19,833 results match your criteria july 2017

Clobetasol Compared With Fractionated Carbon Dioxide Laser for Lichen Sclerosus: A Randomized Controlled Trial.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Department of Obstetrics and Gynecology, Section of Female Pelvic Medicine and Reconstructive Surgery, MedStar Washington Hospital Center and Georgetown University School of Medicine, Washington, DC; the Department of Biostatistics, Medstar Health Research Institute, Hyattsville, Maryland; the Department of Obstetrics and Gynecology, Magee-Womens Hospital, University of Pittsburgh Health System, Pittsburgh, Pennsylvania; the Department of Urogynecology, Brown Women & Infants Hospital of Rhode Island, Providence, Rhode Island; and the Department of Subspecialty Care for Women's Health, Cleveland Clinic, Cleveland, Ohio.

Objective: To compare 6-month safety and efficacy outcomes of fractionated CO2 laser (laser) with topical clobetasol propionate (steroid) for treatment of symptomatic vulvar lichen sclerosus.

Methods: We conducted a single-center randomized controlled trial that compared fractionated CO2 laser with steroid treatment for patients with biopsy-proven lichen sclerosus. Randomization was stratified by prior clobetasol propionate use. Read More

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Impact of Oral Abrocitinib Monotherapy on Patient-Reported Symptoms and Quality of Life in Adolescents and Adults with Moderate-to-Severe Atopic Dermatitis: A Pooled Analysis of Patient-Reported Outcomes.

Am J Clin Dermatol 2021 May 5. Epub 2021 May 5.

Pfizer Inc., New York, NY, USA.

Background: Atopic dermatitis imparts a substantial patient burden, including itch, sleep disturbance, and decreased health-related quality of life.

Objective: This analysis evaluated changes in patient-reported outcomes of disease-specific signs/symptoms and health-related quality of life in adult and adolescent patients with moderate-to-severe atopic dermatitis treated with once-daily oral abrocitinib 200-mg or 100-mg monotherapy.

Methods: Pooled data from one phase IIb (NCT02780167) and two phase III (NCT03349060, JADE MONO-1; NCT03575871, JADE MONO-2) monotherapy trials in adult and adolescent patients with moderate-to-severe atopic dermatitis were analyzed. Read More

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Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation: A retrospective, single center study.

World J Transplant 2021 Apr;11(4):114-128

Department of Anesthesiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States.

Background: There is an abundant need to increase the availability of deceased donor kidney transplantation (DDKT) to address the high incidence of kidney failure. Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients; thus the identification of modifiable risk factors associated with poor outcomes is paramount.

Aim: To identify risk factors associated with delayed graft function (DGF). Read More

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Investigating the neuroPRotective effect of Oral Omega-3 Fatty acid Supplementation in type 1 diabetes (nPROOFS1): a randomised, placebo-controlled trial.

Diabetes 2021 May 5. Epub 2021 May 5.

Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Australia.

This randomised, double-masked, placebo-controlled trial (ACTRN12618000705280) evaluated the effects of oral omega-3 fatty acid supplementation on peripheral nerves in type 1 diabetes. Participants with type 1 diabetes were assigned (1:1) to omega-3 (fish oil; 1800 mg/day) or placebo (olive oil; 600 mg/day) supplements for 180 days. Primary outcome was change from baseline in central corneal nerve fibre length (CNFL) at day 180. Read More

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Prediction of labour onset in women who present with symptoms of preterm labour using cervical length.

BMC Pregnancy Childbirth 2021 May 5;21(1):359. Epub 2021 May 5.

Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore.

Background: Diagnosis of preterm labour is difficult because initial symptoms and signs are often mild and may occur in continuing pregnancies. This study aims to investigate the utility of measuring cervical length, using transvaginal ultrasound, in women presenting to the delivery suite with symptoms of preterm labour.

Methods: This was a prospective cohort study performed in KK Women's and Children's Hospital, Singapore from September 2017 to July 2018. Read More

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Safety and Efficacy of Perioperative Sublingual Tacrolimus in Pancreas Transplant Compared With Oral Tacrolimus.

Exp Clin Transplant 2021 May 6. Epub 2021 May 6.

From the Department of Pharmacy Services, Medical University of South Carolina, Charleston, South Carolina, USA.

Objectives: Early posttransplant, the administration of oral or enteral medications in pancreas transplant is challenging because of the management of postoperative ileus and gastroparesis. The use of sublingual tacrolimus may offer a promising alternative. The objective of this study was to compare the pharmacokinetics and perioperative outcomes between oral and sublingual tacrolimus in pancreas transplant. Read More

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Application of Enhanced Recovery after Surgical Treatment of the Occipitocervical Region.

Orthop Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Eastern Hospital, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.

Objective: The concept of enhanced recovery after surgery (ERAS) has been proposed to provide guidance for the improved postoperative rehabilitation of patients with occipitocervical region disease (ORD).

Methods: This study retrospectively investigated 208 consecutive patients (116 men and 92 women) ranging in age from 22 to 76 years with ORD between July 2014 and June 2017 in our medical center, who were divided into three groups that received different preoperative, intraoperative, and postoperative management plans: traditional group (n = 73), ameliorated group (n = 70), and ERAS group (n = 65). We compiled a range of data relating to demographics and postoperative changes in hemoglobin and albumin, surgery duration, intraoperative blood loss, number of postoperative hospitalization days and expenses, readmission rates, and visual analog scale pain symptoms. Read More

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Estimating the economic cost of nurse sensitive adverse events amongst patients in medical and surgical settings.

J Adv Nurs 2021 May 5. Epub 2021 May 5.

School of Nursing and Midwifery, University College Cork, Cork, Ireland.

Aims: To identify the costs associated with nurse sensitive adverse events and the impact of these events on patients' length of stay.

Design: Retrospective cohort study using administrative hospital data.

Methods: Data were sourced from patient discharge information (N = 5544) from six acute wards within three hospitals (July 2016-October 2017). Read More

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Influence of Opioid Prescription Policy on Overdoses and Related Adverse Effects in a Primary Care Population.

J Gen Intern Med 2021 May 4. Epub 2021 May 4.

Department of Medicine, Maine Medical Center, Portland, Maine, 04102, USA.

Background: In response to the opioid epidemic, many states have enacted policies limiting opioid prescriptions. There is a paucity of evidence of the impact of opioid prescribing interventions in primary care populations, including whether unintended consequences arise from limiting the availability of prescribed opioids.

Objective: Our aim was to compare changes in opioid overdose and related adverse effects rate among primary care patients following the implementation of state-level prescribing policies. Read More

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Effect of ankle joint fixation on tibialis anterior muscle activity during split-belt treadmill walking in healthy subjects: A pilot study.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):11-16. Epub 2021 Mar 4.

Department of Rehabilitation, Fujita Health University Bantane Hospital, Nagoya, Japan.

Objectives: This study aims to examine the characteristics of muscle activity change of the tibialis anterior (TA) muscle in healthy adults while they walked on a split-belt treadmill with one fixed ankle.

Patients And Methods: This randomized controlled trial was conducted between November 2017 and July 2018. Fourteen healthy male individuals (mean age 31. Read More

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Is continuity of primary care declining in England? Practice-level longitudinal study from 2012 to 2017.

Br J Gen Pract 2020 Dec 14. Epub 2020 Dec 14.

Centre for Academic Primary Care, University of Bristol, Bristol.

Background: Continuity of care is a core principle of primary care related to improved patient outcomes and reduced healthcare costs. Evidence suggests continuity of care in England is declining.

Aim: To confirm reports of declining continuity of care, explore differences in decline according to practice characteristics, and examine associations between practice populations or appointment provision and changes in continuity of care. Read More

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December 2020

Single-Dose del Nido Cardioplegia Compared With Standard Cardioplegia During Coronary Artery Bypass Grafting at a Veterans Affairs Hospital.

Tex Heart Inst J 2021 Jan;48(1)

Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston, Texas.

Del Nido cardioplegic solution (DNC), used chiefly in pediatric patients, rapidly induces prolonged cardiac arrest during cardiac surgery. To determine whether surgical outcomes after coronary artery bypass grafting in a United States military veteran population differed when DNC was used instead of our standard Plegisol cardioplegia, we retrospectively reviewed 155 consecutive operations performed from July 2016 through June 2017. Del Nido cardioplegia was used to induce cardiac arrest in 70 patients, and Plegisol in 85. Read More

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January 2021

α2-Adrenergic Agonists or Stimulants for Preschool-Age Children With Attention-Deficit/Hyperactivity Disorder.

JAMA 2021 May 4. Epub 2021 May 4.

Perelman School of Medicine at University of Pennsylvania.

Importance: Attention-deficit/hyperactivity disorder (ADHD) is diagnosed in approximately 2.4% of preschool-age children. Stimulants are recommended as first-line medication treatment. Read More

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Treatment of Degenerative Lumbar Scoliosis with Oblique Lumbar Interbody Fusion in Conjunction with Unilateral Pedicle Screw Fixation via the Wiltse Approach.

Orthop Surg 2021 May 4. Epub 2021 May 4.

Department of Orthopedics, General Hospital of Ningxia Medical University, Yinchuan, China.

Objective: To evaluate the clinical outcomes of oblique lumbar interbody fusion (OLIF) in conjunction with unilateral pedicle screw fixation (UPSF) via the Wiltse approach in treating degenerative lumbar scoliosis (DLS).

Methods: The article is a retrospective analysis. Twelve patients with DLS who underwent combined OLIF and UPSF between July 2017 and December 2018 were included. Read More

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Development of a Clinical Reasoning Documentation Assessment Tool for Resident and Fellow Admission Notes: a Shared Mental Model for Feedback.

J Gen Intern Med 2021 May 4. Epub 2021 May 4.

NYU Grossman School of Medicine, New York, NY, USA.

Background: Residents and fellows receive little feedback on their clinical reasoning documentation. Barriers include lack of a shared mental model and variability in the reliability and validity of existing assessment tools. Of the existing tools, the IDEA assessment tool includes a robust assessment of clinical reasoning documentation focusing on four elements (interpretive summary, differential diagnosis, explanation of reasoning for lead and alternative diagnoses) but lacks descriptive anchors threatening its reliability. Read More

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Accounting for the Competing Risk of Death to Predict Kidney Failure in Adults With Stage 4 Chronic Kidney Disease.

JAMA Netw Open 2021 May 3;4(5):e219225. Epub 2021 May 3.

Cumming School of Medicine, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Importance: Kidney failure risk prediction has implications for disease management, including advance care planning in adults with severe (ie, estimated glomerular filtration rate [eGFR] category 4, [G4]) chronic kidney disease (G4-CKD). Existing prediction tools do not account for the competing risk of death.

Objective: To compare predictions of kidney failure (defined as estimated glomerular filtration rate [eGFR] <10 mL/min/1. Read More

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One in four die from acute infectious illness in an emergency department in Eastern Cape Province, South Africa.

S Afr Med J 2021 Feb 1;111(2):129-136. Epub 2021 Feb 1.

Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Md., USA.

Background: Despite the breadth of data supporting evidence-based practice for sepsis care in high-resource settings, there are relatively few data to guide the management of sepsis in low-resource settings, particularly in areas where HIV and tuberculosis (TB) are prevalent. Furthermore, few studies had broadened sepsis parameters to include all patients with acute infectious illness or followed patients up after hospital discharge. Understanding the epidemiology and outcomes of acute infections in a local context is the critical first step to developing locally informed targeted management strategies. Read More

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February 2021

First Report of causing postharvest rot on tomato () in Italy.

Plant Dis 2021 May 4. Epub 2021 May 4.

University of Torino, DISAFA - Dept. Agricultural, Forestry and Food Sciences, Largo Braccini 2, Grugliasco, TO, Italy, 10095.

Italy is the largest tomato (Solanum lycopersicum)-producing country in Europe with a cultivated area of 97,092 ha and a production of 5,798,103 tons/year in 2018 (FAOSTAT, 2020). During July 2020, a postharvest rot occurred in fresh tomatoes 'Piccadilly' cultivated in Sicily (Pachino, RG) and commercialized in Northern Italy (Torino, TO). Affected fruit showed circular black rot on the blossom end. Read More

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Penile circumference and stretched penile length in prepubertal children: A retrospective, single-center pilot study.

Investig Clin Urol 2021 May;62(3):324-330

Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Purpose: To determine references for penile circumference according to age in prepubertal children and whether this measurement can be used as a basic penile parameter along with stretched penile length in prepubertal children.

Materials And Methods: A total of 750 children (mean age, 4.2±3. Read More

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Comparison of vital capacity rapid inhalation and tidal ventilation induction with sevoflurane in adults: a prospective cohort study.

Med Gas Res 2021 Jul-Sep;11(3):100-103

Department of Anaesthesiology, Amala Institute of Medical Sciences, Thrissur, Kerala, India.

Vital capacity rapid inhalation induction (VCRII) results in faster achievement of desired minimum alveolar concentration while reducing the incidence of excitatory phenomenon compared to conventional incremental technique. This study aimed to determine whether the VCRII can achieve faster induction of anesthesia in adults compared to the traditional tidal ventilation (TV) technique. Following the approval from the Institutional Ethics Committee, Amala Institute of Medical Sciences, with an approval No. Read More

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Relationship Between Non-contrast Computed Tomography Imaging Markers and Perihemorrhagic Edema Growth in Intracerebral Hemorrhage.

Neurocrit Care 2021 May 3. Epub 2021 May 3.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Objectives: Perihemorrhagic edema (PHE) growth has been gradually considered as predictor for outcome of Intracerebral hemorrhage (ICH) patients. The aim of our study was to investigate correlation between non-contrast computed tomography (CT) markers and early PHE growth.

Methods: ICH patients between July 2011 and March 2017 were included in this retrospective analysis. Read More

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How common is add-on use and how do patients decide whether to use them? A national survey of IVF patients.

Hum Reprod 2021 May 4. Epub 2021 May 4.

Department of Obstetrics and Gynaecology, Royal Women's Hospital, University of Melbourne, Melbourne, VIC, Australia.

Study Question: What is the prevalence and pattern of IVF add-on use in Australia?

Summary Answer: Among women having IVF in the last 3 years, 82% had used one or more IVF add-on, most commonly acupuncture, preimplantation genetic testing for aneuploidy and Chinese herbal medicine.

What Is Known Already: IVF add-ons are procedures, techniques or medicines which may be considered nonessential to IVF, but usually used in attempts to improve the probability of conception and live birth. The use of IVF add-ons is believed to be widespread; however, there is little information about the prevalence and patterns of use in different settings. Read More

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An audit of transfusion reaction monitoring and reporting at a cancer hospital in Pakistan - a step towards haemovigilance.

J Pak Med Assoc 2021 Feb;71(2(B)):699-703

Department of Pathology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan.

Objective: To monitor the frequencies of different adverse transfusion reactions and to assess the compliance of clinical staff with the process of sending proper transfusion reaction workup within the specified time.

Methods: The retrospective audit was conducted at the blood bank of Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised all transfusion reaction forms received from July 1, 2017, to June 30, 2018. The forms were analysed for type of blood component, time in which it was received by the blood bank, whether or not the form was completely filled, whether or not all required samples were provided, and the type of reaction. Read More

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February 2021

Explaining variance in perceived research misbehavior: results from a survey among academic researchers in Amsterdam.

Res Integr Peer Rev 2021 May 3;6(1). Epub 2021 May 3.

Research Institute of Child Development and Education, University of Amsterdam, Nieuwe Achtergracht 127, 1018 WS, Amsterdam, The Netherlands.

Background: Concerns about research misbehavior in academic science have sparked interest in the factors that may explain research misbehavior. Often three clusters of factors are distinguished: individual factors, climate factors and publication factors. Our research question was: to what extent can individual, climate and publication factors explain the variance in frequently perceived research misbehaviors?

Methods: From May 2017 until July 2017, we conducted a survey study among academic researchers in Amsterdam. Read More

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Intergenerational transmission of child maltreatment in South Australia, 1986-2017: a retrospective cohort study.

Lancet Public Health 2021 Apr 30. Epub 2021 Apr 30.

Australian Centre for Precision Health, Cancer Research Institute, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.

Background: The extent of intergenerational transmission of child maltreatment is unclear due to methodological limitations in previous studies. In this study, we aimed to examine factors associated with intergenerational transmission of child maltreatment and quantify its extent in a population sample over a 30-year period in South Australia.

Methods: In this retrospective cohort study, we used linked administrative data from the South Australian Birth Registry to identify dyads of mothers and their children both born in South Australia between July 1, 1986, and June 30, 2017. Read More

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Chronic wet cough in Australian children: Societal costs and quality of life.

Pediatr Pulmonol 2021 May 3. Epub 2021 May 3.

Australian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.

Introduction: Children with chronic wet cough regularly use the health system, experience considerable variability in care, have reduced quality of life (QoL), and, left untreated, poorer health outcomes. Despite this, little is known about the associated economic burden. This study aimed to quantify the cost of chronic wet cough among Australian children from the perspectives of families and the health system. Read More

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Inherited retinal diseases are the most common cause of blindness in the working-age population in Australia.

Ophthalmic Genet 2021 May 3:1-9. Epub 2021 May 3.

Centre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute), The University of Western Australia, Nedlands, Australia.

This study examined the frequency of inherited retinal diseases (IRDs) as the reason for blindness registrations over the last two decades and the demographic and clinical phenotypes of inherited retinal disease (IRD)-related registrations. Retrospective, observational study of individuals registered with a state-wide blind and vision-impaired registry. Low-vision or blindness-only (≤20/200 or ≤20°) certificates issued to children (0-15 years), working-age (16-64 years) and older-age (65 and older) adults were assessed. Read More

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Effect of a Scalable School-Based Intervention on Cardiorespiratory Fitness in Children: A Cluster Randomized Clinical Trial.

JAMA Pediatr 2021 May 3. Epub 2021 May 3.

Priority Research Centre for Physical Activity and Nutrition, Callaghan, University of Newcastle, New South Wales, Australia.

Importance: Cardiorespiratory fitness is an important marker of childhood health and low fitness levels are a risk factor for disease later in life. Levels of children's fitness have declined in recent decades. Whether school-based physical activity interventions can increase fitness at the population level remains unclear. Read More

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Factors Associated With Access to and Timing of Coronavirus Testing Among US Adults After Onset of Febrile Illness.

JAMA Netw Open 2021 05 3;4(5):e218500. Epub 2021 May 3.

Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco.

Importance: Active SARS-CoV-2 (coronavirus) transmission continues in the US. It is unclear whether better access to coronavirus testing and more consistent use of testing could substantially reduce transmission.

Objective: To describe coronavirus testing in persons with new onset of febrile illness and analyze whether there are changes over time and differences by race and ethnicity. Read More

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The Glenn procedure: Clinical outcomes in patients with congenital heart disease in pakistan.

Ann Card Anaesth 2021 Jan-Mar;24(1):30-35

Cardiothoracic Section, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Objectives: Congenital heart defects (CHDs) affect more than 40,000 children annually in Pakistan. Approximately 80' of patients require at least one surgical intervention to achieve a complete or palliative cardiac repair. The Glenn shunt, a palliative procedure is established between superior vena cava (SVC) and the right pulmonary artery to provide an anastomosis offering minimal risk to patients with univentricular heart disease. Read More

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