4,271 results match your criteria ketamine group


[Energy metabolism disorder and functional magnetic resonance imaging of the medial prefrontal cortex in mice with chronic unpredictable mild stress].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):521-528

Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To analyze spontaneous activities and energy metabolism in the medial prefrontal cortex (mPFC) of mice with chronic unpredictable mild stress (CUMS) and explore the correlation of these changes with the mTORC1 signaling pathway.

Objective: Normal C57Bl/6 mice were randomly divided into control group (=16) and depression model group (= 16), and the mice in the latter group were subjected to 8 weeks of modeling with CUMS. Behavioral tests including open field test, sucrose consumption test, tail suspension test and forced swimming test were performed, and the changes in prefrontal gray matter volume and the amplitude of low frequency fluctuation (ALFF) in the mice were detected with functional magnetic resonance imaging. Read More

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Effects of treatment refractoriness and brain-derived neurotrophic factor Val66Met polymorphism on antidepressant response to low-dose ketamine infusion.

Eur Arch Psychiatry Clin Neurosci 2021 May 7. Epub 2021 May 7.

Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Beitou district, Taipei, 112, Taiwan.

Evidence suggests that levels of treatment refractoriness and brain-derived neurotrophic factor (BDNF) rs6265 polymorphism are related to the antidepressant effects of conventional antidepressants and repetitive transcranial magnetic stimulation. However, whether these factors are associated with the antidepressant effects of low-dose ketamine remains unclear. In total, 71 patients with treatment-resistant depression (TRD) were randomized to 0. Read More

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Clinical Randomized Comparison of Medetomidine and Xylazine for Isoflurane Balanced Anesthesia in Horses.

Front Vet Sci 2021 20;8:603695. Epub 2021 Apr 20.

Section Anesthesiology, Department of Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

To assess drug plasma levels, preanesthetic sedation, cardiopulmonary effects during anesthesia and recovery in horses anesthetized with isoflurane combined with medetomidine or xylazine. Prospective blinded randomized clinical study. Sixty horses undergoing elective surgery. Read More

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Investigation Of The Effects Of Propofol/Ketamine Versus Propofol/Fentanyl On Nausea-Vomiting Administered For Sedation In Children Undergoing Magnetic Resonance Imaging: A Prospective Randomized Double-Blinded Study.

Turk J Med Sci 2021 May 7. Epub 2021 May 7.

Purpose: In this study, we aimed to compare the effects of propofol-ketamine and propofol-fentanyl sedations on post-procedure nausea-vomiting in children undergoing magnetic resonance imaging (MRI).

Materials And Methods: This study included 100 pediatric patients (2-10 years old) who had propofol-ketamine and propofol-fentanyl for sedation to undergo MRI. The patients were divided into two groups, and sedation was performed through propofol-ketamine (Group K; n=50) or propofol-fentanyl (Group F; n=50). Read More

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Clinical validation of the short and long UNESP-Botucatu scales for feline pain assessment.

PeerJ 2021 12;9:e11225. Epub 2021 Apr 12.

Department of Veterinary Surgery and Animal Reproduction / School of Veterinary Medicine and Animal Science, São Paulo State University (Unesp), Botucatu, São Paulo, Brazil.

Background: The UNESP-Botucatu multidimensional feline pain assessment scale (UFEPS) is a valid and reliable instrument for acute pain assessment in cats. However, its limitations are that responsiveness was not tested using a negative control group, it was validated only for ovariohysterectomy, and it can be time-consuming. We aimed to evaluate the construct and criterion validity, reliability, sensitivity, and specificity of the UFEPS and its novel short form (SF) in various clinical or painful surgical conditions. Read More

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Adjunctive music improves the tolerability of intravenous ketamine for bipolar depression.

Int Clin Psychopharmacol 2021 Apr 23. Epub 2021 Apr 23.

Douglas Mental Health Research Institute, McGill University, McGill Group for Suicide Studies, Montréal, Québec, Canada.

Intravenous ketamine is an effective treatment of bipolar depression. One of its most important side-effects is a transient altered state of consciousness commonly referred to as dissociation. These states can be anxiety-provoking, distressing and even treatment-limiting, warranting research into mitigation strategies. Read More

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A survey of acute pain service in Canadian teaching hospitals.

Braz J Anesthesiol 2021 Mar-Apr;71(2):116-122. Epub 2021 Feb 3.

Western University, London Health Science Centre, University Hospital, Department of Anesthesia and Perioperative Medicine, Complex Pain Management Program, London, Canada.

Background: The first national survey to ascertain the prevalence, structure, and functioning of the APS in Canadian university affiliated hospitals was conducted in 1991. This is a follow-up survey to assess the current status of the APS in Canada.

Methods: We requested completion of a 26-question survey from lead personnel of the APS teams or Anesthesia departments of Canadian teaching hospitals. Read More

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February 2021

Management of cardiorespiratory function of rabbits by a customized chest drain: An experimental study.

J Adv Vet Anim Res 2021 Mar 8;8(1):138-145. Epub 2021 Mar 8.

Department of Paediatrics, Cumilla Medical College Hospital, Cumilla, Bangladesh.

Objective: This study aimed to salvage the study population from the fatality that occurs due to iatrogenic injury to the thoracic cavity's pleural membrane.

Materials And Methods: An experimental study of temporomandibular joint arthroplasty with costochondral graft was carried out on 72 healthy '' species of male rabbits. The rabbits were distributed into two age groups: growing (3-4 months) and adult (12-18 months). Read More

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Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study.

Anesthesiol Res Pract 2021 23;2021:6674658. Epub 2021 Mar 23.

Department of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt.

Background: Emotional and psychological effects following abortion are more common than physical side effects and can range from mild regret to more serious complications such as depression. In the last decade, it has been suggested that low dose of ketamine is a fast-acting antidepressant.

Purpose: The aim of this study was to investigate the impact of intraoperative ketamine infusion on postoperative mood score in patients undergoing Dilation and Curettage (D&C) under spinal anesthesia. Read More

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Evaluation of Three Medetomidine-Based Anesthetic Protocols in Free-Ranging Wild Boars ().

Front Vet Sci 2021 29;8:655345. Epub 2021 Mar 29.

Department of Forestry and Wildlife Management, Inland Norway University of Applied Sciences, Koppang, Norway.

Three medetomidine-based drug protocols were compared by evaluating time courses, reliability and physiological effects in wild boars. A total of 21 cage-trapped wild boars () were immobilized using one of the following drug combinations; MTZ: medetomidine (0.2 mg/kg) + tiletamine-zolazepam (2. Read More

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Opioid-free anesthesia for patients with joint hypermobility syndrome undergoing craneo-cervical fixation: a case-series study focused on anti-hyperalgesic approach.

Orphanet J Rare Dis 2021 Apr 13;16(1):172. Epub 2021 Apr 13.

Servei Central D'Anestesiología (Anestalia), Centro Médico Teknon, Carrer Vilana 12, 08022, Barcelona, Spain.

Background: Patients with Ehlers-Danlos Syndrome/Hypermobility Type (EDS-HT/JHS) and Craneo-Cervical Instability frequently suffer from severe widespread pain which is difficult to control. Chronic neuroinflammation, opioid-induced hyperalgesia, and central sensitization may explain this painful condition. The aim of this study was to determine if opioid-free anesthesia plus the postoperative administration of lidocaine, ketamine and dexmedetomidine can reduce postoperative pain and the need of methadone rescues in comparison with opioid-based management in these patients undergoing Craneo-Cervical Fixation (CCF). Read More

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Influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition of elderly surgical patients.

Am J Transl Res 2021 15;13(3):1701-1709. Epub 2021 Mar 15.

Department of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.

Objective: To analyze the influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition in elderly surgical patients.

Methods: A total of 80 elderly surgical patients were randomly divided into a control group (n=40) and a study group (n=40). The control group received anesthetic induction with propofol combined with sufentanil, while the study group received anesthetic induction with propofol combined with esketamine. Read More

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Prophylactic low dose ketamine infusion for prevention of shivering during spinal anesthesia: A randomized double blind clinical trial.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):506-510. Epub 2021 Jan 18.

Department of Biostatistics, Pondicherry Institute of Medical Sciences, Pondicherry, India.

Background And Aims: Regional anesthesia is known to produce perioperative hypothermia and shivering. We aimed to evaluate if prophylactic low dose ketamine bolus followed by infusion would prevent intraoperative and postoperative shivering under spinal anesthesia.

Material And Methods: Sixty patients belonging to American Society of Anaesthesiologists (ASA) 1 and 2 undergoing abdominal and lower limb surgery were randomized to receive either 0. Read More

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January 2021

Topical ketamine as a local anesthetic agent in reducing venipuncture pain: A randomized controlled trial.

Am J Emerg Med 2021 Apr 3;48:48-53. Epub 2021 Apr 3.

Department of General Surgery, Ealing Hospital, London North West University Healthcare NHS Trust, London, Uxbridge Road, Southall UB1 3HW, UK.

Aim: Pain control is an important aspect of ED patient management, and there are many different protocols used around the world influenced by both availability of local resources as well as staff competency and experience. This study aims to evaluate the use of topical ketamine in acute pain reduction by directly comparing it to lidocaine-prilocaine (EMLA) cream.

Materials And Methods: In this randomized clinical trial, 300 adult patients classified as level 4 or 5 by ESI triage system were enrolled. Read More

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The role of ketamine in opioid-free spinal deformity surgery: is it possible and beneficial?

J Spine Surg 2021 Mar;7(1):55-61

The Och Spine Hospital, NewYork-Presbyterian/Columbia University Medical Center, New York, NY, USA.

Background: As the opioid epidemic in the United States has continued to gain momentum in recent years, the current study aims to explore the efficacy of ketamine in a traditionally challenging setting regarding pain control, and contribute toward developing an opioid-free intraoperative pain protocol in spinal deformity surgery.

Methods: Fifty-four patients who underwent spinal deformity surgery between January 1, 2017 and December 31, 2017 by one senior surgeon were included. Demographic data and preoperative opioid use was collected. Read More

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The comparison of ketamine with tramadol for postoperative pain relief on children following adenotonsillectomy or tonsillectomy: A meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Apr;100(14):e22541

Department of Pediatrics, The First People's Hospital of Xiaoshan, Hangzhou, Zhejiang Province, P.R. China.

Introduction: The comparison of ketamine with tramadol for pain control remains controversial in pediatric adenotonsillectomy or tonsillectomy. We conduct a systematic review and meta-analysis to explore the efficacy of ketamine vs tramadol for pain relief in children following adenotonsillectomy or tonsillectomy.

Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through October 2019 for randomized controlled trials (RCTs) assessing the effect of ketamine vs tramadol for pediatric adenotonsillectomy or tonsillectomy. Read More

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Effects of Ketamine Analgesia on Cardiorespiratory Responses and Survival to Trauma and Hemorrhage in Rats.

J Appl Physiol (1985) 2021 Apr 8. Epub 2021 Apr 8.

United States Army Institute of Surgical Research, United States.

Ketamine is the recommended analgesic on the battlefield for Soldiers with hemorrhage, despite a lack of supportive evidence from laboratory or clinical studies. Hence, this study determined the effects of ketamine analgesia on cardiorespiratory responses and survival to moderate (37% blood volume; n=8/group) or severe hemorrhage (50% blood volume; n=10/group) after trauma in rats. We used a conscious hemorrhage model with extremity trauma (fibular fracture + soft tissue injury) while measuring mean arterial pressure (MAP), heart rate (HR), and body temperature (T) by telemetry, and respiration rate (RR), minute volume (MV), and tidal volume (TV) via whole body plethysmography . Read More

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Retrospective Comparison of Intramuscular Admixtures of Ketamine and Dexmedetomidine Versus Ketamine and Midazolam for Preoperative Sedation.

Anesth Prog 2021 03;68(1):3-9

Department of Anesthesiology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.

Precooperative children and patients with intellectual disabilities often require intramuscular (IM) sedation prior to the induction of general anesthesia (GA). Ketamine is an effective preinduction sedative but can produce significant adverse side effects. Dexmedetomidine, a sedative with sympatholytic and analgesic properties, may provide advantages when used in combination with ketamine. Read More

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Neuroprotection by delayed triple therapy following sarin nerve agent insult in the rat.

Toxicol Appl Pharmacol 2021 05 3;419:115519. Epub 2021 Apr 3.

Department of Pharmacology, Israel Institute for Biological, Chemical and Environmental Sciences, Ness-Ziona 74100, Israel. Electronic address:

The development of refractory status epilepticus (SE) induced by sarin intoxication presents a therapeutic challenge. In our current research we evaluate the efficacy of a delayed combined triple treatment in ending the abnormal epileptiform seizure activity (ESA) and the ensuing of long-term neuronal insult. SE was induced in male Sprague-Dawley rats by exposure to 1. Read More

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The impact of vatinoxan on medetomidine-ketamine-midazolam immobilization in Patagonian maras (Dolichotis patagonum).

Vet Anaesth Analg 2021 May 22;48(3):372-379. Epub 2021 Feb 22.

Center for Zoo and Wild Animal Health, Copenhagen Zoo, Frederiksberg, Denmark; School of Veterinary Medicine and Animal Science, University of Copenhagen, Frederiksberg C, Denmark.

Objective: To compare cardiovascular and ventilatory effects, immobilization quality and effects on tissue perfusion of a medetomidine-ketamine-midazolam combination with or without vatinoxan (MK-467), a peripherally acting α-adrenoceptor antagonist.

Study Design: Randomized, blinded, crossover study.

Animals: A group of nine healthy Patagonian maras (Dolichotis patagonum). Read More

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Development of an improved anesthesia protocol to increase CF1 mice survival in a portal vein infection with sensu lato protoscoleces.

Heliyon 2021 Mar 18;7(3):e06496. Epub 2021 Mar 18.

Instituto de Investigaciones en Producción Sanidad y Ambiente (IIPROSAM), CONICET-UNMdP, Centro de Asociación Simple CIC PBA, Argentina.

In order to optimize the survival rate of animals, the purpose of this study was to evaluate an injectable anesthesia protocol for the development of a murine model of hepatic cystic echinococcosis in female CF-1 mice. Three protocols of injectable anesthesia were evaluated during the infection of mice with sensu lato protoscoleces via the portal vein. The use or not of pre-anesthesia [atropine (0. Read More

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Comparative Study Among Ketamine, Fentanyl, and Ropivacaine, as Pre-incisional Analgesic Given by Surgical Site Infiltration, in Cases Posted for Elective Lower Segment Cesarean Section Under General Anesthesia.

Cureus 2021 Feb 28;13(2):e13609. Epub 2021 Feb 28.

Anaesthesiology, Uttar Pradesh University of Medical Sciences, Etawah, IND.

Aim The aim of this study was to evaluate the effect of surgical site infiltration prior to giving incision, with ketamine, fentanyl, and ropivacaine, on perioperative hemodynamic parameters, pain, and any adverse outcomes. Methods The study was carried out on 68 patients divided into four groups of 17 each. After intubation, the study drug was infiltrated subcutaneously at the surgical site, seven min before incision, by the surgeon who was unaware of the injectate. Read More

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February 2021

Discharge readiness after minor gynaecological surgeries comparing dexmedetomidine and ketamine premedication in bispectral index (BIS) guided propofol-based anaesthesia.

Indian J Anaesth 2021 Mar 20;65(Suppl 1):S34-S40. Epub 2021 Mar 20.

Department of Surgery, Life Kare Hospital, Amritsar, Punjab, India.

Background And Aims: Dexmedetomidine and ketamine are commonly used pre-medicants to propofol. Previous literature shows a delay in recovery with their use without any clarity on discharge. This study was planned to find out whether adding these premedicants to Bispectral index (BIS) guided propofol anaesthesia led to delayed discharge in minor gynaecological surgeries. Read More

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Effects of perioperative saphenous and sciatic nerve blocks, lumbosacral epidural or morphine-lidocaine-ketamine infusion on postoperative pain and sedation in dogs undergoing tibial plateau leveling osteotomy.

Vet Anaesth Analg 2021 May 4;48(3):415-421. Epub 2021 Mar 4.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

Objective: To compare the quality of postoperative analgesia and sedation after preoperative saphenous and sciatic nerve blockade, preoperative lumbosacral epidural injection and perioperative intravenous (IV) morphine, lidocaine and ketamine infusions in dogs undergoing stifle arthroscopy and tibial plateau leveling osteotomy (TPLO) under general anesthesia.

Study Design: Prospective, blinded, randomized, clinical comparison study.

Animals: A total of 45 dogs weighing 33. Read More

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The Immunization of Protoscolices P29 DNA Vaccine on Experimental Cystic Echinococosis in Balb/c Mice.

Acta Parasitol 2021 Apr 3. Epub 2021 Apr 3.

Basic Sciences Department, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Purpose: Cystic Echinococosis is one of the important parasitic diseases that is considered as a problem economics and health in many parts of the world. Many efforts have been performed for controlling the disease in the world. To reach a reliable vaccine against Cystic Echinococosis is one of the important duty of governments. Read More

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Somatic Comorbidities and Cardiovascular Safety in Ketamine Use for Treatment-Resistant Depression.

Medicina (Kaunas) 2021 Mar 16;57(3). Epub 2021 Mar 16.

Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, 7 Dębinki St. Build. 25, 80-952 Gdansk, Poland.

There is evidence for ketamine efficacy in treatment-resistant depression (TRD). Several safety and tolerability concerns arise that some psychotropic agents may provide blood pressure or/and heart rate alterations. The aim of this study is to review blood pressure measurements in course of the treatment with ketamine on treatment refractory inpatients with somatic comorbidities in the course of MDD and BP. Read More

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Hypolipemiant Actions and Possible Cardioprotective Effects of Valine and Leucine: An Experimental Study.

Medicina (Kaunas) 2021 Mar 5;57(3). Epub 2021 Mar 5.

Department of Morphofunctional Sciences II, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaşi, Romania.

Considering atherosclerosis as one of the more challenging threats to healthcare worldwide, any novel therapy that counteracts the risks for developing it, provides new opportunities for the management of this process. We performed an experimental research in which we induced a hypercholesterolemia via a cholesterol-rich diet. Our aim was to demonstrate the antiatherogenic potential of two essential amino acids (valine and leucine). Read More

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Accurate Receptor-Ligand Binding Free Energies from Fast QM Conformational Chemical Space Sampling.

Int J Mol Sci 2021 Mar 17;22(6). Epub 2021 Mar 17.

Max Planck Institute for Dynamics of Complex Technical Systems, Molecular Simulations and Design Group, 39106 Magdeburg, Germany.

Small molecule receptor-binding is dominated by weak, non-covalent interactions such as van-der-Waals hydrogen bonding or electrostatics. Calculating these non-covalent ligand-receptor interactions is a challenge to computational means in terms of accuracy and efficacy since the ligand may bind in a number of thermally accessible conformations. The conformational rotamer ensemble sampling tool (CREST) uses an iterative scheme to efficiently sample the conformational space and calculates energies using the semi-empirical 'Geometry, Frequency, Noncovalent, eXtended Tight Binding' (GFN2-xTB) method. Read More

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