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First Record of the Sinus Worm Skrjabingylus petrowi (Nematoda: Metastrongyloidea) in a Pine Marten Martes martes from Poland.

Acta Parasitol 2021 May 12. Epub 2021 May 12.

Musée National D'Histoire Naturelle, 2160, Luxembourg, Luxembourg.

Background: Skrjabingylus spp. are nematodes that parasitize in the frontal and nasal sinuses of small mustelids. In Europe, the two species S. Read More

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Evaluation of an active and early surveillance methodology for visceral leishmaniasis by molecular detection in road-killed wild fauna.

Rev Bras Parasitol Vet 2021 10;30(2):e027920. Epub 2021 May 10.

Departamento de Medicina Veterinária Preventiva, Universidade Estadual de Londrina - UEL, Londrina, PR, Brasil.

The present study aimed to evaluate a methodology for active surveillance of visceral leishmaniasis by detecting Leishmania DNA in organs of wild road-killed animals from November 2016 to October 2018 in the North of Paraná, Brazil. The collection points of road-killed wild animals were georeferenced. The animals were autopsied and samples of bone marrow, lymph node, liver, spleen, and ear skin were collected. Read More

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Single-Domain Antibodies for the Detection of SARS-CoV-2 Nucleocapsid Protein.

Anal Chem 2021 May 6. Epub 2021 May 6.

Center for Biomolecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, District of Columbia 20375, United States.

The goal of this work was to develop recombinantly expressed variable domains derived from camelid heavy-chain antibodies known as single-domain antibodies (sdAbs) directed against the SARS-CoV-2 nucleocapsid protein for incorporation into detection assays. To achieve this, a llama was immunized using a recombinant SARS-CoV-2 nucleocapsid protein and an immune phage-display library of variable domains was developed. The sdAbs selected from this library segregated into five distinct sequence families. Read More

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Spatial and Temporal Distribution of Complex Infection in Eurasian Badger () and Cattle in Asturias, Spain.

Animals (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071 León, Spain.

The present work investigated the prevalence, spatial distribution, and temporal distribution of tuberculosis (TB) in free-ranging Eurasian badgers () and cattle in Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a TB reservoir for cattle and other sympatric wild species in the region. Between 2008 and 2020, 673 badgers (98 trapped and 575 killed in road traffic accidents) in Asturias were necropsied, and their tissue samples were cultured for the complex (MTC) isolation. Read More

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Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells).

Bioorg Chem 2021 Apr 7;111:104892. Epub 2021 Apr 7.

Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:

Cervical cancer is one of the important cancers in women. Research on novel treatment approach can reduce the mortality and burden. Although radiotherapy is a common treatment, its negative side effects have concerned physician. Read More

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Novel NIR-II semiconducting molecule incorporating sorafenib for imaging guided synergetic cancer phototherapy and anti-angiogenic therapy.

J Mater Chem B 2021 Apr 1;9(14):3235-3248. Epub 2021 Apr 1.

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, China.

Tumor tissues are not only independent of cancer cells, but also tumor blood vessels. Thus, targeting the tumor blood vessels is as important as targeting the tumor for cancer treatment. Herein, an organic semiconducting molecule named T8IC is developed for the potential phototeranostics in the second near-infrared window (NIR-II, 1000-1700 nm). Read More

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Tubularized urethral reconstruction using everted saphenous vein graft in a beagle model.

BMC Urol 2021 Apr 17;21(1):63. Epub 2021 Apr 17.

Department of Urology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), 2 Zheshan West Road, Wuhu, 241000, Anhui Province, China.

Background: A long segment stricture in the anterior urethra is a challenge in urology. We conducted a study to investigate the efficacy of anterior urethral reconstruction using an everted saphenous vein graft (SVG) in a tubular fashion.

Methods: Twelve male beagles were randomly divided into three groups: experimental group (n = 5), control group (n = 5) and normal group (n = 2). Read More

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Economic burden of childhood diarrhea in Burundi.

Glob Health Res Policy 2021 Apr 12;6(1):13. Epub 2021 Apr 12.

Division of Social and Administrative Pharmacy, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayuthaya Road, Rajathevi, Bangkok, Thailand.

Background: In 2016, diarrhea killed around 7 children aged under 5 years per 1000 live births in Burundi. The objective of this study was to estimate the economic burden associated with diarrhea in Burundi and to examine factors affecting the cost to provide economic evidence useful for the policymaking about clinical management of diarrhea.

Methods: The study was designed as a prospective cost-of-illness study using an incidence-based approach from the societal perspective. Read More

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Coronavirus Pandemic: a major public health crisis for the developed and developing world.

J Infect Dev Ctries 2021 Mar 31;15(3):366-369. Epub 2021 Mar 31.

Department of Microbiology, Harbin Medical University, Harbin, China.

Pandemic of novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in China is now become global public health crisis. At present 87.64% of the world is infected by this deadly illness. Read More

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Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Infection in the First Free Living Wolf ( Linnaeus, 1758) Found Dead in the Friuli Venezia Giulia Region.

Int J Environ Res Public Health 2021 03 3;18(5). Epub 2021 Mar 3.

Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università, 35020 Legnaro, Italy.

Leptospirosis is a worldwide-spread zoonosis causing disease and death in dogs and in humans. A Leptospiral infection has been recorded in several wild carnivore species in Europe, but tissue pathological changes were not commonly described. The Grey wolf () has been expanding its distribution range in north-eastern Italy during the last decade. Read More

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Keeping Safe on Australian Roads: Overview of Key Determinants of Risky Driving, Passenger Injury, and Fatalities for Indigenous Populations.

Int J Environ Res Public Health 2021 03 2;18(5). Epub 2021 Mar 2.

Vice-Chancellor's Division, The University of Newcastle, Callaghan, NSW 2308, Australia.

Social and cultural barriers associated with inequitable access to driver licensing and associated road safety education, as well as socioeconomic issues that preclude ongoing vehicle maintenance and registration, result in unsafe in-car behaviours such as passenger overcrowding. This in turn is associated with improper seatbelt usage, noncompliance with child restraint mandates, and driver distraction. For example, in Australia, where seatbelt use is mandatory, Indigenous road users are three times less likely to wear seatbelts than non-Indigenous road users. Read More

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In vitro potency of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione against drug-resistant and non-replicating persisters of Mycobacterium tuberculosis.

J Glob Antimicrob Resist 2021 Mar 28;25:202-208. Epub 2021 Mar 28.

Clinical Microbiology and PK/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar 190005, Jammu & Kashmir, India; Academy of Scientific and Innovative Research, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi 180001, Jammu & Kashmir, India. Electronic address:

Objectives: New antituberculosis agents active against drug-resistant and non-replicating tubercle bacilli are required. We evaluated a previously identified hit, 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione (PAMCHD), against several clinical Mycobacterium tuberculosis isolates, including multidrug-resistant (MDR) strains and non-replicating drug-tolerant persisters of M. tuberculosis H37Rv. Read More

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Helminthfauna of road-killed cougars (Puma concolor) from the Northeastern Region of São Paulo State, Brazil.

Rev Bras Parasitol Vet 2021 29;30(1):e024120. Epub 2021 Mar 29.

Departamento de Patologia, Reprodução e Saúde Única, Laboratório de Enfermidades Parasitárias dos Animais Domésticos - LabEPar, Faculdade de Ciências Agrárias e Veterinárias - FCAV, Universidade Estadual Paulista - UNESP, Jaboticabal, SP, Brasil.

As the second-largest Neotropical carnivore, cougars (Puma concolor) are especially important for maintenance of the biodiversity and ecosystem health. Five wild adult cougars (Puma concolor), found roadkilled in highways in the Northeastern region of São Paulo, were evaluated in search for parasites. Ten species representing nine families were identified. Read More

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Analysing the main and interaction effects of commercial vehicle mix and roadway attributes on crash rates using a Bayesian random-parameter Tobit model.

Accid Anal Prev 2021 May 24;154:106089. Epub 2021 Mar 24.

School of Civil Engineering and Transportation, South China University of Technology, Guangzhou, Guangdong, 510641, PR China. Electronic address:

In previous research, the effects of commercial vehicle proportions (CVP) on overall crash propensity have been found to be significant, but the results have been varied in terms of the effect direction. In addition, the mediating or moderating effects of roadway attributes on the CVP-vs-safety relationships, have not been investigated. In addressing this gap in the literature, this study integrates databases on crashes, traffic, and inventory for Hong Kong road segments spanning 2014-2017. Read More

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The antitumor capacity of mesothelin-CAR-T cells in targeting solid tumors in mice.

Mol Ther Oncolytics 2021 Mar 24;20:556-568. Epub 2021 Feb 24.

Shanghai Yihao Biological Technology, Co., Ltd., Shanghai 200231, China.

Since the approval of chimeric antigen receptor (CAR) T cell therapy targeting CD19 by the FDA, CAR-T cell therapy has received increasing attention as a new method for targeting tumors. Although CAR-T cell therapy has a good effect against hematological malignancies, it has been less effective against solid tumors. In the present study, we selected mesothelin (MSLN/MESO) as a target for CAR-T cells because it is highly expressed by solid tumors but only expressed at low levels by normal tissues. Read More

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Alcohol and drug use among road users involved in fatal crashes in Norway.

Traffic Inj Prev 2021 16;22(4):267-271. Epub 2021 Mar 16.

Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway.

Objective: To study the prevalence of alcohol and drugs in biological samples from drivers, motorcycle riders, bicyclists, and pedestrians involved in fatal road traffic crashes (RTCs) during 2016-2018 in Norway, both among fatally injured victims and those who survived fatal RTCs.

Methods: Anonymous information was extracted from police data. No personal data were recorded. Read More

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Drug presence in driving deaths in Maryland: Comparing trends and prevalence in medical examiner and FARS data.

Accid Anal Prev 2021 May 11;154:106066. Epub 2021 Mar 11.

Department of Epidemiology, West Virginia University School of Public Health, United States.

Accurate and reliable information on drug use by road users is essential to inform safety policy development but the reliability of national data has been questioned. There are two primary repositories of drug test information from fatal motor vehicle crashes in Maryland: (1) the Fatality Analysis Reporting System (FARS), which is a national crash database managed by the US Department of Transportation, and (2) the Maryland Medical Examiner (ME). In this study, we compared drug test information for people killed in crashes in Maryland between the FARS system and ME from 2006 - 2018. Read More

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Heat-killed Lactobacillus acidophilus mediates Fusobacterium nucleatum induced pro-inflammatory responses in epithelial cells.

FEMS Microbiol Lett 2021 Apr;368(5)

Center of Craniofacial Orthodontics, Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.

Probiotics is widespreadly used nowadays. However, the safety issue with the use of live probiotics is still a matter of contention. In recent years, an expanding body of evidence supports the beneficial role of heat-killed probiotics in the maintenance of systemic health, whereas the role of these heat-killed bacteria on periodontal health remains unclear. Read More

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An analysis on the risk of being injured and killed in road travel injuries in Namibia.

Int J Inj Contr Saf Promot 2021 Mar 8:1-9. Epub 2021 Mar 8.

Research Department of Epidemiology and Public Health, Univeristy College London (UCL), London, UK.

Road traffic injuries (RTIs) are a major, global problem. Few studies on RTIs have been conducted in Namibia, despite having one of the highest RTI rates globally. We conducted multinomial logistic regression on national Namibian datasets on RTIs 2012-2014. Read More

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Efficacy of lotilaner (Credelio™) against experimentally induced infestations of the adult cat flea, Ctenocephalides felis, and flea eggs following oral administration to cats.

Parasit Vectors 2021 Mar 5;14(1):139. Epub 2021 Mar 5.

Elanco Animal Health, Mattenstrasse 24a, 4058, Basel, Switzerland.

Background: Credelio™ (lotilaner; Elanco) is indicated for the treatment of flea and tick infestations on cats at a recommended lotilaner dose rate of 6-24 mg/kg. This study evaluated the efficacy and safety of lotilaner following a single oral administration to cats for the treatment and prevention of adult Ctenocephalides felis fleas and flea egg production under laboratory conditions.

Methods: Two treatment groups of ten cats each were used in this study. Read More

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Evaluating the speed camera sites selection criteria in the UK.

J Safety Res 2021 02 17;76:90-100. Epub 2020 Dec 17.

School of Transportation, Southeast University, China; Jiangsu Key Laboratory of Urban ITS, China; Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies, China.

Introduction: Speed cameras have been implemented to improve road safety over recent decades in the UK. Although the safety impacts of the speed camera have been estimated thoroughly, the criteria for selecting camera sites have rarely been studied. This paper evaluates the current speed camera sites selection criteria in the UK based on safety performance. Read More

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February 2021

Exploring bicyclist injury severity in bicycle-vehicle crashes using latent class clustering analysis and partial proportional odds models.

J Safety Res 2021 02 13;76:101-117. Epub 2020 Dec 13.

USDOT Center for Advanced Multimodal Mobility Solutions and Education (CAMMSE), Department of Civil and Environmental Engineering, University of North Carolina at Charlotte, EPIC Building, Room 3261, 9201 University City Boulevard, Charlotte, NC 28223-0001, United States. Electronic address:

Introduction: Bicyclists are more vulnerable compared to other road users. Therefore, it is critical to investigate the contributing factors to bicyclist injury severity to help provide better biking environment and improve biking safety. According to the data provided by National Highway Traffic Safety Administration (NHTSA), a total of 8,028 bicyclists were killed in bicycle-vehicle crashes from 2007 to 2017. Read More

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February 2021

Novel CD37, Humanized CD37 and Bi-Specific Humanized CD37-CD19 CAR-T Cells Specifically Target Lymphoma.

Cancers (Basel) 2021 Feb 26;13(5). Epub 2021 Feb 26.

Promab Biotechnologies, 2600 Hilltop Drive, Richmond, CA 94806, USA.

CD19 and CD37 proteins are highly expressed in B-cell lymphoma and have been successfully targeted with different monotherapies, including chimeric antigen receptor (CAR)-T cell therapy. The goal of this study was to target lymphoma with novel CD37, humanized CD37, and bi-specific humanized CD37-CD19 CAR-T cells. A novel mouse monoclonal anti-human CD37 antibody (clone 2B8D12F2D4) was generated with high binding affinity for CD37 antigen (KD = 1. Read More

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February 2021

Complete genome sequencing of Peyer's patches-derived Lactobacillus taiwanensis CLG01, a potential probiotic with antibacterial and immunomodulatory activity.

BMC Microbiol 2021 Feb 27;21(1):68. Epub 2021 Feb 27.

Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 107 Wenhuaxi Road, Jinan, 250012, Shandong Province, China.

Background: The genus Lactobacillus is an important component of the gastrointestinal tract of human and animals and commonly considered as probiotic. L. taiwanensis has long been proposed to be a probiotic whereas understanding on this species is still in its infancy. Read More

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February 2021

Differential insecticidal properties of Spodoptera frugiperda multiple nucleopolyhedrovirus isolates against corn-strain and rice-strain fall armyworm, and genomic analysis of three isolates.

J Invertebr Pathol 2021 Feb 25;183:107561. Epub 2021 Feb 25.

Invasive Insect Biocontrol and Behavior Laboratory, Beltsville Agricultural Research Center, USDA Agricultural Research Service, 10300 Baltimore Avenue, Beltsville, MD 20705, USA. Electronic address:

The fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a destructive crop pest native to North, Central, and South America that recently has spread to Africa and Asia. Read More

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February 2021

Parasites in road-killed wild felines from North of Paraná state, Brazil.

Rev Bras Parasitol Vet 2021 12;30(1):e016320. Epub 2021 Feb 12.

Laboratório de Protozoologia, Departamento de Medicina Veterinária Preventiva, Universidade Estadual de Londrina - UEL, Londrina, PR, Brasil.

This study aimed to identify the intestinal parasites of road-killed wild felines in the North Central and North, Paraná state, southern Brazil. The animals were monitored by sampling previously established transects. The places where the felines were run over were mapped, the animals were identified, and the gastrointestinal tract was evaluated. Read More

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February 2021

Helminth infracommunity in a maned wolf, Chrysocyon brachyurus, from the humid Chaco, Argentina.

Parasitol Int 2021 Jun 16;82:102303. Epub 2021 Feb 16.

Estación Biológica Corrientes (EBCo), CCT Nordeste CONICET, Nuestra Señora de Lourdes 1200, 3401 San Cayetano, Corrientes, Argentina.

Parasitism is an important factor in conservation worldwide, especially for endangered species, as it can affect host populations by reducing growth rates, fecundity and affecting nutritional status. The maned wolf Chrysocyon brachyurus, a near-threatened species, is distributed across different habitats from the south Amazonian forest in Brazil to northern Argentina, Paraguay and eastern Bolivia. Most studies on gastrointestinal parasites in wild maned wolves are based on coprological findings, and there is little information about adult parasites and parasite species richness. Read More

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HUNTING PRESSURE MODULATES PRION INFECTION RISK IN MULE DEER HERDS.

J Wildl Dis 2020 10;56(4):781-790

Colorado Division of Parks and Wildlife, 317 W Prospect Road, Fort Collins, Colorado 80526-2097, USA.

The emergence of chronic wasting disease, an infectious prion disease of multiple deer species, has motivated international calls for sustainable, socially accepted control measures. Here, we describe long-term, spatially replicated relationships in Colorado, US, mule deer (Odocoileus hemionus) herds that show hunting pressure can modulate apparent epidemic dynamics as reflected by prevalence trends. Across 12 areas in Colorado studied between 2002-18, those with the largest declines in annual hunting license numbers (pressure) showed the largest increases in the proportion of infected adult (≥2-yr-old) male deer killed by hunters (prevalence); prevalence trends were comparatively flat in most areas where license numbers had been maintained or increased. Read More

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October 2020

Schulz, 1933 (Trichostrongylidae: Haemonchinae) in mountain ecosystems - a potential risk for the Tatra chamois (Blahout, 1971/1972).

Int J Parasitol Parasites Wildl 2021 Apr 2;14:117-120. Epub 2021 Feb 2.

Research Station and Museum of the Tatra National Park, Tatranská Lomnica 66, 059 60, Vysoké Tatry, Slovakia.

The Asian native is now in Europe, and several dozen years after its introduction, it is a widespread parasite of all wild cervids. For bovids, the nematode is a significant threat to the European bison () population and has also been found in mouflon (). Our study aimed to assess the risk of infection for the endemic subspecies of northern (Alpine) chamois () - the Tatra chamois (. Read More

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Prevalence and predictors of posttraumatic stress disorder, depression and anxiety among hospitalized patients with coronavirus disease 2019 in China.

BMC Psychiatry 2021 02 8;21(1):80. Epub 2021 Feb 8.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.

Background: Coronavirus disease 2019 (COVID-19) has affected more than 5 million people around the world and killed more than 300,000 people; thus, it has become a global public health emergency. Our objective was to investigate the mental health of hospitalized patients diagnosed with COVID-19.

Methods: The PTSD checklist for DSM-5 (PCL-5), Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), Trauma Exposure Scale, abbreviated version of the Connor-Davidson Resilience Scale (CD-RISC-10), Perceived Social Support Scale (PSSS) and Demographic Questionnaire were used to examine posttraumatic stress disorder (PTSD), depression, anxiety, trauma exposure, resilience and perceived social support among 898 patients who were hospitalized after being diagnosed with COVID-19 in China. Read More

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February 2021