Search Our Scientific Publications & Authors

Med (N Y) 2022 Jan;3(1):3-5

HPV Cancer Prevention Program, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

HPV vaccination has been routinely recommended in the US since 2006. A new article from Falcaro et al. adds to the growing body of evidence to demonstrate HPV vaccination prevents cancer. Read More

PLoS One 2022 19;17(5):e0268521. Epub 2022 May 19.

Department of Family Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.

Background: Women living with HIV (WLHIV) have a high risk of anal cancer. Identifying risk factors for anal HPV 16 infection, the most significant risk factor for anal cancer, is essential for prevention and screening strategies.

Methods: In the EVVA Cohort study, 151 WLHIV had cervical and anal HPV testing with genotyping every 6 months for 2 years, while demographic and clinical data were collected via questionnaires and chart reviews. Read More

Cancer Causes Control 2022 May 17. Epub 2022 May 17.

GW Cancer Center, School of Medicine and Health Sciences, The George Washington University, 800 22nd Street NW, Suite 8000, Washington, DC, 20052, USA.

Purpose: The Comprehensive Cancer Control Cancer Communication Mentorship Program ("Mentorship Program") was created by the George Washington University Cancer Center (GWCC) to provide technical assistance (TA) in implementing evidence-based cancer screening communication interventions and support networking for comprehensive cancer control (CCC) professionals. The Mentorship Program matched entry-to mid-level CCC professionals with health communication and/or CCC experts and offered monthly web-based discussions with academic researchers and practitioners who shared their knowledge and provided applied learning opportunities throughout mentees' project planning, implementation and evaluation. The program objective was for mentees to improve health communication skills and apply evidence-based knowledge to reduce the burden of cancer. Read More

Front Genet 2022 27;13:848557. Epub 2022 Apr 27.

Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.

Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion's extent, and the presence of nodal metastases. Read More

BMC Womens Health 2022 May 14;22(1):169. Epub 2022 May 14.

The Research Institute of Maternity and Child Medicine, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, No. 2004, Hongli Road, Futian District, Shenzhen, 518000, China.

Background: Little research has been conducted to explore variables associated with the healthcare providers' (HCPs) understanding and recommendation of human papillomavirus vaccine (HPV) since the vaccine was approved for use in China.

Methods: A large-scale cross-sectional survey was conducted in southern China covering Guangdong, Guangxi, and Hainan provinces between April 2019 and October 2019. Firstly, descriptive analysis was used to access awareness, knowledge, barriers, and recommendations toward HPV vaccine among all participants. Read More

Int J Environ Res Public Health 2022 May 7;19(9). Epub 2022 May 7.

College of Nursing, University of Utah, 10 South 2000 East, Salt Lake City, UT 84112, USA.

Caribbean women experience a cervical cancer incidence rate that is three times higher than that among their North American counterparts. In this study, we performed a needs assessment of the knowledge and awareness of HPV, HPV vaccination, and cervical cancer and receipt of cervical cancer screening among an indigenous Caribbean community. We purposively recruited individuals aged ≥18 from a community health care clinic ( = 58) to complete a 57-item structured interview including items on demographics, cancer history, knowledge and awareness of HPV, HPV vaccines, cervical cancer, and cervical cancer screening. Read More

Int J Environ Res Public Health 2022 Apr 25;19(9). Epub 2022 Apr 25.

Department of Obstetrics and Gynecology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

The incidence and mortality rates of cervical cancer are rising among young women in Japan. In November 2021, the Japanese Ministry of Health, Labour, and Welfare reinstated the active recommendation for the human papillomavirus (HPV) vaccine, which was discontinued in June 2013 due to reports of adverse reactions, including chronic pain and motor dysfunction, following vaccination. However, vaccine hesitancy among the younger generation remains, and it is essential to identify the barriers in vaccination uptake. Read More

PLoS One 2022 12;17(5):e0266139. Epub 2022 May 12.

Faculty of Medicine Universitas Indonesia, Division of Gynecologic Oncology, Department of Obstetric and Gynaecology, Dr. Cipto Mangunkusumo Hospital, Greater Jakarta, DKI Jakarta, Indonesia.

Background: Few studies explored Indonesian understanding of cervical cancer (CC) and the human papillomavirus (HPV) vaccination. We aimed to investigate the association between knowledge, attitudes, and practices (KAP) and socio-demographical influences related to HPV, CC, and vaccination among Indonesian urban citizens.

Methods: We conducted an online survey during March 2020-August 2021 using the Snowball sampling technique. Read More

Singapore Med J 2022 May 13. Epub 2022 May 13.

Youth Preventive Services, Health Promotion Board, Singapore.

Introduction: Cervical cancer has a high disease burden in Singapore, and it is strongly associated with human papillomavirus (HPV) infections. Despite constant efforts to encourage vaccination, local HPV vaccine uptake remains low. Universal mass vaccination is a proven cost-effective method to reduce the cervical cancer disease burden. Read More

Expert Rev Vaccines 2022 May 9. Epub 2022 May 9.

VA Caribbean Healthcare System, Pulm/CCM, San Juan, Puerto Rico.

Introduction: HPV is the most common sexually transmitted disease in the United States, the principal cause for cervical cancer, and the principal cause for the recent increase in head and neck squamous cell cancers. Current interventions and research goals fail to sufficiently address the need to prevent HPV, and continued stigmatization of HPV as a female disease further discourages young patients from seeking the vaccine.

Areas Covered: This paper will review the epidemiology of HPV, including the rise in male cases and cancers, the immunogenicity of the vaccine, results of efficacy and effectiveness trials, and the social and operational challenges to preventing HPV infection within the United States. Read More

ACS Sens 2022 May 5. Epub 2022 May 5.

Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.

Photoelectrochemical (PEC) biosensors incorporating biomolecular recognition with photon-to-electron conversion capabilities of the photoactive species have been developed for molecular diagnosis, but most involve difficulty in adjusting band gap positions and are unsuitable for PEC biodetection. In this work, an innovative PEC biosensor combined with quantum size-controlled engineering based on quantum confinement by controlling the quantum size was designed for the detection of human papillomavirus-16 (HPV-16) through CRISPR-Cas12a (Cpf1)-induced disassembly of Z-scheme heterojunction. To the best of our knowledge, quantum size-controlled engineering that precisely tunes the properties of photoactive materials is first utilized in the PEC bioanalysis. Read More

Sao Paulo Med J 2022 May-Jun;140(3):349-355

PhD. Gynecology and Obstetrics Specialist, Department of Gynecology and Obstetrics, Private Yüzyıl Hospitals, Pendik, Istanbul.

Background: Cervical cancer is a type of cancer caused by human papillomavirus (HPV).

Objective: To determine the relationship between awareness of cervical cancer and HPV infection and attitudes towards HPV vaccine among women aged 15-49 years.

Design And Setting: Cross-sectional study conducted at Karabük Training and Research Hospital, Turkey. Read More

J Migr Health 2022 8;5:100102. Epub 2022 Apr 8.

Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Woolloongabba Queensland 4102, Australia.

Cervical cancer commonly caused by Human Papillomavirus (HPV) imposes a significant burden in Asia. This study examined the awareness and knowledge of HPV, cervical cancer, and its early detection methods among South Asian immigrant women in Australia to determine factors associated with knowledge deficits. A cross-sectional internet-based survey was completed by a convenience sample of women (n=148), with South-Asian background, residing in Queensland during May-October 2019. Read More

J Community Health 2022 Apr 27. Epub 2022 Apr 27.

Medical Education Department, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey.

The awareness of Human Papillomavirus (HPV), the most common sexually transmitted disease in the world, and the frequency of vaccination vary across countries. In Turkey, the rate of HPV vaccination is quite low even amongin women, and there is not much data on the frequency of vaccination among men. This study aimedto investigate the difference in knowledge and attitude between Turkish women who had HPV vaccination and those who did not. Read More

J Cancer Educ 2022 Apr 23. Epub 2022 Apr 23.

University of Virginia, School of Nursing, Charlottesville, VA, USA.

HPV vaccination series completion rates have increased steadily in the USA, yet specific areas continue to be burdened by HPV-related cancers, including rural areas of Virginia. The primary purpose of this study is to compare the impact of an community driven educational film about HPV on intention to vaccinate and knowledge gained in urban and rural areas of Virginia. From October 2016 to September 2019, the CDC-approved documentary "Someone You Love: The HPV Epidemic" was screened and followed by a Q&A session. Read More

J Cancer Educ 2022 Apr 22. Epub 2022 Apr 22.

Department of Public Health Sciences, Henry Ford Health System, One Ford Place, Detroit, MI, 48202, USA.

We describe the level of awareness of the link between HPV and HPV-associated cancers and identify demographic and lifestyle factors associated with awareness. This was a cross-sectional study of college students (n = 862) at a public Midwestern university conducted between February and May 2021. The outcomes were student's awareness-accessed by asking students if they knew whether HPV was causally link with anal, cervical, vaginal, oropharyngeal, vulvar, and penile cancers. Read More

J Clin Med 2022 Apr 8;11(8). Epub 2022 Apr 8.

Department of Obstetrics and Gynecology, Rīga Stradiņš University, LV-1007 Riga, Latvia.

Objective: To compile existing knowledge on the level of cervical regeneration (detected by ultrasound) after loop electrosurgical excision procedure (LEEP) and to suggest research protocol for further studies.

Methods: We conducted a literature search of Medline, Web of Science, Scopus, and Cochrane databases using the keywords "cervix" and "regeneration" without year restrictions. Our eligibility criteria included studies that analysed cervical volume and length regeneration using ultrasound. Read More

Vaccines (Basel) 2022 Apr 6;10(4). Epub 2022 Apr 6.

Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, 1001 Shadow Lane, Las Vegas, NV 89106, USA.

This study was a retrospective analysis of previously collected anonymous survey data regarding vaccine awareness, beliefs, and knowledge among dental (DMD) students and postgraduate (PG) residents. The protocol for this study was approved by the Institutional Review Board (IRB) as exempt. A total of 341 responses were collected from n = 293 DMD students and n = 48 PG residents. Read More

Vaccines (Basel) 2022 Apr 5;10(4). Epub 2022 Apr 5.

Pharmaceutical Care Research Group, School of Pharmacy, University College Cork, T12 K8AF Cork, Ireland.

The aim of this study was to design, develop, and evaluate the feasibility of a theory- and evidence-based intervention to improve human papillomavirus (HPV) and HPV vaccine knowledge and intention to vaccinate, among parent-daughter dyads. A theory- and evidence-based online behavioral intervention, "", was developed to improve HPV and HPV vaccine knowledge and intention to vaccinate. Knowledge, intention to vaccinate, and feasibility of the intervention were evaluated in a prospective, randomized, controlled feasibility trial. Read More

Diagnostics (Basel) 2022 Mar 29;12(4). Epub 2022 Mar 29.

Department of Gynecological Endocrinology and Gynecology, Jagiellonian University Medical College, 31-501 Krakow, Poland.

Human papillomavirus (HPV) infection is the most common sexually transmitted infection (STI) in the United States, and persistent HPV infection has been established as playing a major role in the development of cervical cancer. Providing HPV vaccination and regular screening tests have reduced the risk of developing cervical cancer or helped to detect the cancer at an early stage. Despite the above measures, cervical cancer still remains a major public health problem worldwide. Read More

BMC Womens Health 2022 Apr 21;22(1):126. Epub 2022 Apr 21.

Department of Health Sciences, Faculty of Health and Applied Sciences, Namibia University of Science and Technology, Private Bag 13388, Windhoek, 9000, Namibia.

Background: Cervical cancer is one of the leading malignancies globally and has taken third place in Namibia amongst women aged 15-44 years. Infection with the Human Immunodeficiency Virus (HIV) has been proven to increase women's susceptibility to developing cervical carcinoma. Sadly, Namibia carries a twin burden of HIV and cervical cancer. Read More

Hum Vaccin Immunother 2022 Apr 21. Epub 2022 Apr 21.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing Office for Cancer Prevention and Control, Peking University Cancer Hospital & Institute, Beijing, China.

Background: This study was conducted to characterize the long-term effect of mobile-based education on Chinese female freshmen and disclose the possible predictors of their willingness to get vaccinated based on the information-motivation-behavioral skills (IMB) model.

Methods: We randomly assigned 509 participants to a 7-day mobile-based educational intervention or control group and collected information about general information, health, and sexual behavior, HPV vaccination intention and action, HPV-related knowledge, cognition, and behavioral skill by an online self-administrated questionnaire at baseline, post-intervention, and at the 1-month and 3-month follow-ups.

Results: The intervention arm showed an improvement in IMB scores after education. Read More

Am J Health Promot 2022 Apr 20:8901171221091438. Epub 2022 Apr 20.

Department of Preventive Medicine, 12223University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

: This study examined factors associated with healthcare providers' (HCPs') recommendation of HPV vaccination for younger and older adolescents. : This is a cross-sectional study, using web-based survey of HCPs in New Jersey in 2018. The study outcome was a dichotomous measure of HCPs' recommendation of the HPV vaccine. Read More

PLoS One 2022 19;17(4):e0267167. Epub 2022 Apr 19.

Department of Orofacial Sciences, University of California San Francisco School of Dentistry, San Francisco, California, United States of America.

Background: Human Papillomavirus associated oropharyngeal cancers have been on the rise in the past three decades. Dentists are uniquely positioned to discuss vaccination programs with their patients. The goal of this project was to assess the readiness of dentists in the state of Indiana in being able to administer vaccines. Read More

Radiother Oncol 2022 Apr 13;171:91-100. Epub 2022 Apr 13.

German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), Partner Site Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Germany.

Purpose: The aim of this study was to develop and validate a novel gene signature from full-transcriptome data using machine-learning approaches to predict loco-regional control (LRC) of patients with human papilloma virus (HPV)-negative locally advanced head and neck squamous cell carcinoma (HNSCC), who received postoperative radio(chemo)therapy (PORT-C).

Materials And Methods: Gene expression analysis was performed using Affymetrix GeneChip Human Transcriptome Array 2.0 on a multicentre retrospective training cohort of 128 patients and an independent validation cohort of 114 patients from the German Cancer Consortium - Radiation Oncology Group (DKTK-ROG). Read More

J Infect Dis 2022 Apr 16. Epub 2022 Apr 16.

Division of Cancer Epidemiology, Department of Oncology, McGill University, 5100 Boulevard de Maisonneuve West, Suite 720, Quebec H4A 3T2, Montreal, Quebec, Canada.

Background: Previous studies examining the association between male circumcision (MC) and human papillomavirus (HPV) infections have reported inconsistent results. We used data from the HITCH cohort study to examine the association between MC and HPV infections in males and their female sexual partners.

Methods: We enrolled monogamous couples in a longitudinal study between 2005 and 2011 in Montreal, Canada. Read More

Cancer Inform 2022 8;21:11769351221084808. Epub 2022 Apr 8.

Departments of Public health, College of Medicine and Health Science in Dire Dawa University, Dire Dawa, Eastern Ethiopia.

Introduction: Cervical cancer is preventable and, in most cases, curable if identified at an early stage. Cervical cancer is the second leading cause of cancer-related mortality Ethiopia with screening accounting for only 0.8%. Read More

Oncol Lett 2022 May 28;23(5):164. Epub 2022 Mar 28.

Department of Otorhinolaryngology, Head and Neck Surgery, University Clinic Schleswig-Holstein, D-24105 Kiel, Germany.

Previous retrospective studies have elucidated a correlation between secretory leucocyte protease inhibitor (SLPI) and Annexin A2 (AnxA2), patient smoking status and tonsillar human papilloma virus (HPV) status. The current study assessed these parameters prospectively and to the best of our knowledge, analyzed SLPI-/AnxA2-expression for the first time in tonsillar swabs and sputum. Samples were obtained from 52 patients with tonsillar squamous cell carcinoma and 163 patients with tonsillar hyperplasia (H; n=56) and chronic or recurrent tonsillitis (CRT; n=107). Read More

Int J Environ Res Public Health 2022 04 1;19(7). Epub 2022 Apr 1.

Department of Virological Pathology, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.

Background: Cervical cancer is mainly caused by human papillomavirus (HPV). Worldwide, knowledge of HPV and cervical cancer among women is reported to be inadequate. The study aimed to assess the knowledge and awareness of HPV and cervical cancer among women attending gynecology clinics at a tertiary hospital in Pretoria, South Africa. Read More

Cells 2022 03 29;11(7). Epub 2022 Mar 29.

Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.

Cervical cancer is one of the leading causes of death in gynecology cancer worldwide. High-risk human papillomaviruses (HPVs) are the major etiological agents for cervical cancer. Still, other factors also contribute to cervical cancer development because these cancers commonly arise decades after initial exposure to HPV. Read More