Biomed Mater 2022 May 24. Epub 2022 May 24.
Department of Radiopharmacy and Medicinal Chemistry, Tehran University of Medical Sciences, 16 Azar Street, Tehran, 1439644545, Iran (the Islamic Republic of).
Multifunctional nanocarriers, specifically for tumor targeting and traceable features, have been increasingly considered in cancer therapies. Herein, a novel targeting agent (TA), tryptophan(TRP), was proposed for the synthesis of functionalized APTES-iron oxide nanoparticles using two methods, creating a smart drug delivery system (DDS). In one method, two-step, glutaraldehyde (GA) as a linker, bonded TRP and amino-functionalized magnetite (AMFM), and in the second method, one step, TRP binding was carried out by (3-dimethyl aminopropyl)-N'-ethyl carbodiimide hydrochloride (EDC)/ N-hydroxysuccinimide ester (NHS). Read More