431,631 results match your criteria joint dysfunction


CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish.

Immunol Lett 2021 May 2. Epub 2021 May 2.

SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

The number and function of T cells are abnormal as observed in cystic fibrosis (CF) patients and CF mouse models, and our previous work shows that the CFTR mutant leads to deficiency of primitive and definitive hematopoietic in zebrafish. However, the functions and underlying mechanisms of CFTR in T cell development during early embryogenesis have not been explored. Here, we report that the genetic ablation of CFTR in zebrafish resulted in abrogated embryonic T lymphopoiesis, which was ascribed to impaired thymic homing and expansion of hematopoietic stem cells (HSCs). Read More

View Article and Full-Text PDF

Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3.

Mov Disord 2021 May 5. Epub 2021 May 5.

IXICO Plc, London, United Kingdom.

Background: Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity.

Objective: The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease.

Methods: We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers and 63 healthy controls. Read More

View Article and Full-Text PDF

Intramuscular fatty infiltration and physical function in controlled acromegaly.

Eur J Endocrinol 2021 May 1. Epub 2021 May 1.

E Valassi, Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Introduction: Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased intramuscular fat fraction is a known cause of muscle dysfunction in several disorders.

Objective: To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients, and its relationship with muscle dysfunction. Read More

View Article and Full-Text PDF

Mitochondrial abnormalities: a hub in metabolic syndrome-related cardiac dysfunction caused by oxidative stress.

Heart Fail Rev 2021 May 5. Epub 2021 May 5.

Department of Anesthesiology, Shengjing Hospital, China Medical University, Liaoning, China.

Metabolic syndrome (MetS) refers to a group of cardiovascular risk elements comprising insulin resistance, obesity, dyslipidemia, increased glucose intolerance, and increased blood pressure. Individually, all the MetS components can lead to cardiac dysfunction, while their combination generates additional risks of morbidity and mortality. Growing evidence suggests that oxidative stress, a dominant event in cellular damage and impairment, plays an indispensable role in cardiac dysfunction in MetS. Read More

View Article and Full-Text PDF

Usability and Accuracy of a Smartwatch for the Assessment of Physical Activity in the Elderly Population: Observational Study.

JMIR Mhealth Uhealth 2021 May 5;9(5):e20966. Epub 2021 May 5.

Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Background: Regular physical activity (PA) contributes to the primary and secondary prevention of several chronic diseases and reduces the risk of premature death. Physical inactivity is a modifiable risk factor for cardiovascular disease and a variety of chronic disorders such as diabetes, obesity, hypertension, bone and joint diseases (eg, osteoporosis and osteoarthritis), depression, and colon and breast cancer. Population aging and the related increase in chronic diseases have a major impact on the health care systems of most Western countries and will produce an even more significant effect in the future. Read More

View Article and Full-Text PDF

Pathological mechanism of chondrocytes and the surrounding environment during osteoarthritis of temporomandibular joint.

J Cell Mol Med 2021 May 5. Epub 2021 May 5.

Department of Orthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of the TMJ. In order to explore its aetiology and pathological mechanism, many animal models and cell models have been constructed to simulate the pathological process of TMJ osteoarthritis. The main pathological features of TMJ osteoarthritis include chondrocyte death, extracellular matrix (ECM) degradation and subchondral bone remodelling. Read More

View Article and Full-Text PDF

NeuroCrypt: Machine Learning Over Encrypted Distributed Neuroimaging Data.

Neuroinformatics 2021 May 4. Epub 2021 May 4.

Georgia State University, Atlanta, GA, USA.

The field of neuroimaging can greatly benefit from building machine learning models to detect and predict diseases, and discover novel biomarkers, but much of the data collected at various organizations and research centers is unable to be shared due to privacy or regulatory concerns (especially for clinical data or rare disorders). In addition, aggregating data across multiple large studies results in a huge amount of duplicated technical debt and the resources required can be challenging or impossible for an individual site to build. Training on the data distributed across organizations can result in models that generalize much better than models trained on data from any of organizations alone. Read More

View Article and Full-Text PDF

Polycystic ovary syndrome and (pre)osteoarthritis: assessing the link between hyperandrogenism in young women and cartilage oligomeric matrix protein as a marker of cartilage breakdown.

Clin Rheumatol 2021 May 4. Epub 2021 May 4.

Clinic of Endocrinology, University Hospital "Alexandrovska", Department of Internal Medicine, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria.

Introduction: OBJECTIVES: Our aim was to analyze the link between hyperandrogenism and early clinical manifestations of osteoarthritis (OA), knee cartilage thickness, and serum cartilage oligomeric matrix protein (sCOMP) levels in patients with polycystic ovary syndrome (PCOS) and to compare them with healthy volunteers.

Methods: Fifty-four PCOS patients who met the Rotterdam criteria with phenotypes A, B, and C were included. They were compared with 26 age- and body mass index (BMI)-matched controls. Read More

View Article and Full-Text PDF

Undifferentiated connective tissue disease presenting with optic neuritis and concomitant axial spondyloarthritis: A rare case report.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):111-114. Epub 2021 Mar 4.

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.

Undifferentiated connective tissue disease (UCTD) represents a group of diseases which do not fulfill the criteria of rheumatologic diseases or may be considered as an early stage of any of these diseases. Axial spondyloarthritis (axSpA) is a disease accompanied by symptoms of inflammatory low back pain and peripheral symptoms, with more spine and sacroiliac joint involvement. In this report, we, for the first time, present a case of UCTD presenting with axSpA in whom the initial finding was optic neuritis, which is rarely seen in UCTD. Read More

View Article and Full-Text PDF

Post-traumatic tenosynovial chondromatosis following a triquetrum fracture: a case report.

Oxf Med Case Reports 2021 Apr 28;2021(4):omab007. Epub 2021 Apr 28.

Orthopaedic Surgery Department, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.

Tenosynovial chondromatosis (TC) is a rare progressive benign tumor from the synovial lining of tendon sheath. The TC mostly affects males between the ages 30 to 50 years old at the ventral side of wrist. There are two different forms of TC that have been proposed in previous studies: an idiopathic cause (primary TC) and a joint related diseases cause (secondary TC). Read More

View Article and Full-Text PDF

Anatomy and Correlation of the Coracoid Process and Coracoclavicular Ligament Based on Three-Dimensional Computed Tomography Reconstruction and Magnetic Resonance Imaging.

Med Sci Monit 2021 Apr 24;27:e930435. Epub 2021 Apr 24.

Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).

BACKGROUND The anatomy of the coracoid process and coracoclavicular (CC) ligament have been described and the correlation between them has been assessed based on 3-dimensional computed tomography (CT) reconstruction and magnetic resonance imaging (MRI), which provide a guide for coracoclavicular ligament reconstruction. MATERIAL AND METHODS Data were collected from 300 patients who underwent both CT and MRI of the shoulder joint from January 2017 to January 2019 at the Jiang'an Hospital of Traditional Chinese Medicine. The coracoid process was observed and classified and parameters of the CC ligament were measured according to different corneal types. Read More

View Article and Full-Text PDF

Genomic Identification of Multidrug-Resistant Virchow Monophasic Variant Causing Human Septic Arthritis.

Pathogens 2021 Apr 29;10(5). Epub 2021 Apr 29.

Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Wenhui East Road 48, Yangzhou 225009, China.

The monophasic variant of Typhimurium has emerged and increased rapidly worldwide during the past two decades. The loss of genes encoding the second-phase flagella and the acquirement of the multi-drug resistance cassette are the main genomic characteristics of the Typhimurium monophasic variant. In this study, two strains were isolated from the knee effusion and feces of a 4-year-old girl who presented with a case of septic arthritis and fever, respectively. Read More

View Article and Full-Text PDF

Screening for Interacting Proteins with Peptide Biomarker of Blood-Brain Barrier Alteration under Inflammatory Conditions.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

INSERM U1049 and U1029 Neuroinflammation and Angiogenesis Group, Bordeaux University, F33000 Bordeaux, France.

Neurodegenerative diseases are characterized by increased permeability of the blood-brain barrier (BBB) due to alterations in cellular and structural components of the neurovascular unit, particularly in association with neuroinflammation. A previous screening study of peptide ligands to identify molecular alterations of the BBB in neuroinflammation by phage-display, revealed that phage clone 88 presented specific binding affinity to endothelial cells under inflammatory conditions in vivo and in vitro. Here, we aimed to identify the possible target receptor of the peptide ligand 88 expressed under inflammatory conditions. Read More

View Article and Full-Text PDF

Assessment of Good Practices in Community-Based Interventions for Physical Activity Promotion: Development of a User-Friendly Tool.

Int J Environ Res Public Health 2021 Apr 29;18(9). Epub 2021 Apr 29.

Programa Nacional para a Promoção da Atividade Física, Direção-Geral da Saúde, 1049 Lisboa, Portugal.

Tools to identify good practices in the design, implementation, and evaluation of physical activity community-based interventions (PACIs) are key to address the physical inactivity pandemic. Existing tools tend to be extensive and with limited applicability to assess small-scale PACIs. This work aimed to report the development and preliminary validity results of a simple, practical, and user-friendly tool to evaluate PACIs in local/municipal contexts. Read More

View Article and Full-Text PDF

Minimum Radiant Exposure and Irradiance for Triggering Adequate Polymerization of a Photo-Polymerized Resin Cement.

Materials (Basel) 2021 Apr 30;14(9). Epub 2021 Apr 30.

Fujian Key Laboratory of Oral Diseases, Fujian Provincial Engineering Research Center of Oral Biomaterial, Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou 350000, China.

This study aimed to establish the minimum radiant exposure and irradiance to trigger an adequate polymerization of a photo-polymerized resin cement. In total, 220 disc-shaped specimens (diameter of 10 mm and thickness of 0.1 mm) were fabricated using a photo-polymerized resin cement (Variolink N-transparent, Ivoclar Vivadent). Read More

View Article and Full-Text PDF

Toll-Like Receptor and Cytokine Responses to Infection with Endogenous and Exogenous Koala Retrovirus, and Vaccination as a Control Strategy.

Curr Issues Mol Biol 2021 Apr 30;43(1):52-64. Epub 2021 Apr 30.

Transboundary Animal Diseases Centre, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.

Koala populations are currently declining and under threat from koala retrovirus (KoRV) infection both in the wild and in captivity. KoRV is assumed to cause immunosuppression and neoplastic diseases, favoring chlamydiosis in koalas. Currently, 10 KoRV subtypes have been identified, including an endogenous subtype (KoRV-A) and nine exogenous subtypes (KoRV-B to KoRV-J). Read More

View Article and Full-Text PDF

Pediatric Acetabular Osteomyelitis Treated With Hip Arthroscopy.

J Am Acad Orthop Surg Glob Res Rev 2021 May 4;5(5):e21.00011. Epub 2021 May 4.

From the Division of Orthopaedic Surgery, Western University, London, Ontario, Canada (Dr. Lovse); the Division of Orthopaedic Surgery, University of Ottawa, Ottawa, Ontario, Canada (Dr. Coupal); the Division of Orthopaedic Surgery, CHEO, Ottawa, Ontario, Canada (Dr. Tice, Dr. Carsen); and the Division of Infectious Diseases, CHEO, Ottawa, Ontario, Canada (Dr. Le Saux).

Osteomyelitis of the acetabulum is a rare condition accounting for only 12% of pelvic osteomyelitis cases. This report describes a previously healthy 10-year-old girl with subacute acetabular osteomyelitis and subsequent development of secondary septic arthritis of the hip. The patient presented with 3 weeks of groin pain, elevated erythrocyte sedimentation rate and C-reactive protein, synovial thickening of the hip on ultrasonography and diffuse signal uptake in the acetabulum on magnetic resonance imaging. Read More

View Article and Full-Text PDF

Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p.

Cell Cycle 2021 May 4:1-15. Epub 2021 May 4.

Department of Orthopedics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P.R. China.

The relevance of circular RNAs (circRNAs) has been indicated in the progression of various diseases. Nevertheless, the precise function of circRNAs in osteoarthritis (OA) remains to be established. Therefore, we aimed to investigate changes in the expression of a specific circRNA, hsa_circ_0134111 (circ_PDE1C) and predict its functions in OA. Read More

View Article and Full-Text PDF

PTH-induced EndMT via miR-29a-5p/GSAP/Notch1 pathway contributed to valvular calcification in rats with CKD.

Cell Prolif 2021 May 4:e13018. Epub 2021 May 4.

Institute of Nephrology, School of Medicine, Zhong Da Hospital, Southeast University, Nanjing, China.

Background: Endothelial-to-mesenchymal transition (EndMT) is a common pathophysiology in valvular calcification (VC) among non-chronic kidney disease (CKD) patients. However, few studies were investigated in CKD-induced VC. Parathyroid hormone (PTH) was considered to be an important component of EndMT in CKD-induced cardiovascular diseases. Read More

View Article and Full-Text PDF

ICD-10 Coding of Musculoskeletal Conditions in the Veterans Health Administration.

Pain Med 2021 May 3. Epub 2021 May 3.

Pain Research, Informatics, Multimorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT.

Objective: We describe the most frequently used musculoskeletal diagnoses in Veterans Health Administration (VHA) care. We report the number of visits and patients associated with common musculoskeletal ICD-10 codes and compare trends across primary and specialty care settings.

Design: Secondary analysis of a longitudinal cohort study. Read More

View Article and Full-Text PDF

Synovial Cell Count Before Reimplantation Can Predict the Outcome of Patients with Periprosthetic Knee Infections Undergoing Two-stage Exchange.

Clin Orthop Relat Res 2021 05 3. Epub 2021 May 3.

T. Ascione, P. Pagliano, Department of Infectious Diseases, D. Cotugno Hospital, AORN dei Colli - Naples.

Background: Although synovial fluid can be used to diagnose periprosthetic joint infections (PJI) effectively, only the cutoff values adopted at the time of PJI diagnosis have been standardized, and few data are currently available about effectiveness of synovial fluid examination before definitive reimplantation.

Questions/purposes: We asked: (1) What are the most appropriate thresholds for synovial fluid leukocyte counts (WBC) and neutrophil percentage (PMN percentage) in a patient group undergoing definitive reimplantation after an uninterrupted course of antibiotic therapy for chronic PJI? (2) What is the predictive value of our synovial WBC and PMN percentage threshold compared with previously proposed thresholds?

Methods: In all, 101 patients with PJI were evaluated for inclusion from January 2016 to December 2018. Nineteen percent (19 of 101) of patients were excluded because of the presence of a chronic inflammatory disease, acute/late hematogenous infection, low amount of synovial fluid for laboratory investigations or infection persistence after spacer placement, and adequate antibiotic therapy. Read More

View Article and Full-Text PDF

Foot and Ankle Problems in Patients With Rheumatoid Arthritis in 2019: Still an Important Issue.

ACR Open Rheumatol 2021 May 4. Epub 2021 May 4.

Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark, and University of Southern Denmark, Odense, Denmark, and Lund University, Lund, Sweden.

Objective: To study the prevalence of foot pain in patients with rheumatoid arthritis (RA) and whether including a 12-joint foot count in addition to the 28-joint count (from the Disease Activity Score 28 [DAS28]) improved detection of foot or ankle pain. In addition, the association between the self-reported foot and ankle score (SEFAS), patient-reported function, and disease-specific factors was studied.

Methods: Physician-reported data (swollen/tender 12-joint foot count, DAS28, and medication) and patient-reported data (foot/ankle pain, physical function, global health, and SEFAS) were assessed during a clinical visit. Read More

View Article and Full-Text PDF

Mass testing - an underexplored strategy for COVID-19 control.

Innovation (N Y) 2021 Apr 29:100114. Epub 2021 Apr 29.

China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.

View Article and Full-Text PDF

Cast immobilisation in situ versus open reduction and internal fixation of displaced medial epicondyle fractures in children between 7 and 16 years old. A study protocol for a randomised controlled trial.

BMJ Open 2021 May 3;11(5):e044627. Epub 2021 May 3.

Department of Pediatric Orthopedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Uusimaa, Finland.

Introduction: Medial epicondyle fracture of the humerus is a common injury in childhood. There is uniform agreement that minimally displaced fractures (dislocation ≤2 mm) can be treated nonoperatively with immobilisation. Open fractures, fractures with joint incarceration or ulnar nerve dysfunction require surgery. Read More

View Article and Full-Text PDF