult patients. Read More

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An unmet need for paediatric LGBTQ training.

Clin Teach 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatrics, Population and Family Health, Columbia University Irving Medical Center, New York City, New York, USA.

Background: Lesbian, gay, bisexual, transgender, queer/questioning (LGBTQ) youth have increased health risks, exacerbated by discrimination and lack of provider training. Currently, no graduate medical education requirements address the need for LGBTQ health training, particularly for paediatric providers. We aimed to perform a needs assessment of provider knowledge, comfort and awareness of community resources regarding LGBTQ youth. Read More

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Real-World Clinical and Economic Outcomes in Selected Immune-Related Adverse Events Among Cancer Patients Receiving Immune Checkpoint Inhibitors.

Oncologist 2021 Jul 30. Epub 2021 Jul 30.

Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

Background: With increased use of immune checkpoint inhibitors (ICIs) among cancer patients, there is substantial interest in understanding clinical, economics outcomes and management of immune-related adverse events (irAEs).

Patients And Methods: A retrospective study was conducted using Premier Healthcare Database, a US national hospital discharge database, from March 1, 2015 through December 31, 2017. The database comprises more than 880 million inpatient and hospital-based outpatient encounters with more than 200 million unique patients reported by 966 hospitals. Read More

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Br J Clin Pharmacol 2021 Jul 29. Epub 2021 Jul 29.

Service de Pharmacologie médicale et Clinique, CHU de Toulouse.

Aim: A better knowledge of opioid prescribing patterns would help to identify areas of potential improvement in cancer pain management. This study aimed to identify potential inappropriate use (PIU) of strong opioid analgesics in cancer outpatients in their last year of life.

Methods: A retrospective cohort of cancer patients who died between 2011 and 2014 and who were exposed as outpatient to a strong opioid analgesic in the last year of life was identified in the "Echantillon Généraliste de Bénéficiaires" (a 1/97th random sample of the French general population). Read More

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[COVID-19 patients in Germany: exposure risks and associated factors for hospitalization and severe disease].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 Jul 29. Epub 2021 Jul 29.

Abteilung für Infektionsepidemiologie, Robert Koch-Institut, Seestr. 10, 13353, Berlin, Deutschland.

The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spread worldwide in 2020. By the end of June 2021, over 3.7 million people had been infected in Germany. Read More

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Murine Models of Alcohol Consumption: Imperfect but Still Potential Source of Novel Biomarkers and Therapeutic Drug Discovery for Alcoholic Liver Disease.

J Cell Immunol 2021 ;3(3):177-181

Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush Medical College, Chicago, IL 60612, USA.

Animal models of liver disease are fundamentally important to strengthen our knowledge and understanding of human liver diseases. Murine models of alcohol consumption are utilized to investigate alcoholic liver injury to develop new therapeutic targets. The well accepted and commonly used murine models of chronic alcohol consumption are Meadows-Cook (MC) and Lieber-DeCarli (LD). Read More

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January 2021

Ten things to know about ten imaging studies: A preventive cardiology perspective ("ASPC top ten imaging").

Am J Prev Cardiol 2021 Jun 27;6:100176. Epub 2021 Mar 27.

CGH Medical Cener, Sterling, IL 61081 USA.

Knowing the patient's current cardiovascular disease (CVD) status, as well as the patient's current and future CVD risk, helps the clinician make more informed patient-centered management recommendations towards the goal of preventing future CVD events. Imaging tests that can assist the clinician with the diagnosis and prognosis of CVD include imaging studies of the heart and vascular system, as well as imaging studies of other body organs applicable to CVD risk. The American Society for Preventive Cardiology (ASPC) has published "Ten Things to Know About Ten Cardiovascular Disease Risk Factors. Read More

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Stroke in young adults: Current trends, opportunities for prevention and pathways forward.

Am J Prev Cardiol 2020 Sep 9;3:100085. Epub 2020 Sep 9.

Division of Cardiovascular Prevention & Wellness, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.

Cardiovascular disease remains a major contributor to morbidity and mortality in the US and elsewhere, and stroke is a leading cause of disability worldwide. Despite recent success in diminishing stroke incidence in the general US population, in parallel there is now a concerning propensity for strokes to happen at younger ages. Specifically, the incidence of stroke for US adults 20-44 years of age increased from 17 per 100,000 US adults in 1993 to 28 per 100,000 in 2015. Read More

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September 2020

An interprofessional training to improve advance care planning skills among medicine, nursing, and social work students.

J Interprof Educ Pract 2020 Dec 31;21. Epub 2020 Aug 31.

University of Maryland School of Social Work, University of Maryland, Baltimore, United States.

Suboptimal training for healthcare students is a recognized barrier to successful completion of advance care planning (ACP) with patients and families. Our study sought to enhance ACP knowledge and communication skills for interprofessional healthcare students. During academic year 2017-2018, 46 students (19-medicine, 16-nursing, and 11-social work), received three training modules delivered by interprofessional faculty. Read More

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December 2020