5,757 results match your criteria jewish populations


Data-driven methods distort optimal cutoffs and accuracy estimates of depression screening tools: a simulation study using individual participant data.

J Clin Epidemiol 2021 Apr 7. Epub 2021 Apr 7.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada; Members of the DEPRESSD EPDS Group: Ying Sun, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada. Electronic address:

Objective: To evaluate, across multiple sample sizes, the degree that data-driven methods result in (1) optimal cutoffs different from population optimal cutoff and (2) bias in accuracy estimates.

Study Design And Setting: 1,000 samples of sample size 100, 200, 500 and 1,000 each were randomly drawn to simulate studies of different sample sizes from a database (N=13,255) synthesized to assess Edinburgh Postnatal Depression Scale (EPDS) screening accuracy. Optimal cutoffs were selected by maximizing Youden's J (sensitivity+specificity-1). Read More

View Article and Full-Text PDF

Cross-cultural adaptation of the Perceived Risk of HIV Scale in Brazilian Portuguese.

Health Qual Life Outcomes 2021 Apr 9;19(1):117. Epub 2021 Apr 9.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada.

Background: Valid and reliable instruments are needed to measure the multiple dimensions of perceived risk. The Perceived Risk of HIV Scale is an 8-item measure that assesses how people think and feel about their risk of infection. We set out to perform a cross-cultural adaptation of the scale to Brazilian Portuguese among key populations (gay, bisexual and other men who have sex with men and transgender/non-binary) and other populations (cisgender heterosexual men and cisgender women). Read More

View Article and Full-Text PDF

Effectiveness and safety of direct oral anticoagulants in patients with cancer associated venous thromboembolism.

Thromb Res 2021 Mar 29;202:128-133. Epub 2021 Mar 29.

Department of Medicine, McGill University, Montreal, QC, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada; Division of General Internal Medicine, Jewish General Hospital, Montreal, QC, Canada. Electronic address:

Introduction: Real-world evidence on the effects of direct oral anticoagulants (DOACs) in patients with cancer associated venous thromboembolism (VTE) is limited. Thus, our population-based cohort study aimed to assess the effectiveness and safety of DOACs compared to the standard of care low-molecular-weight heparin (LMWH) in this vulnerable population.

Materials And Methods: Using linked administrative healthcare databases from the province of Québec, Canada, we identified patients with incident VTE from 2012 to 2015 and a cancer diagnosis in the year before the VTE, who initiated treatment with anticoagulants within 30 days after the VTE. Read More

View Article and Full-Text PDF

Reasons Older Veterans Use the Veterans Health Administration and Non-VHA Care in an Urban Environment.

J Am Board Fam Med 2021 Mar-Apr;34(2):291-300

From the Geriatric Research Education and Clinical Center (GRECC), James J Peters VA Medical Center, Bronx, NY (MRA, TM, AB-L, KB); Icahn School of Medicine at Mount Sinai, Department of Medicine, New York, NY (MRA); Icahn School of Medicine at Mount Sinai, Department of Geriatrics and Palliative Medicine, New York, NY (AB-L, KB); Community Wellness Department, Reading Hospital, Reading, PA (TM); Research Institute on Aging, The New Jewish House, New York, NY (KB).

Background: Older veterans in urban settings rely less on the Veterans Health Administration (VHA) health care, suggesting deficits of access and services for aging veterans. We aimed to identify reasons for VHA and non-VHA use across the health status of older, urban-dwelling veterans.

Methods: We examined open-ended responses from 177 veterans who were enrolled in primary care at the Bronx VA Medical Center, used non-VHA care in prior 2 years, and completed baseline interviews in a care coordination trial from March 2016 to August 2017. Read More

View Article and Full-Text PDF

Bloom syndrome in a Mexican American family with rhabdomyosarcoma: evidence of a Mexican founder mutation.

Cold Spring Harb Mol Case Stud 2021 Apr 8;7(2). Epub 2021 Apr 8.

Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas 78229, USA.

Bloom syndrome is a rare autosomal recessive disorder with less than 300 cases reported in the literature. Bloom syndrome is characterized by chromosome instability, physical stigmata, growth deficiency, immunodeficiency, and a predisposition to cancer, most commonly leukemias, although solid tumors are reported as well. Bloom syndrome occurs in multiple ethnic groups with a higher incidence in persons of Ashkenazi Jewish origin. Read More

View Article and Full-Text PDF

First-episode psychosis in the ultra-Orthodox Jewish population.

Transcult Psychiatry 2021 Apr 6:13634615211001706. Epub 2021 Apr 6.

Tel Aviv University.

Few if any methodologically robust studies of first-episode psychosis have been carried out in the ultra-Orthodox Jewish population. The opening of an inpatient psychiatry department within an ultra-Orthodox neighborhood in Israel offered the unique opportunity to study the specifics of first -episode psychosis in this subpopulation. Medical records of 60 ultra-Orthodox male Jewish patients with first-episode psychosis were examined over the first 18 months of the new department's operation. Read More

View Article and Full-Text PDF

Harnessing the Chaplain's Capacity to Identify Unmet Palliative Needs of Vulnerable Older Adults in the Emergency Department.

J Palliat Care 2021 Apr 5:8258597211003359. Epub 2021 Apr 5.

Palliative Medicine, Scripps Health, San Diego, CA, USA.

Objective: To explore chaplains' ability to identify unmet palliative care (PC) needs in older emergency department (ED) patients.

Methods: A palliative chaplain-fellow conducted a retrospective chart review evaluating 580 ED patients, age ≥80 using the Palliative Care and Rapid Emergency Screening (P-CaRES) tool. An emergency medicine physician and chaplain-fellow screened 10% of these charts to provide a clinical assessment. Read More

View Article and Full-Text PDF

Prevalence and characteristics of self-reported hypothyroidism and its association with nonorgan-specific manifestations in US sarcoidosis patients: a nationwide registry study.

ERJ Open Res 2021 Jan 29;7(1). Epub 2021 Mar 29.

Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.

Little is known about the prevalence, clinical characteristics and impact of hypothyroidism in patients with sarcoidosis. We aimed to determine the prevalence and clinical features of hypothyroidism and its relation to organ involvement and other clinical manifestations in patients with sarcoidosis. We conducted a national registry-based study investigating 3835 respondents to the Sarcoidosis Advanced Registry for Cures Questionnaire between June 2014 and August 2019. Read More

View Article and Full-Text PDF
January 2021

Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines.

Cancers (Basel) 2021 Mar 15;13(6). Epub 2021 Mar 15.

Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.

The benefit of PARP inhibitor olaparib in relapsed and advanced high-grade serous ovarian carcinoma (HGSOC) is well established especially in mutation carriers. Identification of additional biomarkers can help expand the population of patients most likely to benefit from olaparib treatment. To identify candidate markers of olaparib response we analyzed genomic and in vitro olaparib response data from two independent groups of cancer cell lines. Read More

View Article and Full-Text PDF

From emigration to remigration: The Jewish pathologist Fritz Meyer (1875-1953) and his extraordinary life course.

Pathol Res Pract 2021 Mar 19;221:153411. Epub 2021 Mar 19.

Institute for History, Theory and Ethics in Medicine, Medical Faculty, RWTH Aachen University, Wendlingweg 2, D-52074 Aachen, Germany.

Fritz Meyer (1875-1953) is undoubtedly one of the most enigmatic pathologists and internists of his time: He emerged early as a major researcher in the field of infectious diseases. Later, he also focused on heart and lung diseases and became a celebrity doctor who treated ambassadors and prominent contemporaries of the United States. The course of his life was as unusual as his professional activities: At the beginning of the Third Reich, Meyer experienced far-reaching repression due to his Jewish ancestry, which led to forced emigration to the USA. Read More

View Article and Full-Text PDF

Using a biopsychosocial approach to examine differences in post-traumatic stress symptoms between Arab and Jewish Israeli mothers following a child's traumatic medical event.

Int J Equity Health 2021 Mar 31;20(1):89. Epub 2021 Mar 31.

Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel.

Background: Parents of children following traumatic medical events (TMEs) are known to be at high risk for developing severe post-traumatic stress symptoms (PTSS). Findings on the negative impact of TMEs on parents' PTSS have been described in different cultures and societies. Parents from ethnic minority groups may be at particularly increased risk for PTSS following their child's TME due to a host of sociocultural characteristics. Read More

View Article and Full-Text PDF

A polygenic risk score to predict future adult short stature amongst children.

J Clin Endocrinol Metab 2021 Mar 31. Epub 2021 Mar 31.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada.

Context: Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height.

Objective: To develop a polygenic risk score for adult height and evaluate its clinical utility.

Design: A polygenic risk score was constructed based on meta-analysis of genome-wide association studies and evaluated on the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Read More

View Article and Full-Text PDF

A Mentored Pathway into the Sciences for Underrepresented Populations: A Newly Crafted Educational Modality for Women Exploring Career Opportunities in Science, Technology, Engineering, Mathematics, and Medicine.

Womens Health Rep (New Rochelle) 2020 28;1(1):413-423. Epub 2020 Sep 28.

Center for Cancer Research, National Cancer Institutes of Health, Bethesda, Maryland, USA.

The barriers generally facing women wishing to pursue careers in the disciplines of science, technology, engineering, mathematics, and medicine (STEMM) in the United States have been well described. However, additional layers of cultural beliefs and needs may pose further obstructions to women in certain cultural subgroups who wish to enter STEMM. Recognition of the challenges faced by such subgroups is important and culturally sensitive educational and training approaches may be necessary. Read More

View Article and Full-Text PDF
September 2020

"Don't talk to them about goals of care": Understanding disparities in advance care planning.

J Gerontol A Biol Sci Med Sci 2021 Mar 29. Epub 2021 Mar 29.

Research on Ethics, Aging, and Community Health (REACH Lab), Tufts University, Medford, MA.

Background: Structurally marginalized groups experience disproportionately low rates of advance care planning (ACP). To improve equitable patient-centered end-of-life care, we examine barriers and facilitators to ACP among clinicians as they are central participants in these discussions.

Methods: In this national study, we conducted semi-structured interviews with purposively selected clinicians from six diverse health systems between August 2018 and June 2019. Read More

View Article and Full-Text PDF

Impact of Discharge to Rehabilitation on Postdischarge Morbidity Following Multilevel Posterior Lumbar Fusion.

Clin Spine Surg 2021 Mar 24. Epub 2021 Mar 24.

Department of Orthopedic Surgery, North Shore University Hospital-Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra University, New Hyde Park, NY.

Study Design: This was a retrospective cohort study.

Objective: The objective of this study was to compare 30-day postdischarge morbidity for 3-or-more level (multilevel) posterior lumbar fusion in patients who were discharged to home versus rehabilitation.

Summary Of Background Data: Spine surgery has been increasingly performed in the elderly population, with many of these patients being discharged to rehabilitation and skilled nursing facilities. Read More

View Article and Full-Text PDF

Pre- and Postoperative Circulating IGF-I, IGFBP-3, and IGFBP-7 Levels in Relation to Endocrine Treatment and Breast Cancer Recurrence: A Nested Case-Control Study.

Front Oncol 2021 9;11:626058. Epub 2021 Mar 9.

Department of Clinical Sciences Lund, Oncology, Lund University and Skåne University Hospital, Lund, Sweden.

Insulin-like growth factor-I (IGF-I) and its binding proteins (BPs) have been associated with breast cancer risk, especially high IGF-I concentrations and the biologically active fraction estimated as the IGF-I/IGFBP-3 molar ratio. The relation of circulating IGF-I and IGFBP-3 concentrations with risk of breast cancer recurrence has been less documented. In addition a new member to a sub-group of the IGFBP-superfamily was recently identified, the low affinity IGFBP-7. Read More

View Article and Full-Text PDF

Accounting for Repeat Pregnancies in Risk Prediction Models.

Epidemiology 2021 Mar 24. Epub 2021 Mar 24.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada Department of Medicine, McGill University, Montreal, QC, Canada Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, BC, Canada Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada McGill University Health Center Research Institute, Montreal, QC, Canada Department of Pediatrics, McGill University, Montreal, QC, Canada.

Background: In perinatal epidemiology, the development of risk prediction models is complicated by parity; how repeat pregnancies influence the predictive accuracy of models that include obstetrical history is unclear.

Methods: To assess the influence of repeat pregnancies on the association between predictors and the outcomes, as well as the influence of ignoring the non-independence between pregnancies, we created four analytical cohorts using the Clinical Practice Research Datalink. The cohorts included (1) first deliveries, (2) a random sample of one delivery per woman, (3) all eligible deliveries per woman, and (4) all eligible deliveries and censoring of follow-up at subsequent pregnancies. Read More

View Article and Full-Text PDF

Prescribing Trends of Antidepressants and Psychotropic Coprescription for Youths in UK Primary Care, 2000-2018.

J Affect Disord 2021 Mar 11;287:19-25. Epub 2021 Mar 11.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Québec, Canada; Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Québec, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, Québec, Canada. Electronic address:

Background: There is lack of recent information on the prescribing trends of antidepressants and coprescription with other psychotropic medications in the United Kingdom (UK) pediatric population.

Methods: Using the Clinical Practice Research Datalink, we estimated the annual rates of patients newly prescribed an antidepressant (selective serotonin reuptake inhibitors (SSRIs), other newer generation antidepressants, and tricyclic antidepressants (TCAs)) and the percentage of new users of antidepressants with a same-day coprescription for other psychotropic medications. We also estimated the prevalence of patients with antidepressant prescriptions and percentage of coprescription for other psychotropic medications. Read More

View Article and Full-Text PDF

Maternal and fetal outcomes following elexacaftor-tezacaftor-ivacaftor use during pregnancy and lactation.

J Cyst Fibros 2021 Mar 21. Epub 2021 Mar 21.

Departments of Medicine and Pediatrics, National Jewish Health, 1400 Jackson Street; J318, Denver, CO 80206.

Background: With the improved health afforded by cystic fibrosis transmembrane conductance regulator (CFTR) modulators, pregnancy rates are increasing in women with CF. In animal reproductive models, the three components of elexacaftor-tezacaftor-ivacaftor (ETI) did not cause teratogenicity at normal human doses. Although the limited human data available in the literature for previously approved modulators did not suggest cause for concern, there is currently no data in the literature regarding use of ETI in pregnant women. Read More

View Article and Full-Text PDF

[MEASLES VACCINATION IN CONTEMPORARY HALAKHAH].

Harefuah 2021 Feb;160(2):117-121

Fordham University Law School, New York.

Introduction: One of the features of the recent measles outbreak world-wide has been the resurgence of the opposition to vaccination in the religious Jewish community. The present article presents the positions of a broad spectrum of Orthodox rabbinical rulings ranging from Haredi to National Religious to Modern Orthodox on this issue. The overwhelming majority of the halakhic authorities cited are in favor of the vaccination of both adults and children. Read More

View Article and Full-Text PDF
February 2021

[DOES SCREENING FOR DEPRESSION AS A QUALITY MEASUREMENT IMPACT DIAGNOSIS RATE OF DEPRESSION IN PATIENTS UNDERGOING REHABILITATION FOLLOWING A STROKE].

Harefuah 2021 Feb;160(2):76-80

Shoham Geriatric Medical Center, Pardes Hanna, Israel.

Background: The Israeli National Program for Quality Measures determined the need for screening for depression during rehabilitation following stroke as a quality measure in the elderly; this is in order to better diagnose and treat post-stroke depression. The study's goal was to investigate whether adding screening for depression had an effect on the rate of diagnosis. Depression is a culture-dependent phenomenon, therefore the change in the rate of diagnosis of depression in the Arab population and the Jewish population was examined separately. Read More

View Article and Full-Text PDF
February 2021

Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia.

Neuron 2021 Mar 16. Epub 2021 Mar 16.

Department of Computer Science, Columbia University, New York, NY 10027, USA; Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032, USA. Electronic address:

The identification of rare variants associated with schizophrenia has proven challenging due to genetic heterogeneity, which is reduced in founder populations. In samples from the Ashkenazi Jewish population, we report that schizophrenia cases had a greater frequency of novel missense or loss of function (MisLoF) ultra-rare variants (URVs) compared to controls, and the MisLoF URV burden was inversely correlated with polygenic risk scores in cases. Characterizing 141 "case-only" genes (MisLoF URVs in ≥3 cases with none in controls), the cadherin gene set was associated with schizophrenia. Read More

View Article and Full-Text PDF

Clinical Experience with Extended-Release Tacrolimus in Older Adult Kidney Transplant Recipients: A Retrospective Cohort Study.

Drugs Aging 2021 Mar 23. Epub 2021 Mar 23.

Division of Nephrology, Washington University in Saint Louis, Saint Louis, MO, USA.

Background: Extended-release tacrolimus (LCP-Tac) prescribing information states that there is insufficient data in older adult patients from which to make recommendations on use in this population. This study sought to provide information on de novo use of LCP-Tac in the older adult kidney transplant population.

Methods: This single-center retrospective study had two distinct objectives; to determine if weight-based doses of LCP-Tac differ based on recipient age and to compare safety and efficacy between LCP-Tac and immediate-release tacrolimus (IR-Tac) in older adult transplant recipients. Read More

View Article and Full-Text PDF

Childhood obesity and multiple sclerosis: A Mendelian randomization study.

Mult Scler 2021 Mar 22:13524585211001781. Epub 2021 Mar 22.

Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada/Department of Human Genetics, McGill University, Montreal, QC, Canada/Department of Medicine, McGill University Montreal, QC, Canada/Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada/Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.

Background: Higher childhood body mass index (BMI) has been associated with an increased risk of multiple sclerosis (MS).

Objective: To evaluate whether childhood BMI has a causal influence on MS, and whether this putative effect is independent from early adult obesity and pubertal timing.

Methods: We performed Mendelian randomization (MR) using summary genetic data on 14,802 MS cases and 26,703 controls. Read More

View Article and Full-Text PDF

[DISEASE SEVERITY AND PSYCHOLOGICAL HEALTH AMONG POLIOMYELITIS PATIENTS IN JERUSALEM - 10 YEARS FOLLOW-UP STUDY].

Harefuah 2021 Mar;160(3):148-154

Department of Physical Medicine and Rehabilitation, Hadassah Medical Center.

Introduction: More than 7000 patients contracted poliomyelitis (polio) during the major epidemic in the fifties in Israel. In recent years, there is further deterioration in their condition due to the accelerated aging process and post-polio syndrome.

Objectives: To evaluate the correlation between disease severity, functional and psychological parameters among polio patients in Jerusalem over a period of 10 years. Read More

View Article and Full-Text PDF

E-Cigarettes and Cardiopulmonary Health.

Function (Oxf) 2021 8;2(2):zqab004. Epub 2021 Feb 8.

Dorothy M. Davis Heart and Lung Research Institute, Colleges of Medicine and Nursing, The Ohio State University, Columbus, OH, USA.

E-cigarettes have surged in popularity over the last few years, particularly among youth and young adults. These battery-powered devices aerosolize e-liquids, comprised of propylene glycol and vegetable glycerin, typically with nicotine, flavors, and stabilizers/humectants. Although the use of combustible cigarettes is associated with several adverse health effects including multiple pulmonary and cardiovascular diseases, the effects of e-cigarettes on both short- and long-term health have only begun to be investigated. Read More

View Article and Full-Text PDF
February 2021

A study of ethnic, gender and educational differences in attitudes toward COVID-19 vaccines in Israel - implications for vaccination implementation policies.

Isr J Health Policy Res 2021 03 19;10(1):26. Epub 2021 Mar 19.

World Health Organization, European Region, Copenhagen, Denmark.

Background: Vaccines for COVID-19 are currently available for the public in Israel. The compliance with vaccination has differed between sectors in Israel and the uptake has been substantially lower in the Arab compared with the Jewish population.

Aim: To assess ethnic and socio-demographic factors in Israel associated with attitudes towards COVID-19 vaccines prior to their introduction. Read More

View Article and Full-Text PDF

Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation.

Sci China Life Sci 2021 Mar 16. Epub 2021 Mar 16.

State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, China.

Cytotoxic T cells targeting cancer neoantigens harboring driver mutations can lead to durable tumor regression in an HLAI-dependent manner. However, it is difficult to extend the population of patients who are eligible for neoantigen-based immunotherapy, as immunogenic neoantigen-HLA pairs are rarely shared across different patients. Thus, a way to find other human leukocyte antigen (HLA) alleles that can also present a clinically effective neoantigen is needed. Read More

View Article and Full-Text PDF

A Phase 3 Open-Label Study of ELX/TEZ/IVA in Children 6 Through 11 Years of Age With CF and at Least One Allele.

Am J Respir Crit Care Med 2021 Mar 18. Epub 2021 Mar 18.

Ann & Robert H. Lurie Children's Hospital of Chicago, Pulmonary Medicine, Chicago, Illinois, United States.

Rationale: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be efficacious and safe in patients aged 12 years and older with cystic fibrosis and at least one F508del-CFTR allele, but has not been evaluated in children <12 years of age.

Objectives: To assess the safety, pharmacokinetics, and efficacy of ELX/TEZ/IVA in children 6 through 11 years of age with F508del-minimal function or F508del-F508del genotypes.

Methods: In this 24-week open-label Phase 3 study, children (N=66) weighing <30 kg received 50% of the ELX/TEZ/IVA adult daily dose (ELX 100 mg once daily, TEZ 50 mg once daily, and IVA 75 mg every 12 hours) while children weighing ≥30 kg received the full adult daily dose (ELX 200 mg once daily, TEZ 100 mg once daily, and IVA 150 mg every 12 hours). Read More

View Article and Full-Text PDF

Development of the Canadian COVID-19 Emergency Department Rapid Response Network population-based registry: a methodology study.

CMAJ Open 2021 Jan-Mar;9(1):E261-E270. Epub 2021 Mar 17.

Department of Emergency Medicine (Hohl, Taylor, Andolfatto, Ting, Brar, Stachura), University of British Columbia; Centre for Clinical Epidemiology & Evaluation (Hohl), Vancouver Coastal Health Research Institute, Vancouver, BC; Department of Pediatrics (Rosychuk), University of Alberta, Edmonton, Alta.; Department of Emergency Medicine (McRae), Foothills Medical Center, Calgary, Alta.; Department of Emergency Medicine (Brooks), School of Medicine, Queen's University; Kingston Health Sciences Centre (Brooks), Kingston, Ont.; Department of Family Medicine and Emergency Medicine (Archambault), Faculty of Medicine, Université Laval; VITAM (Centre de recherche en santé durable) (Archambault, Mercier), Québec, Que.; Division of EMS (Fok, Dahn, Wiemer), Department of Emergency Medicine, Dalhousie University; Charles V. Keating Emergency and Trauma Centre (Fok, Dahn, Wiemer), QEII Health Sciences Centre, Halifax, NS; Department of Emergency Medicine (Davis), College of Medicine, University of Saskatchewan, Saskatoon, Sask.; Department of Emergency Medicine (Jelic), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Man.; Emergency Department (Turner), Jewish General Hospital; Department of Emergency Medicine (Turner), Faculty of Medicine and Health Sciences, McGill University, Montréal, Que.; Department of Emergency Medicine (Rowe, Hayward, Khangura), Faculty of Medicine & Dentistry, and School of Public Health (Rowe), University of Alberta, Edmonton, Alta.; Centre de recherche (Mercier), CHU de Québec, Université Laval, Québec, Que.; Sunnybrook Health Sciences Centre (Cheng, Atzema); Division of Emergency Medicine (Cheng, Landes, Vaillancourt, Morrison), Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ont.; Emergency Department (Taylor), Royal Columbian Hospital, New Westminster, BC; Départements de médecine de famille et de médecine d'urgence (Daoust), Faculté de médecine, Université de Montréal; Hôpital du Sacré-Coeur-de-Montréal (Daoust), CIUSSS Nord-de-l'ile-de-Montréal, Montréal, Que.; Department of Emergency Medicine (Ohle), Health Sciences North; Northern Ontario School of Medicine (Ohle), Sudbury, Ont.; Lions Gate Hospital (Andolfatto, Stachura), North Vancouver, BC; ICES Central (Atzema); University Health Network (Landes), Toronto, Ont.; Department of Emergency Medicine (Lang), Cumming School of Medicine, University of Calgary; Rockyview General Hospital (Lang), Calgary, Alta.; Department of Family Practice (Martin), Faculty of Medicine, University of British Columbia, Vancouver, BC; Abbotsford Regional Hospital & Cancer Agency (Martin), Abbotsford, BC; Department of Emergency Medicine (Mohindra), North York General Hospital, North York, Ont.; Department of Emergency Medicine (Vaillancourt, Morrison), St. Michael's Hospital, Unity Health Toronto, Toronto, Ont.; Division of Emergency Medicine (Welsford), Department of Medicine, McMaster University; Hamilton Health Sciences (Welsford), Hamilton, Ont.; Surrey Memorial Hospital (Brar), Surrey, BC; Department of Emergency Medicine (Yadav, Perry), University of Ottawa; Ottawa Hospital Research Institute (Yadav, Perry), Ottawa, Ont.; Division of Emergency Medicine (Yan), Department of Medicine, London Health Sciences Centre; Schulich School of Medicine and Dentistry (Yan), Western University, London, Ont.; BC SUPPORT Unit (McGavin), Vancouver, BC.

Background: Emergency physicians lack high-quality evidence for many diagnostic and treatment decisions made for patients with suspected or confirmed coronavirus disease 2019 (COVID-19). Our objective is to describe the methods used to collect and ensure the data quality of a multicentre registry of patients presenting to the emergency department with suspected or confirmed COVID-19.

Methods: This methodology study describes a population-based registry that has been enrolling consecutive patients presenting to the emergency department with suspected or confirmed COVID-19 since Mar. Read More

View Article and Full-Text PDF