154,976 results match your criteria kidney transplant


Impact of Extending Eligibility for Reinstatement of Waiting Time After Early Allograft Failure: A Decision Analysis.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Emergency Medicine, Hackensack University Medical Center, Hackensack, NJ; Department of Biomedical Informatics, Columbia University Medical Center, New York, NY.

Rationale & Objective: The shortage of deceased donor kidneys identified for potential transplantation in the United States is exacerbated by a high proportion of deceased donor kidneys discarded after procurement. We estimated the impact of a policy proposal aiming to increase organ utilization by extending eligibility for waiting time reinstatement for recipients experiencing allograft failure following transplantation.

Study Design: Decision analysis informed by clinical registry data. Read More

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September 2021

Neuropathological variability within a spectrum of NMDAR-encephalitis.

Ann Neurol 2021 Sep 25. Epub 2021 Sep 25.

Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Austria.

Objective: To describe the neuropathological features of N-methyl-D-aspartate receptor (NMDAR)-encephalitis in an archival autopsy cohort.

Methods: We examined four autopsies from patients with NMDAR-encephalitis; two patients were untreated, three had comorbidities: small cell lung cancer (SCLC), brain post-transplant lymphoproliferative disease (PTLD), and overlapping demyelination.

Results: The two untreated patients had inflammatory infiltrates predominantly composed of perivascular and parenchymal CD3 /CD8 T cells and CD79a B cells/plasma cells in basal ganglia, amygdala, and hippocampus with surrounding white matter. Read More

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September 2021

Position statement of the Spanish Society of Nephrology on the SARS-CoV-2 vaccines.

Nefrologia 2021 Sep 21. Epub 2021 Sep 21.

Servicio de Nefrología, Hospital Universitario Infanta Leonor, Madrid, Spain; Junta Directiva de la Sociedad Española de Nefrología, Spain.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide over the last year causing more than one million deaths. Several treatments have tried to modify the natural history of the coronavirus disease 2019 (COVID-19) but only corticosteroids have demonstrated to be effective in moderate or severe affectation. In that situation, the development of vaccines for preventing the SARS-CoV-2 infection has focused the attention of the scientific community. Read More

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September 2021

Effectiveness of a culturally competent care intervention in reducing disparities in Hispanic live donor kidney transplantation: A hybrid trial.

Am J Transplant 2021 Sep 24. Epub 2021 Sep 24.

Department of Surgery-Division of Transplantation, Northwestern University Feinberg School of Medicine.

Hispanic patients receive disproportionately fewer living donor kidney transplants (LDKTs) than non-Hispanic Whites (NHW). The Northwestern Medicine Hispanic Kidney Transplant Program (HKTP), designed to increase Hispanic LDKTs, was evaluated as a non-randomized, implementation-effectiveness hybrid trial of patients initiating transplant evaluation at two intervention and two similar control sites. Using a mixed method, observational design, we evaluated the fidelity of the HKTP implementation at the two intervention sites. Read More

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September 2021

: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications.

Am J Chin Med 2021 Sep 23:1-46. Epub 2021 Sep 23.

School of Pharmacy, Shaanxi University of Chinese Medicine, Xian Yang, Shaanxi 712046, P. R. China.

Rehd. et Wils () is a single species of genus, family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. Read More

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September 2021

Association of Public Reporting of Medicare Dialysis Facility Quality Ratings With Access to Kidney Transplantation.

JAMA Netw Open 2021 Sep 1;4(9):e2126719. Epub 2021 Sep 1.

Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: Improving the quality of dialysis care and access to kidney transplantation for patients with end-stage kidney disease is a national clinical and policy priority. The role of dialysis facility quality in increasing access to kidney transplantation is not known.

Objective: To determine whether patient, facility, and kidney transplant waitlisting characteristics are associated with variations in dialysis center quality. Read More

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September 2021

Evolution of disability pension after renal transplantation: methods and results of a database linkage study of the Swiss Transplant Cohort Study and Swiss Disability Insurance.

Swiss Med Wkly 2021 Sep 23;151:w30027. Epub 2021 Sep 23.

Basel University, Switzerland.

Aims: In Switzerland, certain patients with disabilities and reduced working ability are entitled to a disability pension granted by the Swiss Federal Social Insurance Office (FSIO). The aim was to assess the evolution of disability pension and work capacity after kidney transplantation and thereby pilot the procedures linking FSIO data with Swiss Transplant Cohort Study (STCS) data.

Methods: The current study pilot tested the record linkage of FSIO data with data from the STCS in a single-centre, observational setting. Read More

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September 2021

Dietary Risks for Liver Mortality in NAFLD: Global Burden of Disease Data.

Hepatol Commun 2021 Jul 8. Epub 2021 Jul 8.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA.

Nonalcoholic fatty liver disease (NAFLD) is a common but complex chronic liver disease, driven by environmental and genetic factors. We assessed metabolic and dietary risk factor associations with NAFLD liver mortality using the Global Burden of Disease (GBD) 2017 data. NAFLD liver deaths were calculated (per 100,000) as age-standardized rates (ASRs) from 195 countries and territories (21 GBD regions; 7 GBD superregions). Read More

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The impact of race-adjusted GFR estimation on eligibility for simultaneous liver-kidney transplantation.

Liver Transpl 2021 Sep 24. Epub 2021 Sep 24.

Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Estimated glomerular filtration rate (eGFR) is adjusted for Black race in commonly used formulas. This has potential implications for access to simultaneous liver-kidney transplant (SLKT), as qualifying criteria rely on eGFR.

Methods: We performed a retrospective study of United Network for Organ Sharing (UNOS) national transplant registry data between 2/28/2002 and 3/31/2019 to evaluate the proportion of Black patients who would be reclassified as meeting SLKT criteria (as defined per current policies) if race adjustment were removed from two prominent eGFR equations (MDRD-4 and CKD-EPI). Read More

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September 2021

Quantitation of residual D positive red cells in D negative recipients of D positive solid organ transplants.

Transfus Med 2021 Sep 24. Epub 2021 Sep 24.

Red Cell Immunohaematology, NHS Blood & Transplant, Bristol, UK.

Background: Solid organ transplants (SOT) from D positive donors are potentially sensitising events for D negative recipients. For this reason, it is important to quantify the presence of residual D positive red blood cells (RBCs) in the recipient's circulation and calculate the correct dose of prophylactic anti-D (PAD) required to prevent sensitisation. This is especially important in females of child-bearing potential where the presence of allo anti-D can, at worst, cause the death of the fetus in future pregnancies. Read More

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September 2021

Approach to the patient: Early post-renal transplant hyperglycemia.

J Clin Endocrinol Metab 2021 Sep 24. Epub 2021 Sep 24.

Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio.

Context: Though post-transplant diabetes mellitus (PTDM, occurring >45 days after transplantation) and its complications are well-described, early post-renal transplant hyperglycemia (EPTH) (<45 days) similarly puts kidney transplant recipients at risk of infections, re-hospitalizations, graft failure and is not emphasized much in the literature. Proactive screening and management of EPTH is required given these consequences.

Evidence Acquisition: A PubMed search was conducted for "early post-renal transplant hyperglycemia", "immediate post-transplant hyperglycemia", "post-renal transplant diabetes", "renal transplant", "diabetes" and combinations of these terms. Read More

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September 2021

Page Kidney: A Rare Cause of Resistant Hypertension Early After Renal Transplantation.

Balkan Med J 2021 Sep;38(5):316-317

Division of Nephrology, Department of Internal Medicine, İstanbul School of Medicine, İstanbul University, İstanbul, Turkey.

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September 2021

One-stop preoperative assessment of renal vessels for living donors with 3.0 T non-contrast-enhanced magnetic resonance angiography: compared with computerized tomography angiography and surgical results.

Br J Radiol 2021 Sep 24:20210589. Epub 2021 Sep 24.

Department of Radiology, Tianjin First Center Hospital, Tianjin, China.

Objective: The study was to investigate the feasibility and accuracy of assessment for living renal donors before transplantation by using 3.0 T non-contrast-enhanced magnetic resonance angiography (NCE-MRA).

Methods: Thirty renal donors were investigated and underwent computed tomography angiography (CTA) and 3. Read More

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September 2021

Early biochemical markers in the assessment of acute kidney injury in children after cardiac surgery.

Ther Apher Dial 2021 Sep 23. Epub 2021 Sep 23.

School of Medicine, Zagreb, Croatia.

Our aim was to evaluate biochemical markers in plasma (NGAL, CysC) and urine (NGAL, KIM-1) in children's early onset of acute kidney injury after congenital heart defect surgery using cardiopulmonary bypass. This study prospectively included 100 children with congenital heart defects who developed AKI. Patients with acute kidney injury had significantly higher CysC levels 6 and 12 h after cardiac surgery and plasma NGAL levels 2 and 6 h after cardiac surgery. Read More

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September 2021

Excess Mortality in Solid Organ Transplant Recipients Hospitalized with COVID-19: A Large-Scale Comparison of SOT Recipients Hospitalized With or Without COVID-19.

Clin Transplant 2021 Sep 24:e14492. Epub 2021 Sep 24.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Background: Solid-organ transplant (SOT) recipients with COVID-19 have higher risk of adverse outcomes compared to the general population. Whether hospitalized SOT recipients with COVID-19 are at higher risk of mortality than SOT recipients hospitalized for other causes, including non-COVID-19 pneumonia, remains unclear.

Methods: We used logistic regression to compare outcomes of SOT recipients hospitalized with COVID-19 to non-COVID-19 related admissions and with non-COVID-19 pneumonia. Read More

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September 2021

Increased Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B in Patients With Kidney Allograft Antibody-mediated Rejection.

Transplant Direct 2021 Oct 20;7(10):e768. Epub 2021 Sep 20.

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Antibody-mediated rejection (AMR) causes more than 50% of late kidney graft losses. In addition to anti-human leukocyte antigen (HLA) donor-specific antibodies, antibodies against non-HLA antigens are also linked to AMR. Identifying key non-HLA antibodies will improve our understanding of AMR. Read More

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October 2021

Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease.

Transplant Direct 2021 Oct 20;7(10):e766. Epub 2021 Sep 20.

Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University, Chicago, IL.

Chronic kidney disease (CKD) is associated with cardiovascular (CV) events, a leading complication in liver transplant recipients (LTRs). Timely subspecialty care is associated with improved clinical outcomes in patients with CKD. This study sought to assess associations between nephrology comanagement and CV events among LTRs at risk for or with CKD. Read More

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October 2021

Clostridioides difficile Infection in Patients with Chronic Kidney Disease: A Systematic Review.

Biomed Res Int 2021 13;2021:5466656. Epub 2021 Sep 13.

University of Medicine and Pharmacy "Grigore T. Popa", Iași, Romania.

infection (CDI) is a health issue of utmost significance in Europe and North America, due to its high prevalence, morbidity, and mortality rate. The clinical spectrum of CDI is broad, ranging from asymptomatic to deadly fulminant colitis. When associated with chronic kidney disease (CKD), CDI is more prevalent and more severe than in the general population, due to specific risk factors such as impaired immune system, intestinal dysmotility, high antibiotic use leading to disturbed microbiota, frequent hospitalization, and PPI use. Read More

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September 2021

The Association Between Delayed Graft Function and Renal Resistive Index in Kidney Transplant Recipients.

Cureus 2021 Aug 19;13(8):e17315. Epub 2021 Aug 19.

Internal Medicine, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, TUR.

Background and objectives Delayed graft function (DGF) may increase the risk for kidney graft dysfunction. Renal resistive index (RRI) in Doppler ultrasonography is useful in measuring blood flow changes in kidneys which is indicative of tubulointerstitial damage. Most of the diseases in DGF etiology are related to tubulointerstitium and arteries of the kidneys. Read More

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Integrated Analysis of Prognostic Genes Associated With Ischemia-Reperfusion Injury in Renal Transplantation.

Front Immunol 2021 7;12:747020. Epub 2021 Sep 7.

Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Ischemia-reperfusion injury (IRI) remains an inevitable and major challenge in renal transplantation. The current study aims to obtain deep insights into underlying mechanisms and seek prognostic genes as potential therapeutic targets for renal IRI (RIRI).

Methods: After systematically screening the Gene Expression Omnibus (GEO) database, we collected gene expression profiles of over 1,000 specimens from 11 independent cohorts. Read More

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September 2021

Immune cell behaviour and dynamics in the kidney - insights from in vivo imaging.

Nat Rev Nephrol 2021 Sep 23. Epub 2021 Sep 23.

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.

The actions of immune cells within the kidney are of fundamental importance in kidney homeostasis and disease. In disease settings such as acute kidney injury, anti-neutrophil cytoplasmic antibody-associated vasculitis, lupus nephritis and renal transplant rejection, immune cells resident within the kidney and those recruited from the circulation propagate inflammatory responses with deleterious effects on the kidney. As in most forms of inflammation, intravital imaging - particularly two-photon microscopy - has been critical to our understanding of immune cell responses in the renal microvasculature and interstitium, enabling visualization of immune cell dynamics over time rather than statically. Read More

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September 2021

Aggravation of fibrin deposition and microthrombus formation within the graft during kidney transplantation.

Sci Rep 2021 Sep 23;11(1):18937. Epub 2021 Sep 23.

Department of Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30 001, 9700 RB, Groningen, The Netherlands.

In kidney transplantation, microthrombi and fibrin deposition may lead to local perfusion disorders and subsequently poor initial graft function. Microthrombi are often regarded as donor-derived. However, the incidence, time of development, and potential difference between living donor kidneys (LDK) and deceased donor kidneys(DDK), remains unclear. Read More

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September 2021

Post-Transplant Cardiovascular Disease.

Clin J Am Soc Nephrol 2021 Sep 23. Epub 2021 Sep 23.

Division of Nephrology, Department of Medicine, University of California, San Francisco, California.

Cardiovascular disease remains a leading cause of death and morbidity in kidney transplant recipients and a common reason for post-transplant hospitalization. Several traditional and nontraditional cardiovascular risk factors exist, and many of them present pretransplant and worsened, in part, due to the addition of immunosuppression post-transplant. We discuss optimal strategies for identification and treatment of these risk factors, including the emerging role of sodium-glucose cotransporter 2 inhibitors in post-transplant diabetes and cardiovascular disease. Read More

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September 2021

Barriers and Solutions to Kidney Transplantation for the Undocumented Latinx Community with Kidney Failure.

Clin J Am Soc Nephrol 2021 Sep 23. Epub 2021 Sep 23.

Department of Medicine and Office of Research, Denver Health, Denver, Colorado.

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September 2021

A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease.

J Am Soc Nephrol 2021 Sep 23. Epub 2021 Sep 23.

N Powe, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, United States

A Task Force from the NKF and ASN developed recommendations for reassessing inclusion of race in the estimation of glomerular filtration rate (eGFR) in the U.S. The Task Force recommends immediate implementation of the CKD-EPI creatinine equation refit without the race variable in all laboratories because the calculation does not include race, it included diversity in its development, its potential adverse consequences do not disproportionately affect any one group, and it is immediately available to all laborataries. Read More

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September 2021

Characteristics and technical survival of home hemodialysis in the Valencian Community (1976-2020).

Nefrologia 2021 Sep 20. Epub 2021 Sep 20.

Servicio de Nefrología, Hospital Universitario La Fe de Valencia, Valencia, España.

Introduction: Home hemodialysis (HDD) is implemented in the Valencian Community with a higher prevalence than to the rest of the national territory, with a prevalence of 13.4 patients' pmp in December 2018. We carried out an assessment of the patients' characteristics and the overall and technical survival in HDD depending on the historical moment of onset and its origin. Read More

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September 2021

Is Early COVID-19 in Kidney Transplant Recipients Concerning Enough to Halt Transplantation? A Multicenter Comparative Analysis from India.

Transplant Proc 2021 Aug 30. Epub 2021 Aug 30.

Department of Nephrology, Institute of Kidney Diseases and Research Centre, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.

Background: Limited data exist on the incidence and outcome of early coronavirus disease 2019 (COVID-19) in kidney transplantation recipients (KTR).

Methods: A retrospective multicenter research study was conducted across 12 centers in India. We explored the symptomatology, demographic, laboratory findings, and outcome of COVID-19 within 30 days of transplantation. Read More

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Wünderlich Syndrome in Renal Transplant Recipients: A Case Report and Literature Review.

Transplant Proc 2021 Sep 20. Epub 2021 Sep 20.

Clínica de Nefrologia e Transplantes, Hospital BP - Beneficência Portuguesa, São Paulo, Brazil.

Background: Wünderlich syndrome, or spontaneous atraumatic renal hemorrhage, is a clinical entity rarely described in the native kidney of patients who have undergone renal transplant. Although its manifestation is quite similar in reported cases, it may present few symptoms, from bleeding of unidentified etiology to dramatic pictures associated with hypovolemic shock. There are few reports of spontaneous hemorrhage of a native kidney after kidney transplantation. Read More

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September 2021

The Case | Isolated microscopic hematuria: a diagnostic journey.

Kidney Int 2021 Oct;100(4):955-956

Department of Renal Emergencies and Kidney Transplantation, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Sorbonne Université, Paris, France; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche S1155, Paris, France; Institut des Sciences du Calcul et des Données, Sorbonne Université, Paris, France. Electronic address:

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October 2021