949,526 results match your criteria kidney


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J Pharmacol Exp Ther 2022 May 24. Epub 2022 May 24.

University of Pittsburgh School of Medicine, United States.

8-Aminoguanine and 8-aminoguanosine (via metabolism to 8-aminoguanine) are endogenous 8-aminopurines that induce diuresis, natriuresis and glucosuria by inhibiting purine nucleoside phosphorylase (PNPase); moreover, both 8-aminopurines cause antikaluresis by other mechanisms. Because 8-aminoinosine and 8-aminohypoxanthine are structurally similar to 8-aminoguanosine and 8-aminoguanine, respectively, we sought to define their renal excretory effects. First, we compared the ability of 8-aminoguanine, 8-aminohypoxanthine and 8-aminoinosine to inhibit recombinant PNPase. Read More

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Oxidant-mediated modification and cross-linking of beta-2-microglobulin.

Free Radic Biol Med 2022 May 21. Epub 2022 May 21.

Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark. Electronic address:

Beta-2-microglobulin (B2M) is synthesized by all nucleated cells and forms part of the major histocompatibility complex (MHC) class-1 present on cell surfaces, which presents peptide fragments to cytotoxic CD8 T-lymphocytes, or by association with CD1, antigenic lipids to natural killer T-cells. Knockout of B2M results in loss of these functions and severe combined immunodeficiency. Plasma levels of this protein are low in healthy serum, but are elevated up to 50-fold in some pathologies including chronic kidney disease and multiple myeloma, where it has both diagnostic and prognostic value. Read More

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Tuberculosis incidence in patients with chronic kidney disease: a systematic review and meta-analysis.

Int J Infect Dis 2022 May 21. Epub 2022 May 21.

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.

Objective: To estimate global tuberculosis (TB) incidence in Chronic Kidney Disease (CKD) patients.

Methods: The PRISMA method was followed to perform the study. Electronic and gray literature sources were investigated for studies published between 2000 and 2021. Read More

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Induction of mesenchymal-epithelial transition (MET) by epigallocatechin-3-gallate to reverse epithelial-mesenchymal transition (EMT) in SNAI1-overexpressed renal cells: A potential anti-fibrotic strategy.

J Nutr Biochem 2022 May 21:109066. Epub 2022 May 21.

Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj, Hospital, Mahidol University, Bangkok 10700, Thailand. Electronic address:

Dynamic transdifferentiation of epithelial cells from epithelial-mesenchymal transition (EMT) to its reverse process, mesenchymal-epithelial transition (MET), has gained wide attention for management of cancers and tissue fibrosis. In this study, we addressed beneficial effects of epigallocatechin-3-gallate (EGCG) on EMT-MET reversion using an in vitro EMT model by overexpressing SNAI1 gene encoding Snail1, an EMT-inducing transcription factor, into renal tubular epithelial cells (pcDNA6.2-SNAI1 cells). Read More

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Epinephelus coioides PCSK9 affect the infection of SGIV by regulating the innate immune response.

Fish Shellfish Immunol 2022 May 21. Epub 2022 May 21.

University Joint Laboratory of Guangdong Province, Hong Kong and Macao Region on Marine Bioresource Conservation and Exploitation, Guangdong Laboratory for Lingnan Modern Agriculture, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, Guangdong Province, PR China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, PR China. Electronic address:

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in mammals is a multifunctional protein. In this study, PCSK9 of marine fish Epinephelus coioides was characterized. The full-length cDNA of E. Read More

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Comparative analysis on the immunoregulatory roles of ferritin M in hybrid fish (Carassius cuvieri ♀ × Carassius auratus red var ♂) and its parental species after bacterial infection.

Fish Shellfish Immunol 2022 May 21. Epub 2022 May 21.

State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, 410081, PR China. Electronic address:

Ferritin M is involved in the regulation of fish immunity. In this study, open reading frame (ORF) sequences of ferritin M from hybrid fish and its parental species were 534 bp. Tissue-specific analysis indicated that the highest level of ferritin M from red crucian carp was observed in kidney, while peaked expressions of ferritin M from white crucian carp and hybrid carp were observed in gill. Read More

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Synthesis of smart carriers based on tryptophan-functionalized magnetic nanoparticles and its application in 5- Fluorouracil delivery.

Biomed Mater 2022 May 24. Epub 2022 May 24.

Department of Radiopharmacy and Medicinal Chemistry, Tehran University of Medical Sciences, 16 Azar Street, Tehran, 1439644545, Iran (the Islamic Republic of).

Multifunctional nanocarriers, specifically for tumor targeting and traceable features, have been increasingly considered in cancer therapies. Herein, a novel targeting agent (TA), tryptophan(TRP), was proposed for the synthesis of functionalized APTES-iron oxide nanoparticles using two methods, creating a smart drug delivery system (DDS). In one method, two-step, glutaraldehyde (GA) as a linker, bonded TRP and amino-functionalized magnetite (AMFM), and in the second method, one step, TRP binding was carried out by (3-dimethyl aminopropyl)-N'-ethyl carbodiimide hydrochloride (EDC)/ N-hydroxysuccinimide ester (NHS). Read More

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Going Nuts to Protect Kidneys and to Live Longer with Kidney Disease.

Am J Nephrol 2022 May 24:1-4. Epub 2022 May 24.

Division of Nephrology, Hypertension, and Kidney Transplantation, University of California Irvine, Orange, California, USA.

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Improvement in Kidney Function After Discontinuation of Fenofibrate in Outpatient Nephrology Consultation for Chronic Kidney Disease.

Kidney Blood Press Res 2022 May 24. Epub 2022 May 24.

Background: It has been noted in observational and interventional studies that individuals exposed to fenofibrate can exhibit a rise in serum creatinine (sCr) concentration. However, it is not known to what extent this phenomenon impacts kidney function in patients who are referred to a nephrology clinic for consultation for chronic kidney disease (CKD).

Methods: We conducted a prospective observational study of patients referred to our nephrology clinic for a new evaluation of a rise in sCr or worsening CKD and who were on fenofibrate therapy. Read More

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Nut Consumption and Effects on Chronic Kidney Disease and Mortality in the United States.

Am J Nephrol 2022 May 24:1-10. Epub 2022 May 24.

Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Nuts have been found to have beneficial effects on some diseases, including cardiovascular disease and cancer, in several studies. However, there are few studies to show the effects of nuts on chronic kidney disease (CKD). Thus, we conducted this study to examine the association between the consumption frequency of nuts and the prevalence and mortality of CKD among adults in the USA. Read More

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Effect of high-dose glucocorticoids on markers of inflammation and bone metabolism in patients with primary glomerular disease.

Kidney Blood Press Res 2022 May 24. Epub 2022 May 24.

Background: Glucocorticoids are one of the most commonly used drugs for treatment of inflammatory and autoimmune diseases. Sirtuin-1 (SIRT-1) belongs to family of proteins involved in protection against inflammation and oxidative stress. A role of SIRT-1 in regulation of bone metabolism during high-dose steroid therapy is unknown. Read More

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Histologic diversity in chromophobe renal cell carcinoma does not impact survival outcome: A comparative international multi-institutional study.

Ann Diagn Pathol 2022 May 20;60:151978. Epub 2022 May 20.

Department of Pathology, Charles University, Faculty of Medicine and University Hospital in Plzen, Plzen, Czech Republic. Electronic address:

Predicting the clinical behavior and trajectory of chromophobe renal cell carcinoma (ChRCC) by histologic features has so far proven to be challenging. It is known that ChRCC represents a heterogeneous group of neoplasms demonstrating variable, yet distinctive morphologic and genetic profiles. In this international multi-institutional study, we aimed to assess the impact of histologic diversity in ChRCC (classic/eosinophilic versus rare subtypes) on survival outcome. Read More

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Emerging strategies for treating gout.

Curr Opin Pharmacol 2022 May 19;65:102241. Epub 2022 May 19.

Division of Clinical Immunology and Rheumatology, University of Alabama Birmingham (UAB) and Birmingham VA Medical Center, Birmingham, AL, USA. Electronic address:

Gout is a common and potentially debilitating disease characterized by a painful inflammatory arthritis ("gout flare"), caused by the deposition of monosodium urate crystals in joints and surrounding tissues. Gout is frequently comorbid with other chronic conditions such as chronic kidney disease (CKD) and diabetes mellitus, which can make treatment complex, as traditional mainstays (such as allopurinol, colchicine, and corticosteroids) may not be preferred or could have adverse events in such patients. Understanding the pathophysiology of hyperuricemia, gout, and crystalline-driven inflammation is key for drug development and research. Read More

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Evolving Role of Adjuvant Systemic Therapy for Kidney and Urothelial Cancers.

Am Soc Clin Oncol Educ Book 2022 Apr;42:1-16

Division of Oncology 1, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD.

The role of adjuvant therapy in renal cell carcinoma and urothelial carcinoma is rapidly evolving. To date, the U.S. Read More

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Predictors and outcomes of peritoneal dialysis-related infections due to filamentous molds (MycoPDICS).

PLoS One 2022 24;17(5):e0268823. Epub 2022 May 24.

Division Nephrology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Introduction: We sought to evaluate the predictors and outcomes of mold peritonitis in patients with peritoneal dialysis (PD).

Methods: This cohort study included PD patients from the MycoPDICS database who had fungal peritonitis between July 2015-June 2020. Patient outcomes were analyzed by Kaplan Meier curves and the Log-rank test. Read More

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Feeding cats with chronic kidney disease food supplemented with betaine and prebiotics increases total body mass and reduces uremic toxins.

PLoS One 2022 24;17(5):e0268624. Epub 2022 May 24.

Pet Nutrition Center, Hill's Pet Nutrition, Topeka, Kansas, United States of America.

Cats with chronic kidney disease (CKD) have a decreased ability to maintain body weight. As CKD advances, loss of body weight contributes to morbidity and mortality. The goal of this study was to evaluate the combined effects of feeding betaine and prebiotics on body weight of both CKD and healthy cats. Read More

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Interventions for increasing solid organ donor registration.

Cochrane Database Syst Rev 2021 Apr 4;4:CD10829. Epub 2021 Apr 4.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.

Background: A solution for increasing the number of available organs for transplantation is to encourage more individuals to register a commitment for deceased organ donation. However, the percentage of the population registered for organ donation remains low in many countries.

Objectives: To evaluate the benefits and harms of various interventions used to increase deceased organ donor registration. Read More

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Peptide 17 alleviates early hypertensive renal injury by regulating the Hippo/YAP signaling pathway.

Nephrology (Carlton) 2022 May 24. Epub 2022 May 24.

Internal Medicine of Traditional Chinese Medicine, Xinhua Hospital Chongming Branch Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aim: Hypertensive nephropathy is embodied by kidney tissue fibrosis and glomerular sclerosis, as well as renal inflammation. The Hippo/YAP (yes-associated protein, YAP) axis has been reported to promote inflammation and fibrosis and may participate in the pathogenesis of heart, vascular and renal injuries. However, the role of the Hippo/YAP pathway in hypertensive renal injury has not been reported so far. Read More

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Small molecule inhibitor of intestinal anion exchanger SLC26A3 for therapy of hyperoxaluria and nephrolithiasis.

JCI Insight 2022 May 24. Epub 2022 May 24.

Department of Medicine and Physiology, University of California, San Francisco, San Francisco, United States of America.

Nephrolithiasis is a common and recurrent disease affecting 9% of the US population. Hyperoxaluria is major risk factor for calcium oxalate kidney stones, which constitutes two-thirds of all kidney stones. Gastrointestinal epithelia play an important role in oxalate handling due to the presence of SLC26A family anion exchangers that facilitate oxalate transport. Read More

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Acute Respiratory Distress Syndrome Associated with Multisystem Inflammatory Syndrome in a Child with Covid-19 and Diabetic Ketoacidosis: A Case Report.

Pulm Ther 2022 May 24. Epub 2022 May 24.

Division of Pulmonary, Allergy and Critical Care Medicine, Penn State College of Medicine, Hershey, PA, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (Covid-19), has uncontrollable effects on many organs. A great number of previously published scientific reports have revealed that patients with diabetes mellitus face a more severe form of Covid-19 with a higher death rate. Here we present the case of a 13-year-old unvaccinated boy who was admitted to an intensive care unit (ICU) with a history of fever, cough, dyspnea, throat pain, nausea, and confusion that progressed to lethargy after 24 h. Read More

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Cancer prevalence and cancer screening in patients with acromegaly: a single center experience.

Endocrine 2022 May 24. Epub 2022 May 24.

Ondokuz Mayis University, Faculty of Medicine, Department of Endocrinology and Metabolism, Samsun, Turkey.

Purpose: To investigate the prevalence of cancer in patients with acromegaly and the variables associated with malignant and premalignant lesions detected by cancer screening.

Methods: The data of 214 patients diagnosed with acromegaly in our institution were evaluated retrospectively. Prevalence of cancer was compared with national rates to estimate standardized incidence ratios (SIRs). Read More

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Correction to: Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transporters.

Pflugers Arch 2022 May 24. Epub 2022 May 24.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P. O. Box 9101, Nijmegen, 6500 HB, The Netherlands.

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Corrigendum to "Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway".

Evid Based Complement Alternat Med 2022 14;2022:9828973. Epub 2022 May 14.

The First Hospital, Hebei Medical University, Shijiazhuang 050031, Hebei, China.

[This corrects the article DOI: 10.1155/2021/5545193.]. Read More

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Bone Mineral Density T-Score is an Independent Predictor of Major Blood Loss in Adult Spinal Deformity Surgery.

Global Spine J 2022 May 24:21925682221097912. Epub 2022 May 24.

Department of Orthopaedic Surgery, 1466The Johns Hopkins University, Baltimore, MD, USA.

Study Design: Retrospective Cohort Study.

Objective: The purpose of this study was to determine the effect of low bone mineral density (BMD), as assessed by preoperative Dual-energy X-ray Absorptiometry (DEXA) scans, on intraoperative blood loss following adult spinal deformity (ASD) surgery.

Methods: Patients who received spinal fusion for ASD (>5 levels fused) at a single academic center from 2010-2018 were included in this study. Read More

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First record of isolation and characterization of Vibrio sinaloensis from diseased orange-spotted grouper Epinephelus coioides.

Dis Aquat Organ 2022 May 24;149:71-76. Epub 2022 May 24.

Tianjin Key Lab of Aqua-Ecology and Aquaculture, Fisheries College, Tianjin Agricultural University, Tianjin 300380, PR China.

A dominant bacterium, ZYL-12, isolated from the liver of a diseased orange-spotted grouper Epinephelus coioides, was identified as Vibrio sinaloensis, based on phenotypic and molecular analysis. The median lethal dosage of ZYL-12 was calculated as 1.6 × 105 CFU g-1 fish weight. Read More

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Effects of hemodialysis and reduced estimated glomerular filtration rate in nonhemodialysis on clinical outcomes after fractional flow reserve-guided deferral of revascularization.

Medicine (Baltimore) 2022 May 20;101(20):e29256. Epub 2022 May 20.

Department of Cardiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Abstract: The effect of renal dysfunction on clinical outcomes following fractional flow reserve (FFR)-guided deferral of revascularization remains unelucidated.We retrospectively analyzed 224 patients with atherosclerotic coronary lesions who underwent deferred revascularization based on an FFR of >0.80. Read More

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Abdominal Organ Transplantation: Noteworthy Literature in 2021.

Semin Cardiothorac Vasc Anesth 2022 May 24:10892532221093955. Epub 2022 May 24.

Department of Anesthesiology and Perioperative Medicine, UPMC (University of Pittsburgh Medical Center), Pittsburgh, PA, USA.

This review highlights noteworthy literature pertinent to anesthesiologists and critical care physicians caring for patients undergoing abdominal organ transplantation. In 2021, we identified noteworthy papers from over 1,200 peer-reviewed publications on pancreatic transplantation, over 1,400 on intestinal transplantation, and over 9,000 on kidney transplantation. The liver transplantation section focuses on clinical trials and systematic reviews and meta-analyses published in 2021 and features 20 selected papers. Read More

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Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients.

J Bras Nefrol 2022 May 23. Epub 2022 May 23.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Endocrinology Department, México City, Mexico.

Objective: To evaluate hypothalamic-pi- tuitary-gonadal (HPG) axis alterations at 1 and 12 months after kidney transplan- tation (KT) and their association with in- sulin resistance.

Methods: A retrospective clinical study was conducted in a tertiary care center in kidney transplantation recipients (KTRs) aged 18- 50 years with primary kidney disease and stable renal graft function. LH, FSH, E2/T, and HOMA-IR were assessed at 1 and 12 months after KT. Read More

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Chemokines, Soluble PD-L1, and Immune Cell Hyporesponsiveness are Distinct Features of SARS-CoV-2 Critical Illness.

Am J Physiol Lung Cell Mol Physiol 2022 May 24. Epub 2022 May 24.

Benaroya Research Institute, Seattle, WA, United States.

Critically ill patients manifest many of the same immune features seen in COVID-19, including both "cytokine storm" and "immune suppression." However, direct comparisons of molecular and cellular profiles between contemporaneously enrolled critically ill patients with and without SARS-CoV-2 are limited. We sought to identify immune signatures specifically enriched in critically ill patients with COVID-19 compared to patients without COVID-19. Read More

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