14,624 results match your criteria knowledge documented

A snapshot of the immunogenicity, efficacy and safety of a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors: a longitudinal cohort study.

ESMO Open 2021 Sep 1;6(5):100272. Epub 2021 Sep 1.

Molecular Virology Unit, Department of Microbiology and Virology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: Very few cancer patients were enrolled in coronavirus disease-2019 vaccine studies. In order to address this gap of knowledge, real-world studies are mandatory. The aim of this study was to assess both humoral and cellular response after a messenger RNA vaccination schedule. Read More

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September 2021

Barriers to Effective Diabetes Mellitus Self-Management (DMSM) Practice for Glycemic Uncontrolled Type 2 Diabetes Mellitus (T2DM): A Socio Cultural Context of Indonesian Communities in West Sulawesi.

Eur J Investig Health Psychol Educ 2019 Nov 26;10(1):250-261. Epub 2019 Nov 26.

Department of Family Health, Faculty of Public Health, Mahidol University, Bangkok 10400, Thailand.

Diabetes mellitus self-management (DMSM) is an essential strategy used to maintain blood glucose levels and to prevent severe complications. Several barriers have been documented while implementing DMSM practices. A qualitative study aimed to explore barriers to effective DMSM practice among uncontrolled glycemic type 2 diabetes mellitus (T2DM) patients in Indonesia. Read More

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November 2019

Skeletal Muscle and Childhood Cancer: Where are we now and where we go from here.

Aging Cancer 2021 Jun 20;2(1-2):13-35. Epub 2021 May 20.

Epidemiology and Cancer Control Department, St. Jude Children's Research Hospital, Memphis, TN, USA.

Skeletal muscle (muscle) is essential for physical health and for metabolic integrity, with sarcopenia (progressive muscle mass loss and weakness), a pre-curser of aging and chronic disease. Loss of lean mass and muscle quality (force generation per unit of muscle) in the general population are associated with fatigue, weakness, and slowed walking speed, eventually interfering with the ability to maintain physical independence, and impacting participation in social roles and quality of life. Muscle mass and strength impairments are also documented during childhood cancer treatment, which often persist into adult survivorship, and contribute to an aging phenotype in this vulnerable population. Read More

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Scoping Review on the Impact of Outbreaks on Sexual and Reproductive Health Services: Proposed Frameworks for Pre-, Intra-, and Postoutbreak Situations.

Biomed Res Int 2021 8;2021:9989478. Epub 2021 Sep 8.

UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland.

Introduction: Recent experiences from global outbreaks have highlighted the severe disruptions in sexual and reproductive health services that expose women and girls to preventable health risks. Yet, to date, there is no review studying the possible impact of outbreaks on sexual and reproductive health (SRH). . Read More

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September 2021

Using the World Apheresis Association Registry Helps to Improve the Treatment Quality of Therapeutic Apheresis.

Transfus Med Hemother 2021 Aug 5;48(4):234-239. Epub 2021 Jan 5.

Department of Nephrology, University Hospital, Huddinge, Sweden.

Therapeutic apheresis (TA) is prescribed to patients that suffer from a severe progressive disease that is not sufficiently treated by conventional medications. A way to gain more knowledge about this treatment is usually by the local analysis of data. However, the use of large quality assessment registries enables analyses of even rare findings. Read More

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Validation of metacognitive academic writing strategies and the predictive effects on academic writing performance in a foreign language context.

Metacogn Learn 2021 Sep 14:1-24. Epub 2021 Sep 14.

Faculty of Education, University of Macau, Macau, China.

This empirical study serves two purposes. The first purpose is to validate a newly developed instrument, the Metacognitive Academic Writing Strategies Questionnaire (MAWSQ), which represents the multifaceted structure of metacognition in an English as a Foreign Language (EFL) academic writing setting. The second purpose is to delineate the predictive effects of different metacognitive strategies on EFL academic writing performance. Read More

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September 2021

Systemic lupus erythematosus and critical illness polyneuropathy.

Reumatologia 2021 26;59(4):265-269. Epub 2021 Aug 26.

Rehabilitation Clinic, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Systemic lupus erythematosus (SLE) is a chronic disease of connective tissue with multi-organ involvement. Manifestation in the nervous system is one of the most difficult symptoms to assess and interpret. The aim of the study is to indicate diagnostic problems in patients with SLE in whom neurological symptoms are present at the time of diagnosis of SLE but also with complications that occurred after diagnosis. Read More

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First report of interspecific transmission of sarcoptic mange from Iberian ibex to wild boar.

Parasit Vectors 2021 Sep 19;14(1):481. Epub 2021 Sep 19.

Espacio Natural de Sierra Nevada and Wildlife Ecology & Health Group (WE&H), Pinos Genil, Granada, Spain.

Background: Sarcoptic mange is a globally distributed parasitic disease caused by the burrowing mite Sarcoptes scabiei. This mite has a certain degree of host specificity, although interspecific transmission can occur among phylogenetically related species or through prey-predator mediated exposure. In 2018, a wild boar (Sus scrofa) with lesions compatible with sarcoptic mange was hunted in Ports de Tortosa i Beseit Natural Park (PTB, north-eastern Spain), where an active epizootic outbreak of sarcoptic mange is affecting Iberian ibexes (Capra pyrenaica) since 2014. Read More

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September 2021

[Knowledge, beliefs, and attitudes about obesity and overweight in a sample of dietitians-nutritionists in Spain].

Nutr Hosp 2021 Sep 20. Epub 2021 Sep 20.

Departamento de Psicología Clínica, Psicobiología y Metodología. Facultad de Psicología y Logopedia. Universidad de La Laguna.

Introduction: overweight and obesity make up one of the greatest public health challenges worldwide. Dietitians-nutritionists promote the acquisition of healthy habits to adjust weight. There are interesting contributions by psychology to be considered. Read More

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September 2021

Three years of surveillance associates agro-environmental factors with wireworm infestations in Manitoba, Canada.

Pest Manag Sci 2021 Sep 18. Epub 2021 Sep 18.

Department of Biology, Brandon University, Brandon, MB, R78 6A9, Canada.

Background: Wireworms, the soil-dwelling larvae of click beetles, are a major threat to global agricultural production. This is largely due to their generalist polyphagous feeding capabilities, extended and cryptic life cycles, and limited management options available. Although wireworms are well-documented as economically important pests in the Canadian Prairies, including Manitoba, there are gaps in knowledge on species distributions, subterranean behaviour and life cycles, feeding ecology and damage capacity, and economic thresholds for crop yield loss. Read More

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September 2021

Soil degradation in the European Mediterranean region: Processes, status and consequences.

Sci Total Environ 2021 Sep 4;805:150106. Epub 2021 Sep 4.

Department of Physical Geography and Bolin Centre for Climate Research, Stockholm University, SE-106 91 Stockholm, Sweden; Navarino Environmental Observatory, Costa Navarino, Navarino Dunes Messinia 24001, Greece; Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden.

Soil, a non-renewable resource, sustains life on Earth by supporting around 95% of global food production and providing ecosystem services such as biomass production, filtration of contaminants and transfer of mass and energy between spheres. Unsustainable management practices and climate change are threatening the natural capital of soils, particularly in the Mediterranean region, where increasing population, rapid land-use changes, associated socio-economic activities and climate change are imposing high pressures on the region's shallow soils. Despite evidence of high soil susceptibility to degradation and desertification, the true extent of soil degradation in the region is unknown. Read More

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September 2021

Postresuscitation care and prognostication.

Curr Opin Crit Care 2021 Sep 15. Epub 2021 Sep 15.

Warwick Clinical Trials Unit, University of Warwick Royal United Hospital, Bath, UK Center for Resuscitation Science, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Most patients who are successfully resuscitated after cardiac arrest are initially comatose and require mechanical ventilation and other organ support in an ICU. Knowledge about the optimal strategy for treating these patients is evolving rapidly. This review will summarize the evidence on key aspects of postarrest care and prognostication, with a focus on actionable parameters that may impact patient survival and neurologic outcomes. Read More

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September 2021

PROLIDASE: A Review from Discovery to its Role in Health and Disease.

Front Mol Biosci 2021 31;8:723003. Epub 2021 Aug 31.

Center for AIDS Health Disparities Research, Nashville, TN, United States.

Prolidase (peptidase D), encoded by the gene, is a ubiquitously expressed cytosolic metalloproteinase, the only enzyme capable of cleaving imidodipeptides containing C-terminal proline or hydroxyproline. Prolidase catalyzes the rate-limiting step during collagen recycling and is essential in protein metabolism, collagen turnover, and matrix remodeling. Prolidase, therefore plays a crucial role in several physiological processes such as wound healing, inflammation, angiogenesis, cell proliferation, and carcinogenesis. Read More

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Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding.

Pharmacol Ther 2021 Sep 13:107974. Epub 2021 Sep 13.

Dept. of OBGYN and Reproductive Sciences, University of California San Diego, La Jolla, CA 92093, United States of America. Electronic address:

Kisspeptin (encoded by the Kiss1 gene) and its receptor, KISS1R (encoded by the Kiss1r gene), have well-established roles in stimulating reproduction via central actions on reproductive neural circuits, but recent evidence suggests that kisspeptin signaling also influences metabolism and energy balance. Indeed, both Kiss1 and Kiss1r are expressed in many metabolically-relevant peripheral tissues, including both white and brown adipose tissue, the liver, and the pancreas, suggesting possible actions on these tissues or involvement in their physiology. In addition, there may be central actions of kisspeptin signaling, or factors co-released from kisspeptin neurons, that modulate metabolic, feeding, or thermoregulatory processes. Read More

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September 2021

Ocean warming threatens key trophic interactions supporting a commercial fishery in a climate change hotspot.

Glob Chang Biol 2021 Sep 16. Epub 2021 Sep 16.

Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Victoria, Australia.

Worldwide, rising ocean temperatures are causing declines and range shifts in marine species. The direct effects of climate change on the biology of marine organisms are often well documented, yet knowledge on the indirect effects, particularly through trophic interactions, is largely lacking. We provide evidence of ocean warming decoupling critical trophic interactions supporting a commercially important mollusc in a climate change hotspot. Read More

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September 2021

Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence.

Patient Prefer Adherence 2021 9;15:1991-2007. Epub 2021 Sep 9.

Medical Outcomes Specialists (EAM, LLM, CJP); Patient Centered Outcome Assessment (LSD); Biostatistics (JCC), Pfizer Inc., New York, NY, USA.

Purpose: The purpose of this research was to conceptualize and develop a tool for identifying persons who are, or are likely to be, non-adherent to medications prescribed by their healthcare provider(s) by identifying concerns that patients have regarding their treatments.

Patients And Methods: The target populations were persons diagnosed with atrial fibrillation or osteoarthritis, who were prescribed anticoagulants or over-the-counter or prescription pain medications, respectively. In this two-stage, multi-year, qualitative research study, relevant concepts were explored, confirmed and refined. Read More

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September 2021

Performance of peripheral catheters inserted with ultrasound guidance versus landmark technique after a simulation-based mastery learning intervention.

J Vasc Access 2021 Sep 15:11297298211044363. Epub 2021 Sep 15.

Feinberg School of Medicine, Departments of Medicine and Medical Education, Northwestern University, Chicago, IL, USA.

Problem: Ultrasound-guided peripheral intravenous catheter (USGPIV) insertion is an effective method to gain vascular access in patients with difficult intravenous access (DIVA). While USGPIV success rates are reported to be high, some studies have reported a concerning incidence of USGPIV premature failures.

Aims: The purpose of this study was to compare differences in USGPIV and landmark peripheral intravenous catheter (PIV) utilization and failure following a hospital-wide USGPIV training program for nurses. Read More

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September 2021

Ecological implications beyond the ecotoxicity of plastic debris on marine phytoplankton assemblage structure and functioning.

Environ Pollut 2021 Sep 3;290:118101. Epub 2021 Sep 3.

Department of Biomolecular Sciences, University of Urbino, Campus E. Mattei, 61121, Urbino, Italy; CoNISMa, National Inter-University Consortium for Marine Sciences, 00196, Rome, Italy; Fano Marine Center, The Inter-Institute Center for Research on Marine Biodiversity, Resources and Biotechnologies, 61032, Fano, Italy.

Plastic pollution is a global issue posing a threat to marine biota with ecological implications on ecosystem functioning. Micro and nanoplastic impact on phytoplankton autotrophic species (e.g. Read More

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September 2021

Caribbean Women's Health and Transnational Ethnobotany.

Econ Bot 2021 Sep 10:1-22. Epub 2021 Sep 10.

The New York Botanical Garden, Institute of Economic Botany, 2900 Southern Boulevard, Bronx, NY 10458 USA.

Immigrants from the Dominican Republic (DR) and Haiti are among the top foreign-born communities in New York City (NYC). As people migrate to new countries, they bring their ethnomedical beliefs and practices, and adapt their plant pharmacopoeias. Haiti and the DR share a flora on the island of Hispaniola. Read More

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September 2021

The use of teledentistry in facilitating oral health for older adults: A scoping review.

J Am Dent Assoc 2021 Sep 11. Epub 2021 Sep 11.

Background: Teledentistry is used in many countries to provide oral health care services. However, using teledentistry to provide oral health care services for older adults is not well documented. This knowledge gap needs to be addressed, especially when accessing a dental clinic is not possible and teledentistry might be the only way for many older adults to receive oral health care services. Read More

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September 2021

The role of follicular anti-Mullerian hormone in women undergoing IVF/ICSI with regard to size, oocyte presence, sociodemographic parameters, treatment variables, and other hormones and vitamins.

Gynecol Endocrinol 2021 Sep 14:1-6. Epub 2021 Sep 14.

Department Gynecology Endocrinology and Reproductive Medicine, University Hospital Giessen and Marburg, Marburg, Germany.

Aims: The aim of this study was to evaluate the relationship between follicular anti-Mullerian hormone (fAMH) regarding follicle size, the presence of an oocyte, sociodemographic parameters, and other hormones and vitamins in follicular fluid.

Materials And Methods: This prospective exploratory cohort study included 376 follicles from 61 women undergoing IVF/ICSI cycles. The size of each follicle was measured individually, and they were divided into a large and a small group according to their size. Read More

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September 2021

Advancing Our Understanding of the Risk Factors Associated with Crossover Youth in the Child Welfare and Juvenile Justice Systems: A Trauma-Informed Research Agenda.

Clin Child Fam Psychol Rev 2021 Sep 13. Epub 2021 Sep 13.

Department of Psychology, University of Utah, Salt Lake City, UT, 84112, USA.

Previous research has provided robust evidence demonstrating that a notable proportion of youth become involved in both the child welfare (CW) system and the juvenile justice (JJ) system, a population often referred to as crossover youth. Prior work has identified a number of risk factors associated with crossing over between these systems. However, there are limitations to the extant literature, key among which is a lack of systematic attention to the influence of trauma exposure and posttraumatic sequelae on the crossover trajectory. Read More

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September 2021

Traditional medicinal knowledge and practices among the tribal communities of Thakht-e-Sulaiman Hills, Pakistan.

BMC Complement Med Ther 2021 Sep 13;21(1):230. Epub 2021 Sep 13.

Institute of Systematic and Evolutionary Botany, University of Zurich, Zurich, Switzerland.

Background: Little is known about the medical material and practices of tribes in the western border areas of Pakistan. The local population has inhabited this remote and isolated area for centuries, and gained medicinal knowledge with personal experiences and knowledge learned from forefathers. Due to the geographical isolation of the communities in the Sulaiman hills of Pakistan and their unique culture, the area is of importance for exploration and assessment. Read More

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September 2021

Thymoma originating from the cervical component of the thymus in a degu.

J Vet Diagn Invest 2021 Sep 13:10406387211045643. Epub 2021 Sep 13.

Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa, Japan.

A 5-y-old, male degu () was presented with a subcutaneous mass in the ventral aspect of the cervical area. The mass was removed surgically. Histologically, the mass was a densely cellular, expansile neoplasm, with compression of thymic tissue to the periphery. Read More

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September 2021

Southeast and East Asian immigrant women's transnational postpartum experiences: A meta-ethnography.

Timothea Vo

J Clin Nurs 2021 Sep 12. Epub 2021 Sep 12.

School of Nursing, University of Connecticut, Storrs, Connecticut, USA.

The increase in births to Southeast and East Asian (SEEA) immigrants in their adopted countries is of international importance. SEEA women experience the postpartum period differently than that of the general population. Despite the documented difference, there is limited representation of SEEA women in the literature. Read More

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September 2021

CADA: phenotype-driven gene prioritization based on a case-enriched knowledge graph.

NAR Genom Bioinform 2021 Sep 3;3(3):lqab078. Epub 2021 Sep 3.

Fraunhofer SCAI, Department of Bioinformatics, 53757 Sankt Augustin, Germany.

Many rare syndromes can be well described and delineated from other disorders by a combination of characteristic symptoms. These phenotypic features are best documented with terms of the Human Phenotype Ontology (HPO), which are increasingly used in electronic health records (EHRs), too. Many algorithms that perform HPO-based gene prioritization have also been developed; however, the performance of many such tools suffers from an over-representation of atypical cases in the medical literature. Read More

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September 2021

Goyal-Naqvi Syndrome (Concurrent Trisomy 10p and Terminal 14q Deletion): A Review of the Literature.

Cureus 2021 Jul 26;13(7):e16652. Epub 2021 Jul 26.

Community Physiotherapy, Mahatma Gandhi Mission School of Physiotherapy, Aurangabad, IND.

Goyal-Naqvi syndrome (GNS) is a newly documented clinical entity that comprises trisomy 10p and terminal 14q deletion, though trisomy 10p and terminal 14q deletion have been discovered as distinct conditions in 1974 and 1997, respectively. Nevertheless, to date, the total number of reported cases of each of these conditions is estimated to be in double digits. Both manifest as a constellation of features like craniofacial dysmorphism, hypotonia, intellectual impairment and global developmental delay. Read More

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Risk management in occupational safety: A systematic mapping.

Work 2021 Sep 4. Epub 2021 Sep 4.

Federal University of Paraná -Advanced Campus in Jandaia do Sul, Brazil.

Background: Occupational safety risk management is a systemic process capable of promoting technical engineering solutions, considering a wide range of predictable, unexpected and subjective factors related to accident occurrences. In Brazil, the behavior of managers in relation to risk management tends to be reactive, and facilitates access to information for crucial practical and academic purposes when it comes to changing the attitude of managers, so that their actions become increasingly more proactive.

Objective: To identify, classify, analyze, and discuss the existing literature related to the topic, produced from 2008 to 2020, besides contributing to a broader understanding of risk management in occupational safety. Read More

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September 2021

Targeting lymphangiogenesis and lymph node metastasis in liver cancer.

Am J Pathol 2021 Sep 9. Epub 2021 Sep 9.

Department of Medical Physiology, College of Medicine, Texas A&M University Health Science Center, Bryan TX, USA. Electronic address:

Increased lymphangiogenesis and lymph node metastasis are important prognostic indicators of aggressive hepatobiliary malignancies such as hepatocellular cancer and cholangiocarcinoma, and associated with poor patient outcome. The liver produces 25-50% of total lymphatic fluid in the body and has a dense network of lymphatic vessels. The lymphatic system has been shown to play critical roles in fluid homeostasis and inflammation and immune response. Read More

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September 2021

A scoping review of the determinants of foetal alcohol spectrum disorder in South Africa: an intersectional perspective.

Health Policy Plan 2021 Sep 11. Epub 2021 Sep 11.

School of Public Health, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, Cape Town, Republic of South Africa.

Foetal alcohol spectrum disorder (FASD) affects babies born to mothers who consume alcohol while pregnant. South Africa has the highest prevalence of FASD in the world. We review the social determinants underpinning FASD in South Africa and add critical insight from an intersectional feminist perspective. Read More

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September 2021