30,180,691 results match your criteria journal


Venetoclax combinations induce high response rates in newly diagnosed Acute Myeloid Leukemia patients ineligible for intensive chemotherapy in routine practice.

Am J Hematol 2021 Apr 9. Epub 2021 Apr 9.

Department of Hematology, Shamir Medical Center (formerly Assaf Harofe Medical Center), Zerifin, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Combinations of the BCL-2 inhibitor, venetoclax, with either hypomethylating agents (HMA), or low dose cytarabine (LDAC), have shown promising results in clinical trials of AML patients unfit for intensive therapy. We report on the efficacy and safety of AML patients that were treated with venetoclax combinations outside of clinical trials. Data on 133 patients with a mean age of 77 years is included. Read More

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Acute gastrointestinal bleeding: results from the prospective German electronic registry of nearly 11 000 endoscopies (ALGK GI-bleeding registry).

Z Gastroenterol 2021 Apr 9. Epub 2021 Apr 9.

ALGK (Arbeitsgemeinschaft Leitende Gastroenterologische Krankenhausärzte; Working Group of Leading German Gastroenterologists in Hospitals).

Background And Study Aims:  Gastrointestinal bleeding is frequently observed in the German population. However, recent epidemiological data are not available. This study aimed to elucidate gastrointestinal bleeds under real-life conditions in 3 German hospitals. Read More

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Intracranial 131I-chTNT Brachytherapy in Patients with Deep-Seated Glioma: A Single-center Experience with 10-Year Follow-up from China.

Nuklearmedizin 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurosurgery, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China.

Objective:  The intracranial brachytherapy has been applied for decades, however, no results with long-term follow-up have been reported. This study investigated the long-term efficiency of intra-tumoral injection of I-chTNT in patients with deep-seated glioma.

Method:  Thirty-five patients undergoing I-chTNT brachytherapy between December 2004 and May 2009 were enrolled. Read More

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The value of (18)F-FDG PET/CT in Diagnosis and Evaluation of Response to Treatment in Retroperitoneal Fibrosis.

Nuklearmedizin 2021 Apr 9. Epub 2021 Apr 9.

Nuclear Medicine, Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.

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[Management of Infection in Threatened Preterm Birth - A Survey of German Perinatal Centers].

Z Geburtshilfe Neonatol 2021 Apr 9. Epub 2021 Apr 9.

Universitätsfrauenklinik, Medizinische Fakultät der Universität Rostock, Rostock, Deutschland.

Introduction: In spite of insufficient evidence, we assume a high willingness to diagnose and treat vaginal infections in threatened preterm births in Germany.

Methods: Online survey on the management of infection in threatened preterm birth in all 212 German perinatal centers.

Results: The response rate was 31. Read More

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Severe Preeclampsia is Associated with Functional and Structural Cardiac Alterations: A Case-control Study.

Z Geburtshilfe Neonatol 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, Pamukkale University, Denizli, Turkey.

Background: The aim of the current study is to compare electrocardiographic and echocardiographic changes in patients with severe preeclampsia (PE) and those with uncomplicated pregnancies.

Methods: This is a case-controlled prospective study consisting of 21 pregnant women with severe preeclampsia and a control group consisting of age- and gestational age-matched 24 healthy pregnant women. All patients underwent electrocardiographic and echocardiographic investigation. Read More

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[Neurophysiological parameters for speech recognition in patients with cochlear implants].

Laryngorhinootologie 2021 Apr 9. Epub 2021 Apr 9.

Klinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg, Germany.

Objectives:  Cochlea Implants (CI) are the preferred treatment for deaf and highly hearing imparied people. While deaf people already profit enormously from any regained hearing perception, it is not as easy to predict a profitable outcome for people with a remaining sense of hearing. To provide patients the best possible outcome in speech understanding, a lot of parameters have to be identified and adjusted. Read More

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[Obvious case of Morbus Menière?]

Laryngorhinootologie 2021 Apr 9. Epub 2021 Apr 9.

Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Gießen und Marburg - Standort Marburg, Germany.

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Reference Ranges for Vermis Biometry on Prenatal Ultrasound: Systematic Review and Meta-Analysis.

Ultraschall Med 2021 Apr 9. Epub 2021 Apr 9.

Obstetrics and Gynecology Hadassah Medical Organization and Faculty of Medicine Hebrew University of Jerusalem Jerusalem, Israel.

Purpose:  To conduct a systematic review and meta-analysis of published nomograms for fetal vermis biometry.

Materials And Methods:  A structured literature search was conducted to identify studies that reported normal measurements of the fetal vermis. A customized quality assessment tool was used to review the selected articles. Read More

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How safe is it to use ultrasound in prenatal medicine? Facts and contradictions - Part 2 - Laboratory experiments regarding non-thermal effects and epidemiological studies.

Ultraschall Med 2021 Apr 9. Epub 2021 Apr 9.

Centre for Ultrasound and Prenatal Medicine Frankfurt/Main, Germany.

The first part of this CME article (issue 5/20) provided a detailed examination of the biophysical effects of ultrasound waves, the exposure values, and in particular the thermal effect. In vivo and in vitro measurements have shown that the temperature increase in tissue associated with B-mode ultrasound is far too low to pose a potential risk. Even experiments with exposure values in the range of pulsed Doppler have shown that temperature increases of over 1. Read More

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Personalia.

Authors:

Nuklearmedizin 2021 Apr 9;60(2):197. Epub 2021 Apr 9.

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Nachruf auf Prof. Dr. rer. nat. habil. Gerd-Jürgen Beyer.

Authors:

Nuklearmedizin 2021 Apr 9;60(2):124. Epub 2021 Apr 9.

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Zum Beitrag: Gemeinsame Handlungsempfehlung (S1-Leitlinie) von DGN, OGNMB und SGNM – Radiosynoviorthese – AWMF-Registriernummer 031-023.

Nuklearmedizin 2021 Apr 9;60(2):113-114. Epub 2021 Apr 9.

Klinik und Poliklinik für Orthopädie, Universitätsklinikum Hamburg-Eppendorf, Hamburg.

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[Joint DGN, OGNMB and SGNM S1 guideline for radiosynoviorthesis].

Nuklearmedizin 2021 Apr 9;60(2):78-89. Epub 2021 Apr 9.

Privatklinik Villach GmbH & Co KG, Institut für Nuklearmedizin, Österreich.

This recommendation is intended to provide a guideline for radiosynoviorthesis (RSO) in the effective local treatment of chronic inflammatory (non-infectious) joint diseases. It was developed in an interdisciplinary manner and describes the general objectives, definitions, clinical background information, indication and contraindications of this radionuclide therapy. The requirements to be met by a treatment center, the results of pretherapeutic examinations as well as recommendations on how the treatment should be carried out. Read More

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Grußwort zur „NuklearMedizin 2021 – digital“.

Authors:

Nuklearmedizin 2021 Apr 9;60(2):76-77. Epub 2021 Apr 9.

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Comprehensive Review of Cardiovascular Involvement in COVID-19.

AACN Adv Crit Care 2021 Apr 15:e1-e19. Epub 2021 Apr 15.

Ruff Joseph Macale Cajanding is Charge Nurse, Adult Critical Care Unit, 6th Floor, King George V Building, St. Bartholomew's Hospital, Barts Health NHS Trust, 2 King Edward Street, London EC1A 1HQ, United Kingdom

COVID-19 has emerged as one of the most devastating and clinically significant infectious diseases of the last decade. It has reached global pandemic status at an unprecedented pace and has placed significant demands on health care systems worldwide. Although COVID-19 primarily affects the lungs, epidemiologic reports have shown that the disease affects other vital organs of the body, including the heart, vasculature, kidneys, brain, and the hematopoietic system. Read More

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Costs of TB care incurred by adult patients with newly diagnosed drug-sensitive TB in Ballabgarh block in northern India.

Trans R Soc Trop Med Hyg 2021 Apr 9. Epub 2021 Apr 9.

Centre for Community Medicine (CCM), Old OT Block, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.

Background: India's National Tuberculosis Elimination Programme (NTEP) provides free diagnosis and treatment services but does not monitor TB-related costs. This study aimed to estimate the direct and indirect costs borne by adult patients with newly diagnosed TB.

Methods: A longitudinal study in Ballabgarh block, Haryana (North India) was conducted. Read More

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An exploratory focus group study on experiences with snakebites: health-seeking behaviour and challenges in rural communities of Kenya.

Trans R Soc Trop Med Hyg 2021 Apr 9. Epub 2021 Apr 9.

Health Action International, Overtoom 60 (2), 1054 HK Amsterdam, the Netherlands.

Background: Snakebite envenoming is a long-hidden public health threat in the rural communities of Kenya. This study aimed to shed light on the health-seeking behaviour of people bitten by snakes, views on prevention measures and community needs and the consequences for snakebite patients in these areas.

Methods: Six focus group interviews were conducted in communities in the Kajiado (n=3) and Kilifi (n=3) counties. Read More

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Limited Evidence of Associations Between Executive Functioning and Alcohol Involvement In UK Adolescents.

Alcohol Alcohol 2021 Apr 9. Epub 2021 Apr 9.

Department of Psychology, Institute of Population Health, Eleanor Rathbone Building, Bedford Street South, University of Liverpool, L69 7ZA, UK.

Aims: Deficits in motor inhibitory control and working memory have been hypothesized to be both a cause and consequence of heavy alcohol use. Adolescence is a critical developmental stage for inhibitory control and working memory, and it is also a stage when individuals are most likely to initiate alcohol use. This study aimed to examine whether inhibitory control and working memory would predict alcohol use and involvement in a group of UK adolescents. Read More

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Cytologic Assessment of Cystic/Intraductal Lesions of the Pancreatobiliary Tract.

Authors:
Michelle D Reid

Arch Pathol Lab Med 2021 Apr 9. Epub 2021 Apr 9.

From the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.

Context.—: Because of new and improved imaging techniques, cystic/intraductal pancreatobiliary tract lesions are increasingly being discovered, and brushings or endoscopic ultrasound/computed tomography/magnetic resonance imaging-guided fine-needle aspiration biopsies from these lesions have become an integral part of pathologists' daily practice. Because patient management has become increasingly conservative, accurate preoperative diagnosis is critical. Read More

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LncRNA small nucleolar RNA host gene 16 (SNHG16) silencing protects lipopolysaccharide (LPS)-induced cell injury in human lung fibroblasts WI-38 through acting as miR-141-3p sponge.

Biosci Biotechnol Biochem 2021 Feb 1. Epub 2021 Feb 1.

Department of oral and maxillofacial surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, China.

Long noncoding RNA (LncRNA) small nucleolar RNA host gene 16 (SNHG16) is correlated with cell injuries, including pneumonia. However, its role and mechanism remain vague in pneumonia. The interplay among genes was confirmed by dual-luciferase reporter assay, RNA immunoprecipitation, and RNA pull-down assay. Read More

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February 2021

Molecular mechanisms and highly functional development for stress tolerance of the yeast Saccharomyces cerevisiae.

Authors:
Hiroshi Takagi

Biosci Biotechnol Biochem 2021 Feb 12. Epub 2021 Feb 12.

Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan.

In response to environmental stress, microorganisms adapt to drastic changes while exerting cellular functions by controlling gene expression, metabolic pathways, enzyme activities, and protein-protein interactions. Microbial cells that undergo a fermentation process are subjected to stresses, such as high temperature, freezing, drying, changes in pH and osmotic pressure, and organic solvents. Combinations of these stresses that continue over long terms often inhibit cells' growth and lead to their death, markedly limiting the useful functions of microorganisms (eg their fermentation ability). Read More

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February 2021

Toward a Healthy and Environmentally Sustainable Campus Food Environment: A Scoping Review of Postsecondary Food Interventions.

Adv Nutr 2021 Apr 9. Epub 2021 Apr 9.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Interventions are urgently needed to transform the food system and shift population eating patterns toward those consistent with human health and environmental sustainability. Postsecondary campuses offer a naturalistic setting to trial interventions to improve the health of students and provide insight into interventions that could be scaled up in other settings. However, the current state of the evidence on interventions to support healthy and environmentally sustainable eating within postsecondary settings is not well understood. Read More

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Effective Dose in Pediatric Interventional Cardiology.

Authors:
S S Sarycheva

Radiat Prot Dosimetry 2021 Apr 9. Epub 2021 Apr 9.

Radiation Protection Laboratory, Saint-Petersburg Research Institute of Radiation Hygiene, Saint Petersburg, Mira st. 8, 197101 St.Petersburg, Russian Federation, Russia.

The aim of this study was to estimate the effective doses (EDs) to children undergoing pediatric interventional cardiology examinations in hospitals of St.-Petersburg, to calculate associated dose conversion coefficients (DCCs) and to investigate their dependence of different parameters of the various procedures. Basic parameters of pediatric cardiology examinations and patient doses were studied in three main pediatric city hospitals. Read More

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Atrial fibrillation and stroke prevention.

Authors:
Basil S Lewis

Eur Heart J Cardiovasc Pharmacother 2021 Apr;7(FI1):f1-f2

Cardiovascular Clinical Research Institute, Lady Davis Carmel Medical Center and the Ruth and Bruce Rappaport School of Medicine, Technion-IIT, 7 Michal Street, Haifa 3436212, Israel.

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Gastrointestinal Tract Lymphomas: A Review of the Most Commonly Encountered Lymphomas.

Arch Pathol Lab Med 2021 Apr 9. Epub 2021 Apr 9.

From the Department of Pathology, Division of Hematopathology, Division of Gastrointestinal Pathology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida (Alvarez-Lesmes, Chapman, Cassidy, Zhou, Garcia-Buitrago, Montgomery, Poveda).

Context.—: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin lymphoma, accounting for 20% to 40% of all extranodal lymphomas. The majority of these are systemic processes secondarily involving the GI tract. Read More

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Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis.

ILAR J 2021 Apr 9. Epub 2021 Apr 9.

Department of Comparative Medicine, John Hopkins School of Medicine, Baltimore, Maryland, USA.

The Coronavirus Disease 2019 (COVID-19) pandemic has fueled unprecedented development of animal models to understand disease pathogenesis, test therapeutics, and support vaccine development. Models previously developed to study severe acute respiratory syndrome coronavirus (SARS-CoV) have been rapidly deployed to study SARS-CoV-2. However, it has become clear that despite the common use of ACE2 as a receptor for both viruses, the host range of the 2 viruses does not entirely overlap. Read More

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Association Between Specific Childhood Adversities and Symptom Dimensions in People With Psychosis: Systematic Review and Meta-Analysis.

Schizophr Bull 2021 Apr 9. Epub 2021 Apr 9.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Despite the accepted link between childhood abuse and positive psychotic symptoms, findings between other adversities, such as neglect, and the remaining dimensions in people with psychosis have been inconsistent, with evidence not yet reviewed quantitatively. The aim of this study was to systematically examine quantitatively the association between broadly defined childhood adversity (CA), abuse (sexual/physical/emotional), and neglect (physical/emotional) subtypes, with positive, negative, depressive, manic, and disorganized dimensions in those with psychosis. A search was conducted across EMBASE, MEDLINE, PsychINFO, and Cochrane Libraries using search terms related to psychosis population, CA, and psychopathological dimensions. Read More

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