29,447 results match your criteria keratosis melanocytic


Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses.

Dermatology 2021 Jul 26:1-13. Epub 2021 Jul 26.

Dermatology Service, Memorial Sloan Kettering, New York, New York, USA.

Seborrheic keratoses (SKs) are ubiquitous, generally benign skin tumors that exhibit high clinical variability. While age is a known risk factor, the precise roles of UV exposure and immune abnormalities are currently unclear. The underlying mechanisms of this benign disorder are paradoxically driven by oncogenic mutations and may have profound implications for our understanding of the malignant state. Read More

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Line-field confocal optical coherence tomography of actinic keratosis: a case series.

J Eur Acad Dermatol Venereol 2021 Jul 26. Epub 2021 Jul 26.

Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive imaging technique that was recently developed, combining high penetration depth (up to 500-µm, approaching that of conventional OCT) with high isotropic resolution [lateral: 1.3 µm; axial: 1.1 µm - similar to that of reflectance confocal microscopy (RCM)]. Read More

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Topical tirbanibulin eradication of periungual squamous cell carcinoma.

JAAD Case Rep 2021 Aug 26;14:101-103. Epub 2021 Jun 26.

Arlington Research Center, Arlington, Texas.

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[Causes analysis of mastoid cavity infection after mastoidectomy and key techniques of revision mastoidectomy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jun;35(6):521-524

Department of Otolaryngology Head and Neck Surgery,Peking University Third Hospital,Beijing,100191,China.

To analyze the causes of infected mastoid cavity after mastoidectomy and explore the key techniques of revision mastoidectomy. Ninety-two patients, who underwent revision mastoidectomy due to mastoid cavity infection after mastoidectomy were retrospectively analyzed. There were 56 cases of canal wall up mastoidectomy plus tympanoplasty and 36 cases of canal wall down mastoidectomy plus tympanoplasty in previous surgery. Read More

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Seven key hub genes identified by gene co-expression network in cutaneous squamous cell carcinoma.

BMC Cancer 2021 Jul 23;21(1):852. Epub 2021 Jul 23.

Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, People's Republic of China.

Background: Cutaneous squamous cell carcinoma (cSCC) often follows actinic keratosis (AK) and is the second most common skin cancer worldwide. To reduce metastasis risk, it is important to diagnose and treat cSCC early. This study aimed to identify hub genes associated with cSCC and AK. Read More

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Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.

Int J Mol Sci 2021 Jul 8;22(14). Epub 2021 Jul 8.

Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 Tenerife, Spain.

We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis-e. Read More

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Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions.

Yonsei Med J 2021 Aug;62(8):767-775

Department of Oral Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Dental and Life Science Institute, Yangsan, Korea.

Purpose: We aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs).

Materials And Methods: Subjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Read More

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Seborrheic Keratosis-Like Lesion of the Cervix: First Report of the Cytological Features of a Low-Risk HPV 42-Associated Lesion.

Acta Cytol 2021 Jul 22:1-5. Epub 2021 Jul 22.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom.

Introduction: Seborrheic keratosis-like lesion of the cervix and vagina is a rare lesion and shows similar morphology to vulvar seborrheic keratosis; 3 of the 7 previously reported cases were associated with low-risk human papillomavirus (HPV) type 42. We report a case of seborrheic keratosis-like lesion of the cervix and provide the first description of the cytological features of this lesion.

Case Presentation: A woman in her late forties presented with postcoital bleeding. Read More

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Dermoscopic findings of genital keratotic lesions: Bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum.

Photodiagnosis Photodyn Ther 2021 Jul 19:102448. Epub 2021 Jul 19.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea. Electronic address:

Dermatologists often encounter keratotic or warty lesions in the genital area. Establishing a clear diagnosis may seem challenging, particularly when the differential diagnosis includes bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum. This study aimed to compare the dermoscopic features of bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum in the genital area. Read More

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Netherton syndrome associated to otomycosis.

BMJ Case Rep 2021 Jul 20;14(7). Epub 2021 Jul 20.

Pediatrics, Hassani Abdelkader University Hospital, Sidi Bel Abbes, Algeria.

A 7-year-old girl born to consanguineous parents, had recurrent erythroderma since birth; she presented with intractable pruritus, scaling, dry skin and eczematous lesions, associated to fingers and toes onychogryphosis, along with refractory otitis. The hair was sparse and brittle, the simple light microscopic examination of hair shaft revealed a pathognomonic Bamboo aspect (trichorrehxis invaginata) and ear swab culture revealed as otitis agent. Due to the lack of genetic routine testing, children with recalcitrant erythroderma and otitis, along with hair shaft abnormalities, need to be evaluated for Netherton syndrome. Read More

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Treatment adherence with diclofenac 3% gel among patients with multiple actinic keratoses: an integrated low-intensity intervention program versus standard-of-care.

Ital J Dermatol Venerol 2021 Jul 20. Epub 2021 Jul 20.

Dermatologia, Università Cattolica del Sacro Cuore, Rome, Italy -

Background: Diclofenac 3% gel is a widely used topical treatment with proven efficacy in reducing the burden of Actinic Keratosis (AK), however clinical benefit might not fully translate in clinical practice as non-adherence is substantial for prolonged treatment regimens. We evaluated the efficacy of an integrated low-intensity intervention program versus standard-of-care on treatment adherence among patients with multiple AK receiving diclofenac in hyaluronic acid gel 3%.

Methods: We designed an open label, randomized, parallel group, interventional, multicenter, longitudinal cohort study including patients with multiple, grade I/II AKs. Read More

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Seborrheic keratosis of the cheek simulating squamous cell carcinoma.

Int J Surg Case Rep 2021 Jul 7;84:106175. Epub 2021 Jul 7.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco; Department of Stomatology and Maxillofacial Surgery, CHU Ibn Rochd, B.P 2698, Casablanca, Morocco.

Introduction: Seborrheic keratoses are benign tumours that occur electively on the head, neck and trunk. It can be confused on its clinical appearance with other skin tumours and it is the histological examination that establishes the diagnosis. We report a case of seborrheic keratosis simulating squamous cell carcinoma. Read More

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[Pathology of the apex of the temporal bone pyramid: cholesterol granuloma and congenital cholesteatoma].

Vestn Otorinolaringol 2021 ;86(3):127-133

Kharkov Medical Academy of Postgraduate Education, Kharkov, Ukraine.

The report presents modern views on the origin and pathomorphological characteristics of the cholesterol granuloma of the petrous apex of temporal bone, its clinical comparison with congenital cholesteatoma of the same localization. The differential diagnostic features in CT and MRI scans are analyzed in detail, and the principles of surgical treatment, indications and contraindications are discussed. Also the case of atypical course of cholesterol granuloma is presented, which was difficult in the diagnostics but with a successful treatment result. Read More

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Arthroscopic Sesamoidectomy for Hallux Sesamoid Disorders.

J Foot Ankle Surg 2021 Jun 18. Epub 2021 Jun 18.

Department of Orthopedic Surgery, Yashio Central General Hospital, Saitama, Japan. Electronic address:

In this retrospective case series, we aimed to study arthroscopic sesamoidectomy, including surgical methods, clinical outcomes, and complications. We retrospectively reviewed the medical records of patients with hallux sesamoid disorders who underwent arthroscopic sesamoidectomy from July 2015 to July 2017. The visual analog scale for rating pain, Japanese Society for Surgery of the Foot scale scores, number of days taken to return to normal daily living, number of months taken to return to playing sports, and complications were analyzed. Read More

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Effectiveness of a cosmetic device containing a combination of alpha- and beta-hydroxy acids, urea and thuja for the treatment of seborrheic keratoses.

J Cosmet Dermatol 2021 Jul 15. Epub 2021 Jul 15.

Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy.

Background: Seborrheic keratosis is a benign epidermal tumour of cosmetic concern - as it progressively increases in size, thickness and pigmentation - on which topical treatments are poorly effective. Considering its keratotic component, effective products may include active principles with keratolytic action.

Objectives: Evaluate the efficacy and tolerability of a topical cosmetic product with urea and hydroxy acids, in the treatment of seborrheic keratoses. Read More

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In vivo two-photon-excited cellular fluorescence of melanin, NAD(P)H, and keratin enables an accurate differential diagnosis of seborrheic keratosis and pigmented cutaneous melanoma.

J Biomed Opt 2021 Jul;26(7)

University of Heidelberg, Department of Dermatology, Heidelberg, Germany.

Significance: Seborrheic keratoses (SKs) are harmless pigmented skin lesions (PSLs) that may be confused clinically not only with other benign conditions but also with cutaneous melanoma (CM). As SKs are one of the most common neoplasms in adults, the importance of their correct diagnosis is high. Misclassifying SK as malignant is not rare and leads to a high number of unnecessary biopsies. Read More

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Association of Actinic Keratosis with Rheumatoid Arthritis and Psoriasis: A Nationwide Population-Based Study in Korea.

Acta Derm Venereol 2021 Jul 15. Epub 2021 Jul 15.

Department of Dermatology, Changwon Fatima Hospital, 51394 Changwon, Korea.

There have been no epidemiological studies identifying associations between systemic inflammatory diseases and actinic keratosis. This study used a large nationwide database to investigate the associations between actinic keratosis and systemic inflammatory diseases. Records of patients over 20 years of age newly diagnosed with actinic keratosis (n = 64,659) from 2012 to 2017 were analysed. Read More

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Case of large lentigo maligna melanoma of the scalp treated with 5% and 3.75% Imiquimod.

An Bras Dermatol 2021 Jul 12. Epub 2021 Jul 12.

Department of Dermatology, University of Parma, Parma, Italy.

The paper presents a case of lentigo maligna melanoma of the scalp in an elderly patient treated for the nodular part with surgery and the residual melanoma in situ with 5% Imiquimod and subsequently with 3.75% Imiquimod (each concentration for 4 months, 5 times per week), with complete regression of the lesion. 3. Read More

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Evaluation of Long-term Cholesteatoma Recidivism: Using the JOS, EAONO-JOS, and STAMCO Cholesteatoma Staging Systems.

Otol Neurotol 2021 08;42(7):1031-1038

Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objective: To assess the prognostic value of the Japanese Otological Society (JOS), EAONO-JOS, and STAMCO classifications in predicting the severity of acquired cholesteatoma and to identify other factors that could influence residual and recurrent cholesteatoma, as well as adverse events (AE).

Method: A retrospective chart review of patients undergoing primary cholesteatoma surgery in our tertiary referral center. Primary outcome measures were based on three groups of follow-up (FU): Group A, studying residual cholesteatoma, FU > 52 weeks of last-look surgery or magnetic resonance imaging, diffusion-weighted imaging; group B, studying recurrent disease, FU > 52 weeks of last outpatient clinic visit; and group C, studying AE, FU > 12 weeks after surgery. Read More

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Malignant Transformation Rate of Non-reactive Oral Hyperkeratoses Suggests an Early Dysplastic Phenotype.

Head Neck Pathol 2021 Jul 13. Epub 2021 Jul 13.

Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.

The presence of epithelial dysplasia (ED) in oral leukoplakia is the single most important predictor of malignant transformation (MT). The majority of leukoplakias, however, do not show evidence of ED and yet MT of these lesions is well-recognized. These lesions have been referred to as "hyperkeratosis/hyperplasia, no dysplasia," "keratosis of unknown significance" and "hyperkeratosis, not reactive (HkNR). Read More

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Distant Resolution of Actinic Keratosis following Cryosurgery: An Unusual Phenomenon.

Authors:
Karim Saleh

Case Rep Dermatol 2021 May-Aug;13(2):289-292. Epub 2021 Jun 14.

Division of Dermatology and Venereology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden.

Early after the introduction of cryosurgery to clinical practice, there were reports of metastasis regressing after cryosurgery of a primary tumour, mainly prostate and breast cancer, suggesting a systemic immunological effect to a local reaction. Colleagues within dermatology have occasionally experienced similar systemic effects following cryosurgery. However, published reports of such cases are lacking. Read More

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[Analysis of clinical feature and genetic basis of a rare case with Olmsted syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Jul;38(7):674-677

Medical Genetic Center of Guangdong Women and Children Hospital, Key Laboratory of Maternal and Children's Metabolic-Genetic Diseases of Guangdong Province, Guangzhou, Guangdong 511442, China.

Objective: To analyze the clinical and genetic characteristics of a patient featuring autosomal dominant Olmsted syndrome.

Methods: Clinical features of the patient was reviewed. High-throughput sequencing was carried out to detect potential genetic variants. Read More

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Glottic Keratosis: Significance and Identification of Laryngoscopic Findings.

OTO Open 2021 Jan-Mar;5(1):2473974X21994743. Epub 2021 Feb 25.

Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Objective: Glottic keratosis poses a challenge because a decision to biopsy must weigh the likelihood of dysplasia and cancer against the voice outcome after biopsy. We determined the significance of laryngoscopic findings and agreement among clinicians to identify those specific findings.

Study Design: Retrospective case-control study. Read More

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February 2021

Usefulness of Dermoscopy to Provide Accurate Assessment of Skin Cancers.

Clin Cosmet Investig Dermatol 2021 29;14:733-746. Epub 2021 Jun 29.

Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, 20-080, Poland.

Seborrheic keratosis (SK) is the most common benign tumour of epidermal origin. In most cases, it is simple to recognize in the clinical examination. However, sometimes SK can be a problematic lesion. Read More

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PD-L1 Expression, T-lymphocyte Subpopulations and Langerhans Cells in Cutaneous Squamous Cell Carcinoma and Precursor Lesions.

Anticancer Res 2021 Jul;41(7):3439-3448

Department of Pathology, School of Medicine, University of Patras, Patras, Greece;

Background/aim: The role of immune cells and PD-L1 in cutaneous squamous carcinogenesis is unclear. This study examines T-cell populations, Langerhans cells (LCs) and PD-L1 in invasive squamous cell carcinoma (inSCC), adjacent precursors and normal skin (NS) to investigate their participation in tumorigenesis.

Materials And Methods: Cases of cutaneous inSCC with adjacent precursors (n=125) were selected. Read More

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Palmo-plantar hyperkeratosis associated with HTLV-1 infection: a case report.

BMC Infect Dis 2021 Jul 6;21(1):652. Epub 2021 Jul 6.

Internal Medicine, La Samaritana Hospital, Bogotá, Colombia.

Background: Palmoplantar hyperkeratosis is a cutaneous manifestation that had not been clearly associated with infection by the human T-cell lymphotropic virus, which is a retrovirus that in most cases does not develop clinical pathologies and its symptoms may be undetected. The skin is one of the most affected organs, however until now only seborrheic dermatitis, xerosis/ichthyosis and infective dermatitis associated with HTLV-1 have been described as cutaneous clinical manifestations of this disease.

Case Presentation: We present the case of a 36-year-old male patient with serologically documented HTLV-1 infection, who presented symptoms of diarrhea, malabsorption due to Strongyloides stercoralis, and in whom a physical examination revealed an association with generalized xerosis and palmoplantar keratoderma confirmed by skin biopsy. Read More

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Clinical outcomes and 5-year follow-up results of keratosis pilaris treated by a high concentration of glycolic acid.

World J Clin Cases 2021 Jun;9(18):4681-4689

Department of Dermatology, Air Force Characteristic Medical Center, Beijing 100142, China.

Background: Keratosis pilaris is a hereditary abnormal keratosis of the hair follicle orifice. Gray-brown keratotic plugs in the pores and dark red keratotic papules at the openings of hair follicles can be seen, which contain coiled hair and are often accompanied by perifollicular erythema and pigmentation. Glycolic acid can correct the abnormalities of hair follicular duct keratosis and eliminate excessive accumulation of keratinocytes. Read More

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Dermatologic Applications of : A Literature Review.

J Clin Aesthet Dermatol 2021 Feb 1;14(2):50-60. Epub 2021 Feb 1.

Dr. Segars is with the Nova Southeastern University: College of Osteopathic Medicine and Largo Medical Center Department of Dermatology in Largo, Florida.

(PL) is a natural extract from tropical fern leaves with antioxidant and anti-inflammatory properties. It has been implicated as a potential treatment agent in multiple dermatologic conditions. Here, we review the mechanism of action and current dermatologic applications of PL and extrapolate potential future dermatologic applications of PL. Read More

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February 2021

Laser Resurfacing Monotherapy for the Treatment of Actinic Keratosis.

J Cutan Med Surg 2021 Jul 2:12034754211027515. Epub 2021 Jul 2.

Department of Medicine, University of Toronto, ON, Canada.

Treating actinic keratosis (AK) and photodamaged skin is critical to reduce the risk of progression to skin cancer. Laser resurfacing for AK treatment is available as either lesion-directed or field therapy. Laser resurfacing removes the superficial epidermis and dermis containing actinic damage, promoting re-epithelialization of healthy skin. Read More

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