137,637 results match your criteria kidney transplantation


CKD Progression From the Time of Estimated GFR-Based Waitlist Eligibility and Racial Disparities in Transplant Access.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, University of California, San Francisco, San Francisco, CA; Department of Medicine, Priscilla Chan and Mark Zuckerberg San Francisco General Hospital, San Francisco, CA; Center for Vulnerable Populations, University of California, San Francisco, San Francisco, CA.

Rationale & Objective: eGFR equations that incorporate a term for race assign a higher value to Black individuals compared to non-Black individuals not attributable to sex, age, or serum creatinine. This difference may contribute to racial disparities in kidney transplant access. We sought to 1) compare time from meeting a transplant eligibility threshold of eGFR ≤20 ml/min/1. Read More

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September 2021

Latent tuberculosis infection and kidney transplantation.

J Bras Nefrol 2021 Sep 20. Epub 2021 Sep 20.

Pontifícia Universidade Católica do Paraná, Faculdade de Medicina, Laboratório de Doenças Infecciosas Emergentes, Curitiba, PR, Brasil.

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September 2021

Growth hormone treatment in the pre-transplant period is associated with superior outcome after pediatric kidney transplantation.

Pediatr Nephrol 2021 Sep 20. Epub 2021 Sep 20.

Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Background: Recombinant human growth hormone (rhGH) is frequently used for treatment of short stature in children with chronic kidney disease (CKD) prior to kidney transplantation (KT). To what extent this influences growth and transplant function after KT is yet unknown.

Methods: Post-transplant growth (height, sitting height, leg length) and clinical parameters of 146 CKD patients undergoing KT before the age of 8 years, from two German pediatric nephrology centers, were prospectively investigated with a mean follow-up of 5. Read More

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September 2021

Growth hormone therapy in pediatric kidney transplantation-the long-term clinical benefits beyond improvement of growth after withdrawal of pre-transplant therapy.

Authors:
Ryszard Grenda

Pediatr Nephrol 2021 Sep 20. Epub 2021 Sep 20.

Department of Nephrology, Kidney Transplantation & Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.

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September 2021

End-Stage Renal Disease-Related Accelerated Immune Senescence: Is Rejuvenation of the Immune System a Therapeutic Goal?

Front Med (Lausanne) 2021 3;8:720402. Epub 2021 Sep 3.

Inserm, UMR1098, Federation Hospitalo-Universitaire INCREASE, Besançon, France.

End-stage renal disease (ESRD) patients exhibit clinical features of premature ageing, including frailty, cardiovascular disease, and muscle wasting. Accelerated ageing also concerns the immune system. Patients with ESRD have both immune senescence and chronic inflammation that are resumed in the so-called inflammaging syndrome. Read More

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September 2021

Plasma Macrophage Migration Inhibitory Factor Predicts Graft Function Following Kidney Transplantation: A Prospective Cohort Study.

Front Med (Lausanne) 2021 1;8:708316. Epub 2021 Sep 1.

Division of Kidney Transplantation, Organ Transplantation Research Institution, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Delayed graft function (DGF) is a common complication after kidney transplantation (KT) with a poor clinical outcome. There are no accurate biomarkers for the early prediction of DGF. Macrophage migration inhibitory factor (MIF) release during surgery plays a key role in protecting the kidney, and may be a potential biomarker for predicting post-transplant renal allograft recovery. Read More

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September 2021

Kidney Transplantation in Times of Covid-19: Decision Analysis in the Canadian Context.

Can J Kidney Health Dis 2021 14;8:20543581211040332. Epub 2021 Sep 14.

Centre for Outcomes Research and Evaluation, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

Background: The coronavirus disease 2019 (COVID-19) pandemic impacted transplant programs across Canada.

Objective: We evaluated the implications of delays in transplantation among Canadian end-stage kidney disease (ESKD) patients to allow pretransplant vaccination.

Design: We used a Markov microsimulation model and ESKD patient perspective to study the effectiveness (quality-adjusted life years [QALY]) of living (LD) or deceased donor (DD) kidney transplantation followed by 2-dose SARS-CoV-2 vaccine versus delay in LD ("Delay LD") or refusal of DD offer ("Delay DD") to receive 2-dose SARS-CoV-2 vaccine pretransplant. Read More

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September 2021

Superimposition of metabolic syndrome magnifies post-stenotic kidney injury in dyslipidemic pigs.

Am J Transl Res 2021 15;13(8):8965-8976. Epub 2021 Aug 15.

Division of Nephrology and Hypertension, Mayo Clinic Rochester, MN 55905, The United States.

Background: Dyslipidemia aggravates kidney injury distal to atherosclerotic renal artery stenosis (ARAS). Besides dyslipidemia, metabolic syndrome (MetS) also involves development of obesity and insulin-resistance (IR). We hypothesized that concurrent obesity and IR magnify swine stenotic-kidney damage beyond dyslipidemia. Read More

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Conversion From Calcineurin Inhibitors to Mammalian Target of Rapamycin Inhibitors in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Front Immunol 2021 3;12:663602. Epub 2021 Sep 3.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Background: A systematic review and meta-analysis were performed to investigate the efficacy and safety of conversion from calcineurin inhibitors (CNIs) to mammalian target of rapamycin inhibitors (mTORi) in kidney transplant recipients (KTRs).

Methods: MEDLINE, EMBASE, PubMed, and Cochrane Library were searched to identify randomized controlled trials (RCTs) that compared the continuation of CNI with conversion to mTORi therapy.

Results: Twenty-nine RCTs (5,747 KTRs) were included in our analysis. Read More

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September 2021

Multivariate Longitudinal Assessment of Kidney Function Outcomes on Graft Survival after Kidney Transplantation Using Multivariate Joint Modeling Approach: A Retrospective Cohort Study.

Iran J Med Sci 2021 Sep;46(5):364-372

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: The performance of a transplanted kidney is evaluated by monitoring variations in the value of the most important markers. These markers are measured longitudinally, and their variation is influenced by other factors. The simultaneous use of these markers increases the predictive power of the analytical model. Read More

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September 2021

Taguchi versus Lich-Grégoir Extravesical Ureteroneocystostomy in Kidney Transplantation: A Systematic Review.

Urol Int 2021 Sep 17:1-9. Epub 2021 Sep 17.

Department of Urology and Pediatric Urology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Introduction: Ureteric implantation of the transplanted ureter into native urinary bladder tissue in kidney transplantation recipients is essential for post-operative kidney function. We aimed to determine the effects of Taguchi versus Lich-Grégoir extravesical ureteroneocystostomy in kidney transplantation.

Methods: We searched multiple databases (MEDLINE, Cochrane Library, and Web of Science), trial registries, and conference proceedings until March 2021. Read More

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September 2021

The changes of β-catenin expression level before and after kidney transplantation.

Transpl Immunol 2021 Sep 16:101471. Epub 2021 Sep 16.

Department of Medical Biology and Genetics, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey; Tissue Typing Laboratory, Tepecik Training and Research Hospital, University of Health Science, Izmir, Turkey.

Purpose: WNT signaling is an important pathway in kidney development and disease. We aimed to establish the levels of β-catenin expression in CD4 T cells before and after renal transplantation and to associate it with the form of transplant type, rejection and graft dysfunction.

Methods: CD4 T cells were isolated from patients before and after kidney transplantation and their purity was confirmed by flow cytometer. Read More

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September 2021

Risk Factors and Prognosis of New-Onset Chronic Kidney Disease Following Orthotopic Liver Transplantation: A Retrospective Case-Control Study.

Med Sci Monit 2021 Sep 19;27:e931834. Epub 2021 Sep 19.

Department of Anesthesiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China (mainland).

BACKGROUND We have undertaken this investigation to explore the perioperative risk factors of new-onset chronic kidney disease (NOCKD) after orthotopic liver transplantation (OLT), and to provide an early prediction model for the screening of NOCKD high-risk populations. MATERIAL AND METHODS A retrospective case-control study was performed in adult recipients who received OLT in our center between January 2018 and January 2020. Perioperative data were collected using the center's electronic medical record system. Read More

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September 2021

Pre-transplant morphometry by computed tomography scan and post-transplant dialysis risk in overweight or obese kidney transplant recipients.

Int Urol Nephrol 2021 Sep 18. Epub 2021 Sep 18.

Department of Urology and Transplantation Surgery, Hôpital de Bicêtre, AP-HP. Université Paris Saclay, 78 rue du général Leclerc, Le Kremlin-Bicêtre, 94270, Paris, France.

Purpose: Adipose distribution and sarcopenia could better assess kidney transplantation outcomes than body mass index (BMI) and have been poorly evaluated among obese and overweight recipients. We aimed to evaluate morphometric radiologic markers to predict post-operative dialysis within this population.

Methods: We conducted a retrospective study including patients with a BMI > 25 kg/m undergoing kidney transplantation during 5 years. Read More

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September 2021

Changes in Treatment of Patients with Incident End-Stage Kidney Disease During the Novel Coronavirus Disease 2019 Pandemic.

J Am Soc Nephrol 2021 Sep 17. Epub 2021 Sep 17.

E Weinhandl, Chronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, United States.

The COVID-19 pandemic caused major disruptions to care for patients with advanced CKD. We investigated the incidence of documented ESKD, ESKD treatment modalities, changes in eGFR at dialysis initiation, and use of incident central venous catheters (CVCs) by epidemiologic week during the first half of 2020 compared to 2017-2019 historical trends, using Centers for Medicare & Medicaid Services data. We used Poisson and logistic regression for analyses of incidence and binary outcomes, respectively. Read More

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September 2021

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study.

BMJ 2021 09 17;374:n2244. Epub 2021 Sep 17.

Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.

Objectives: To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination.

Design: Prospective, population based cohort study using the QResearch database linked to data on covid-19 vaccination, SARS-CoV-2 results, hospital admissions, systemic anticancer treatment, radiotherapy, and the national death and cancer registries.

Settings: Adults aged 19-100 years with one or two doses of covid-19 vaccination between 8 December 2020 and 15 June 2021. Read More

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September 2021

Self-reported poor quality of sleep in solid organ transplant: A systematic review.

Transplant Rev (Orlando) 2021 Sep 14;35(4):100650. Epub 2021 Sep 14.

School of Nursing, University of Pennsylvania, Claire M. Fagin Hall, 418 Curie Blvd, Philadelphia, PA 19104, USA. Electronic address:

Background: High quality sleep of sufficient duration is vital to overall health and wellbeing. Self-reported poor quality of sleep, sleep reported as irregular in timing, marked by frequent awakenings, or shortened in duration, is common across the solid-organ transplant trajectory.

Aim: This Systematic Review aimed to summarize available literature on rates of self-reported poor quality of sleep among solid organ transplant candidates and recipients. Read More

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September 2021

The semaphorin 4A-neuropilin 1 axis alleviates kidney ischemia reperfusion injury by promoting the stability and function of regulatory T cells.

Kidney Int 2021 Sep 14. Epub 2021 Sep 14.

Department of Urology, The 3(rd) Medical Center of Chinese PLA General Hospital, Beijing, China; Department of Urology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Previous studies have suggested the role of CD4Foxp3 regulatory T cells (Tregs) in protection against kidney ischemia reperfusion injury via their immunosuppressive properties. Unfortunately, the associated mechanisms of Tregs in kidney ischemia reperfusion injury have not been fully elucidated. Semaphorin 4A (Sema4A) is essential for maintaining the immunosuppressive capacity of Tregs in tumors. Read More

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September 2021

Vitamin D metabolism in human kidney organoids.

Nephrol Dial Transplant 2021 Sep 17. Epub 2021 Sep 17.

Erasmus MC Transplant Institute, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Human kidney organoids possess early glomerular and tubular function. However, little is known about their hormone producing ability. In this report, we show that kidney organoids take up and metabolize inactive 25(OH) vitamin D (25(OH)D3). Read More

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September 2021

Liver and/or Kidney Transplantation After SARS-CoV-2 Infection: Prevalence, Short-Term Outcome and Kinetics of Serum IgG Antibodies.

Transplantation 2021 Sep 16. Epub 2021 Sep 16.

Department of Gastroenterology & Hepatology, University Hospitals Leuven; Laboratory of Hepatology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium Clinical Department of Laboratory Medicine and National Reference Center for Respiratory Pathogens, University Hospitals Leuven; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium Department of Abdominal Transplant Surgery, University Hospitals Leuven; Transplantation Research Group, Lab of Abdominal Transplantation, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium Department of Respiratory Diseases, University Hospitals Leuven; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium. Department of Cardiology, University Hospitals Leuven; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium Department of Nephrology & Renal Transplantation, University Hospitals Leuven; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

Background: There is paucity of data on the prevalence, adequate timing and outcome of solid organ transplantation after SARS-CoV-2 infection and the kinetics of IgG antibodies in these patients.

Methods: SARS-CoV-2 anti-nucleocapsid (N) IgG and PCR via nasopharyngeal swab were analyzed in all patients within 24h before liver and/or kidney transplantation. Kinetics of IgG antibodies were analysed and compared with an immune-competent cohort. Read More

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September 2021

New insights into the microbiome in kidney transplantation.

Curr Opin Organ Transplant 2021 Sep 15. Epub 2021 Sep 15.

Weill Cornell Medicine Department of Urology Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine Department of Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York, USA.

Purpose Of Review: Research in the past decade has revealed important implications for the microbiome in human health. Studies have defined a distinct gut microbiota in kidney transplant recipients and have recently linked the microbiota to infectious complications, similar to the allogeneic stem cell transplant population.

Recent Findings: In this review, we focus on the metabolism of immunosuppressive medications by the gut microbiota and on the urinary microbiome in the setting of infectious and immunological complications. Read More

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September 2021

Haemophagocytic syndrome triggered by donor-transmitted Toxoplasmosis as a complication in same-donor recipients of renal transplantation - case report and review of the literature.

Transpl Infect Dis 2021 Sep 17. Epub 2021 Sep 17.

Nephrology Department, Clínico San Carlos University Hospital, Madrid, Spain.

Background: Haemophagocytic syndrome (HPS) is an infrequent complication of transplantation caused by an inflammatory response with a benign proliferation of macrophages and defective lytic capability of T lymphocytes and NK cells that can lead to multiorgan failure. Transplant patients are particularly exposed as a result of the increased risk of both infections and malignancies derived from immunosuppressive drugs. There is no consensus for therapy or immunosuppression; mortality is high. Read More

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September 2021

Employment after renal transplantation vs. the health locus of control and the quality of life.

Int J Occup Med Environ Health 2021 Sep 16. Epub 2021 Sep 16.

Medical University of Gdańsk, Gdańsk, Poland (Clinic of Occupational, Metabolic and Internal Diseases).

Objectives: The aim of the presented study was to compare the health locus of control (HLC) between employed and unemployed patients after kidney transplantation (KT), and to investigate the relationship between HLC and the quality of life (QoL).

Material And Methods: The study group consisted of 101 KT patients and the control group of 60 hemodialysis (HD) patients. The applied methods were: the (MHLC), the (WHOQoL-BREF), and a survey collecting information on the socio-demographic status and work experience. Read More

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September 2021

Histopathologic findings on indication renal allograft biopsies after recovery from acute COVID-19.

Clin Transplant 2021 Sep 16:e14486. Epub 2021 Sep 16.

Current knowledge on histopathological changes occurring after COVID-19 in transplanted kidneys is limited. Herein, we present renal allograft pathology findings in patients recovered from COVID-19. Six patients underwent indication biopsy, and one required allograft nephrectomy after acute COVID-19. Read More

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September 2021

Occurrence of Post-Transplant Lymphoproliferative Disease in a Renal Transplant Patient.

Cureus 2021 Sep 13;13(9):e17930. Epub 2021 Sep 13.

Nephrology, St. Joseph Mercy Oakland Hospital, Pontiac, USA.

Post-transplant lymphoproliferative diseases (PTLD) are a group of lymphoid disorders that occur in the setting of solid organ or hematopoietic transplantation. Risk factors for the development of PTLD include type of organ transplanted, degree/duration of T-cell immunosuppression, and Epstein-Barr virus (EBV) status. After initial infection, EBV lies dormant in memory B-cells and persists at low levels throughout the lifetime. Read More

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September 2021

Overall of kidney transplant recipients with a pretransplantation cancer history.

Clin Case Rep 2021 Sep 12;9(9):e04810. Epub 2021 Sep 12.

Department of Internal Medicine A Charles Nicolle's Hospital Tunis Tunisia.

No significant morbidity from recurrence cancer and no development of secondary type of cancers in pre-existing malignancies. We must be careful about risk of rejection. Read More

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September 2021

Comparison of Outcomes of Kidney Transplantation From Extremely Low Body Weight ≤5kg Larger Body Weight Pediatric Donors.

Front Immunol 2021 31;12:738749. Epub 2021 Aug 31.

Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.

Background: Kidney transplantation from donors who weigh ≤5 kg is performed at only a few transplant centers owing to the high complication and low graft survival rates associated with this approach.

Methods: We retrospectively compared the results of kidney transplantation at our center between January 2015 and December 2019 based on the following pediatric donor criteria: donor body weight ≤5 kg (n=32), 5 kg< donor weight ≤20 kg (n=143), and donor weight >20 kg (n=110). We also perform subgroup analysis of kidney transplantation outcomes from ≤5 kg donors, using conventional (dual separate and classic en-bloc KTx)/novel (en-bloc KTx with outflow tract) surgical methods and allocating to adult/pediatric recipients. Read More

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Immunological Results of Long-Term Use of Mammalian Target of Rapamycin (mTOR) Inhibitors and Its Effects on Renal Graft Functions.

Ann Transplant 2021 Sep 17;26:e932434. Epub 2021 Sep 17.

Department of Internal Medicine, SBU İzmir Tepecik Training and Research Hospital, İzmir, Turkey.

BACKGROUND Calcineurin inhibitor drugs (CNI), which are the basis of immunosuppression in kidney transplantation, contribute to renal graft loss, with increased morbidity and mortality due to their potentially harmful effects on the renal graft, cardiovascular system, and tumor pathology. For this reason, the mammalian target of rapamycin inhibitors (mTORi) such as sirolimus (SRL) and everolimus (EVE) has been preferred more frequently, as they are associated with fewer complications and longer graft function. MATERIAL AND METHODS We enrolled 89 adult renal transplant patients (37 patients on mTORi and 52 on CNI) who had similar age, sex, primary renal disease, dialysis type, post-transplant follow-up period, and donor type. Read More

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September 2021

A Higher Foci Density of Interstitial Fibrosis and Tubular Atrophy Predicts Progressive CKD after a Radical Nephrectomy for Tumor.

J Am Soc Nephrol 2021 Jun 18. Epub 2021 Jun 18.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota

Background: Chronic tubulointerstitial injury on kidney biopsy is usually quantified by the percentage of cortex with interstitial fibrosis/tubular atrophy (IF/TA). Whether other patterns of IF/TA or inflammation in the tubulointerstitium have prognostic importance beyond percentage IF/TA is unclear.

Methods: We obtained, stained, and digitally scanned full cortical thickness wedge sections of renal parenchyma from patients who underwent a radical nephrectomy for a tumor over 2000-2015, and morphometrically analyzed the tubulointerstitium of the cortex for percentage IF/TA, IF/TA density (foci per mm cortex), percentage subcapsular IF/TA, striped IF/TA, percentage inflammation (both within and outside IF/TA regions), and percentage subcapsular inflammation. Read More

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Gypenoside XLIX loaded nanoparticles targeting therapy for renal fibrosis and its mechanism.

Eur J Pharmacol 2021 Sep 13;910:174501. Epub 2021 Sep 13.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, The Key Laboratory of Anti-Inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China. Electronic address:

Renal fibrosis is the main pathological feature of the occurrence and development of chronic nephropathy. At present, there is no effective treatment, except for renal transplantation and dialysis. Previous studies have shown that nano-preparations can be used as a therapeutic tool to target organs. Read More

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September 2021