140,557 results match your criteria july 2009methodology

Esthetic Outcomes of Implant-Supported Single Crowns Related to Abutment Type and Material: A Systematic Review.

Int J Prosthodont 2021 Mar-Apr;34(2):229-249

Purpose: To systematically review the influence of abutment material and configuration on the soft tissue esthetic outcomes of implant-supported single crowns (iSCs) after 3 years.

Materials And Methods: An electronic search on MEDLINE (PubMed) from January 2000 to July 2019 was conducted for clinical trials with no language restrictions. The focus question was: In partially edentulous patients with iSCs, does the abutment material (metal vs ceramic) or the configuration (standardized vs customized) have an effect on the soft tissue esthetic outcomes? Randomized controlled trials, controlled clinical trials, and prospective or retrospective case series with at least 10 patients and a minimum of 3 years of follow-up were included. Read More

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Perceptual Inference, Learning, and Attention in a Multisensory World.

Uta Noppeney

Annu Rev Neurosci 2021 Apr 21. Epub 2021 Apr 21.

Donders Institute for Brain, Cognition and Behavior, Radboud University, 6525 AJ Nijmegen, The Netherlands; email:

Adaptive behavior in a complex, dynamic, and multisensory world poses some of the most fundamental computational challenges for the brain, notably inference, decision-making, learning, binding, and attention. We first discuss how the brain integrates sensory signals from the same source to support perceptual inference and decision-making by weighting them according to their momentary sensory uncertainties. We then show how observers solve the binding or causal inference problem-deciding whether signals come from common causes and should hence be integrated or else be treated independently. Read More

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Predictors of prolonged hospital stay in HIV-positive patients presenting to the emergency department.

PLoS One 2021 21;16(4):e0249706. Epub 2021 Apr 21.

Faculty of Health Sciences, Ezintsha, University of the Witwatersrand, Johannesburg, South Africa.

Background: Prolonged hospitalization places a significant burden on healthcare resources. Compared to the general population, hospital length of stay (LOS) is generally longer in HIV-positive patients. We identified predictors of prolonged hospital length of stay (LOS) in HIV-positive patients presenting to an emergency department (ED). Read More

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Changes in corneal thickness after vitrectomy-Implications for glaucoma practice.

PLoS One 2021 21;16(4):e0249945. Epub 2021 Apr 21.

Glaucoma Services, LV Prasad Eye Institute, Bhubaneswar, India.

Purpose: To evaluate changes in central corneal thickness (CCT) following vitrectomy.

Methods: All consecutive old and new patients referred to glaucoma services for possible secondary glaucoma after vitrectomy and who had undergone corneal pachymetry between July 2013 to June 2020, were included. The eye that developed elevated intraocular pressure (IOP) and was diagnosed clinically as glaucoma after vitrectomy, was labelled as the "affected" eye. Read More

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The prevalence of cigarette, e-cigarette and heated tobacco use among police employees in Poland: a 2020 cross-sectional survey.

Int J Occup Med Environ Health 2021 Apr 16. Epub 2021 Apr 16.

Medical University of Warsaw, Warsaw, Poland (Department of Prevention of Environmental Hazards and Allergology).

Objectives: Uniformed services such as police employees are exposed to acute and chronic stressful events at work that may lead to tobacco use. This study aimed to assess the prevalence of cigarette smoking, e-cigarette use and heated tobacco use among police employees in Poland, and to investigate personal characteristics associated with tobacco or e-cigarette use.

Material And Methods: This cross-sectional study was carried out in June-July 2020 on a randomly selected sample of 8789 police employees from the Mazowieckie Province, Poland. Read More

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Usability and Clinical Evaluation of Self-Sampling for SARS-CoV-2 Diagnostic Testing Using Nasal and Saliva Specimens in South Africa: Study Protocol.

JMIR Res Protoc 2021 Mar 9. Epub 2021 Mar 9.

Department of Prevention and Community Health, Milken Institute School of Public Health, The George Washington University, Washington DC, USA, Washington, US.

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus novel discovered in December 2019 and is currently the cause of a global pandemic. A critical aspect of fighting this pandemic is by obtaining accurate and timeous test results so that positive identified cases can be isolated to reduce the spread. Research has shown that saliva is a promising candidate for SARS-CoV-2 diagnostics because collection is minimally invasive and can reliably be self-administered. Read More

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#StrongerTogether - Utilizing Health Behavior Change and Technology Acceptance Models to Predict Adoption of COVID-19 Contact Tracing Apps: A Cross-Sectional Survey.

J Med Internet Res 2021 Apr 11. Epub 2021 Apr 11.

Department Health and Prevention, Institute of Psychology, University of Greifswald, Robert-Blum-Straße 13, Greifswald, DE.

Background: To combat the global COVID-19 pandemic, contact tracing apps have been discussed as digital health solutions to track infection chains, and provide appropriate information. However, observational studies point to a low acceptance in most countries, and few studies have yet examined theory-based predictors of app use in the general population to guide health communication efforts.

Objective: Therefore, this study utilizes established health behavior change and technology acceptance models to predict adoption intentions and frequency of current app use. Read More

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Mining and Validating Social Media for COVID-19-Related Human Behaviors between January and July 2020; An Infodemiology Study.

J Med Internet Res 2021 Apr 17. Epub 2021 Apr 17.

Analytics, Intelligence, and Technology, Los Alamos National Laboratory, Los Alamos National Laboratory, Los Alamos, US.

Background: Health authorities can minimize the impact of an emergent infectious disease outbreak through effective and timely risk communication, which can build trust and adherence to subsequent behavioral messaging. Monitoring the psychological impacts of an outbreak, as well as public adherence to such messaging is also important for minimizing long-term effects of an outbreak.

Objective: We used social media data to identify human behaviors relevant to COVID-19 transmission, and the perceived impacts of COVID-19 on individuals, as a first step toward real-time monitoring of public perceptions to inform public health communications. Read More

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Neuroimaging Findings of Hospitalized Covid-19 Patients: A Canadian Retrospective Observational Study.

Can Assoc Radiol J 2021 Apr 21:8465371211002815. Epub 2021 Apr 21.

University of Toronto, Toronto, Ontario, Canada.

Purpose: Coronavirus disease (COVID-19) has been associated with neurologic sequelae and neuroimaging abnormalities in several case series previously. In this study, the neuroimaging findings and clinical course of adult patients admitted with COVID-19 to a tertiary care hospital network in Canada were characterized.

Methods: This is a retrospective observational study conducted at a tertiary hospital network in Ontario, Canada. Read More

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Tumor budding as a predictive marker for 5-fluorouracil response in adjuvant-treated stage III colorectal cancer.

Int J Clin Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Background: Tumor budding (TB) has been described as an adverse prognostic marker for operable colorectal cancer (CRC); however, a limited number of studies have demonstrated the prognostic significance of TB in patients with drug therapy. This study was conducted to determine the predictive power of TB in stage III CRC patients who received adjuvant chemotherapy.

Methods: We retrospectively collected clinicopathological data including TB of 237 stage III colorectal cancer patients at Hiroshima University Hospital between July 1, 2006 and June 31, 2019. Read More

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Surgical volume reduction and the announcement of triage during the 1st wave of the COVID-19 pandemic in Japan: a cohort study using an interrupted time series analysis.

Surg Today 2021 Apr 21. Epub 2021 Apr 21.

Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.

Purpose: The coronavirus disease (COVID-19) pandemic has caused unprecedented challenges for surgical staffs to minimize exposure to COVID-19 or save medical resources without harmful patient outcomes, in accordance with the statement of each surgical society. No research has empirically validated declines in surgical volume in Japan, based on the usage of surgical triage. We aimed to identify whether the announcement of surgical priorities by each Japanese surgical society may have affected the surgical volume decline during the 1st wave of this pandemic. Read More

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Fistula Laser Closure (FiLaC™) for fistula-in-ano-yet another technique with 50% healing rates?

Int J Colorectal Dis 2021 Apr 21. Epub 2021 Apr 21.

Digestive Disease Center, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, NV, Denmark.

Purpose: Treatment of ano-cutaneous fistulas remains a therapeutic challenge. Fistula Laser Closure (FiLaC™) is a relatively new technique for the treatment of ano-cutaneous fistulas. This study aimed to determine the success rate of fistula closure using FiLaC™. Read More

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Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression.

JAMA Netw Open 2021 Apr 1;4(4):e215845. Epub 2021 Apr 1.

Department of Neurology, Mount Sinai Beth Israel, and Icahn School of Medicine, Mount Sinai, New York, New York.

Importance: Despite a hypothesis that harboring a leucine-rich repeat kinase 2(LRRK2) G2019S variation and a glucocerebrosidase (GBA) variant would have a combined deleterious association with disease pathogenesis, milder clinical phenotypes have been reported in dual LRRK2 and GBA variations Parkinson disease (PD) than in GBA variation PD alone.

Objective: To evaluate the association of LRRK2 G2019S and GBA variants with longitudinal cognitive and motor decline in PD.

Design, Setting, And Participants: This longitudinal cohort study of continuous measures in LRRK2 PD, GBA PD, LRRK2/GBA PD, and wild-type idiopathic PD used pooled annual visit data ranging from 2004 to 2019 from the Mount Sinai Beth Israel, Parkinson Disease Biomarker Program, Harvard Biomarkers Study, Ashkenazi Jewish-LRRK2-Consortium, Parkinson Progression Marker Initiative, and SPOT-PD studies. Read More

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Axillary Pathologic Complete Response After Neoadjuvant Systemic Therapy by Breast Cancer Subtype in Patients With Initially Clinically Node-Positive Disease: A Systematic Review and Meta-analysis.

JAMA Surg 2021 Apr 21:e210891. Epub 2021 Apr 21.

Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.

Importance: An overview of rates of axillary pathologic complete response (pCR) for all breast cancer subtypes, both for patients with and without pathologically proven clinically node-positive disease, is lacking.

Objective: To provide pooled data of all studies in the neoadjuvant setting on axillary pCR rates for different breast cancer subtypes in patients with initially clinically node-positive disease.

Data Sources: The electronic databases Embase and PubMed were used to conduct a systematic literature search on July 16, 2020. Read More

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Association of Multigenerational Family History of Depression With Lifetime Depressive and Other Psychiatric Disorders in Children: Results from the Adolescent Brain Cognitive Development (ABCD) Study.

JAMA Psychiatry 2021 Apr 21. Epub 2021 Apr 21.

Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

Importance: Three-generation family studies of depression have established added risk of psychopathology for offspring with 2 previous generations affected with depression compared with 1 or none. Because of their rigorous methodology, there are few of these studies, and existing studies are limited by sample sizes. Consequently, the 3-generation family risk paradigm established in family studies can be a critical neuropsychiatric tool if similar transmission patterns are reliably demonstrated with the family history method. Read More

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Nutritional Implications of Baby-Led Weaning and Baby Food Pouches as Novel Methods of Infant Feeding: Protocol for an Observational Study.

JMIR Res Protoc 2021 Apr 21;10(4):e29048. Epub 2021 Apr 21.

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.

Background: The complementary feeding period is a time of unparalleled dietary change for every human, during which the diet changes from one that is 100% milk to one that resembles the usual diet of the wider family in less than a year. Despite this major dietary shift, we know relatively little about food and nutrient intake in infants worldwide and virtually nothing about the impact of baby food "pouches" and "baby-led weaning" (BLW), which are infant feeding approaches that are becoming increasingly popular. Pouches are squeezable containers with a plastic spout that have great appeal for parents, as evidenced by their extraordinary market share worldwide. Read More

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[Abundance Dynamic of Oocysts in the Groundwater of Mbankomo, a Sub-urban Area Yaounde: Physico-chemical Factors and Health Risk].

Bull Soc Pathol Exot 2020 ;113(3):278-288

Département de biologie et physiologie animales, université de Yaoundé I, BP 812, Cameroun.

To determine the dynamics of dissemination of the different forms of enteric sporozoa in the groundwater of Mbankomo, a study was carried out from August 2018 to July 2019. The physico-chemical analyzes were carried out both in the field and in the hydrobiology and environment laboratory of the University of Yaoundé I. The observation of protozoan oocysts was carried out after application of the Ziehl-Neelsen staining. Read More

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January 2020

Feasibility of next-generation sequencing (Oncomine™ DX Target Test) for the screening of oncogenic mutations in advanced non-small-cell lung cancer patients.

Jpn J Clin Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan.

Background: The Oncomine™ Dx Target Test based on next-generation sequencing has been approved for the screening of oncogenic mutations in advanced non-small-cell lung cancer patients.

Methods: We assessed the tissue sample factors that affect the success rate of Oncomine™ Dx Target Test companion diagnostics and the feasibility of using biopsy specimens for Oncomine™ Dx Target Test companion diagnostics in advanced non-small-cell lung cancer patients.

Results: Ninety-nine biopsy samples were subjected to genetic testing using the Oncomine™ Dx Target Test companion diagnostics to detect v-raf murine sarcoma viral oncogene homologue B1 mutations (Cohort 1), and 136 biopsy samples were examined using Oncomine™ Dx Target Test companion diagnostics for the detection of multiple oncogenic mutations (Cohort 2) between July 2018 and April 2020. Read More

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Dental Services and Health Outcomes in the New York State Medicaid Program.

J Dent Res 2021 Apr 21:220345211007448. Epub 2021 Apr 21.

College of Dentistry, New York University, New York, NY, USA.

Previous reports suggest that periodontal treatment is associated with improved health care outcomes and reduced costs. Using data from the New York State Medicaid program, rates of emergency department (ED) use and inpatient admissions (IPs), as well as costs for ED, IPs, pharmacy, and total health care, were studied to determine the association of preventive dental care to health care outcomes. Utilization of dental services in the first 2 y (July 2012-June 2014) was compared to health care outcomes in the final year (July 2014-June 2015). Read More

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Long-Term Outcomes of Acute Kidney Injury After Different Types of Cardiac Surgeries: A Population-Based Study.

J Am Heart Assoc 2021 Apr 21:e019718. Epub 2021 Apr 21.

Division of Thoracic and Cardiovascular Surgery Department of Surgery Chang Gung Memorial Hospital Linkou Medical Center Chang Gung University Taoyuan City Taiwan.

Background Dialysis-requiring acute kidney injury (D-AKI) is a major complication of cardiovascular surgery that results in worse prognosis. However, the incidence and impacts of D-AKI in different types of cardiac surgeries have not been fully investigated. Methods and Results Patients admitted for cardiovascular surgery between July 1, 2004, and December 31, 2013, were identified from the National Health Insurance Research Database of Taiwan. Read More

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Assessing Risk Scores for Predicting Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B.

J Viral Hepat 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.

Chronic hepatitis B (CHB) infection-associated hepatocellular carcinoma (HCC) is a major health problem in Asian countries. Several HCC risk prediction models have been developed using either treated or untreated CHB patients. However, there is limited validation of these risk scores in a treated and untreated mixed CHB patient cohort. Read More

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Pharmacist-led interventions to reduce adverse drug events in older people living in residential aged care facilities: A systematic review.

Br J Clin Pharmacol 2021 Apr 20. Epub 2021 Apr 20.

School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, 7005, Australia.

Aims: We aimed to investigate the efficacy and effectiveness of pharmacist-led interventions to reduce adverse drug events (ADEs) in older people living in residential aged care facilities (RACFs).

Methods: We systematically searched MEDLINE via PubMed, Embase, Cochrane Central Register of Controlled Trials and PsycINFO from their inceptions to July 2020. We investigated experimental study designs that employed a control group, or quasi-experimental studies conducted in RACFs. Read More

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Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting.

Heart Vessels 2021 Apr 20. Epub 2021 Apr 20.

Department of Cardiovascular and Gastroenterological Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, 890-8520, Japan.

Platelet functions are thought to contribute to clinical outcomes after heart surgery. This study was conducted to assess the pivotal roles of vascular endothelial growth factor-A (VEGF-A) and microRNA-126 (miR-126) during coronary artery bypass grafting (CABG). Whole blood was collected for platelet isolation from 67 patients who underwent CABG surgery between July 2013 and March 2014. Read More

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Underlying conditions and risk of hospitalisation, ICU admission and mortality among those with COVID-19 in Ireland: A national surveillance study.

Lancet Reg Health Eur 2021 Jun 15;5:100097. Epub 2021 Apr 15.

Health Service Executive, Health Protection Surveillance Centre, Dublin, Ireland.

Background: To date, over 2 million people worldwide have died with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To describe the experience in Ireland, this study examined associations between underlying conditions and the following outcomes: mortality, admission to hospital or admission to the intensive care unit (ICU) among those infected with COVID-19.

Methods: This study used data from the Health Protection Surveillance Centre in Ireland and included confirmed cases of COVID-19 from the first wave of the pandemic between March and July 2020. Read More

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Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk.

EClinicalMedicine 2021 Apr 15:100835. Epub 2021 Apr 15.

Barts Heart Centre, St. Bartholomew's Hospital, London, United Kingdom.

Background: : Healthcare workers (HCWs) have increased rates of SARS-CoV-2 infection compared with the general population. We aimed to understand ethnic differences in SARS-CoV-2 seropositivity among hospital healthcare workers depending on their hospital role, socioeconomic status, Covid-19 symptoms and basic demographics.

Methods: A prospective longitudinal observational cohort study. Read More

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COVID-19 Mitigation With Appropriate Safety Measures in an Essential Workplace: Lessons for Opening Work Settings in the United States During COVID-19.

Open Forum Infect Dis 2021 Apr 22;8(4):ofab086. Epub 2021 Feb 22.

Division of HIV, Infectious Diseases, and Global Medicine, University of San Francisco, California (UCSF), San Francisco, California, USA.

Background: Nonpharmaceutical interventions (NPIs) mitigate coronavirus disease 2019 (COVID-19). Essential workplaces remained open during COVID-19, but few US-based settings detail outcomes.

Methods: Mercury Systems is a US-based manufacturing company that remained open during COVID-19. Read More

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Role and Risk Factors of Glycosylated Hemoglobin Levels in Early Disease Screening.

J Diabetes Res 2021 8;2021:6626587. Epub 2021 Apr 8.

Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, China.

Objective: To clarify the correlation among glycosylated hemoglobin (HbA1c), gender, age, fatty liver, and biochemical indicators through the analysis of big database, and to further investigate the risk factors affecting HbA1c, so as to lay a foundation for the study of HbA1c-related diseases and disease management.

Methods: People who have been examined in Health Promotion Center from July 2018 to June 2019 were selected as the research objects. All data were analyzed using the Windows R software (version 3. Read More

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Contraceptive Method Utilization and Determinant Factors among Young Women (15-24) in Ethiopia: A Mixed-Effects Multilevel Logistic Regression Analysis of the Performance Monitoring for Action 2018 Household Survey.

Biomed Res Int 2021 5;2021:6642852. Epub 2021 Apr 5.

Department of Population and Family Health, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia.

Despite highly effective modern contraceptive methods (both short and long acting) are made widely available and accessible globally, their utilization remains low among young women in low- and middle-income countries, including Ethiopia. Hence, this study is aimed at determining its status and identifying the determinant factors by using nationally representative data. A multilevel analysis of the nationwide Performance Monitoring for Action 2018 of Ethiopia round 6 data, collected from June to July, 2018, was conducted. Read More

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Kidney Disease-Specific Quality of Life among Patients on Hemodialysis.

Int J Nephrol 2021 7;2021:8876559. Epub 2021 Apr 7.

Medicine Department, Mohap, Dubai, UAE.

Introduction: Quality of life (QoL) of hemodialysis patients can be examined in two aspects: kidney-specific quality of life and general quality of life.

Objective: To determine the QoL among patients undergoing hemodialysis, to assess patients' QoL on hemodialysis, and to determine the factors associated with QoL among hemodialysis patients in Oman.

Method: A cross-sectional study was carried out with 205 patients to measure the QoL across various demographic and clinical variables in Oman. Read More

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Impact of Switching to Fingolimod Versus Injectable Disease-Modifying Therapy Cycling on Risk of Multiple Sclerosis-Related Relapses: A Retrospective Analysis.

Int J MS Care 2021 Mar-Apr;23(2):73-78. Epub 2020 Apr 28.

Background: Clinical and real-world studies have shown significant reductions in multiple sclerosis (MS) relapses with fingolimod versus injectable disease-modifying therapies (DMTs). Multiple sclerosis relapse rate and incidence were compared in patients switching from an injectable DMT to fingolimod and those cycling from one injectable DMT to another or remaining on their original injectable DMT.

Methods: Retrospective analysis was performed using Commercial and Medicare Supplemental claims data (July 1, 2010, to June 30, 2016) of adults with MS receiving ≥1 injectable DMT. Read More

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