240,516 results match your criteria kidney failure

Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice.

Phytomedicine 2021 Jul 18;91:153675. Epub 2021 Jul 18.

Department of Pharmacology, Basic Medical College, Anhui Medical University, Hefei 230032, China. Electronic address:

Background: Xin-Ji-Er-Kang (XJEK) as a herbal formula of traditional Chinese medicine (TCM) has shown the protective effects on myocardial function as well as renal function in mouse models of myocardial infarction.

Hypothesis/purpose: We investigated the effects of XJEK on cardiovascular- and renal-function in a heart failure mouse model induced by high salt (HS) and the associated mechanisms.

Study Design: For the purpose of assessing the effects of XJEK on a hypertensive heart failure model, mice were fed with 8% high salt diet. Read More

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Pancreatic damage in COVID-19: Why? How?

Int J Clin Pract 2021 Jul 31:e14692. Epub 2021 Jul 31.

University of Health Sciences, Diyabakır Gazi Yasargil Education and Research Hospital, Division of Gastroenterology, Diyarbakır, Turkey.

Object: We aimed to evaluate the elevation of amylase and lipase enzymes in coronavirus disease 2019 (COVID-19) patients and their relationship with the severity of COVID-19.

Method: In this study, 1378 patients with COVID-19 infection were included. Relation of elevated amylase and lipase levels and comorbidities with the severity of COVID-19 was analyzed. Read More

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Hemadsorption as rescue therapy for patients with multisystem organ failure in pediatric intensive care -two case reports and review of the literature.

Artif Organs 2021 Jul 31. Epub 2021 Jul 31.

Division of Neonatology, Pediatric Intensive Care & Neuropediatrics, Department of Pediatric and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Background: Hemadsorption via the cytokine-adsorber CytoSorb has successfully been used as an adjunctive method in adults, mainly for the purpose of immunomodulation under acute inflammatory conditions such as sepsis and cardiac surgery. In recent years, there has been growing interest in its use in pediatric intensive care to improve outcomes in patients with multiple organ failure following inflammatory illness. Literature on the application of CytoSorb in neonatal and pediatric patients is scarce, though the implication is that it could be an effective last-resort treatment option in critically ill pediatric patients. Read More

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Bariatric surgery prior to transplantation and risk of early hospital re-admission, graft failure, or death following kidney transplantation.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Hennepin County Medical Center, Division of Nephrology, Department of Medicine, USA.

Bariatric surgery has been shown to be safe in the dialysis population. Whether bariatric surgery before kidney transplantation influences post-transplant outcomes has not been examined nationally. We included severely obese (BMI>35) dialysis patients between 18-70 years who received a kidney transplant according to the US Renal Data System. Read More

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Intact fibroblast growth factor 23 levels and outcome prediction in patients with acute heart failure.

Sci Rep 2021 Jul 30;11(1):15507. Epub 2021 Jul 30.

Department of Internal Medicine I, St. Katharinen Hospital Frechen, Kapellenstrasse 1-5, 50226, Frechen, Germany.

Elevated fibroblast growth factor 23 (FGF23) levels are associated with adverse outcome in populations with cardiovascular disease and chronic kidney failure. It is unclear if FGF23 has significance in prognosis estimation in patients with acute heart failure (HF) when compared to traditional risk estimation tools. Serum levels of intact FGF23 were assessed in 139 patients admitted to the Intermediate Care Unit of a tertiary hospital for acute HF. Read More

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Using electronic health records to develop and validate a machine-learning tool to predict type 2 diabetes outcomes: a study protocol.

BMJ Open 2021 07 30;11(7):e046716. Epub 2021 Jul 30.

NIHR Imperial Patient Safety Translational Research Centre, Imperial College London, London, UK.

Introduction: Type 2 diabetes mellitus (T2DM) is a major cause of blindness, kidney failure, myocardial infarction, stroke and lower limb amputation. We are still unable, however, to accurately predict or identify which patients are at a higher risk of deterioration. Most risk stratification tools do not account for novel factors such as sociodemographic determinants, self-management ability or access to healthcare. Read More

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Novel Insights into Mechanisms of Intestinal Phosphate Absorption in Patients with Chronic Kidney Disease.

J Am Soc Nephrol 2021 Aug;32(8):1830-1832

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota

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Lithium use in a patient on haemodialysis with bipolar affective disorder and lithium-induced nephropathy.

BMJ Case Rep 2021 Jul 30;14(7). Epub 2021 Jul 30.

Renal and Transplant, Imperial College Healthcare NHS Trust, London, UK

Lithium is an effective mood stabiliser used to treat bipolar affective disorder (BPAD); however, it can also adversely affect the kidneys, causing acute toxic effects, nephrogenic diabetes insipidus, chronic renal dysfunction and end-stage kidney disease (ESKD) in a minority of patients. We describe the case of a man with a 34-year history of BPAD type-1 and a 2-year history of ESKD secondary to lithium-induced nephropathy who experienced a manic relapse. He previously responded well to lithium but, following a deterioration in kidney function, was switched to olanzapine and sodium valproate. Read More

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[Attending COVID-19 patients during the first wave of the pandemic in a Medium Stay Hospital: Variables associated with mortality in hospitalized patients in an acute situation].

Rev Esp Geriatr Gerontol 2021 May 21. Epub 2021 May 21.

Geriatría, Hospital de Guadarrama, Guadarrama, Madrid, España.

Background And Objective: Spain has been one of the countries most affected by the SARS-CoV-2 pandemic. The objective of this study is to describe the characteristics of the patients treated for COVID-19 at Guadarrama Hospital and to identify the associated mortality factors in those admitted in an acute situation.

Material And Methods: Retrospective observational study of COVID-19 patients admitted from 3/15 to 5/15/2020. Read More

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A Roadmap for Innovation to Advance Transplant Access and Outcomes: A Position Statement From the National Kidney Foundation.

Am J Kidney Dis 2021 Jul 21. Epub 2021 Jul 21.

Department of Surgery, University of Iowa Transplant Institute, Iowa City, IA.

Over the past 65 years, kidney transplantation has evolved into the optimal treatment for patients with kidney failure, dramatically reducing suffering through improved survival and quality of life. However, access to transplant is still limited by organ supply, opportunities for transplant are inequitably distributed, and lifelong transplant survival remains elusive. To address these persistent needs, the National Kidney Foundation convened an expert panel to define an agenda for future research. Read More

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Ethical Duties of Nephrologists: When Patients Are Nonadherent to Treatment.

Semin Nephrol 2021 05;41(3):262-271

Bristol Medical School, University of Bristol, Bristol, UK.

When providing care, nephrologists are subject to various ethical duties. Beyond the Hippocratic notion of doing no harm, nephrologists also have duties to respect their patients' autonomy and dignity, to meet their patients' care goals in the least invasive way, to act impartially, and, ultimately, to do what is (clinically) beneficial for their patients. Juggling these often-conflicting duties can be challenging at the best of times, but can prove especially difficult when patients are not fully adherent to treatment. Read More

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In Defense of Patient Autonomy in Kidney Failure Care When Treatment Choices Are Limited.

Semin Nephrol 2021 May;41(3):242-252

Department of Surgery, University of Cape Town, Cape Town, South Africa.

Respect for patient autonomy is a primary ethical obligation of health care providers. In kidney health care, clinical practice recommendations commonly include strategies to promote shared decision making with patients and their families about treatment options to promote patient autonomy and improve patient outcomes. However, for many people with kidney failure, treatment options may be unavailable or inaccessible. Read More

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Priority Setting as an Ethical Imperative in Managing Global Dialysis Access and Improving Kidney Care.

Semin Nephrol 2021 May;41(3):230-241

Department of Medicine, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa.

Priority-setting dilemmas arise when trade-offs must be made regarding the kinds of services that should be provided and to whom, thereby withholding other services from individuals or groups that could benefit from them. Currently, it is practically impossible for lower-income countries to provide dialysis for all patients with kidney failure; however, the fundamental premise of the human right to health, while acknowledging the current resource constraints, is the progressive realization of access to care for all. In this article we outline the rationale for priority setting, starting with the global goal of achieving universal health coverage, the prerequisites for fair and transparent priority setting, and discuss how these may apply to expensive care such as dialysis. Read More

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Ethical Challenges in Dialysis and Transplantation: Perspectives From the Developing World.

Semin Nephrol 2021 May;41(3):211-219

Department of Pediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan. Electronic address:

Renal replacement therapies including dialysis and transplantation for patients with end-stage kidney failure are treatment options beyond the reach of a large segment of the population, particularly in resource-constrained settings. Health care professionals practicing within developing countries face unique ethical issues in the provision of these treatment options despite the existence of free treatment at different centers. Apart from issues of accessibility of dialysis services, initiation of treatment can have disastrous consequences for the entire family unit, which is magnified in collectivist societies. Read More

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Molecular Changes in miRNA in Irradiated Rat Kidneys: Role of miR-34a and its Vascular Targets in the Notch Pathway.

Radiat Res 2021 Jul 30. Epub 2021 Jul 30.

Department of Radiation Oncology, Medical College of Wisconsin, Wauwatosa, Wisconsin.

The mechanism(s) of vascular regression in adult organs remains an unexplored gap. Irradiation to the kidney results in vascular regression and renal failure. The goal of this work was to determine molecular mechanism(s) of radiation-induced vascular regression and its mitigation by the drug lisinopril. Read More

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Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series.

Hum Pathol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pathology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway; Department of Clinical Medicine, University of Bergen, Jonas Lies Vei 87, 5021 Bergen, Norway. Electronic address:

The polymer polyvinylpyrrolidone (PVP) is an excipient widely used in prescription drugs. Depending on the molecular weight (MW), parenterally administered PVP may accumulate in various tissues. Consequently, moderate and high MW PVP has only been used in oral preparations since the late 1970s. Read More

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Endovascular treatment of intrarenal aneurysms bleeding and angiomyolipomas in a patient with tuberous sclerosis and polycystic kidney disease.

J Bras Nefrol 2021 Jul 30. Epub 2021 Jul 30.

Universidade de São Paulo, Instituto do Coração, Departamento de Radiologia, São Paulo, SP, Brasil.

Tuberous sclerosis complex (TSC) and autosomal dominant polycystic kidney disease (ADPKD) are conditions related to renal failure that can rarely occur in association as a contiguous gene syndrome. Angiomyolipomas (AMLs) are renal tumors strongly related to TSC that may rupture and cause life-threatening bleedings. We present a patient with TSC, ADPKD, and renal AMLs with persistent hematuria requiring blood transfusion. Read More

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Kidney failure in Samoa.

Lancet Reg Health West Pac 2020 Dec 20;5:100058. Epub 2020 Nov 20.

Department of Medicine, Otago Medical School, University of Otago, Dunedin, New Zealand.

Background: There is limited literature on kidney disease in the Pacific Region, despite it being recognised as a leading cause of death in some Pacific Island nations. Kidney replacement therapy is only available in a handful of Pacific Islands. This paper reports the epidemiology of haemodialysis patients in Samoa. Read More

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December 2020

Trends in kidney failure and kidney replacement therapy in people with diabetes in Hong Kong, 2002-2015: A retrospective cohort study.

Lancet Reg Health West Pac 2021 Jun 9;11:100165. Epub 2021 Jun 9.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.

Background: There are limited population-wide trend data on kidney failure and kidney replacement therapy (KRT) in people with diabetes. We conducted a retrospective cohort study to report incidence trends of kidney failure and KRT and related mortality in people with diabetes in Hong Kong between 2002 and 2015.

Methods: We used territory-wide electronic medical records including laboratory, diagnostic and procedural data to identify people with kidney failure and KRT. Read More

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Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis with Kidney Involvement in a Patient with AL Amyloidosis.

Case Rep Nephrol Dial 2021 May-Aug;11(2):183-189. Epub 2021 Jul 8.

Division of Nephrology, University of Vermont Medical Center, Burlington, Vermont, USA.

Antineutrophil cytoplasmic autoantibody (ANCA) vasculitis has occasionally been associated with other systemic glomerulonephritis, such as anti-glomerular basement membrane disease. Here, we report the first clinical case of ANCA-associated crescentic glomerulonephritis with AL amyloidosis. An 81-years-old gentleman presented to the hospital with acute kidney injury (serum creatinine 4. Read More

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An Unusual Case of Recurrent Migration of the Peritoneal Dialysis Catheter into the Inguinal Hernia Sac.

Case Rep Nephrol Dial 2021 May-Aug;11(2):152-157. Epub 2021 Jun 28.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

We herein report the first case of a patient with recurrent migration of the peritoneal dialysis (PD) catheter into the inguinal hernia sac. A 58-year-old man suffered from end-stage renal disease due to polycystic kidney disease (PKD). A year before starting PD, a PD catheter was implanted with stepwise initiation of PD using the Moncrief-Popovich technique. Read More

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Structural Brain Changes Associated with Overweight and Obesity.

J Obes 2021 16;2021:6613385. Epub 2021 Jul 16.

Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Mexico.

Obesity is a global health problem with a broad set of comorbidities, such as malnutrition, metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure. This review describes recent findings of neuroimaging and two studies of cell density regarding the roles of overnutrition-induced hypothalamic inflammation in neurodegeneration. These studies provided consistent evidence of smaller cortical thickness or reduction in the gray matter volume in people with overweight and obesity; however, the investigated brain regions varied across the studies. Read More

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Prognostic significance of N-Terminal Pro-BNP in patients with COVID-19 pneumonia without previous history of heart failure.

J Cardiovasc Thorac Res 2021 24;13(2):141-145. Epub 2021 Apr 24.

Cardiology, Health Sciences University, Sultan II. Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

The objective of the present research was to evaluate the possible association between the N-terminal pro-brain type natriuretic peptide (NT-proBNP) levels and in-hospital mortality in coronavirus disease 2019 (COVID-19) pneumonia patients who did not have pre-existing heart failure (HF). A total of 137 consecutive patients without pre-existing HF and hospitalized due to COVID-19 pneumonia were enrolled into the current research. The main outcome of the research was the in-hospital death. Read More

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Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells.

Front Immunol 2021 13;12:705140. Epub 2021 Jul 13.

Department of Immunology, Duke University School of Medicine, Durham, NC, United States.

Antibody-mediated allograft rejection (AMR) causes more kidney transplant failure than any other single cause. AMR is mediated by antibodies recognizing antigens expressed by the graft, and antibodies generated against major histocompatibility complex (MHC) mismatches are especially problematic. Most research directed towards the management of clinical AMR has focused on identifying and characterizing circulating donor-specific HLA antibody (DSA) and optimizing therapies that reduce B-cell activation and/or block antibody secretion by inhibiting plasmacyte survival. Read More

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Abdominal and gastrointestinal manifestations in COVID-19 patients: Is imaging useful?

World J Gastroenterol 2021 Jul;27(26):4143-4159

Diagnostic and Interventional Radiology, Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa 56126, Italy.

Coronavirus disease 2019 (COVID-19) can be considered a systemic disease with a specific tropism for the vascular system, in which the alterations of the microcirculation have an important pathogenetic role. The lungs are the main organ involved in COVID-19, and severe progressive respiratory failure is the leading cause of death in the affected patients; however, many other organs can be involved with variable clinical manifestations. Concerning abdominal manifestations, the gastrointestinal tract and the hepatobiliary system are mainly affected, although the pancreas, urinary tract and spleen may also be involved. Read More

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Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges.

World J Gastroenterol 2021 Jul;27(26):4104-4142

Department of Nephrology, Chang Gung Memorial Hospital and Chang Gung University, Taipei 105, Taiwan.

The population of patients with hepatocellular carcinoma (HCC) overlaps to a high degree with those for chronic kidney disease (CKD) and end-stage renal disease (ESRD). The degrees of renal dysfunction vary, from the various stages of CKD to dialysis-dependent ESRD, which often affects the prognosis and treatment choice of patients with HCC. In addition, renal dysfunction makes treatment more difficult and may negatively affect treatment outcomes. Read More

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Acute kidney injury and hepatorenal syndrome in cirrhosis.

World J Gastroenterol 2021 Jul;27(26):3984-4003

Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, United States.

Acute kidney injury (AKI) in cirrhosis, including hepatorenal syndrome (HRS), is a common and serious complication in cirrhotic patients, leading to significant morbidity and mortality. AKI is separated into two categories, non-HRS AKI and HRS-AKI. The most recent definition and diagnostic criteria of AKI in cirrhosis and HRS have helped diagnose and prognosticate the disease. Read More

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Haemodialysed patient with lung cancer in the COVID-19 era: a clinical challenge.

BMJ Case Rep 2021 Jul 29;14(7). Epub 2021 Jul 29.

Medical Oncology, Hospital do Espirito Santo de Evora EPE, Evora, Portugal.

A 66-year-old man was referred to the oncological pneumology consultation due to a mass in the right upper lobe observed in a routine X-ray of the chest. The CT scan confirmed a mass in the same location. The biopsy revealed a lung adenocarcinoma. Read More

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Interplay between worsening kidney function and cardiovascular events in patients with type 2 diabetes: an analysis from the ACCORD trial.

BMJ Open Diabetes Res Care 2021 Jul;9(1)

Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal.

Introduction: Patients with type 2 diabetes (T2D) have an increased risk of worsening kidney function (WKF) over time compared with patients without diabetes. Data evaluating the inter-relation between WKF, cardiovascular risk, and clinical events are scarce. We aim to study the association of WKF with subsequent cardiovascular events and the probabilities of transition from WKF to hospitalization or death according to patients' risk. Read More

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Is routine 24-hour urine calcium measurement useful during the evaluation of primary hyperparathyroidism?

Surgery 2021 Jul 26. Epub 2021 Jul 26.

Department of Surgery, University of Pittsburgh, PA; Division of Endocrine Surgery, University of Pittsburgh, PA. Electronic address:

Background: Primary hyperparathyroidism and familial hypocalciuric hypercalcemia have similar biochemical profiles, and calcium-to-creatinine-clearance ratio helps distinguish the two. Additionally, 24-hour urine calcium >400 mg/day indicates surgery and guidelines recommend obtaining 24-hour urine calcium preoperatively. Our aim was to assess how 24-hour urine calcium altered care in the evaluation of suspected primary hyperparathyroidism. Read More

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