945,116 results match your criteria kidneys


Finerenone (Kerendia) for chronic kidney disease.

Authors:

Med Lett Drugs Ther 2021 Aug;63(1631):131-132

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Comparison of Outcomes between Percutaneous and Surgical Placement of Peritoneal Dialysis Catheters in Uremic Patients: A Meta-Analysis.

Blood Purif 2021 Sep 20:1-17. Epub 2021 Sep 20.

Division of Nephrology, Kidney Institute of CPLA, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background: The optimal technique for inserting peritoneal dialysis catheters in uremic patients remains debated. This meta-analysis aimed to summarize the current evidence evaluating the efficacy and safety of percutaneous insertion methods compared to surgical methods.

Method: A literature search was performed in the PubMed, EMBASE, Cochrane, and Web of Science databases. Read More

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September 2021

B-mode ultrasound and ecobiometric parameters to assess embryonic and fetal development and estimate gestational age in goats.

Theriogenology 2021 Sep 4;175:123-133. Epub 2021 Sep 4.

Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

The aim of this study was to monitor maternal-fetal ecobiometric parameters during physiological pregnancy in goats using ultrasound to predict gestational age by establishing mathematical equations. Twenty-five Saanen goats were included in the study. Assessments were performed weekly from the 21 day of pregnancy until parturition. Read More

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September 2021

Age-related viral load and severity of systemic pathological lesions in acute naturally occurring African swine fever virus genotype II infections.

Comp Immunol Microbiol Infect Dis 2021 Sep 13;79:101709. Epub 2021 Sep 13.

Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address:

African swine fever (ASF) causes a contagious hemorrhagic disease in all ages of pigs without sex predilections. The objective of this study was to determine the age-related viral loads and severity of systemic pathological lesions among three different swine group ages (weaned pigs, fattening pigs, and sows) during a recent outbreak of acute ASF in Vietnam. Age-related viral loads were determined in 5 major organs (lung, liver, spleen, kidney, and lymph node) by immunohistochemistry as well as in the blood by real-time polymerase chain reaction (PCR). Read More

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September 2021

Hypoparathyroidism, neutropenia and nephrotic syndrome in a patient with mitochondrial trifunctional protein deficiency: A case report and review of the literature.

Eur J Med Genet 2021 Sep 17:104344. Epub 2021 Sep 17.

Department of Neurology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400014, China; Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China. Electronic address:

Introduction: Mitochondrial trifunctional protein (TFP) deficiency is an autosomal recessive disorder that causes a clinical spectrum of diseases ranging from severe infantile cardiomyopathy to mild chronic progressive neuromyopathy, however, parathyroid glands, hematologic system and kidney damage are not the common presentations of this disease.

Methods: We describe the clinical, biochemical and molecular features of the TFP deficiency patient at our institution. We also provide an extensive literature review of previous published cases with emphasis on the clinical/biochemical phenotype-genotype correlation of this disorder. Read More

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September 2021

Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA.

Rationale And Objective: The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in those with and without CKD.

Study Design: Neuroimaging substudy of a randomized trial. Read More

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September 2021

CKD Progression From the Time of Estimated GFR-Based Waitlist Eligibility and Racial Disparities in Transplant Access.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, University of California, San Francisco, San Francisco, CA; Department of Medicine, Priscilla Chan and Mark Zuckerberg San Francisco General Hospital, San Francisco, CA; Center for Vulnerable Populations, University of California, San Francisco, San Francisco, CA.

Rationale & Objective: eGFR equations that incorporate a term for race assign a higher value to Black individuals compared to non-Black individuals not attributable to sex, age, or serum creatinine. This difference may contribute to racial disparities in kidney transplant access. We sought to 1) compare time from meeting a transplant eligibility threshold of eGFR ≤20 ml/min/1. Read More

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September 2021

Alpinone: A positive regulator molecule of immune antiviral response in Atlantic salmon kidney cells.

Dev Comp Immunol 2021 Sep 17:104262. Epub 2021 Sep 17.

Natural Product Chemistry Laboratory, Aquatic Biotechnology Center, Chemistry and Biology Faculty, Environmental Sciences Department, University of Santiago of Chile, Av. Bernardo O'Higgins, 3363, Santiago, Chile. Electronic address:

Alpinone is a flavonoid obtained from the resinous exudate of Heliotropium huascoense. This flavonoid shows antiviral activity against the infectious salmon anemia virus (ISAV), which causes severe disease in farmed Atlantic salmon. Here, we aim to elucidate mechanisms underlying the antiviral effects of the flavonoid. Read More

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September 2021

THE BLEEDING RISK TREATMENT PARADOX AT THE PHYSICIAN 1 AND HOSPITAL LEVEL: IMPLICATIONS FOR REDUCING BLEEDING IN PATIENTS UNDERGOING PCI.

Am Heart J 2021 Sep 17. Epub 2021 Sep 17.

The Duke Clinical Research Institute, Durham, NC.

Background: Bleeding is a common and costly complication of percutaneous coronary intervention (PCI). Bleeding avoidance strategies (BAS) are used paradoxically less in patients at high-risk of bleeding: "bleeding risk-treatment paradox" (RTP). We determined whether hospitals and physicians, who do not align BAS to PCI patients' bleeding risk (i. Read More

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September 2021

Association between oral health, pneumonia and mortality in patients of intensive care.

Rev Med Inst Mex Seguro Soc 2020 ;58(4):468-476

Fundación Universitaria Autónoma de las Américas, Facultad de Odontología. Pereira, Risaralda, Colombia.

IntroducciÓn: Los pacientes con ventilación mecánica corren riesgo de adquirir neumonía cuando la higiene bucodental es deficiente, a causa de la colonización bacteriana del tracto respiratorio. Se sugiere verificar esta asociación para implementar acciones de prevención.

Objetivo: Identificar la asociación entre el estado de salud bucal, la neumonía asociada a ventilador y la mortalidad en pacientes con ventilación mecánica en un hospital de tercer nivel de Pereira, Colombia. Read More

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January 2020

Vitamin D in systemic lupus erythematosus with and without lupus nephritis.

Rev Med Inst Mex Seguro Soc 2020 ;58(4):394-399

Laboratorios Clínicos de Puebla, Sucursal Anzures, Dirección de Proyectos Especiales. Puebla, Puebla, México.

IntroducciÓn: Las concentraciones séricas subóptimas de vitamina D se presentan en múltiples enfermedades crónicas, como las enfermedades autoinmunitarias. Los objetivos del estudio fueron: 1) comparar las concentraciones séricas de 25-hidroxivitamina D (25OHD3) en pacientes con lupus eritematoso sistémico (LES) con y sin nefritis lúpica (NL), y 2) evaluar la asociación de las concentraciones séricas de 25OHD3 con la actividad de la enfermedad.

Material Y MÉtodos: Estudio comparativo, transversal, que incluyó 48 mujeres con LES, con y sin NL. Read More

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January 2020

On normalizing of urinary KIM-1 level to urine creatinine in patients with renal cell cancer.

Klin Lab Diagn 2021 Sep;66(9):517-524

Federal State Budgetary Institution "National Medical Research Radiological Centre", Ministry of Health of the Russian Federation.

KIM-1 (kidney injury molecule 1), a marker of acute kidney injury, is produced by epithelial cells of renal proximal tubules. Elevated KIM-1 levels in urine and plasma are associated with renal cell carcinoma (RCC). The aim of this study was to compare the significance of non-normalized uKIM-1 values and those normalized to urine creatinine, as urinary biomarkers in RCC. Read More

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September 2021

Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis.

J Pathol 2021 Sep 20. Epub 2021 Sep 20.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China.

Upstream stimuli for myofibroblast activation are of considerable interest for understanding the mechanisms underlying renal fibrosis. Activin B, a member of the TGF-β family, exists as a homodimer of Inhibin Subunit Beta B (INHBB), but its role in renal fibrosis remains unknown. We found that INHBB expression was significantly increased in various renal fibrosis models and human chronic kidney disease specimens with renal fibrosis. Read More

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September 2021

Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD.

J Clin Endocrinol Metab 2021 Sep 20. Epub 2021 Sep 20.

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.

Context: The effect of daily vitamin D supplementation on the serum concentration of vitamin D (the parent compound) may offer insight into vitamin D disposition.

Objective: To assess the total serum vitamin D response to vitamin D3 supplementation and whether it varies according to participant characteristics. To compare results with corresponding results for total serum 25-hydroxyvitamin D (25(OH)D), which is used clinically and measured in supplementation trials. Read More

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September 2021

Latent tuberculosis infection and kidney transplantation.

J Bras Nefrol 2021 Sep 20. Epub 2021 Sep 20.

Pontifícia Universidade Católica do Paraná, Faculdade de Medicina, Laboratório de Doenças Infecciosas Emergentes, Curitiba, PR, Brasil.

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September 2021

Predicting COVID-19 progression from diagnosis to recovery or death linking primary care and hospital records in Castilla y León (Spain).

PLoS One 2021 20;16(9):e0257613. Epub 2021 Sep 20.

Department of Statistics and Operations Research, Universidad de Valladolid, Valladolid, Spain.

This paper analyses COVID-19 patients' dynamics during the first wave in the region of Castilla y León (Spain) with around 2.4 million inhabitants using multi-state competing risk survival models. From the date registered as the start of the clinical process, it is assumed that a patient can progress through three intermediate states until reaching an absorbing state of recovery or death. Read More

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September 2021

Factors associated with severe sepsis in diarrheal adults and their outcome at an urban hospital, Bangladesh: A retrospective analysis.

PLoS One 2021 20;16(9):e0257596. Epub 2021 Sep 20.

Nutrition and Clinical Services Division (NCSD), International Centre for Diarhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

Background: To describe factors associated with severe sepsis in diarrheal adults and their outcomes and offender in blood and stool to understand their interplay as clinical features of sepsis and severe diarrhea often overlap.

Methods And Results: We used this retrospective chart analysis employing an unmatched case-control design to study critically ill diarrheal adults aged ≥18 years treated in ICU of Dhaka hospital, icddr,b between January 2011 to December 2015. Of 8,863 in-patient diarrheal adults, 350 having severe sepsis were cases and an equal number of randomly selected non-septic patients were the controls. Read More

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September 2021

The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium.

PLoS Med 2021 Sep 20;18(9):e1003786. Epub 2021 Sep 20.

Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.

Background: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulating metabolites that predispose kidney cancer and to evaluate the extent to which they are influenced by body mass index (BMI).

Methods And Findings: We assessed the association between circulating levels of 1,416 metabolites and incident kidney cancer using pre-diagnostic blood samples from up to 1,305 kidney cancer case-control pairs from 5 prospective cohort studies. Read More

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September 2021

Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities.

PLoS One 2021 20;16(9):e0249256. Epub 2021 Sep 20.

European Institute of Molecular Imaging, University of Münster, Münster, Germany.

Lymphatic vessels are indispensable for tissue fluid homeostasis, transport of solutes and dietary lipids and immune cell trafficking. In contrast to blood vessels, which are easily visible by their erythrocyte cargo, lymphatic vessels are not readily detected in the tissue context. Their invisibility interferes with the analysis of the three-dimensional lymph vessel structure in large tissue volumes and hampers dynamic intravital studies on lymphatic function and pathofunction. Read More

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September 2021

Urinary Neutrophil Gelatinase-Associated Lipocalin/Hepcidin-25 Ratio for Early Identification of Patients at Risk for Renal Replacement Therapy After Cardiac Surgery: A Substudy of the BICARBONATE Trial.

Anesth Analg 2021 Sep 20. Epub 2021 Sep 20.

Department of Anesthesiology and Intensive Care, Helios Klinikum Leisnig, Leisnig, Germany.

Background: Acute kidney injury requiring renal replacement therapy (AKI-RRT) is strongly associated with mortality after cardiac surgery; however, options for early identification of patients at high risk for AKI-RRT are extremely limited. Early after cardiac surgery, the predictive ability for AKI-RRT even of one of the most extensively evaluated novel urinary biomarkers, neutrophil gelatinase-associated lipocalin (NGAL), appears to be only moderate. We aimed to determine whether the NGAL/hepcidin-25 ratio (urinary concentrations of NGAL divided by that of hepcidin-25) early after surgery may compare favorably to NGAL for identification of high-risk patients after cardiac surgery. Read More

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September 2021

Efficacy and safety of valsartan in children aged 1-5 years with hypertension, with or without chronic kidney disease: a randomized, double-blind study followed by open-label phase.

Curr Med Res Opin 2021 Sep 20:1-23. Epub 2021 Sep 20.

Novartis Healthcare Pvt. Ltd., Hyderabad, India.

Objective: To assess dose-response reduction in mean systolic blood pressure (MSBP) with valsartan solution, in young children with hypertension with or without chronic kidney disease (CKD).

Methods: In this multicenter, randomized, double-blind, double-dummy study, 127 young children aged 1-5 years with hypertension (MSBP ≥95 percentile) were randomized (1:1) to receive valsartan 0.25 or 4 mg/kg/day for 6 weeks, followed by a 20-week open-label phase, where patients received valsartan 1 mg/kg/day for 4 weeks, and then optionally titrated to 2 mg/kg/day or up to 4 mg/kg/day. Read More

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September 2021

Severe aortic stenosis and transcatheter aortic valve replacement in elderly patients: utility vs futility.

Minerva Med 2021 Sep 20. Epub 2021 Sep 20.

SICGe - Società Italiana di Cardiologia Geriatrica, Firenze, Italy.

Introduction: Recently, transcatheter aortic valve replacement (TAVR) has emerged as established standard treatment for symptomatic severe aortic stenosis, providing an effective, less-invasive alternative to open cardiac surgery for inoperable or high-risk older patients.

Evidence Acquisition: In order to assess the anticipated benefit of aortic replacement, considerable interest now lies in better identifying factors likely to predict outcome. In the elderly population frailty and medical comorbidities have been shown to significantly predict mortality, functional recovery and quality of life after transcatheter aortic valve replacement. Read More

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September 2021

Transporter hypothesis in pharmacoresistant epilepsies Is it at the central or peripheral level?

Epilepsia Open 2021 Sep 20. Epub 2021 Sep 20.

Institute for Research in Physiopathology and Clinical Biochemistry (INFIBIOC), Clinical Biochemistry Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.

The multidrug resistance (MDR) phenotype is typically observed in patients with refractory epilepsy (RE) whose seizures are not controlled despite receiving several combinations of more than two antiseizure medications (ASMs) directed against different ion channels or neurotransmitter receptors. Since the use of bromide in 1860, more than 20 ASMs have been developed; however, historically ~30% of cases of RE with MDR phenotype remains unchanged. Irrespective of metabolic biotransformation, the biodistribution of ASMs and their metabolites depends on the functional expression of some ATP-binding cassette transporters (ABC-t) in different organs, such as the blood-brain barrier (BBB), bowel, liver, and kidney, among others. Read More

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September 2021

Hypotension - what we say and what we do.

Authors:
C Lyons I K Moppett

Anaesthesia 2021 Sep 20. Epub 2021 Sep 20.

Anaesthesia and Critical Care Section, Academic Unit of Injury, Inflammation and Recovery Science, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

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September 2021

Potential Long-Term Health Problems Associated with Ultra-Endurance Running: A Narrative Review.

Sports Med 2021 Sep 20. Epub 2021 Sep 20.

Centro de Investigación y Diagnóstico en Salud y Deporte (CIDISAD), Escuela Ciencias del Movimiento Humano y Calidad de Vida (CIEMHCAVI), Universidad Nacional, Heredia, Costa Rica.

It is well established that physical activity reduces all-cause mortality and can prolong life. Ultra-endurance running (UER) is an extreme sport that is becoming increasingly popular, and comprises running races above marathon distance, exceeding 6 h, and/or running fixed distances on multiple days. Serious acute adverse events are rare, but there is mounting evidence that UER may lead to long-term health problems. Read More

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September 2021

A Presumed Synonymous Mutation of PKD2 Caused Autosomal Dominant Polycystic Kidney Disease in a Chinese Family.

Curr Med Sci 2021 Sep 20. Epub 2021 Sep 20.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Objective: Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by the pathogenic mutation of PKD1 or PKD2 gene and usually affects bilateral kidneys. Synonymous mutations are generally assumed to be neutral as they do not alter amino acids. Herein, we described an extremely rare ADPKD child caused by a heterozygous synonymous mutation of PKD2 gene accompanied by massive proteinuria and congenital solitary kidney. Read More

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September 2021

Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China.

Curr Med Sci 2021 Sep 20. Epub 2021 Sep 20.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objective: Although relatively rare, adult immunoglobulin A vasculitis (IgAV) can lead to severe complications and longer hospitalization, and result in poor prognosis, when compared to childhood IgAV. Hence, early identification and prevention for patients prone to develop systemic involvement are essential. The purpose of this study was to explore the correlations of common serological markers with the development of systemic involvement in adult IgAV. Read More

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September 2021