22,452 results match your criteria knowledge facilitate


Longitudinal Large-Scale Semiquantitative Proteomic Data Stability Across Multiple Instrument Platforms.

J Proteome Res 2021 Oct 20. Epub 2021 Oct 20.

Division of Oncology, Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States.

With the rapid developments in mass spectrometry (MS)-based proteomics methods, label-free semiquantitative proteomics has become an increasingly popular tool for profiling global protein abundances in an unbiased manner. However, the reproducibility of these data across time and LC-MS platforms is not well characterized. Here, we evaluate the performance of three LC-MS platforms (Orbitrap Elite, Q Exactive HF, and Orbitrap Fusion) in label-free semiquantitative analysis of cell surface proteins over a six-year period. Read More

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October 2021

Windows of opportunity: ocean warming shapes temperature-sensitive epigenetic reprogramming and gene expression across gametogenesis and embryogenesis in marine stickleback.

Glob Chang Biol 2021 Oct 20. Epub 2021 Oct 20.

Coastal Ecology Section, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Wadden Sea Station, Sylt, Germany.

Rapid climate change is placing many marine species at risk of local extinction. Recent studies show that epigenetic mechanisms (e.g. Read More

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October 2021

Effects of and Response to Mechanical Loading on the Knee.

Sports Med 2021 Oct 20. Epub 2021 Oct 20.

Department of Physical Therapy, Arcadia University, Glenside, PA, USA.

Mechanical loading to the knee joint results in a differential response based on the local capacity of the tissues (ligament, tendon, meniscus, cartilage, and bone) and how those tissues subsequently adapt to that load at the molecular and cellular level. Participation in cutting, pivoting, and jumping sports predisposes the knee to the risk of injury. In this narrative review, we describe different mechanisms of loading that can result in excessive loads to the knee, leading to ligamentous, musculotendinous, meniscal, and chondral injuries or maladaptations. Read More

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October 2021

Outcomes of Team-Centered, Occupational Adaptation-Based Versus Traditional Dementia Workforce Training : Résultats comparés d'une formation axée sur l'équipe et l'adaptation occupationnelle et de l'approche de formation traditionnelle pour le personnel travaillant auprès des personnes atteintes de démence.

Can J Occup Ther 2021 Oct 20:84174211048017. Epub 2021 Oct 20.

Dementia workforce training aligned with Occupational Adaptation (OA) theory may facilitate teams resolving challenges in the care environment more than traditional skills-based (SB) training, although comparisons are needed. This pilot study compared effectiveness of an OA and SB program on relative mastery and team development for dementia care teams at a continuing care retirement community. In a quasi-experimental study, employees underwent nine sessions in an OA or SB program. Read More

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October 2021

Teaching Ultrasound at the Point of Care in Times of Social Distancing.

ATS Sch 2021 Sep 8;2(3):341-352. Epub 2021 Sep 8.

Department of Medicine and.

Point-of-care ultrasound has become an integral aspect of critical care training. The Bedside Assessment by Sonography In Critical Care Medicine Curriculum was established at the University of Toronto to train critical care trainees in basic echocardiography and general critical care ultrasound. During the coronavirus disease (COVID-19) pandemic, our program needed to adapt quickly to ensure staff safety and adherence to infection-control protocols. Read More

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September 2021

Coronavirus disease 2019 morbid pulmonary pathology: What did we learn from autopsy examinations?

J Clin Transl Res 2021 Aug 4;7(4):479-484. Epub 2021 Aug 4.

Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS, Foundation Trust, Eagelstone, Milton Keynes, Buckinghamshire, UK.

Background: Despite the rapidly expanding data on clinical, epidemiological and radiological aspects of coronavirus disease 2019 (COVID-19), little is known about the disease's pathological aspects. The scarcity of pathological data on COVID-19 can be explained by the limited autopsy procedures performed on deceased patients.

Aim: This work aims to review and summarize the pulmonary pathological findings observed in COIVD-19 deceased individuals based on recent case series reports published in English up to September 2020. Read More

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A learning health systems approach to integrating electronic patient-reported outcomes across the health care organization.

Learn Health Syst 2021 Oct 1;5(4):e10263. Epub 2021 Mar 1.

Surgical Outcomes Research Center, Department of Surgery University of Washington Seattle Washington USA.

Introduction: Foundational to a learning health system (LHS) is the presence of a data infrastructure that can support continuous learning and improve patient outcomes. To advance their capacity to drive patient-centered care, health systems are increasingly looking to expand the electronic capture of patient data, such as electronic patient-reported outcome (ePRO) measures. Yet ePROs bring unique considerations around workflow, measurement, and technology that health systems may not be poised to navigate. Read More

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October 2021

Barriers and requirements in the off-line emergency medical protocols implementation in Iranian Pre-hospital system: A qualitative study.

J Educ Health Promot 2021 31;10:312. Epub 2021 Aug 31.

Department of Neurobiology, Care Sciences and Society (NVS), H1, Division of Family Medicine and Primary Care, Huddinge, Sweden.

Background: To avoid making decisions based on the unproven opinions of emergency medical technicians (EMTs), many emergency medical service (EMS) systems rely on emergency medical protocols. As protocol-based on-scene decision-making is influenced by many challenges, identifying these challenges can result in providing appropriate conditions for EMTs' decision-making. Therefore, this study aimed to identify the barriers and requirements in the off-line emergency medical protocols implementation m in the prehospital emergency medical system. Read More

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Finding common (research) ground between general practitioners and neuroscientists: the vital role of knowledge circulation in closing the evidence-to-practice gap.

BMC Fam Pract 2021 Oct 20;22(1):211. Epub 2021 Oct 20.

Faculty of Medicine, Otto-von-Guericke-University Magdeburg, Institute of General Practice, Leipziger Straße 44, 39120, Magdeburg, Germany.

Background: It may take 15 years or longer before research evidence is integrated into clinical practice. This evidence-to-practice gap has deleterious effects on patients as well as research and clinical processes. Bringing clinical knowledge into the research process, however, has the potential to close the evidence-to-practice gap. Read More

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October 2021

Early initiation of breastfeeding and factors associated with its delay among mothers at discharge from a single hospital.

Clin Exp Pediatr 2021 Oct 18. Epub 2021 Oct 18.

Department of Community Medicine, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, India.

Background: According to the National Family Health Survey - 4, in India, 78.9% of deliveries occur in institutions, although only 42.6% of new mothers initiate breastfeeding within one hour of delivery. Read More

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October 2021

Renal nurses' experiences of patients with severe mental health conditions receiving acute haemodialysis: A qualitative study.

J Ren Care 2021 Oct 19. Epub 2021 Oct 19.

School of Health and Social Care, Buckinghamshire New University Uxbridge, Uxbridge, UK.

Background: Patients receiving acute haemodialysis treatment and living with severe mental illness may display behaviours that are perceived as challenging and stressful for renal nurses to manage in the acute haemodialysis unit. Renal nurses are historically trained on the technical aspects of acute haemodialysis and can provide a level of psychological support to patients. However, they have not been trained to manage patients with severe mental illness. Read More

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October 2021

He is the Same as Me Key Populations' Acceptability and Experience of a Community-Based Peer Navigator Intervention to Support Engagement in HIV Care in Tijuana, Mexico.

AIDS Patient Care STDS 2021 Oct 19. Epub 2021 Oct 19.

Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA.

Engagement in the HIV care continuum among people living with HIV is essential to prevent ongoing transmission. Although there is evidence for the need for comprehensive approaches (e.g. Read More

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October 2021

[Construction methods of urban ecological corridor for birds: A review].

Ying Yong Sheng Tai Xue Bao 2021 Aug;32(8):3010-3022

Zhuhai Institute of Urban Planning and Design, Government Planning and Urban Development Research Center, Zhuhai 519099, Guangdong, China.

The ecological corridors considering bird movement characteristics and habitat requirements would mitigate species extinction caused by habitat loss or habitat fragmentation and facilitate species gene dispersal and exchange. These functions may in turn benefit urban residents' physical and mental health as well as appreciation of real estates. Nonetheless, main ecological corridor construction methods developed by foreign scholars have not internally considered the movement and habitat characteristics of birds, while corridor research for birds by domestic scholars have focused on explorations of foreign technical methods yet lacked enough knowledge on studied birds' characteristics. Read More

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Disclosure of salicylic acid and jasmonic acid-responsive genes provides a molecular tool for deciphering stress responses in soybean.

Sci Rep 2021 Oct 18;11(1):20600. Epub 2021 Oct 18.

Plant Biochemistry & Molecular Biology Unit, Department of Plant Physiology, RWTH Aachen University, 52074, Aachen, Germany.

Hormones orchestrate the physiology of organisms. Measuring the activity of defense hormone-responsive genes can help understanding immune signaling and facilitate breeding for plant health. However, different from model species like Arabidopsis, genes that respond to defense hormones salicylic acid (SA) and jasmonic acid (JA) have not been disclosed in the soybean crop. Read More

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October 2021

Mnemonic prediction errors promote detailed memories.

Learn Mem 2021 Nov 18;28(11):422-434. Epub 2021 Oct 18.

Department of Psychology, Columbia University, New York, New York 10027, USA.

When our experience violates our predictions, it is adaptive to update our knowledge to promote a more accurate representation of the world and facilitate future predictions. Theoretical models propose that these mnemonic prediction errors should be encoded into a distinct memory trace to prevent interference with previous, conflicting memories. We investigated this proposal by repeatedly exposing participants to pairs of sequentially presented objects (A → B), thus evoking expectations. Read More

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November 2021

Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection.

Pharmacol Rev 2021 Oct;73(4):33-97

Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering (S.K.P., V.L.D., T.M.D.), Departments of Neurology (S.K.P., L.S.R., V.L.D., T.M.D.), Departments of Physiology (V.L.D.), Solomon H. Snyder Department of Neuroscience (V.L.D., T.M.D.), Department of Pharmacology and Molecular Sciences (T.M.D.), Johns Hopkins University School of Medicine, Baltimore, Maryland; Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana (S.K.P., V.L.D., T.M.D.); and Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana (S.K.P., V.L.D., T.M.D.)

Parkinson disease (PD) used to be considered a nongenetic condition. However, the identification of several autosomal dominant and recessive mutations linked to monogenic PD has changed this view. Clinically manifest PD is then thought to occur through a complex interplay between genetic mutations, many of which have incomplete penetrance, and environmental factors, both neuroprotective and increasing susceptibility, which variably interact to reach a threshold over which PD becomes clinically manifested. Read More

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October 2021

The global burden and trends of maternal sepsis and other maternal infections in 204 countries and territories from 1990 to 2019.

BMC Infect Dis 2021 Oct 18;21(1):1074. Epub 2021 Oct 18.

Department of Obstetrics and Gynecology, Wuhan No.1 Hospital, Wuhan, China.

Background: Maternal sepsis and other maternal infections (MSMI) have considerable impacts on women's and neonatal health, but data on the global burden and trends of MSMI are limited. Comprehensive knowledge of the burden and trend patterns of MSMI is important to allocate resources, facilitate the establishment of tailored prevention strategies and implement effective clinical treatment measures.

Methods: Based on data from the Global Burden of Disease database, we analysed the global burden of MSMI by the incidence, death, disability-adjusted life year (DALY) and maternal mortality ratio (MMR) in the last 30 years. Read More

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October 2021

AdmixSim 2: a forward-time simulator for modeling complex population admixture.

BMC Bioinformatics 2021 Oct 18;22(1):506. Epub 2021 Oct 18.

Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

Background: Computer simulations have been widely applied in population genetics and evolutionary studies. A great deal of effort has been made over the past two decades in developing simulation tools. However, there are not many simulation tools suitable for studying population admixture. Read More

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October 2021

Occupational therapy's contributions to combating climate change and lifestyle diseases.

Scand J Occup Ther 2021 Oct 18:1-8. Epub 2021 Oct 18.

School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Canada.

Background: The interdependence between human occupations, lifestyle diseases and climate change provides an opportunity to address them simultaneously. Occupational therapists' training in lifestyle modification and knowledge about the impact of the physical environment on daily occupations puts them in a unique position to contribute to global efforts of combating climate change and lifestyle diseases through the promotion of sustainable occupations.

Aim: To illustrate how occupational therapists can contribute to global efforts of combating climate change and lifestyle diseases by framing climate change from a personal and public health perspective. Read More

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October 2021

The Multiple Sclerosis Treatment Optimization Program.

Ann Clin Transl Neurol 2021 Oct 18. Epub 2021 Oct 18.

Department of Clinical Science, Bernard J. Tyson School of Medicine, Pasadena, California, USA.

Objective: To design and implement a health system level intervention to reduce escalating multiple sclerosis (MS) disease modifying treatment (DMT) expenditures and improve outcomes.

Methods: We conducted stakeholder meetings, reviewed pharmacy utilization data, and abstracted information in subsets of persons with MS (pwMS) from the electronic health record to identify gaps in, and barriers to improving, quality, and affordability of MS care in Kaiser Permanente Southern California. These results informed the development and implementation of the MS Treatment Optimization Program (MSTOP). Read More

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October 2021

"Black ring-shaped burn" in button battery ingestion is not a burn - Comparison with charring using spectral CT.

Br J Radiol 2021 Oct 18:20210271. Epub 2021 Oct 18.

Section of Legal Medicine, Department of Social Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Objectives: To compare "black ring-shaped burn" (BRSB) and charring using spectral computed tomography (CT).

Methods: Spectral CT was performed using chicken pectoralis minor muscle, processed in three ways and unprocessed as a control: a) BRSB generated by bringing the negative pole surface of a 3 V button battery (BB) into contact with the muscle; b) BRSB caused by a 1.5 V BB; c) charring caused by broiling; and d) control. Read More

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October 2021

Assessment of knowledge, attitudes, and practices regarding travel health among (King Abdulaziz) international airport travelers in Jeddah, Kingdom of Saudi Arabia 2019.

J Family Med Prim Care 2021 Aug 27;10(8):3013-3020. Epub 2021 Aug 27.

Family Medicine, Trainer at the Joint Program of Family Medicine, Jazan City, Kingdom of Saudi Arabia.

Background: Travelers to different countries have endemic/pandemic diseases can increase the risk of exposure to various infectious agents and can facilitate their spread across borders.

Objectives: To determine the levels of travel health knowledge, attitudes and practices among travelers at international airports of KSA.

Methods: An observational cross-sectional study was conducted starting from 30 September, 2019 at the departure halls of King Abdulaziz International airport (KAIA). Read More

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Using Assessment for Learning: Multi-Case Studies of Three Chinese University English as a Foreign Language (EFL) Teachers Engaging Students in Learning and Assessment.

Front Psychol 2021 30;12:725132. Epub 2021 Sep 30.

Higher Education Development Centre, The University of Otago, Dunedin, New Zealand.

Student engagement is an important issue in learning and teaching given its positive effects on students' learning outcomes. Assessment for Learning (AfL), an assessment and pedagogic innovation, if done well, can fully engage students in the learning and assessment process. Adopting a multi-case design, the present study explored how Chinese university English as a Foreign Language (EFL) teachers used AfL to facilitate student engagement in their classrooms and what factors influenced their AfL practices. Read More

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September 2021

Creativity in Motion: Examining the Creative Potential System and Enriched Movement Activities as a Way to Ignite It.

Front Psychol 2021 30;12:690710. Epub 2021 Sep 30.

School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, QLD, Australia.

In a global and highly competitive world, the importance of creativity is increasing as it supports adaptability, health, and actualization. Yet, because most research focuses on what it takes to produce creative artifacts, interventions supporting growth in creative potential remains underexplored. To address this limitation, the first goal of this paper is to review the creativity science literature to identify the elements that underpin the realization of an individual's creative potential. Read More

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September 2021

Simulation-based multi-criteria decision making: an interactive method with a case study on infectious disease epidemics.

Ann Oper Res 2021 Oct 12:1-30. Epub 2021 Oct 12.

Institute of Operations Research, Discrete Optimization and Logistics, Karlsruhe Institute of Technology, Kaiserstr. 12, 76131 Karlsruhe, Germany.

Whenever a system needs to be operated by a central decision making authority in the presence of two or more conflicting goals, methods from multi-criteria decision making can help to resolve the trade-offs between these goals. In this work, we devise an interactive simulation-based methodology for planning and deciding in complex dynamic systems subject to multiple objectives and parameter uncertainty. The outline intermittently employs simulation models and global sensitivity analysis methods in order to facilitate the acquisition of system-related knowledge throughout the iterations. Read More

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October 2021

Assessment of minority language skills in English-Irish-speaking bilingual children: A survey of SLT perspectives and current practices.

Int J Lang Commun Disord 2021 Oct 18. Epub 2021 Oct 18.

School of Health Science, Ulster University, Newtownabbey, Northern Ireland.

Background: An increasing number of children in the UK and Ireland are growing up speaking more than one language. The many advantages of bilingualism are acknowledged; however, this increased linguistic diversity presents particular challenges for speech and language therapists (SLTs). The case is often more complex with speakers of minority languages such as Welsh and Irish, which are acquired almost exclusively in bilingual contexts. Read More

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October 2021

PaísDI: Feasibility and effectiveness of an advocacy program for adults with intellectual disability and their stakeholders' groups in Chile.

J Appl Res Intellect Disabil 2021 Oct 17. Epub 2021 Oct 17.

Millennium Institute for Caregiving Research, Santiago, Chile.

Background: People with intellectual disability in Chile face individual and collective barriers to social participation. Lack of knowledge about their rights and tools for effective self-advocacy seem to be key elements that need to be improved to facilitate participation.

Method: We present PaísDI, a 16 h long manualised program created by self-advocates in collaboration with an interdisciplinary team, with four modules: rights and intellectual disability, leadership in intellectual disability, effective communication and financial considerations of social projects. Read More

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October 2021

A new classification system for autism based on machine learning of artificial intelligence.

Technol Health Care 2021 Sep 28. Epub 2021 Sep 28.

IT Programme, Auckland Institute of Studies, Auckland, New Zealand.

Background: Autistic Spectrum Disorder (ASD) is a neurodevelopment condition that is normally linked with substantial healthcare costs. Typical ASD screening techniques are time consuming, so the early detection of ASD could reduce such costs and help limit the development of the condition.

Objective: We propose an automated approach to detect autistic traits that replaces the scoring function used in current ASD screening with a more intelligent and less subjective approach. Read More

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September 2021

How to facilitate guideline use? A bottom-up qualitative approach developing a training programme for professionals involved in work participation of people with a chronic disease.

Work 2021 Oct 12. Epub 2021 Oct 12.

Amsterdam UMC, University of Amsterdam, Coronel Institute of Occupational Health, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Background: A guideline for occupational health professionals (OHPs) is developed which provides them with knowledge and skills to optimize their guidance to people with a chronic disease.

Objective: Developing a training programme to acquire and apply knowledge and skills provided by the guideline, through a bottom-up approach.

Methods: First, OHPs training needs were explored using focus groups. Read More

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October 2021

Automated assessment and classification of spine, hip, and knee pathologies from sit-to-stand movements collected in clinical practice.

J Biomech 2021 Oct 8;128:110786. Epub 2021 Oct 8.

Department of Physical Therapy and Rehabilitation Science, University of California at San Francisco, San Francisco, 94158, CA, USA. Electronic address:

Efficient, cost-effective methods for quantifying patient biomechanics at the point of care can facilitate faster and more accurate diagnoses. This work presents a new method to diagnose pre-surgical back, hip, and knee patients by analysing their sit-to-stand motion captured by a Kinect camera. Kinematic and dynamic time-series features were extracted from patient movements collected in clinic. Read More

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October 2021