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Association of Temporomandibular Disorders and Tinnitus with Health-Related Quality of Life: A Cross-Sectional Study Using the Fifth Korea National Health and Nutrition Examination Survey.

J Oral Rehabil 2021 Dec 4. Epub 2021 Dec 4.

Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea.

Background: Few studies have examined the associations of temporomandibular disorders (TMDs) and tinnitus with health-related quality of life on a national level.

Objective: We aimed to investigate the associations of TMDs, tinnitus, and quality of life among the Korean population, aged 19 years or older.

Methods: Data was obtained from the fifth Korea National Health and Nutrition Examination Survey (2012; N = 5,786). Read More

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December 2021

Functional, physical, and psychosocial impact of degenerative Temporomandibular joint disease.

J Oral Rehabil 2021 Dec 4. Epub 2021 Dec 4.

Centre for TMD & Orofacial Pain, Peking University School & Hospital of Stomatology, Beijing, China.

Objectives: This study evaluated the functional, physical, and psychosocial impacts of TMJ degenerative joint disease (DJD). The bearing of TMJ osteoarthrosis/osteoarthritis and early/late TMJ DJD on oral health-related quality of life (OHRQoL) were also compared.

Methods: Participants were enrolled from a TMD/orofacial pain centre. Read More

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December 2021

Preoperative morbidity and joint awareness while awaiting hip arthroscopy for femoroacetabular impingement.

J Exp Orthop 2021 Dec 4;8(1):113. Epub 2021 Dec 4.

Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.

Purpose: The Forgotten Joint Score (FJS-12) is a valid tool in the evaluation of patients undergoing hip arthroscopy, assessing the unique concept of joint awareness in the setting of a patient's hip pathology. The preoperative burden on patients' mental wellbeing of impaired joint function or symptoms is well established. The purpose of this study was to determine patients' awareness of their hip joint whilst awaiting hip arthroscopy for femoroacetabular impingement, to explore any association between joint awareness and mental health status, and to determine whether this relates to time spent waiting for arthroscopy preoperatively. Read More

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December 2021

Transformation from calcium sulfate to calcium phosphate in biological environment.

J Mater Sci Mater Med 2021 Dec 4;32(12):146. Epub 2021 Dec 4.

Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

The formation of a nano-apatite surface layer is frequently considered a measure of bioactivity, especially for non-phosphate bioceramics. In the present study, strontium-doped calcium sulfate, (Ca,Sr)SO, was used to verify the feasibility of this measure. The (Ca,Sr)SO specimen was prepared by mixing 10% SrSO by weight with 90% CaSO·½HO powder by weight. Read More

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December 2021

[Development Status of Irreversible Electric Perforated Tumor Ablation Device].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Nov;45(6):655-661

National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061.

This study firstly introduced the mechanism, benefits and applications of irreversible electroporation(IRE) for tumor ablation. In addition, this study also introduced the most advanced IRE systems cleared by FDA or CFDA and IRE research equipment. The clinically licensed IRE systems include the Nanoknife 3. Read More

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November 2021

[Design of Magnamosis System for Endoscopic Tissue Clamping].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Nov;45(6):612-615

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061.

Based on the principle of magnetic anastomosis technique, the design of magnetic anastomosis system for endoscopic tissue clamping is proposed. The system includes a semi-ring magnet, a special structure transparent cap and a detachable push rod. With the help of the existing digestive endoscopy and endoscopic tissue gripper, the endoscopic close clamping and anastomosis of the bleeding or perforated tissue can be completed. Read More

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November 2021

Recent advances and perspectives of postoperative neurological disorders in the elderly surgical patients.

CNS Neurosci Ther 2021 Dec 3. Epub 2021 Dec 3.

Department of Anesthesiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China.

Postoperative neurological disorders, including postoperative delirium (POD), postoperative cognitive dysfunction (POCD), postoperative covert ischemic stroke, and hemorrhagic stroke, are challenging clinical problems in the emerging aged surgical population. These disorders can deteriorate functional outcomes and long-term quality of life after surgery, resulting in a substantial social and financial burden to the family and society. Understanding predisposing and precipitating factors may promote individualized preventive treatment for each disorder, as several risk factors are modifiable. Read More

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December 2021

Proprioceptive and Clinical Outcomes after Remnant Preserved Anterior Cruciate Ligament Reconstruction: Assessment with Minimal Confounding Factors.

Orthop Surg 2021 Dec 4. Epub 2021 Dec 4.

Department of Sports Medicine, Chinese PLA General Hospital, Beijing, China.

Objective: To evaluate the proprioceptive and clinical function of the knee joint after anterior cruciate ligament reconstruction (ACLR) with various amounts of remnant preserved with as few confounding factors as possible.

Methods: This retrospective study included 46 patients who underwent ACLR with remnant preservation between March 2013 and February 2019. These patients had less than 6 months injury-to-surgery interval and no concomitant injuries. Read More

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December 2021

Common diseases of the nail: Diagnosis and therapy.

J Dtsch Dermatol Ges 2021 Dec 4. Epub 2021 Dec 4.

Center for Dermatology, Allergology and Dermatosurgery, HELIOS University Hospital Wuppertal, University of Witten/Herdecke, Wuppertal.

This review focuses on nail changes that do not belong to the group of benign or malignant nail tumors. These common afflictions of the nail include structural changes in and under the nail plate as well as inflammation around and in the nail bed. They include onychomycoses, nail psoriasis, onychodystrophies, subungual hematoma, paronychia, ingrown nails and pincer nails. Read More

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December 2021

XGBoost-based intelligence yield prediction and reaction factors analysis of amination reaction.

J Comput Chem 2021 Dec 4. Epub 2021 Dec 4.

College of Chemistry and Chemical Engineering, Henan University, Kaifeng, China.

Buchwald-Hartwig amination reaction catalyzed by palladium plays an important role in drug synthesis. In the last few years, machine learning-assisted strategies emerged and quickly gained attention. In this article, an importance and relevance-based integrated feature screening method is proposed to effectively filter high-dimensional feature descriptor data. Read More

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December 2021

How frequent is burnout among informal caregivers of disabled children? Findings from a cross-sectional study in Karachi, Pakistan.

Child Care Health Dev 2021 Dec 3. Epub 2021 Dec 3.

APPNA Institute of Public Health, Jinnah Sindh Medical University, Karachi, Sindh, Pakistan.

Background: Informal caregivers are those who care for children without getting paid. They are often more prone to stress due to their extra daily tasks which leads to burnout. This study aimed to determine the frequency and associated risk factors of burnout among informal caregivers of children with disabilities in Karachi. Read More

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December 2021

In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses.

J Vet Pharmacol Ther 2021 Dec 3. Epub 2021 Dec 3.

Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Intra-articular administration of sustained-release anti-inflammatory drugs is indicated in horses suffering from joint inflammation, but no such drugs are labelled for veterinary use. To obtain initial data on synovial disposition and safety of a new sustained-release formulation of diclofenac (SYN321) in the joints of horses, an experimental interventional study of elimination and side effects of intra-articular administration of SYN321 was conducted. Nine clinically sound horses were included in the study, and SYN321 was administered by the intra-articular route. Read More

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December 2021

Validation of Four Cutaneous Squamous Cell Carcinoma Staging Systems Using Nationwide Data.

Br J Dermatol 2021 Dec 3. Epub 2021 Dec 3.

Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands, Department of Dermatology - Dr. Molewaterplein 40, 3015 GD, PO Box 2040, 3000 CA, Rotterdam.

Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer worldwide with relatively low metastatic potential (2-5%). Developments in therapeutic options have highlighted the need to better identify high-risk patients who could benefit from closer surveillance, adjuvant therapies, and baseline/follow-up imaging, while at the same time safely omitting low-risk patients from further follow-up. Controversy remains regarding the predictive performance of current cSCC staging systems and which methodology to adopt. Read More

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December 2021

Sounds familiar(?): Expertise with specific musical genres modulates timing perception and micro-level synchronization to auditory stimuli.

Atten Percept Psychophys 2021 Dec 3. Epub 2021 Dec 3.

Carleton College, Northfield, MN, USA.

Musical expertise improves the precision of timing perception and performance - but is this expertise generic, or is it tied to the specific style(s) and genre(s) of one's musical training? We asked expert musicians from three musical genres (folk, jazz, and EDM/hip-hop) to align click tracks and tap in synchrony with genre-specific and genre-neutral sound stimuli to determine the perceptual center ("P-center") and variability ("beat bin") for each group of experts. We had three stimulus categories - Organic, Electronic, and Neutral sounds - each of which had a 2 × 2 design of the acoustic factors Attack (fast/slow) and Duration (short/long). We found significant effects of Genre expertise, and a significant interaction for both P-center and P-center variability: folk and jazz musicians synchronize to sounds typical of folk and jazz in a different manner than the EDM/hip-hop producers. Read More

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December 2021

Erasing the memory of arthritis in joints.

Authors:
Sarah Onuora

Nat Rev Rheumatol 2021 Dec 3. Epub 2021 Dec 3.

Nature Reviews Rheumatology, .

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December 2021

Single-cell analysis of salt-induced hypertensive mouse aortae reveals cellular heterogeneity and state changes.

Exp Mol Med 2021 Dec 3. Epub 2021 Dec 3.

Wuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.

Elevated blood pressure caused by excessive salt intake is common and associated with cardiovascular diseases in most countries. However, the composition and responses of vascular cells in the progression of hypertension have not been systematically described. We performed single-cell RNA sequencing on the aortic arch from C57BL/6J mice fed a chow/high-salt diet. Read More

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December 2021

The importance of selecting the correct site to apply spinal manipulation when treating spinal pain: Myth or reality? A systematic review.

Sci Rep 2021 Dec 3;11(1):23415. Epub 2021 Dec 3.

Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.

The concept that spinal manipulation therapy (SMT) outcomes are optimized when the treatment is aimed at a clinically relevant joint is commonly assumed and central to teaching and clinical use (candidate sites). This systematic review investigated whether clinical effects are superior when this is the case compared to SMT applied elsewhere (non-candidate sites). Eligible study designs were randomized controlled trials that investigated the effect of spinal manipulation applied to candidate versus non-candidate sites for spinal pain. Read More

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December 2021

Does alar ligament injury predict conservative treatment failure of atlantoaxial rotatory subluxation in adults: Case report and review of the literature.

Spinal Cord Ser Cases 2021 Dec 3;7(1):103. Epub 2021 Dec 3.

Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY, 10595, USA.

Introduction: The alar ligament is an important structure in restraining the rotational movement at the atlantoaxial joint. While bony fractures generally heal, rupture of ligaments may heal poorly in adults and often requires surgical stabilization. Atlantoaxial rotatory subluxation (AARS) is a rare injury in adults, and the prognostic importance of the presence of alar ligament injury with regard to the success of nonoperative management is unknown. Read More

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December 2021

Longitudinal Comparison of Continuing Medical Education Learning Objectives and Intent-to-Change Statements of Participants.

J Contin Educ Health Prof 2021 Dec 1. Epub 2021 Dec 1.

Dunson: Medical Student, Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT. Dr. Park: Associate Professor and Associate Head of Medical Education, Department of Medical Education, University of Illinois, Chicago, IL. Dr. Park's current affiliation is Massachusetts General Hospital, Havard Medical School, Boston, MA. Dr. Richards: Professor of Pediatrics on the Lecturer Track,School of Medicine, University of Utah, Salt Lake City, UT. Dr. Hirshfield: Associate Professor, Co-director of the PhD program in Curriculum Studies/HPE and the Associate Director of Graduate Studies, Department of Medical Education, University of Illinois, Chicago, IL. Dr. Jensen: Professor of Neurosurgery, Radiation Oncology, and Oncological Sciences; Neurosurgery Vice Chair of Education and Residency Program Director, Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT.

Introduction: Successful completion of continuing medical education (CME) activities is often required for ongoing physician board certification, licensure, and hospital privileges. CME activities are designed to address professional knowledge or practice gaps. The authors examined participants' "intent to change" after CME activities to evaluate whether CME activity content was suitably linked with the stated learning objectives. Read More

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December 2021

Risk factors for progression of juvenile-onset non-radiographic axial spondyloarthritis to juvenile-onset ankylosing spondylitis: a nested case-control study.

RMD Open 2021 Dec;7(3)

Department of Rheumatology and Immunology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Objective: To evaluate the clinical characteristics of juvenile-onset non-radiographic axial spondyloarthritis (nr-axSpA) and to investigate risk factors associated with progression to juvenile-onset ankylosing spondylitis (JoAS).

Methods: A nested case-control study was conducted using the retrospectively collected data of 106 patients with juvenile-onset nr-axSpA (age at disease onset, <16 years) in the Clinical characteristic and Outcome in Chinese Axial Spondyloarthritis study cohort. Baseline demographic and clinical characteristics and prognosis were reviewed. Read More

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December 2021

Exploring key stakeholders' attitudes and opinions on medical assistance in dying and palliative care in Canada: a qualitative study protocol.

BMJ Open 2021 Dec 3;11(12):e055789. Epub 2021 Dec 3.

Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Introduction: Canadians have had legal access to medical assistance in dying (MAiD) since 2016. However, despite substantial overlap in populations who request MAiD and who require palliative care (PC) services, policies and recommended practices regarding the optimal relationship between MAiD and PC services are not well developed. Multiple models are possible, including autonomous delivery of these services and formal or informal coordination, collaboration or integration. Read More

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December 2021

SNMMI Clinical Trials Network Research Series for Technologists: Ethical Issues and Regulations in the Medical Workplace.

J Nucl Med Technol 2021 Dec;49(4):303-310

Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.

Ethical principles and laws have developed as medical practice and research have grown. This article discusses regulatory policies in patient care and the governing bodies that provide oversight. These include but are not limited to the Food and Drug Administration, Office for Human Research Protection, Nuclear Regulatory Commission, Joint Commission, Health Insurance Portability and Accountability Act, Occupational Safety and Health Administration, World Health Organization, and International Conference on Harmonization. Read More

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December 2021

The superior parietal lobule of macaque monkey: relative influence of gaze and static arm position during reaching.

eNeuro 2021 Dec 3. Epub 2021 Dec 3.

Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.

The superior parietal lobule (SPL) integrates somatosensory, motor, and visual signals to dynamically control arm movements. During reaching, visual and gaze signals are used to guide the hand to the desired target location, while proprioceptive signals allow to correct arm trajectory, and keep the limb in the final position at the end of the movement. Three SPL areas are particularly involved in this process: V6A, PEc, PE. Read More

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December 2021

Molecular modeling of nanoplastic transformations in alveolar fluid and impacts on the lung surfactant film.

J Hazard Mater 2021 Nov 27:127872. Epub 2021 Nov 27.

Institute of Coastal Environmental Pollution Control, Key Laboratory of Marine Environment and Ecology, Ministry of Education, Ocean University of China, Qingdao 266100, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address:

Airborne nanoplastics can be inhaled to threaten human health, but research on the inhaled nanoplastic toxicity is in its infancy, and interaction mechanisms are largely unknown. By means of molecular dynamics simulation, we employed spherical nanoplastics of different materials and aging properties to predict and elucidate nanoplastic transformations in alveolar fluid and impacts on the lung surfactant (LS) film at the alveolar air-water interface. Results showed spontaneous adsorption of LS molecules on nanoplastics of 10 nm in diameter, and the adsorption layer can be defined as coronas, which increased the particle size, reduced and equalized the surface hydrophobicity, and endowed nanoplastics with negative surface charges. Read More

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November 2021

Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis.

J Ayurveda Integr Med 2021 Nov 30:100529. Epub 2021 Nov 30.

Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Electronic address:

Osteoarthritis (OA) is the most commonly observed arthritic disease causing severe pain and impairing patient's quality of life. This study aimed to investigate and compare the effect of Elaeagnus angustifolia extract and quercetin on the mouse model of knee osteoarthritis (OA). Sixty Balb-C mice were used to establish the monosodium iodoacetate (MIA) model of OA. Read More

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November 2021

Mid-term outcomes following transfemoral revision of total hip arthroplasty for Vancouver B2/B3 periprosthetic fractures.

Injury 2021 Nov 17. Epub 2021 Nov 17.

Department of Orthopaedics and Traumatology, Kantonsspital St. Gallen, St.Gallen, Switzerland. Electronic address:

Introduction: Periprosthetic femoral fractures (PFF) are often the reason for revising total hip arthroplasty (RTHA). Converting these fractures into modified extended trochanteric osteotomy (mETO) facilitates stem revision. Modular revision stems are a common choice with good results. Read More

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November 2021

How to Report: Ankle MRI.

Semin Musculoskelet Radiol 2021 Oct 3;25(5):700-708. Epub 2021 Dec 3.

Department of Imaging and Interventional Radiology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.

Reporting ankle magnetic resonance imaging involves the assessment of multiple joints, tendons, and ligaments in several planes and numerous sequences. This article describes an approach using four anatomical categories (subcutaneous fat, bones and joints, tendons, and ligaments) to simplify and improve reporting efficiency. The main pathologies are covered, emphasizing the specific features to comment on, as well as suggesting terminology and phrases to use when reporting. Read More

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October 2021

How to Report: Knee MRI.

Semin Musculoskelet Radiol 2021 Oct 3;25(5):690-699. Epub 2021 Dec 3.

Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.

The knee is the most commonly examined joint with magnetic resonance imaging (MRI) and, as such, it is the joint that most trainee radiologists start reporting. This article addresses the main pathologies encountered on MRI examination of the knee, outlining the key features to note and report, as well as providing examples of terminology used to describe these findings. Read More

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October 2021