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COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop.

ALTEX 2022 Jan 3. Epub 2022 Jan 3.

US Consumer Product Safety Commission, Bethesda, MD, USA.

On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome, such as respiratory distress, anosmia or multiorgan failure. Read More

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January 2022

AetSRG1 contributes to the inhibition of wheat Cd accumulation by stabilizing phenylalanine ammonia lyase.

J Hazard Mater 2022 Jan 7;428:128226. Epub 2022 Jan 7.

School of Life Sciences, Guizhou Normal University, Guiyang, Guizhou Province, China. Electronic address:

Cadmium (Cd) is a toxic heavy metal that poses a serious threat to crop safety, productivity, and human health. Aegilops tauschii is the D genome donor of common wheat and shows abundant genetic variation. However, the tolerance of Ae. Read More

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January 2022

2D/3D S-scheme heterojunction of carbon nitride/iodine-deficient bismuth oxyiodide for photocatalytic hydrogen production and bisphenol A degradation.

J Colloid Interface Sci 2022 Jan 6;612:722-736. Epub 2022 Jan 6.

School of Materials Engineering, Changshu Institute of Technology, Changshu, China; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China. Electronic address:

A novel 2D/3D S-scheme carbon nitride/iodine-deficient bismuth oxyiodide (g-CN/BiOI) heterojunction was constructed for the first time by calcining a mixture of g-CN nanosheets and flower-like BiOI. Irradiated by visible light, this g-CN/BiOI heterojunction exhibited excellent photocatalytic hydrogen production and BPA degradation activity with high cycle stability. In particular, the photocatalytic activity of 0. Read More

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January 2022

Computational characterization of transducer recognition of β2 adrenergic receptor.

Biochem Biophys Res Commun 2022 Jan 7;592:67-73. Epub 2022 Jan 7.

State Key Laboratory of Drug Research and Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou, 310024, China. Electronic address:

As an important drug target, β2 adrenergic receptor (B2AR) regulates many physiological processes, including cardiac function, airway tone and metabolic functions. The selective coupling between B2AR and specific transducers is critical for the physiological action of the receptor. However, the molecular mechanism by which B2AR recognizes different transducers remains elusive. Read More

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January 2022

Ultrasensitive microfluidic immunosensor with stir bar enrichment for point-of-care test of Staphylococcus aureus in foods triggered by DNAzyme-assisted click reaction.

Food Chem 2022 Jan 8;378:132093. Epub 2022 Jan 8.

Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo 315211, China. Electronic address:

This work demonstrated an ultrasensitive and simple microfluidic immunosensor for point-of-care test of Staphylococcus aureus (S. aureus) based on the stir bar enrichment and DNAzyme-assisted click reaction. Initially, S. Read More

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January 2022

A ratiometric fluorescent probe for hydrogen sulfide in neat aqueous solution and its application in lysosome-targetable cell imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Dec 30;270:120835. Epub 2021 Dec 30.

Key Laboratory of Chemo/Biosensing and Detection, College of Chemical and Materials Engineering, Xuchang University, 461000, PR China; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450052, PR China. Electronic address:

Hydrogen sulfide (HS) has been recently regarded as one of the most important gasotransmitters in the metabolic system, while abnormal HS concentration is associated with various diseases. Although numerous fluorescent probes have been developed for the detection of cellular HS, only a few of them can monitor lysosomal HS with ratiometric fluorescent output. Here, we developed a water-soluble probe 1 toward HS by introducing 2,4-dinitrophenyl ether into a novel merocyanine-based dye. Read More

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December 2021

Investigation of partition coefficients and fingerprints of atmospheric gas- and particle-phase intermediate volatility and semi-volatile organic compounds using pixel-based approaches.

J Chromatogr A 2022 Jan 7;1665:462808. Epub 2022 Jan 7.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, International Joint Laboratory for Regional Pollution Control, Ministry of Education (IJRC), College of Environmental Sciences and Engineering, Beijing, 100871, China.

Ambient gas- and particle-phase intermediate volatility and semi-volatile organic compounds (I/SVOCs) of Beijing were analyzed by a thermal desorption comprehensive two-dimensional gas chromatography quadrupole mass spectrometry (TD-GC × GC-qMS). A pixel-based scheme combing the integration-based approach was applied for partition coefficients estimation and fingerprints identification. Blob-by-blob recognition was firstly utilized to characterize I/SVOCs from the molecular level. Read More

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January 2022

Integrated hepatic single-cell RNA sequencing and untargeted metabolomics reveals the immune and metabolic modulation of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia.

Phytomedicine 2022 Jan 2;97:153922. Epub 2022 Jan 2.

School of Pharmacy, Second Military Medical University, Shanghai 200433, China; The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Background: Although Qing-Fei-Pai-Du decoction (QFPDD) is extensively used clinically to treat COVID-19 patients, the mechanism by which it modulates the immunological and metabolic functions of liver tissue remains unknown.

Purpose: The purpose of this study is to investigate the mechanism of action of QFPDD in the treatment of mice with coronavirus-induced pneumonia by combining integrated hepatic single-cell RNA sequencing and untargeted metabolomics.

Methods: We developed a human coronavirus pneumonia model in BALB/c mice by infecting them with human coronavirus HCoV-229E with stimulating them with cold-damp environment. Read More

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January 2022

Associations of multiple plasma metals with the risk of metabolic syndrome: A cross-sectional study in the mid-aged and older population of China.

Ecotoxicol Environ Saf 2022 Jan 13;231:113183. Epub 2022 Jan 13.

Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address:

Background: Metal exposures have been reported to be related to the progress of metabolic syndrome (MetS), however, the currents results were still controversial, and the evidence about the effect of multi-metal exposure on MetS were limited. In this study, we intended to evaluate the relationships between metal mixture exposure and the prevalence of MetS in a mid-aged and older population of China.

Methods: The plasma levels of 13 metals (aluminum, magnesium, calcium, iron, manganese, cobalt, copper, arsenic, zinc, selenium, cadmium, molybdenum and thallium) were detected by inductively coupled plasma mass spectrometry (ICP-MS) in 1277 adults recruited from the Eighth Affiliated Hospital of Sun Yat-Sen University (Shenzhen, China). Read More

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January 2022

Untargeted GC-MS metabolomics reveals the metabolic responses in the gills of Chinese mitten crab (Eriocheir sinensis) subjected to air-exposure stress.

Ecotoxicol Environ Saf 2022 Jan 12;231:113159. Epub 2022 Jan 12.

Department of Marine Technology, School of Marine and Biological Engineering, Yancheng Institute of Technology, Yancheng 224051, China.

Desiccation is a common stress experienced by crabs during aquaculture and transportation. In China, the crustacean, Chinese mitten crab (Eriocheir sinensis), is economically important. However, little is known about the molecular pathways underlying physiological stress. Read More

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January 2022

Single-cell Transcriptomic Profiling of the Hypothalamic Median Eminence during Aging.

J Genet Genomics 2022 Jan 12. Epub 2022 Jan 12.

State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing 100101, China; Chinese Institute for Brain Research, Beijing 102206, China; Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. Electronic address:

Aging is a slow and progressive natural process that compromises the normal functions of cells, tissues, organs and systems. The aging of the hypothalamic median eminence (ME), a structural gate linking neural and endocrine systems, may impair hormone release, energy homeostasis and central sensing of circulating molecules, leading to systemic and reproductive aging. However, the molecular and cellular features of ME aging remain largely unknown. Read More

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January 2022

The RppC-AvrRppC NLR-effector Interaction Mediates the Resistance to Southern Corn Rust in Maize.

Mol Plant 2022 Jan 12. Epub 2022 Jan 12.

Center of Biotechnology, Beijing Lantron Seed, Zhengzhou 450001, China.

Southern corn rust (SCR), caused by the fungal pathogen Puccinia polysora, is a major threat to maize production worldwide. Efficient breeding and deployment of resistant hybrids are key to the durable control of SCR. Here, we report molecular cloning and characterization of RppC, encoding an NLR-type immune receptor that is responsible for a major SCR resistance QTL. Read More

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January 2022

A viral protein orchestrates rice ethylene signaling to coordinate viral infection and insect vector-mediated transmission.

Mol Plant 2022 Jan 12. Epub 2022 Jan 12.

Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus frequently transmitted by planthopper. However, the molecular mechanism underlying its propagation in the host and epidemic in the field is largely unknown. Read More

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January 2022

Weedy rice, a hidden gold mine in the paddy field.

Mol Plant 2022 Jan 12. Epub 2022 Jan 12.

Zhejiang University City College, Hangzhou 310015 & College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China. Electronic address:

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January 2022

The role of 5-HTR in the memory impairment of mice induced by long-term isoflurane anesthesia.

Neurobiol Learn Mem 2022 Jan 12:107584. Epub 2022 Jan 12.

Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China. Electronic address:

General anesthesia is widely utilized in the clinic for surgical and diagnostic procedures. However, growing evidence suggests that anesthetic exposure may affect cognitive function negatively. Unfortunately, little is known about the underlying mechanisms and efficient prevention and therapeutic strategies for the anesthesia-induced cognitive dysfunction. Read More

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January 2022

Fighting fire with fire: the immune system might be key in our fight against Alzheimer's disease.

Drug Discov Today 2022 Jan 12. Epub 2022 Jan 12.

Barriers in Inflammation Lab, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

The ultimate cause of Alzheimer's disease (AD) is still unknown and no disease-modifying treatment exists. Emerging evidence supports the concept that the immune system has a key role in AD pathogenesis. This awareness leads to the idea that specific parts of the immune system must be engaged to ward off the disease. Read More

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January 2022

The function of specialized pro-resolving endogenous lipid mediators, vitamins, and other micronutrients in the control of the inflammatory processes: Possible role in patients with SARS-CoV-2 related infection.

Prostaglandins Other Lipid Mediat 2022 Jan 12:106619. Epub 2022 Jan 12.

Comune di Bologna, Bologna, Italy.

Inflammation is an essential protective response against harmful stimuli, such as invading pathogens, damaged cells, or irritants. Physiological inflammation eliminates pathogens and promotes tissue repair and healing. Effective immune response in humans depends on a tightly regulated balance among inflammatory and anti-inflammatory mechanisms involving both innate and adaptive arms of the immune system. Read More

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January 2022

Phylogenetics And The Evolution Of Terrestriality In Mudskippers (Gobiidae: Oxudercinae).

Mol Phylogenet Evol 2022 Jan 12:107416. Epub 2022 Jan 12.

Department of Biological Science, 327 Stadium Dr., Florida State University, Tallahassee Florida, 32306-4295, USA.

The initial vertebrate conquest of land by stegocephalians (Sarcopterygia) allowed access to new resources and exploitation of untapped niches precipitating a major phylogenetic diversification. However, a paucity of fossils has left considerable uncertainties about phylogenetic relationships and the eco-morphological stages in this key transition in Earth history. Among extant actinopterygians, three genera of mudskippers (Gobiidae: Oxudercinae), Boleophthalmus, Periophthalmus and Periophthalmodon are the most terrestrialized, with vertebral, appendicular, locomotory, respiratory, and epithelial specializations enabling overland excursions up to 14 hours. Read More

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January 2022

Highly sensitive detection of three protein toxins via SERS-lateral flow immunoassay based on [email protected] nanoparticles.

Nanomedicine 2022 Jan 12:102522. Epub 2022 Jan 12.

Beijing Institute of Radiation Medicine, Beijing 100850, P. R. China; Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing 100850, P. R. China. Electronic address:

We developed surface-enhanced Raman scattering-lateral flow immunoassay (SERS-LFIA) biosensor strips based on [email protected] nanoparticles (NPs) for the specific and highly sensitive detection of ricin, staphylococcal enterotoxin B (SEB), and botulinum neurotoxin type A (BoNT/A). [email protected] NPs were used to prepare SERS tags with useful properties, such as light weight, uniform particle size, good dispersion, and high SERS performance. The detection limit of the SERS-LFIA strips developed herein for ricin, SEB, and BoNT/A was 0. Read More

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January 2022

Tanshinone IIA and its derivative activate thermogenesis in adipocytes and induce "beiging" of white adipose tissue.

Mol Cell Endocrinol 2022 Jan 12:111557. Epub 2022 Jan 12.

Department of Biochemistry, Molecular Cancer Research Center, School of Medicine, Sun yat-sen University, Shenzhen, 518107, Guangdong Province, China. Electronic address:

Tanshinone IIA (TAN2A) is a major active ingredient of Salvia miltiorrhiza used in traditional Chinese medicine and tanshinone 20 (TAN20) is a derivative of TAN2A. In this study, we examined the effects of TAN2A and TAN20 on adipogenesis, lipid metabolism, and thermogenesis. Our experiments showed that both TAN2A and TAN20 increased mitochondria content in adipose tissue, enhanced energy expenditure, reduced body weight, and improved insulin sensitivity and metabolic homeostasis in obese and diabetic mouse models. Read More

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January 2022

Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling.

Toxicol Lett 2022 Jan 12. Epub 2022 Jan 12.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, Jiangsu 210093, China. Electronic address:

Early experimental studies have demonstrated that microcystin-leucine arginine (MC-LR) is able to induce multiple organ damage. Female reproductive disorders caused by MC-LR have attracted increased attention in recent years. However, the underlying mechanisms of female reproductive malfunctions are not yet fully understood. Read More

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January 2022

Design and Synthesis of Osthole-based Compounds as Potential Nrf2 Agonists.

Bioorg Med Chem Lett 2022 Jan 12:128547. Epub 2022 Jan 12.

Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address:

A total of 23 compounds based on Osthole skeleton were designed and synthesized. Their agonistic activity for Nrf2 were evaluated by Dual-luciferase Reporter Gene Assay. Most of the compounds showed better activities compared with Osthole, especially O15 and O21. Read More

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January 2022

Combination of molecular docking and liver transcription sequencing analysis for the evaluation of salt-processed psoraleae fructus-induced hepatotoxicity in ovariectomized mice.

J Ethnopharmacol 2022 Jan 12:114955. Epub 2022 Jan 12.

Jiangsu Key Laboratory of Chinese Medicine Processing, Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China. Electronic address:

Ethnopharmacological Relevance: Salt-processed Psoraleae fructus (SPF) is widely used as a phytoestrogen-like agent in the treatment of osteoporosis. However, SPF-associated hepatotoxicity is a known health hazard. Cholestasis is often associated with SPF-induced hepatotoxicity. Read More

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January 2022

Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis.

J Ethnopharmacol 2022 Jan 12:114988. Epub 2022 Jan 12.

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Ethnic Medicine Academic Heritage Innovation Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Ethnopharmacological Relevance: Dengzhan Xixin injection (DX), a preparation of extracts from traditional Chinese medicine Erigeron breviscapus (Vaniot) Hand.-Mazz., has been widely used in clinical treatment of cerebral ischemia sequelae in China for a long history. Read More

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January 2022

Transcriptomic changes in the hypothalamus of ovariectomized mice: Data from RNA-seq analysis.

Ann Anat 2022 Jan 12:151886. Epub 2022 Jan 12.

Department of Anatomy and Histoembryology, School of Basic Medical Science, Peking University, Beijing 100191, China. Electronic address:

Background: Menopausal symptoms can affect the physical and mental health of females and are often related to abnormal function of the hypothalamus. In this study, we evaluated changes in the hypothalamus transcriptome in ovariectomized mice to identify key mRNAs, and systematically elucidated the possible molecular mechanisms underlying the menopausal syndrome to provide a theoretical basis for clinical diagnosis and treatment.

Methods: Forty-six adult female C57BL/6J mice were randomly divided into SHAM and OVX groups, 23 mice per group. Read More

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January 2022

Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling-Mediated Sensory Neuron-Dendritic Cell Communication.

J Invest Dermatol 2022 Jan 12. Epub 2022 Jan 12.

Shanghai Institute of Immunology, Precision Research Center for Refractory Diseases, Shanghai General Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Psoriasis is a chronic immune-mediated skin disorder with the nervous system contributing to its pathology. The neurogenic mediators of psoriasis are elusive and whether the intervention of cutaneous nervous system can treat psoriasis remains to be determined. Here we conducted a pilot study using epidural injection of lidocaine to treat patients with psoriasis. Read More

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January 2022

Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes.

Biochem Pharmacol 2022 Jan 12:114913. Epub 2022 Jan 12.

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road 38, Beijing, 100191, China. Electronic address:

Nitazoxanide and related thiazolides are a novel class of anti-infectious agents against protozoan parasites, bacteria and viruses. In recent years, it is demonstrated thatthiazolides also can induced cell cycle arrest and apoptotic cell death in cancer cells. Due to their fast proliferating nature, cancer cells highly depend on the proteasome system to remove aberrant proteins. Read More

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January 2022

Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.

Biochem Pharmacol 2022 Jan 12:114912. Epub 2022 Jan 12.

State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences, Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, University of Macau, Taipa, Macao SAR 999078, China. Electronic address:

The roots of Glycine tabacina are used to treat rheumatoid arthritis (RA) and joint infection in folk medicine. Glytabastan B (GlyB), a newly reported coumestan isolated from this species, was found to significantly attenuate IL-1β-induced inflammation in SW982 human synovial cells at 3 and 6 μM, as evidenced by the decreased levels of pro-inflammatory mediators and matrix metalloproteinases (MMPs). GlyB also suppressed RANKL-induced osteoclastogenesis, decreased the expression of osteoclastogenic markers (NFATc1, CTSK, MMP-9) and osteoclast-mediated bone resorption. Read More

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January 2022

Simultaneously Achieving Highly Efficient and Stable Polymer:Non-Fullerene Solar Cells Enabled By Molecular Structure Optimization and Surface Passivation.

Adv Sci (Weinh) 2022 Jan 15:e2104588. Epub 2022 Jan 15.

School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, 230026, P. R. China.

Despite the tremendous efforts in developing non-fullerene acceptor (NFA) for polymer solar cells (PSCs), only few researches are done on studying the NFA molecular structure dependent stability of PSCs, and long-term stable PSCs are only reported for the cells with low efficiency. Herein, the authors compare the stability of inverted PM6:NFA solar cells using ITIC, IT-4F, Y6, and N3 as the NFA, and a decay rate order of IT-4F > Y6 ≈ N3 > ITIC is measured. Quantum chemical calculations reveal that fluorine substitution weakens the C═C bond and enhances the interaction between NFA and ZnO, whereas the β-alkyl chains on the thiophene unit next to the C═C linker blocks the attacking of hydroxyl radicals onto the C═C bonds. Read More

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January 2022

NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation.

Aging Cell 2022 Jan 15:e13551. Epub 2022 Jan 15.

The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases, Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.

Senescence of bone marrow mesenchymal stem cells (BMSCs) impairs stemness and osteogenic differentiation, but the key regulators for senescence and the related osteogenesis are not well defined. Herein, we screened the gene expression profiles of human BMSCs from young and old donors and identified that elevation of the nucleosome assembly protein 1-like 2 (NAP1L2) expression was correlated with BMSC senescence and impaired osteogenesis. Elevated NAP1L2 expression was observed in replicative cell senescence and induced cell senescence in vitro, and in age-related senescent human and mouse BMSCs in vivo, concomitant with significantly augmented chromatin accessibility detected by ATAC-seq. Read More

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January 2022