34,527 results match your criteria knowledge chemical


Assessment of per- and polyfluoroalkyl substances in Biscayne Bay surface waters and tap waters from South Florida.

Sci Total Environ 2021 Sep 17;806(Pt 1):150393. Epub 2021 Sep 17.

Institute of Environment, Florida International University, 11200 SW 8th Street, Modesto A. Maidique Campus, Miami, FL 33199, USA; Department of Chemistry and Biochemistry, Florida International University, 3000 NE 151st street, Biscayne Bay Campus, North Miami, FL 33181, USA. Electronic address:

Per- and polyfluoroalkyl substances (PFAS) are persistent anthropogenic pollutants present in many environmental media worldwide due to their extensive uses in many industrial and commercial products combined with their high thermal and chemical stabilities. Its ubiquitous presence in surface and drinking water supply and significant adverse health effects observed in wildlife and humans, associated with its bioaccumulation potential, pose big concerns. In this study, we have developed and validated a semi-automated solid phase extraction (SPE) followed by liquid chromatography-mass spectrometry (LC-MS/MS) for the determination of legacy and emerging short-chain PFAS substitutes in surface and tap water at low parts-per-trillion (ppt) levels in South Florida environments. Read More

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September 2021

Development and validation of multiple machine learning algorithms for the classification of G-protein-coupled receptors using molecular evolution model-based feature extraction strategy.

Amino Acids 2021 Sep 25. Epub 2021 Sep 25.

School of Information Engineering, Zhejiang Ocean University, Zhoushan, China.

Machine learning is one of the most potential ways to realize the function prediction of the incremental large-scale G-protein-coupled receptors (GPCR). Prior research reveals that the key to determining the overall classification accuracy of GPCR is extracting valuable features and filtering out redundancy. To achieve a more efficient classification model, we put the feature synonym problem into consideration and create a new method based on functional word clustering and integration. Read More

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September 2021

Abiotic stress responses in plants.

Nat Rev Genet 2021 Sep 24. Epub 2021 Sep 24.

Shanghai Center for Plant Stress Biology, Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.

Plants cannot move, so they must endure abiotic stresses such as drought, salinity and extreme temperatures. These stressors greatly limit the distribution of plants, alter their growth and development, and reduce crop productivity. Recent progress in our understanding of the molecular mechanisms underlying the responses of plants to abiotic stresses emphasizes their multilevel nature; multiple processes are involved, including sensing, signalling, transcription, transcript processing, translation and post-translational protein modifications. Read More

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September 2021

Coffee Leaves: An Upcoming Novel Food?

Planta Med 2021 Sep 24. Epub 2021 Sep 24.

RD3 Department-Unit of Pharmacognosy, Bioanalysis and Drug Discovery, Faculty of Pharmacy, Université libre de Bruxelles, Brussels, Belgium.

Unlike those of coffee beans, the healthy properties of coffee leaves have been overlooked for a long time, even if they are consumed as a beverage by local communities of several African countries. Due to the presence of xanthines, diterpenes, xanthones, and several other polyphenol derivatives as main secondary metabolites, coffee leaves might be useful to prevent many daily disorders. At the same time, as for all bioactive molecules, careless use of coffee leaf infusions may be unsafe due to their adverse effects, such as the excessive stimulant effects on the central nervous system or their interactions with other concomitantly administered drugs. Read More

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September 2021

Structural and functional characterization of a novel biosurfactant from Bacillus sp. IITD106.

J Hazard Mater 2021 Sep 15;423(Pt B):127201. Epub 2021 Sep 15.

Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi 110016, India. Electronic address:

Plant saponins are attractive biosurfactants and have been used to enhance phytoremediation. There are only limited reports on saponins produced by bacteria. Here, we report structural and functional characterization of a novel saponin produced by Bacillus sp. Read More

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September 2021

Connecting research and teaching introductory cell and molecular biology using an Arabidopsis mutant screen.

Biochem Mol Biol Educ 2021 Sep 24. Epub 2021 Sep 24.

MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, Michigan, USA.

A complex research project was translated into a Course-based Undergraduate Research Experience (CURE), which was implemented in sections of an introductory Cell and Molecular Biology laboratory course. The research laboratory generated an engineered plant line producing a growth-inhibiting, lipid-derived plant hormone and mutagenized this line. Students in the CURE cultured the mutagenized plant population and selected and characterized suppressor mutants. Read More

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September 2021

Investigation of Raman Spectroscopic Signatures with Multivariate Statistics: An Approach for Cataloguing Microbial Biosignatures.

Astrobiology 2021 Sep 23. Epub 2021 Sep 23.

Center for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.

Spectroscopic instruments are increasingly being implemented in the search for extraterrestrial life. However, microstructural spectral analyses of alien environments could prove difficult without knowledge on the molecular identification of individual spectral signatures. To bridge this gap, we introduce unsupervised -means clustering as a statistical approach to discern spectral patterns of biosignatures without prior knowledge of spectral regions of biomolecules. Read More

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September 2021

Temperature affects growth, geosmin/2-methylisoborneol production, and gene expression in two cyanobacterial species.

Environ Sci Pollut Res Int 2021 Sep 23. Epub 2021 Sep 23.

Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, Japan.

Cyanobacterial blooms accompanied by taste and odor (T&O) compounds affect the recreational function and safe use of drinking water. Geosmin and 2-methylisoborneol (2-MIB) are the most common T&O compounds. In this study, we investigated the effect of temperature on geosmin and 2-MIB production in Dolichospermum smithii and Pseudanabaena foetida var. Read More

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September 2021

Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies.

Braz J Microbiol 2021 Sep 23. Epub 2021 Sep 23.

Department of Molecular Biology and Biotechnology, Tezpur University (A Central University), Napaam, Tezpur, 784028, Assam, India.

The assembly of microorganisms over a surface and their ability to develop resistance against available antibiotics are major concerns of interest. To survive against harsh environmental conditions including known antibiotics, the microorganisms form a unique structure, referred to as biofilm. The mechanism of biofilm formation is triggered and regulated by quorum sensing, hostile environmental conditions, nutrient availability, hydrodynamic conditions, cell-to-cell communication, signaling cascades, and secondary messengers. Read More

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September 2021

Adsorption and desorption mechanisms on graphene oxide nanosheets: Kinetics and tuning.

Innovation (N Y) 2021 Aug 18;2(3):100137. Epub 2021 Jun 18.

Center for Advanced Analytical Science, c/o School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China.

A knowledge of the adsorption and desorption behavior of sorbates on surface adsorptive site (SAS) is the key to optimizing the chemical reactivity of catalysts. However, direct identification of the chemical reactivity of SASs is still a challenge due to the limitations of characterization techniques. Here, we present a new pathway to determine the kinetics of adsorption/desorption on SASs of graphene oxide (GO) based on total internal reflectance fluorescence microscopy. Read More

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Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach.

Front Physiol 2021 7;12:733009. Epub 2021 Sep 7.

Department of Biomedical Engineering, Erasmus Medical Center, Rotterdam, Netherlands.

Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of atherosclerotic coronaries remains to be scarce. Read More

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September 2021

Systematic analysis of chemical-protein interactions from zebrafish embryo by proteome-wide thermal shift assay, bridging the gap between molecular interactions and toxicity pathways.

J Proteomics 2021 Sep 20:104382. Epub 2021 Sep 20.

Department of Biomedical and Clinical Sciences, Department of Cell Biology, Faculty of Medicine, Linköping University, Linköping, Sweden; Ikerbasque, Basque Foundation for Sciences, Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Spain. Electronic address:

The molecular interaction between chemicals and proteins often promotes alteration of cellular function. One of the challenges of the toxicology is to predict the impact of exposure to chemicals. Assessing the impact of exposure implies to understand their mechanism of actions starting from identification of specific protein targets of the interaction. Read More

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September 2021

Characteristics and genome analysis of a novel bacteriophage IME1323_01, the first temperate bacteriophage induced from Staphylococcus caprae.

Virus Res 2021 Sep 20:198569. Epub 2021 Sep 20.

College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:

Temperate phages play an important role in the evolution of bacteria. So far, lytic phages have been wildly reported, but there is still limited knowledge regarding temperate phages in the genome of pathogenic Staphylococcus caprae. Here we present the characteristics and genome analysis of a novel bacteriophage IME1323_01, which is the first isolated bacteriophage of S. Read More

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September 2021

Biological treatment of coke plant effluents: from a microbiological perspective.

Biol Futur 2020 Dec 20;71(4):359-370. Epub 2020 Aug 20.

Department of Microbiology, ELTE Eötvös Loránd University, Pázmány Péter stny. 1/c., Budapest, 1117, Hungary.

During coke production, large volume of effluent is generated, which has a very complex chemical composition and contains several toxic and carcinogenic substances, mainly aromatic compounds, cyanide, thiocyanate and ammonium. The composition of these high-strength effluents is very diverse and depends on the quality of coals used and the operating and technological parameters of coke ovens. In general, after initial physicochemical treatment, biological purification steps are applied in activated sludge bioreactors. Read More

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December 2020

Microbial communities of soda lakes and pans in the Carpathian Basin: a review.

Authors:
Tamás Felföldi

Biol Futur 2020 Dec 31;71(4):393-404. Epub 2020 Jul 31.

Department of Microbiology, Institute of Biology, ELTE Eötvös Loránd University, Pázmány Péter stny. 1/c., Budapest, 1117, Hungary.

In this review, I would like to summarize the current knowledge on the microbiology of soda lakes and pans of the Carpathian Basin. First, the characteristic physical and chemical features of these sites are described. Most of the microbiological information presented deals with prokaryotes and algae, but protists and viruses are also mentioned. Read More

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December 2020

A Systematic Review on Occurrence and Ecotoxicity of Organic UV Filters in Aquatic Organisms.

Rev Environ Contam Toxicol 2021 Sep 24. Epub 2021 Sep 24.

Ecotoxicology Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.

The growing production of cosmetic products such as organic UV filters (OUVFs) in recent years has raised concern regarding their safety to human and environmental health. The inability of wastewater treatment plants in removing these chemical entities and their high octanol-water partition coefficient values tend to result in the persistence of OUVFs in several environmental matrices, leading these to be categorized as "emerging environmental contaminants" because of their unknown risk. Besides aquatic ecosystem contamination, the application of sludge disposal equally threatens terrestrial biota. Read More

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September 2021

Seasonal characterization of municipal solid waste for selecting feasible waste treatment technology for Guwahati city, India.

J Air Waste Manag Assoc 2021 Sep 23. Epub 2021 Sep 23.

Department of Civil Engineering, Indian Institute of Technology Kharagpur, West Bengal, India.

As quantities and composition of municipal solid waste (MSW) vary significantly with seasons, a seasonal characterization study is critical for developing an efficient MSW management system. MSW was characterized in three different seasons for selecting an appropriate waste treatment and management strategy for Guwahati city. Results of the study shows that the major components of the MSW were organics (42. Read More

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September 2021

Photolysis of the nonsteroidal anti-inflammatory drug sulindac: elucidation of kinetic behaviour and photodegradation pathways in water.

Environ Sci Process Impacts 2021 Sep 23;23(9):1405-1417. Epub 2021 Sep 23.

Centro de Investigación y de Servicios Químicos y Microbiológicos (CEQIATEC), School of Chemistry, Instituto Tecnológico de Costa Rica, Cartago 159-7050, Costa Rica.

Non-steroidal anti-inflammatory drugs are recognized widely as emerging contaminants. Sulindac has received additional attention as a prodrug in cancer treatment and because of its detection in drinking water and wastewaters. Nevertheless, there is limited knowledge about its kinetic behaviour and fate in the aquatic environment. Read More

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September 2021

Neonatal burns: a 10-year review of community- and hospital-acquired neonatal burns in Western Australia.

ANZ J Surg 2021 Sep 22. Epub 2021 Sep 22.

Total Care Burns Unit, Perth Children's Hospital, Nedlands, Western Australia, Australia.

Background: There are very few studies in the literature focusing on neonatal burns, and to our knowledge this is the largest study on this topic.

Methods: A retrospective review was conducted over a 10-year period from 2010 to 2020 to investigate the incidence, mechanisms involved and outcomes for burn injuries in neonates in Western Australia. This study included children aged 4 weeks or younger who sustained a burns injury requiring admission to hospital or during their hospital admission. Read More

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September 2021

Core curriculum in pathology for future Irish medical students.

Ir J Med Sci 2021 Sep 23. Epub 2021 Sep 23.

Department of Chemical Pathology, St James's Hospital, D08 NHY1, Dublin, Ireland.

Pathology is important in training to become a medical doctor but as curricula become more integrated, there is a risk that key aspects of pathology may be excluded. Following a survey of the current delivery of teaching in Ireland under the auspices of the Faculty of Pathology at the Royal College of Physicians of Ireland, suggested components of a core curriculum in pathology have been developed to be delivered at some stage during the medical course. These have been based on key principles and themes required by the Medical Council in Ireland. Read More

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September 2021

A scalable workflow to characterize the human exposome.

Nat Commun 2021 Sep 22;12(1):5575. Epub 2021 Sep 22.

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University, Atlanta, GA, USA.

Complementing the genome with an understanding of the human exposome is an important challenge for contemporary science and technology. Tens of thousands of chemicals are used in commerce, yet cost for targeted environmental chemical analysis limits surveillance to a few hundred known hazards. To overcome limitations which prevent scaling to thousands of chemicals, we develop a single-step express liquid extraction and gas chromatography high-resolution mass spectrometry analysis to operationalize the human exposome. Read More

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September 2021

Rhizobacteria impact colonization of on roots.

Appl Environ Microbiol 2021 Sep 22:AEM0141121. Epub 2021 Sep 22.

Program in Systems Biology, University of Massachusetts Medical School, Worcester, MA 01605.

In spite of its relevance as a food-borne pathogen, we have limited knowledge about in the environment. ' outbreaks have been linked to fruits and vegetables; thus, a better understanding of the factors influencing its ability to colonize plants is important. We tested how environmental factors and other soil- and plant-associated bacteria influenced ' ability to colonize plant roots using seedlings in a hydroponic growth system. Read More

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September 2021

Toward Chemotactic Supramolecular Nanoparticles: From Autonomous Surface Motion Following Specific Chemical Gradients to Multivalency-Controlled Disassembly.

ACS Nano 2021 Sep 22. Epub 2021 Sep 22.

Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.

Nature designs chemotactic supramolecular structures that can selectively bind specific groups present on surfaces, autonomously scan them moving along density gradients, and react once a critical concentration is encountered. Since such properties are key in many biological functions, these also offer inspirations for designing artificial systems capable of similar bioinspired autonomous behaviors. One approach is to use soft molecular units that self-assemble in an aqueous solution generating nanoparticles (NPs) that display specific chemical groups on their surface, enabling multivalent interactions with complementarily functionalized surfaces. Read More

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September 2021

Accurate Binding Configuration Prediction of a G-Protein-Coupled Receptor to Its Antagonist Using Multicanonical Molecular Dynamics-Based Dynamic Docking.

J Chem Inf Model 2021 Sep 22. Epub 2021 Sep 22.

Graduate School of Information Science, University of Hyogo, 7-1-28 Minatojima Minami-machi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

We have performed dynamic docking between a prototypic G-protein-coupled receptor (GPCR) system, the β-adrenergic receptor, and its antagonist, alprenolol, using one of the enhanced conformation sampling methods, multicanonical molecular dynamics (McMD), which does not rely on any prior knowledge for the definition of the reaction coordinate. Although we have previously applied our McMD-based dynamic docking protocol to various globular protein systems, its application to GPCR systems would be difficult because of their complicated design, which include a lipid bilayer, and because of the difficulty in sampling the configurational space of a binding site that exists deep inside the GPCR. Our simulations sampled a wide array of ligand-bound and ligand-unbound structures, and we measured 427 binding events during our 48 μs production run. Read More

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September 2021

Advancing urban ethnopharmacology: a modern concept of sustainability, conservation and cross-cultural adaptations of medicinal plant lore in the urban environment.

Conserv Physiol 2021 16;9(1):coab073. Epub 2021 Sep 16.

Ethnopharmacology and Natural Product Research Laboratory, Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, West Bengal, India.

The discipline 'urban ethnopharmacology' emerged as a collection of traditional knowledge, ancient civilizations, history and folklore being circulated since generations, usage of botanical products, palaeobotany and agronomy. Non-traditional botanical knowledge increases the availability of healthcare and other essential products to the underprivileged masses. Intercultural medicine essentially involves 'practices in healthcare that bridge indigenous medicine and western medicine, where both are considered as complementary'. Read More

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September 2021

Predicting scalar coupling constants by graph angle-attention neural network.

Sci Rep 2021 Sep 21;11(1):18686. Epub 2021 Sep 21.

School of Physics and Electronics, Central South University, Changsha, 410083, China.

Scalar coupling constant (SCC), directly measured by nuclear magnetic resonance (NMR) spectroscopy, is a key parameter for molecular structure analysis, and widely used to predict unknown molecular structure. Restricted by the high cost of NMR experiments, it is impossible to measure the SCC of unknown molecules on a large scale. Using density functional theory (DFT) to theoretically calculate the SCC of molecules is incredibly challenging, due to the cost of substantial computational time and space. Read More

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September 2021

Exploration of the structural requirements of Aurora Kinase B inhibitors by a combined QSAR, modelling and molecular simulation approach.

Sci Rep 2021 Sep 21;11(1):18707. Epub 2021 Sep 21.

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Aurora kinase B plays an important role in the cell cycle to orchestrate the mitotic process. The amplification and overexpression of this kinase have been implicated in several human malignancies. Therefore, Aurora kinase B is a potential drug target for anticancer therapies. Read More

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September 2021

Mechanical and microstructural studies in a polysaccharide-acrylate double network hydrogel.

J Mech Behav Biomed Mater 2021 Sep 14;124:104839. Epub 2021 Sep 14.

Polymer Science and Engineering Division, CSIR - National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411 008, India. Electronic address:

Polymeric hydrogels continue to find a wide range of applications. However, a major drawback of hydrogels is the lack of mechanical strength. In this regard, "Double Network Hydrogels" (DN) have shown great promise recently. Read More

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September 2021

Combined chemical exposure using exposure loads on human biomonitoring data of the 4th Flemish Environment and Health Study (FLEHS-4).

Int J Hyg Environ Health 2021 Sep 18;238:113849. Epub 2021 Sep 18.

VITO, Flemish Institute for Technological Research, Unit Health, Boeretang 200, 2400, Mol, Belgium; Department of Biomedical Sciences, University of Antwerp, 2610, Wilrijk, Belgium.

To improve our understanding of internal exposure to multiple chemicals, the concept exposure load (EL) was used on human biomonitoring (HBM) data of the 4th FLEHS (Flemish Environment and Health Study; 2016-2020). The investigated chemicals were per- and polyfluoroalkyl substances (PFASs), bisphenols, phthalates and alternative plasticizers, flame retardants, pesticides, toxic metals, organochlorine compounds and polycyclic aromatic hydrocarbons (PAHs). The EL calculates "the number of chemicals to which individuals are internally exposed above a predefined threshold". Read More

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September 2021

Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes.

PLoS Pathog 2021 Sep 21;17(9):e1009920. Epub 2021 Sep 21.

Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America.

RTX leukotoxins are a diverse family of prokaryotic virulence factors that are secreted by the type 1 secretion system (T1SS) and target leukocytes to subvert host defenses. T1SS substrates all contain a C-terminal RTX domain that mediates recruitment to the T1SS and drives secretion via a Brownian ratchet mechanism. Neutralizing antibodies against the Bordetella pertussis adenylate cyclase toxin, an RTX leukotoxin essential for B. Read More

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September 2021