27,354 results match your criteria kidney stone

The safety and efficacy of mini-percutaneous nephrolithotomy retrograde intrarenal surgery for treatment of renal lithiasis in pelvic ectopic kidney: an exploratory pilot study.

Junfeng Wu Jun Shen

Transl Androl Urol 2021 Apr;10(4):1734-1742

Department of Urology, Qiandongnan People's Hospital Affiliated to Guizhou Medical University, Kaili, China.

Background: To compare the safety and efficacy of mini-percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) for the treatment of renal lithiasis in patients with pelvic ectopic kidney.

Methods: From January 2015 to October 2017, mini-PCNL and RIRS were performed in ten patients diagnosed with lithiasis in pelvic ectopic kidneys, including three cases under laparoscopy-assisted mini-PCNL. Patient demographics and perioperative characteristics (age, gender, BMI, side of pelvic kidney, stone size, stone number, stone location, special medical history, and ASA physical status classification), and operative and post-operative related details (operation time, hospital stay, blood loss, VAS, analgesic requirement, complications, and stone free outcome) were reviewed. Read More

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Genetic Background but Not Intestinal Microbiota After Co-Housing Determines Hyperoxaluria-Related Nephrocalcinosis in Common Inbred Mouse Strains.

Front Immunol 2021 21;12:673423. Epub 2021 Apr 21.

Division of Nephrology, Department of Medicine IV, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

Calcium oxalate (CaOx) crystal formation, aggregation and growth is a common cause of kidney stone disease and nephrocalcinosis-related chronic kidney disease (CKD). Genetically modified mouse strains are frequently used as an experimental tool in this context but observed phenotypes may also relate to the genetic background or intestinal microbiota. We hypothesized that the genetic background or intestinal microbiota of mice determine CaOx crystal deposition and thus the outcome of nephrocalcinosis. Read More

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Validation of a novel diagnostic test for assessing the risk of urinary uric acid crystallization.

Clin Chim Acta 2021 May 5. Epub 2021 May 5.

Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research (IUNICS-IdISBa), University of Balearic Islands, Palma de Mallorca 07122, Spain. Electronic address:

Background And Aims: Uric acid (UA) kidney stones account for 10 to 11% of all kidney stones, and this percentage has increased over time. An accurate, rapid, simple, and low-cost test is needed to distinguish urine that is susceptible and resistant to the formation of UA crystals. The aim of this paper is to develop a test to assess the risk for UA crystallization (RUAC) and to validate its utility in routine clinical practice by analysis of urine samples of UA stone formers and healthy volunteers. Read More

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The prevalence of renal stone and outcomes of conservative treatment in kidney transplantation: A systematic review and meta-analysis.

Urol J 2021 May 8. Epub 2021 May 8.

Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nephrolithiasis is a rare complication in transplanted kidneys and limited information is available about its therapeutic options. This study aimed to review the conservative management of urinary lithiasis and its outcomes in renal transplanted patients.

Methods: A systematic review and meta-analysis of the scientific literature were performed in the Medline, Scopus, and Embase databases. Read More

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The relationship between vascular calcifications and urolithiasis in a large, multiethnic patient population.

Urolithiasis 2021 May 7. Epub 2021 May 7.

Department of Urology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, 10461, USA.

Several studies have reported associations between vascular calcifications and urinary stone disease (USD). However, results have been inconsistent and the majority of studies did not report on race/ethnicity. We examined the association between vascular calcifications and USD in a large, racially/ethnically diverse patient population. Read More

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Visual-Electromagnetic System: A Novel Fusion-based Monocular Localization, Reconstruction, and Measurement for Flexible Ureteroscopy.

Int J Med Robot 2021 May 7. Epub 2021 May 7.

Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310027, P. R. China.

Background: During flexible ureteroscopy (FURS), surgeons may lose orientation due to intrarenal structural similarities and complex shape of the pyelocaliceal cavity. Decision-making required after initially misjudging stone size will also increase the operative time and risk of severe complications.

Methods: A intraoperative navigation system based on electromagnetic tracking (EMT) and simultaneous localization and mapping (SLAM) was proposed to track the tip of the ureteroscope and reconstruct a dense intrarenal three-dimensional (3D) map. Read More

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[Unilateral combination of staghorn stone with kidney tumor].

A D Kochkin

Urologiia 2021 May(2):106-108

Privolzhskiy Research Medical University, Nizhny Novgorod, Russia.

This manuscript provides an overview of the available literature about unilateral combination of nephrolithiasis and renal tumor. Analysis of publications has shown that ipsilateral staghorn calculus and kidney tumors are an extremely rare combination. The majority of these infrequent papers describe case reports where the method of treating such patients is limited by the capabilities and competence of the surgeon or clinic. Read More

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[Decrease in time of transurethral laser litotripsy due to micro-drainage applications].

Urologiia 2021 May(2):21-26

V.I. Vernadsky Crimean Federal University, St. Luke s Clinical Medical Multidisciplinary Center, Simferopol, Russia.

Introduction: The length of the operation to remove urinary concernments has a marked effect on the occurrence of postoperative complications in the time of the postoperative patients in the hospital. A significant factor contributing to the increase in time is the clouding of the fragmentation region, which increases the operation time and the number of complications.

Purpose: to develop a method of reducing the time of additional costs in contact lithotripsy with a holmium laser in order to reduce the risk of postoperative complications. Read More

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Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.

PLoS One 2021 6;16(5):e0251235. Epub 2021 May 6.

Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurrent kidney stones. PubMed, SCOPUS, EMBASE, and Cochrane Library databases were searched through May 28th, 2020 to identify eligible studies. Read More

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Retained calcified guidewire in the kidney mimicking a renal stone.

BMJ Case Rep 2021 May 5;14(5). Epub 2021 May 5.

Department of Urology, San Raffaele Hospital, Milano, Lombardia, Italy.

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Various fatal complications of urolithiasis.

Forensic Sci Med Pathol 2021 May 5. Epub 2021 May 5.

Institute of Forensic Medicine, University Hospital Ostrava, 17. listopadu 1790/5, Ostrava, 70852, Czech Republic.

This article describes two cases of fatal complications of urolithiasis. The first case discusses the development of fatal urosepsis in a patient with a known mental health issue. The patient had self-introduced a thermometer into her bladder, which led to stone formation around the thermometer and consequently to fatal urosepsis. Read More

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[Medical management of uric acid renal stones, case description.]

Arch Esp Urol 2021 May;74(4):442-445

Servicio de Urología. Hospital Universitario San Cecilio. Granada. España.

Uric acid renal stones are a frequent and important part of our clinical practice. Conservative treatment through diet and urine alkalinization with citrate and teobromina seem a promising combination for treatment of those stones. We show on our cases a complete resolution of staghorn stone at 12 weeks of allopurinol and lit-control pH Up treatment, without adverse events and avoiding surgical treatment. Read More

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[Preoperative double J stent placement in the endoscopic treatment of ureteral and renal Stone: A multicenter, national study.]

Arch Esp Urol 2021 May;74(4):389-396

Oficina de Investigación. Confederación Americana de Urología (CAU). Departamento de Cirugía/Urología. Escuela de Medicina. Universidad del Valle. Cali. Colombia.

Objective: Aim of our study was to evaluate the effectiveness and safety of the preoperative placement of JJ stent compared to not doing in patients undergoing ureteroscopy for ureteral and kidney stone.

Materials And Methods: Prospective, observational, multicenter study. Adult patients, who underwent ureteroscopy treatment for ureteral and kidney stone, were recruited from August 2017 to March 2019, in 23 Argentine institutions. Read More

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Comparative evaluation of upper versus lower calyceal approach in percutaneous nephrolithotomy (PCNL) for managing renal calculi.

J Pak Med Assoc 2021 Feb;71(2(B)):602-607

College of Physicians and Surgeons of Pakistan, Karachi.

Objective: To compare upper versus lower calyceal approaches in percutaneous nephrolithotomy for managing renal calculi.

Methods: The retrospective study was conducted in the Department of Urology, The Kidney Centre Post-Graduate Training Institute, Karachi, and comprised data of patients who underwent percutaneous nephrolithotomy from January 2014 to January 2015. Patients were divided into upper pole puncture group A and lower pole puncture group B. Read More

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February 2021

Kidney stones are common in patients with short bowel syndrome receiving long-term parenteral nutrition. A predictive model for urolithiasis.

JPEN J Parenter Enteral Nutr 2021 May 2. Epub 2021 May 2.

Department of General Intensive Care and Institute for Nutrition Research, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Tel Aviv University, Israel.

Background: In short bowel syndrome (SBS) treated with parenteral nutrition (PN), multiple complications can occur. The etiology of kidney stones may be linked to the underlying disease (mesenteric thrombosis, surgical complications and injury, complications of therapy for cancer, Crohn's disease), metabolic abnormalities resulting from morphological and functional changes in the gastrointestinal tract, and to treatment used. We analyzed all these parameters in a large cohort of patients receiving home parenteral nutrition (HPN), to define the incidence of kidney stones and groups of patients particularly at risk of stone formation. Read More

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.


Lancet 2021 May;397(10285):1637-1645

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.

Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg-800 mg (depending on weight) given intravenously. Read More

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The effect of music on state anxiety in patients undergoing extracorporeal shockwave lithotripsy?

Int J Clin Pract 2021 Apr 30:e14293. Epub 2021 Apr 30.

Yüksek İhtisas Education and Research Hospital, Urology Department, Ankara, Turkey.

Aim: Extracorporeal shockwave lithotripsy is a commonly used method to break down kidney stones in urology clinics. This study aims to investigate whether or not listening to music is effective against state anxiety in patients undergoing kidney stone treatment with this method.

Methods: A total of 80 patients (50 males, 30 females) undergoing extracorporeal shockwave lithotripsy for the first time at our clinic were included in the study. Read More

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Artificial Intelligence and Its Impact on Urological Diseases and Management: A Comprehensive Review of the Literature.

J Clin Med 2021 Apr 26;10(9). Epub 2021 Apr 26.

Department of Urology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Recent advances in artificial intelligence (AI) have certainly had a significant impact on the healthcare industry. In urology, AI has been widely adopted to deal with numerous disorders, irrespective of their severity, extending from conditions such as benign prostate hyperplasia to critical illnesses such as urothelial and prostate cancer. In this article, we aim to discuss how algorithms and techniques of artificial intelligence are equipped in the field of urology to detect, treat, and estimate the outcomes of urological diseases. Read More

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COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

Nature 2021 Apr 29. Epub 2021 Apr 29.

Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.

COVID-19, caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple-organ failure, but little is known about its pathophysiology. Here, we generated single-cell atlases of 23 lung, 16 kidney, 16 liver and 19 heart COVID-19 autopsy donor tissue samples, and spatial atlases of 14 lung donors. Integrated computational analysis uncovered substantial remodeling in the lung epithelial, immune and stromal compartments, with evidence of multiple paths of failed tissue regeneration, including defective alveolar type 2 differentiation and expansion of fibroblasts and putative TP63 intrapulmonary basal-like progenitor cells. Read More

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[A patient with a palpable mass, haematuria and flank pain].

Ned Tijdschr Geneeskd 2021 04 26;165. Epub 2021 Apr 26.

Ziekenhuisgroep Twente, afd. Urologie, Almelo.

In this case report we present a 54-year-old female with progressive pain in the left flank. Physical examination showed a non-mobile, painless mass in the left upper abdomen. CT revealed an exceptionally large kidney stone. Read More

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Acute decrease of urine calcium by amiloride in healthy volunteers under high sodium diet.

Nephrol Dial Transplant 2021 Apr 29. Epub 2021 Apr 29.

Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland and Service of Nephrology, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.

Background: Amiloride is a competitive blocker of the epithelial sodium channel (ENaC) in the renal collecting duct. It is a less potent diuretic than thiazides or loop diuretics, but is often used in association for its potassium-sparing profile. Whether amiloride has hypocalciuric effect similar to thiazides remains unclear. Read More

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Acute life-threatening hyperkalaemia in a patient with giant hydronephrosis: a case report.

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Department of Emergency Medicine, Catharina Hospital Eindhoven, Eindhoven, Netherlands.

A 52-year-old man with a history of urolithiasis presents to the emergency department with a sudden, sharp, continuous right flank colicky pain. Laboratory workup demonstrates acute kidney injury with a mild hyperkalaemia. During the observation period, the patient develops an atypical broad complex sinus bradycardia and eventually short asystolic periods. Read More

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Genetics of kidney stone disease-Polygenic meets monogenic.

Jan Halbritter

Nephrol Ther 2021 Apr;17S:S88-S94

Medical Department III, Endocrinology, Nephrology and Rheumatology, Division of Nephrology, University of Leipzig Medical Center, Leipzig, Germany. Electronic address:

Kidney stone disease comprising nephrolithiasis and nephrocalcinosis is a clinical syndrome of increasing prevalence with remarkable heterogeneity. Stone composition, age of manifestation, rate of recurrence, and impairment of kidney function varies with underlying etiologies. While calcium-based kidney stones account for the vast majority their etiology is still poorly understood. Read More

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Nephrol Ther 2021 Apr;17S:S100-S107

Service de physiologie - explorations fonctionnelles rénales et métaboliques, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.

Cystinuria is the most common monogenic nephrolithiasis disorder. Because of its poor solubility at a typical urine pH of less than 7, cystine excretion results in recurrent urinary cystine stone formation. A high prevalence of high blood pressure and of chronic kidney disease has been reported in these patients. Read More

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Systematic Review of the Prevalence of Kidney Stones in Cystic Fibrosis.

J Endourol 2021 Apr 28. Epub 2021 Apr 28.

University of Toronto, 7938, Surgery, 61 Queen Street East, Suite 9-103, Toronto, Ontario, Canada, M5C 2T2;

Purpose: To investigate the prevalence of urolithiasis in cystic fibrosis (CF) and to summarize the available clinical features within this unique population.

Methods: Studies reporting the prevalence of urolithiasis in CF patients were identified by a systematic search of the literature from inception to July 31, 2020 on three databases: Ovid Medline, Ovid Embase, and Web of Science. Data was extracted on a pre-determined standardized form by two independent authors. Read More

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Perinephric Hematoma Associated with Pyelonephritis Following Ureteral Stent Placement for Ureteral Obstruction Causing Hydronephrosis.

Am J Case Rep 2021 Apr 27;22:e931404. Epub 2021 Apr 27.

Department of Internal Medicine, Benefis Health System, Great Falls, MT, USA.

BACKGROUND Perinephric hematomas are rare, especially following ureteral stent placement. Etiologies of perinephric hematomas include post-extracorporeal shockwave lithotripsy, Wunderlich syndrome, and renal cell carcinoma, none of which occurred in our patient, who underwent stent replacement. Subcapsular renal hematoma, rather than a perinephric hematoma, can occur following double-J ureteral stent placement. Read More

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Disparities in Kidney Stone Disease: A Scoping Review.

J Urol 2021 Apr 27:101097JU0000000000001846. Epub 2021 Apr 27.

Department of Urology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.

Purpose: To review the available evidence regarding health disparities in kidney stone disease and identify knowledge gaps in this area.

Materials And Methods: A literature search was conducted using PubMed, Embase, and Scopus, limited to articles published in English, from 1971 to 2020. Articles were selected based on their relevance to disparities in kidney stone disease among adults in the United States. Read More

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Natural History of Post-treatment Kidney Stone Fragments: A Systematic Review and Meta-Analysis.

J Urol 2021 Apr 27:101097JU0000000000001836. Epub 2021 Apr 27.

Department of Urology, University Hospital Southampton, Southampton, England.

Purpose: To assess the literature around post-treatment asymptomatic residual stone fragments, and to perform a meta-analysis. The main outcomes were intervention rate and disease progression.

Materials And Methods: We searched Ovid Medline, Embase, Cochrane library and Clinicaltrials. Read More

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Investigating fluid intake in an underserved community: what factors are associated with low urine volume on 24-hour urine collection?

J Endourol 2021 Apr 24. Epub 2021 Apr 24.

Albert Einstein Healthcare Network, 6528, Urology, 1200 Tabor Road, 3rd Floor/MossRehab, Philadelphia, Pennsylvania, United States, 19141-3098;

Background Stone prevention is dependent on high fluid intake, with evidence that low urine volume (LUV) can promote nephrolithiasis in the absence of other metabolic abnormalities. Herein, we investigate patient-related factors associated with LUV on initial 24-hour urine collection in an underserved population. Materials and Methods A retrospective chart review was performed of patients treated by a single surgeon for nephrolithiasis from August 2014-January 2019. Read More

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The evaluation of morphology of renal pelvicalyceal system's and infundibulopelvic anatomy of kidney's lower pole in post-mortem series.

Folia Morphol (Warsz) 2021 Apr 26. Epub 2021 Apr 26.

Cumhuriyet University, Faculty of Medicine, Department of Urology,, Sivas, Turkey.

Background: Urinary system stones are frequently encountered in the community. Together with technological developments, introduction of new treatment procedures such as extracorporeal shock wave lithotripsy, percutaneous nephrolithotomy and retrograde intrarenal surgery has furtherly reduced morbidity, mortality and hospitalization time of patients. In order to maximize success and to reduce complications of these procedures, it is necessary to evaluate anatomy and morphological differences of kidney collector system before the procedure. Read More

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