676,683 results match your criteria kidney disease


Ataxia Telangiectasia and Rad3-Related Activation by DNA Damage Mitigates Maladaptive Repair after Acute Kidney Injury.

Nephron 2021 Oct 14:1-4. Epub 2021 Oct 14.

Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

DNA damage is an important consequence of injury to the proximal tubule. The proximal tubule cell responds to this damage by mounting a DNA damage response (DDR). Two protein kinases, ataxia-telangiectasia mutated (ATM) or ataxia telangiectasia and Rad3-related (ATR), play an important role in this DDR. Read More

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October 2021

Neutrophil-to-Lymphocyte Ratio and Erythropoietin Resistance among Maintenance Hemodialysis Patients.

Blood Purif 2021 Oct 14:1-6. Epub 2021 Oct 14.

Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Introduction: Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are recent prognostic biomarkers associated with inflammation. Increased erythropoiesis resistance index (ERI) may predict the risk of all-cause and cardiovascular mortality in hemodialysis (HD) patients. However, the roles of NLR and PLR in erythropoietin (EPO) responsiveness remain unclear in HD patients. Read More

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October 2021

Deiodinase-3 is a thyrostat to regulate podocyte homeostasis.

EBioMedicine 2021 Oct 11;72:103617. Epub 2021 Oct 11.

Department of Internal Medicine, Rush University, Chicago, IL 60612. Electronic address:

Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves' disease. Therefore, the present study was designed to ascertain if and how podocytes respond to and regulate the input of biologically active thyroid hormone (TH), 3,5,3'-triiodothyronine (T3); and also to decipher the pathophysiological role of type 3 deiodinase (D3), a membrane-bound selenoenzyme that inactivates TH, in kidney disease.

Methods: To study D3 function in healthy and injured (PAN, puromycin aminonucleoside and LPS, Lipopolysaccharide-mediated) podocytes, immunofluorescence, qPCR and podocyte-specific D3 knockout mouse were used. Read More

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October 2021

Circular RNAs; powerful microRNA sponges to overcome diabetic nephropathy.

Pathol Res Pract 2021 Sep 15;227:153618. Epub 2021 Sep 15.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran; Department of Clinical Biochemistry, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Diabetic nephropathy (DN), also known as diabetic kidney disease (DKD), is a drastic renal complication of type 1 and type 2 diabetes mellitus (DM). Poorly controlled DM over the years, may disrupt kidneys' blood vessels, leading to the hypertension (HTN) and DN onset. During DN, kidneys' waste filtering ability becomes disturbed. Read More

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September 2021

Advance Care Planning Coaching in CKD Clinics: A Pragmatic Randomized Clinical Trial.

Am J Kidney Dis 2021 Oct 11. Epub 2021 Oct 11.

George Washington University Milken Institute School of Public Health.

Rationale And Objective: Although guidelines recommend more and earlier advance care planning (ACP) for patients with chronic kidney disease (CKD), scant evidence exists to guide incorporation of ACP into clinical practice for patients not yet requiring maintenance dialysis. Involving nephrology team members in addition to primary care providers in this important patient-centered process may increase its accessibility. Our objective was to examine the effect of coaching implemented in CKD clinics on patient engagement with ACP. Read More

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October 2021

A renaissance in the treatment of diabetic kidney disease, hypertension in chronic kidney disease, and beyond.

J Osteopath Med 2021 Oct 14. Epub 2021 Oct 14.

Department of Nephrology and Hypertension, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

Chronic kidney disease (CKD) affects approximately 15% of the US population and is associated with significant cardiovascular morbidity and mortality. The two leading causes of end stage kidney disease are hypertension and diabetes mellitus, both of which are modifiable risk factors. The cornerstones of CKD care include early detection, management of associated risk factors, modification of cardiovascular disease risk, slowing progression of disease, and management of complications including anemia, acid base disturbance, and mineral and bone disorders. Read More

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October 2021

Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.

PLoS One 2021 14;16(10):e0258494. Epub 2021 Oct 14.

Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal.

Background: Chronic kidney disease (CKD) is an emerging public health issue globally. The prevalence estimates on CKD in South Asia are however limited. This study aimed to examine the prevalence of CKD among the general and high-risk population in South Asia. Read More

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October 2021

Estimated glomerular filtration rate may be an independent predictor for clinical outcomes regardless of acute kidney injury complication in the emergency department.

PLoS One 2021 14;16(10):e0258665. Epub 2021 Oct 14.

Department of Acute Medicine, The University of Tokyo Hospital, Bunkyo, Tokyo, Japan.

Study Objective: Acute kidney injury (AKI), chronic kidney disease (CKD), and decreased estimated glomerular filtration rate (eGFR) are all associated with poor clinical outcomes among emergency department (ED) patients. This study aimed to evaluate the effect of different types of renal dysfunction and the degree of eGFR reduction on the clinical outcomes in a real-world ED setting.

Methods: Adult patients with an eGFR lower than 60 mL/min/1. Read More

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October 2021

Thrombotic microangiopathy associated with arboviral infection: Report of 3 cases.

PLoS Negl Trop Dis 2021 Oct 14;15(10):e0009790. Epub 2021 Oct 14.

Department of Pathology, Ribeirão Preto Medical School, University of São Paulo (FM-USP), Ribeirão Preto, Brazil.

Dengue fever and chikungunya are viral diseases that have spread rapidly throughout the world in recent decades. The occurrence of complications is well known, including prerenal acute kidney injury (AKI), which is usually thought to be caused by dehydration and fluid loss. Thrombotic microangiopathy (TMA) is an uncommon aggravation of dengue fever and chikungunya, with only a few cases described in the medical literature. Read More

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October 2021

Chronic Kidney Disease as A Potential Risk Factor for Uveitis: A 13-Year Nationwide Population-Based Cohort Study in Taiwan.

Ocul Immunol Inflamm 2021 Oct 14:1-7. Epub 2021 Oct 14.

Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Purpose: To investigate whether patients with chronic kidney disease (CKD) are at increased risk of uveitis.

Methods: Data was collected from the Taiwan National Health Insurance system and included patients newly diagnosed with CKD between 2000 and 2012. The endpoint of interest was a diagnosis of uveitis. Read More

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October 2021

Associations of Serum Uric Acid Levels With Macrovascular and Renal Microvascular Dysfunction Among Individuals From Sub-Saharan Africa.

JAMA Netw Open 2021 Oct 1;4(10):e2128985. Epub 2021 Oct 1.

Department of Public Health, Amsterdam University Medical Centre (UMC), University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Importance: Serum uric acid (SUA) level is associated with vascular dysfunction in Eurasian populations, but little is known about this association in individuals from sub-Saharan Africa, who have a high prevalence of both relatively high SUA levels and vascular dysfunction.

Objectives: To assess the associations of SUA levels with macrovascular and kidney microvascular dysfunction in individuals of sub-Saharan African ancestry and evaluate potential factors that could mediate these associations.

Design, Setting, And Participants: Cross-sectional analyses of baseline data from the multicenter Research on Obesity and Diabetes Among African Migrants study, conducted from 2012 to 2015, were performed from January to March 2021. Read More

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October 2021

Rac1 promotes kidney collecting duct integrity by limiting actomyosin activity.

J Cell Biol 2021 Nov 14;220(11). Epub 2021 Oct 14.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

A polarized collecting duct (CD), formed from the branching ureteric bud (UB), is a prerequisite for an intact kidney. The small Rho GTPase Rac1 is critical for actin cytoskeletal regulation. We investigated the role of Rac1 in the kidney collecting system by selectively deleting it in mice at the initiation of UB development. Read More

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November 2021

Migrasomes and exsosomes; different types of messaging vesicles in podocytes.

Cell Biol Int 2021 Oct 14. Epub 2021 Oct 14.

Kidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Podocytes, highly specified kidney epithelial cells, live under several pathological stimuli and stresses during which they adapt themselves to keep homeostasis. Nevertheless, under extreme stress, a complex scenario of podocyte damage and its consequences occur. Podocyte damage causes foot process effacement and their detachment from the glomerular basement membrane, leading to proteinuria. Read More

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October 2021

Presence and clinical impact of human Herpesvirus-6 infection in patients with moderate to critical Coronavirus disease-19.

J Med Virol 2021 Oct 14. Epub 2021 Oct 14.

Multiuser Laboratory for Research Support in Nephrology and Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.

Human herpesvirus-6 (HHV-6) may cause serious diseases in immunocompromised individuals. SARS-CoV-2/HHV-6 co-infection has been emphasized in previous works, mostly case reports, small series or epidemiological studies, but few is known about its real clinical outcomes. Here we present a real-world pilot study aiming to understand the frequency and the clinical impact of HHV-6 co-infection in moderate to critically ill patients hospitalized due to COVID-19. Read More

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October 2021

Tumor necrosis factor alfa (TNFα) and alfa-Klotho (αKL) in children and adolescents with chronic kidney disease (CKD).

Endokrynol Pol 2021 Oct 14. Epub 2021 Oct 14.

Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, Poland.

Introduction: Chronic kidney disease (CKD) in children, despite the progress in science and medical technology, is still a serious challenge. Early CKD detection gives a chance for immediate therapeutic intervention and lowering the progression of the disease. According to several publications indicating the possible use of alfa-Klotho (αKL) and Tumor Necrosis Factor alfa (TNFα) for the early detection of the disease in adults, an attempt was made to evaluate their usefulness in the pediatric population. Read More

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October 2021

[The treatment for Fabry disease: focus on agalsidase alpha and beta].

Recenti Prog Med 2021 Oct;112(10):75e-84e

Cattedra di Nefrologia, Dipartimento di Sanità Pubblica, Università Federico II, Napoli.

Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from the deficiency of the hydrolytic enzyme α-galactosidase A (α-Gal A), with consequent accumulation of globotrioasoylceramide in cells and tissues of the body, resulting in a multi-system pathology. Classically affected hemizygous males may display all the characteristic neurological (pain), cutaneous (angiokeratoma), renal (proteinuria, kidney failure), cardiovascular (cardiomyopathy, arrhythmia), and cerebrovascular (transient ischemic attacks, strokes) signs of the disease, while heterozygous females have symptoms ranging from very mild to severe. End-stage renal disease and cardiovascular or cerebrovascular complications limit life-expectancy of untreated patients. Read More

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October 2021

Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation.

Basic Res Cardiol 2021 Oct 13;116(1):57. Epub 2021 Oct 13.

Institute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

The adrenal glands participate in cardiovascular (CV) physiology and the pathophysiology of CV diseases through their effects on sodium and water metabolism, vascular tone and cardiac function. In the present study, we identified a new adrenal compound controlling mesenchymal cell differentiation that regulates osteoblastic differentiation in the context of vascular calcification. This peptide was named the "calcification blocking factor" (CBF) due to its protective effect against vascular calcification and is released from chromogranin A via enzymatic cleavage by calpain 1 and kallikrein. Read More

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October 2021

A dynamic Markov model to assess the cost-effectiveness of the Kidney Team at Home intervention in The Netherlands.

Eur J Health Econ 2021 Oct 13. Epub 2021 Oct 13.

Erasmus Medical Center, Section of Medical Psychology and Psychotherapy, Department of Psychiatry, Postal Address, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

Objectives: The Kidney Team at Home program is an educational intervention aimed at patients with chronic kidney disease to assist them in their choice for kidney replacement therapy. Previous studies have shown that the intervention results in an increase in knowledge and communication on kidney replacement therapy, and eventually in an increase in the number of living donor kidney transplantations. The study assesses the cost-effectiveness of the intervention compared to standard care. Read More

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October 2021

Robotics-assisted epicardial left atrial appendage clip exclusion.

JTCVS Tech 2021 Oct 21;9:59-68. Epub 2021 Jul 21.

Department of Anesthesiology, Health First Holmes Regional Medical Center, Melbourne, Fla.

Objectives: We demonstrate the feasibility and safety of robotics-assisted left atrial appendage clip exclusion in clinical practice.

Methods: Analysis of a single center robotics-assisted left atrial appendage clip exclusion experience using an epicardial linear clip device in patients with atrial fibrillation with high-risk of thromboembolic stroke and intolerance to oral anticoagulants.

Results: During the period from December 2017 to September 2020, we performed 42 robotics-assisted left atrial appendage clip exclusions in response to increased risk of bleeding in patients with atrial fibrillation and intolerance to oral anticoagulants. Read More

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October 2021

acNASH index to diagnose nonalcoholic steatohepatitis: a prospective derivation and global validation study.

EClinicalMedicine 2021 Nov 1;41:101145. Epub 2021 Oct 1.

MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: There is an unmet need for non-invasive biomarkers for the diagnosis of nonalcoholic steatohepatitis (NASH) in non-specialized settings. We aimed to develop and validate a non-invasive test for diagnosing NASH in individuals with biopsy-proven nonalcoholic fatty liver disease (NAFLD).

Methods: We developed a non-invasive test named the that combines serum creatinine and aspartate aminotransferase levels in a derivation cohort of 390 Chinese NAFLD patients admitted to the hepatology center of the First Affiliated Hospital of Wenzhou Medical University (China) between December 2016 and September 2019 and subsequently validated in five external cohorts of different ethnicities of patients with biopsy-confirmed NAFLD (pooled n=1,089). Read More

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November 2021

Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma.

Adv Radiat Oncol 2021 Sep-Oct;6(5):100692. Epub 2021 May 26.

Kidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas.

Purpose: Oligoprogression, defined as limited sites of progression on systemic therapy, in patients with metastatic renal cell carcinoma (mRCC) is not uncommon, possibly because of inter- and intratumoral heterogeneity. We evaluated the effect of stereotactic ablative radiation therapy (SAbR) for longitudinal control of oligoprogressive mRCC.

Methods And Materials: Patients with extracranial mRCC were included in this retrospective analysis if they progressed in ≤3 sites on systemic therapy while demonstrating response/stability at other sites and received SAbR to all progressing sites without switching systemic therapy. Read More

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COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative.

Transplant Direct 2021 Nov 6;7(11):e775. Epub 2021 Oct 6.

Division of Nephology, Department of Medicine, University of Nebraska Medical Center, Omaha, NE.

Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality in solid organ transplant (SOT) recipients. The National COVID Cohort Collaborative was developed to facilitate analysis of patient-level data for those tested for COVID-19 across the United States.

Methods: In this study, we identified a cohort of SOT recipients testing positive or negative for COVID-19 (COVID+ and COVID-, respectively) between January 1, 2020, and November 20, 2020. Read More

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November 2021

Safety and Efficacy of Sodium-glucose Cotransporter 2 Inhibitors in Kidney Transplant Recipients With Pretransplant Type 2 Diabetes Mellitus: A Retrospective, Single-center, Inverse Probability of Treatment Weighting Analysis of 85 Transplant Patients.

Transplant Direct 2021 Nov 6;7(11):e772. Epub 2021 Oct 6.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Whether sodium-glucose cotransporter 2 (SGLT2) inhibitors can be used effectively and safely in kidney transplant (KT) recipients with pretransplant type 2 diabetes as the primary cause of end-stage renal disease (ESRD) remains unclear. In this study, we retrospectively analyzed the efficacy and safety of SGLT2 inhibitors compared with other oral hypoglycemic agents (OHAs) in KT recipients with pretransplant type 2 diabetes as the primary cause of ESRD.

Methods: In this retrospective, observational, single-center, inverse probability of treatment weighting (IPTW) analysis study, we compared the outcomes of SGLT2 inhibitors (SGLT2 group) and other OHAs (control group) following KT. Read More

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November 2021

A Comparison Between Two Definitions of Contrast-Associated Acute Kidney Injury for Long-Term Mortality in Elderly and Non-elderly Patients After Elective Percutaneous Coronary Intervention.

Front Cardiovasc Med 2021 27;8:720857. Epub 2021 Sep 27.

Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.

Contrast-associated acute kidney injury (CA-AKI) is responsible for a substantial proportion of the observed mortality that occurs after percutaneous coronary intervention (PCI), particularly in elderly patients. However, there has been significant and debate over whether the optimal definition of CA-AKI persists over prolonged periods due to variations in the prevalence and effects on prognosis. In this study, we aimed to identify whether different definitions of CA-AKI exert differential impacts on long-term mortality when compared between elderly and non-elderly patients receiving elective PCI. Read More

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September 2021

Serum Uric Acid and Kidney Disease Measures Independently Predict Cardiovascular and Total Mortality: The Uric Acid Right for Heart Health (URRAH) Project.

Front Cardiovasc Med 2021 27;8:713652. Epub 2021 Sep 27.

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Serum uric acid predicts the onset and progression of kidney disease, and the occurrence of cardiovascular and all-cause mortality. Nevertheless, it is unclear which is the appropriate definition of hyperuricemia in presence of chronic kidney disease (CKD). Our goal was to study the independent impact of uric acid and CKD on mortality. Read More

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September 2021

Mitochondrial Regulation of Diabetic Kidney Disease.

Front Med (Lausanne) 2021 27;8:745279. Epub 2021 Sep 27.

Section of Nephrology, The University of Texas at MD Anderson Cancer Center, Houston, TX, United States.

The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondrial morphology to significant alterations in mitochondrial biogenesis, biosynthetic, bioenergetics and production of reactive oxygen species (ROS). Read More

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September 2021

Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease.

Front Med (Lausanne) 2021 27;8:705159. Epub 2021 Sep 27.

Departamento de Genética, Fisiología y Microbiología, Universidad Complutense de Madrid, Instituto de Investigacin Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.

Kidney transplantation is the best option for patients with end-stage renal disease. Despite the improvement in cardiovascular burden (leading cause of mortality among patients with chronic kidney disease), cardiovascular adverse outcomes related to the inflammatory process remain a problem. Thus, the aim of the present study was to characterize the immune profile and microvesicles of patients who underwent transplantation. Read More

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September 2021