2,122 results match your criteria jet ventilation

In vitro evaluation of disposable transport ventilators with combination aerosol therapy.

BMJ Open Respir Res 2021 Mar;8(1)

R&D Science and Emerging Technologies, Aerogen Ltd, Galway, Ireland

Background: The COVID-19 pandemic has highlighted the need for alternative short-term, reliable means to aid in the treatment of patients requiring ventilatory support. Concurrent aerosol drug delivery is often prescribed to such patients. As such, this study examines one such short-term option, the disposable gas-powered transport ventilator to effectively deliver aerosol therapy. Read More

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Difficult Airway Management in Adult COVID-19 Patients: Statement by the Society of Airway Management.

Anesth Analg 2021 Mar 12. Epub 2021 Mar 12.

Department of Anesthesiology & Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The COVID-19 disease, caused by Coronavirus SARS-CoV-2, often results in severe hypoxemia requiring airway management. Because SARS CoV-2 virus is spread via respiratory droplets, bag-mask ventilation, intubation, and extubation may place health care workers (HCW) at risk. While existing recommendations address airway management in patients with COVID-19, no guidance exists specifically for difficult airway management. Read More

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High frequency jet ventilation through mask contributes to oxygen therapy among patients undergoing bronchoscopic intervention under deep sedation.

BMC Anesthesiol 2021 Mar 2;21(1):65. Epub 2021 Mar 2.

Department of Anesthesiology, Emergency General Hospital, Beijing, 100028, China.

Background: High frequency jet ventilation (HFJV) is an open ventilating technique to maintain ventilation for emergency or difficult airway. However, whether jet ventilation or conventional oxygen therapy (COT) is more effective and safe in maintaining adequate oxygenation, is unclear among patients with airway stenosis during bronchoscopic intervention (BI) under deep sedation.

Methods: A prospective randomized cohort study was conducted to compare COT (high flow oxygen) with normal frequency jet ventilation (NFJV) and HFJV in oxygen supplementation during BI under deep sedation from March 2020 to August 2020. Read More

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Multi-Institutional Analysis of Outcomes in Supraglottic Jet Ventilation with a Team-Based Approach.

Laryngoscope 2021 Feb 20. Epub 2021 Feb 20.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.

Objectives/hypothesis: To evaluate the safety and complications of endoscopic airway surgery using supraglottic jet ventilation with a team-based approach.

Study Design: Retrospective cohort study.

Methods: Subjects at two academic institutions diagnosed with laryngotracheal stenosis who underwent endoscopic airway surgery with jet ventilation between January 2008 and December 2018 were identified. Read More

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February 2021

Bronchoscopy precautions and recommendations in the COVID-19 pandemic.

Paediatr Respir Rev 2021 Mar 29;37:68-73. Epub 2021 Jan 29.

Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa. Electronic address:

As the airways of SARS-CoV-2 infected patients contain a high viral load, bronchoscopy is associated with increased risk of patient to health care worker transmission due to aerosolised viral particles and contamination of surfaces during bronchoscopy. Bronchoscopy is not appropriate for diagnosing SARS-CoV-2 infection and, as an aerosol generating procedure involving a significant risk of transmission, has a very limited role in the management of SARS-CoV-2 infected patients including children. During the SARS-CoV-2 pandemic rigid bronchoscopy should be avoided due to the increased risk of droplet spread. Read More

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Aerial Transmission of the SARS-CoV-2 Virus through Environmental E-Cigarette Aerosols: Implications for Public Policies.

Int J Environ Res Public Health 2021 02 3;18(4). Epub 2021 Feb 3.

Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, 95123 Catania, Italy.

We discuss the implications of possible contagion of COVID-19 through e-cigarette aerosol (ECA) for prevention and mitigation strategies during the current pandemic. This is a relevant issue when millions of vapers (and smokers) must remain under indoor confinement and/or share public outdoor spaces with non-users. The fact that the respiratory flow associated with vaping is visible (as opposed to other respiratory activities) clearly delineates a safety distance of 1-2 m along the exhaled jet to prevent direct exposure. Read More

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February 2021

Nebuliser Type Influences Both Patient-Derived Bioaerosol Emissions and Ventilation Parameters during Mechanical Ventilation.

Pharmaceutics 2021 Feb 2;13(2). Epub 2021 Feb 2.

Aerogen Limited, Galway Business Park, H91 HE94 Galway, Ireland.

COVID-19 may lead to serious respiratory complications which may necessitate ventilatory support. There is concern surrounding potential release of patient-derived bioaerosol during nebuliser drug refill, which could impact the health of caregivers. Consequently, mesh nebulisers have been recommended by various clinical practice guidelines. Read More

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February 2021

High-Frequency Jet Ventilation Is Making Slow Inroads to the Pediatric ICU.

Respir Care 2021 02;66(2):349-350

Department of PediatricsDivision of Critical Care MedicineCincinnati Children's Hospital Medical CenterCincinnati, OhioUniversity of Cincinnati College of MedicineCincinnati, Ohio

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February 2021

Validation of transcutaneous carbon dioxide monitoring using an artificial lung during adult pulsatile cardiopulmonary bypass.

Int J Artif Organs 2021 Jan 9:391398820987855. Epub 2021 Jan 9.

Department of Cardiovascular Perfusion, Franciscan Health Indianapolis, Indianapolis, IN, USA.

Measurements of transcutaneous carbon dioxide (tcCO) have been used in multiple venues, such as during procedures utilizing jet ventilation, hyperbaric oxygen therapy, as well as both the adult and neo-natal ICUs. However, tcCO measurements have not been validated under conditions which utilize an artificial lung, such cardiopulmonary bypass (CPB). The purpose of this study was to (1) validate the use of tcCO using an artificial lung during CPB and (2) identify a location for the sensor that would optimize estimation of PaCO when compared to the gold standard of blood gas analysis. Read More

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January 2021

A case of neonatal diabetes insipidus following dexamethasone for bronchopulmonary dysplasia.

J Neonatal Perinatal Med 2020 Dec 16. Epub 2020 Dec 16.

Foothills Medical Centre, University of Calgary and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.

Background: Diabetes insipidus (DI) is a disease resulting from defects in the arginine vasopressin system responsible for regulating body water homeostasis. It is characterized by polyuria with increased serum osmolality and sodium and can result from congenital or acquired disorders.

Clinical Presentation: A baby was admitted to NICU for extreme prematurity (25 weeks gestation), extreme low birth weight (900 grams) and respiratory distress. Read More

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December 2020

High-Frequency Jet Ventilation for a Patient With Tracheomediastinal Fistula, Tension Pneumomediastinum, and Pneumothorax: A Case Report.

A A Pract 2020 Dec 17;14(14):e01362. Epub 2020 Dec 17.

Surgical Intensive Care, Singapore General Hospital, Sengkang General Hospital, Singapore.

Tracheomediastinal fistula (TMF) is an uncommon condition and carries a high mortality. We report the anesthetic management of a patient with TMF using stent insertion via rigid bronchoscopy. The TMF was a complication of double-lumen endotracheal tube insertion resulting in a tension pneumomediastinum. Read More

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December 2020

Can computational fluid dynamic models help us in the treatment of chronic rhinosinusitis.

Curr Opin Otolaryngol Head Neck Surg 2021 Feb;29(1):21-26

Mechanical & Automotive Engineering, School of Engineering, RMIT University, Bundoora, Victoria, Australia.

Purpose Of Review: The aim of this study was to review the recent literature (January 2017-July 2020) on computational fluid dynamics (CFD) studies relating to chronic rhinosinusitis (CRS), including airflow within the pre and postoperative sinonasal cavity, virtual surgery, topical drug and saline delivery (sprays, nebulizers and rinses) and olfaction.

Recent Findings: Novel CFD-specific parameters (heat flux and wall shear stress) are highly correlated with patient perception of nasal patency. Increased ostial size markedly improves sinus ventilation and drug delivery. Read More

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February 2021

An in vitro investigation into the release of fugitive medical aerosols into the environment during manual ventilation.

J Hosp Infect 2021 Feb 6;108:135-141. Epub 2020 Dec 6.

Aerogen, IDA Business Park, Dangan, Galway, Ireland; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons, Dublin, Ireland; School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, Ireland. Electronic address:

Background: During manual resuscitation, nebulizer therapy may be used to deliver therapeutics to patients in respiratory distress. However, the devices used to generate and deliver these medical aerosols have the potential to release these therapeutics into the local environment and expose caregivers to unwanted medical aerosols.

Aim: To quantify the levels of fugitive medical aerosol released into the environment during aerosol drug delivery using a manual resuscitation bag with and without filtration. Read More

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February 2021

Comparison of two supplemental oxygen methods during gastroscopy with propofol mono-sedation in patients with a normal body mass index.

World J Gastroenterol 2020 Nov;26(43):6867-6879

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Background: Hypoxemia due to respiratory depression and airway obstruction during upper gastrointestinal endoscopy with sedation is a common concern. The Wei nasal jet tube (WNJT) is a new nasopharyngeal airway with the ability to provide supraglottic jet ventilation and oxygen insufflation its built-in wall channel. The available evidence indicates that with a low oxygen flow, compared with nasal cannula, the WNJT does not decrease the occurrence of hypoxemia during upper gastrointestinal endoscopy with propofol sedation. Read More

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November 2020

Supraglottic jet oxygenation and ventilation reduces desaturation during bronchoscopy under moderate to deep sedation with propofol and remifentanil: A randomised controlled clinical trial.

Eur J Anaesthesiol 2021 Mar;38(3):294-301

From the Department of Anesthesiology, 180th Hospital of PLA, Quanzhou, China (BZ, ZW, PX, HX, LX) and Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA (HW).

Background: Hypoxaemia is frequently seen during flexible bronchoscopies that are done with a nasal approach under the traditional sedation with propofol. This study investigated the potential benefits of supraglottic jet oxygenation and ventilation (SJOV) using the Wei nasal jet tube (WNJ) in reducing hypoxaemia in patients undergoing bronchoscopy under moderate to deep intravenous sedation using a propofol, lidocaine and remifentanil cocktail.

Objectives: Our primary objective was to evaluate the efficacy and complications of SJOV via the WNJ during flexible bronchoscopy under moderate to heavy sedation with propofol and remifentanil. Read More

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Pre-emptive extracorporeal membrane oxygenation to support endobronchial stenting for severe airway obstruction.

Eur J Cardiothorac Surg 2021 06;59(6):1345-1346

Department of Thoracic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.

Tracheobronchial stent insertion is a common palliative intervention for the management of dynamic airway collapse due to severe tracheobronchomalacia or tracheal compression due to mass effect [1]. Airway stents are usually placed bronchoscopically with or without fluoroscopy. In more complex cases, airway stents are placed using a rigid bronchoscope under general anaesthesia with conventional or jet ventilation. Read More

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Apnoeic ventilation for shared airway surgery during the COVID-19 pandemic.

Anaesth Rep 2020 Jul-Dec;8(2):e12082. Epub 2020 Nov 8.

Department of Ear, Nose and Throat Surgery Poole Hospital NHS Foundation Trust Poole UK.

This report describes the care provided to a 64-year-old woman presenting with airway obstruction following recovery from COVID-19 pneumonitis, prolonged tracheal intubation and tracheostomy weaning. Her initial admission was with COVID-19 pneumonitis during the first surge of cases in early 2020, and was complicated by multiple bilateral segmental pulmonary emboli, a 28-day stay in intensive care, 16 days of mechanical ventilation and finally, a tracheostomy with subsequent weaning of respiratory support and rehabilitation. On presentation, her symptoms of airway obstruction were because of significant granuloma of the posterior glottis and subglottis, as well as a mild lambdoid deformity at the site of her previous tracheostomy. Read More

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November 2020

Uniportal video-assisted thoracoscopic lung sparing tracheo-bronchial and carinal sleeve resections.

J Thorac Dis 2020 Oct;12(10):6198-6209

Thoracic Surgery Department, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China.

Pathology arising from the intrathoracic portion of the trachea (distal trachea), the carina and the main bronchi is usually neoplastic and is mainly treated with surgery. Resection of the intrathoracic portion of the trachea, the carina and the main bronchi for neoplastic lesions does not necessitate lung resection and is traditionally being conducted via open surgery. Video-assisted thoracic surgery (VATS) is witnessing an exponential growth and is the treatment of choice for early-stage non-small cell lung cancer (NSCLC). Read More

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October 2020

Anesthetic considerations for tracheobronchial surgery.

J Thorac Dis 2020 Oct;12(10):6138-6142

Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Kliniken Essen-Mitte, Essen, Germany.

Tracheobronchial pathology can be related to trauma, infection, tumor, or a combination of these. Per definition, planning for tracheobronchial surgery can be complicated by the overlap of anesthesiological interests in airway management and the primary surgical field. Therefore, following a detailed description of the stenosis, management of tracheobronchial surgery requires an interdisciplinary discussion and individualized planning of the procedure. Read More

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October 2020

Therapeutic bronchoscopy for central airway diseases.

Eur Respir Rev 2020 Dec 18;29(158). Epub 2020 Nov 18.

National and Kapodistrian University of Athens, Interventional Pulmonology Unit, "Sotiria" Hospital, Athens, Greece

Over the past century rigid bronchoscopy has been established as the main therapeutic means for central airway diseases of both benign and malignant aetiology. Its use requires general anaesthesia and mechanical ventilation usually in the form of manual or high-frequency jet ventilation. Techniques applied to regain patency of the central airways include mechanical debulking, thermal ablation (laser, electrocautery and argon plasma coagulation) and cryo-surgery. Read More

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December 2020

The utilization of aerosol therapy in mechanical ventilation patients: a prospective multicenter observational cohort study and a review of the current evidence.

Ann Transl Med 2020 Sep;8(17):1071

Department of Respiratory and Critical Care Medicine, West China Medical Center, Sichuan University, Chengdu, China.

Background: Aerosol delivery via mechanical ventilation has been reported to vary significantly among different intensive care units (ICU). The optimal technique for using each aerosol generator may need to be updated with the available evidence.

Methods: A 2-week prospective multicenter observational cohort study was implemented to record aerosol delivery for mechanically ventilated adult patients in Chinese ICUs. Read More

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September 2020

High-Dose Erythropoietin in Extremely Low Gestational Age Neonates Does Not Alter Risk of Retinopathy of Prematurity.

Neonatology 2020 28;117(5):650-657. Epub 2020 Oct 28.

Division of Neonatology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.

Introduction: The Preterm Erythropoietin (Epo) Neuroprotection (PENUT) Trial sought to determine the safety and efficacy of early high-dose Epo as a potential neuroprotective treatment. We hypothesized that Epo would not increase the incidence or severity of retinopathy of prematurity (ROP).

Methods: A total of 941 infants born between 24-0/7 and 27-6/7 weeks' gestation were randomized to 1,000 U/kg Epo or placebo intravenously for 6 doses, followed by subcutaneous or sham injections of 400 U/kg Epo 3 times a week through 32 weeks post-menstrual age. Read More

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October 2020

Reducing chances of COVID-19 infection by a cough cloud in a closed space.

Phys Fluids (1994) 2020 Oct;32(10):101704

Department of Mechanical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India.

The cough of a COVID-19 infected subject contaminates a large volume of surrounding air with coronavirus due to the entrainment of surrounding air in the jet-like flow created by the cough. In the present work, we estimate this volume of the air, which may help us to design ventilation of closed spaces and, consequently, reduce the spread of the disease. Recent experiments [P. Read More

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October 2020

Unsolved Mysteries: High-Frequency Jet Ventilation in the Neonatal ICU.

Respir Care 2020 11;65(11):1784-1785

Respiratory Care ServicesDuke University Medical CenterDurham, North Carolina.

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November 2020

Oxygen therapy strategies and techniques to treat hypoxia in COVID-19 patients.

B Jiang H Wei

Eur Rev Med Pharmacol Sci 2020 Oct;24(19):10239-10246

Department of Anaesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.

Objective: Hypoxia is one of the primary causes that leads to multiple organ injuries and death in COVID-19 patients. Aggressive oxygen therapy for the treatment of hypoxia is important in saving these patients. We have summarized the mechanisms, efficacy, and side effects of various oxygen therapy techniques and their status or the potential to treat hypoxia in COVID-19 patients. Read More

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October 2020

Revisiting bronchoscopic intratumoral chemotherapy in malignant central airway obstruction via EUS-B approach and its review of literature.

Monaldi Arch Chest Dis 2020 Oct 15;90(4). Epub 2020 Oct 15.

Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur.

Critical central airway obstruction has always been a dreaded complication to which interventional pulmonologist commonly encounters. There have been various modalities which are used for the management and palliation, which includes mechanical coring, laser, cryoextraction, electrocautery and airway stenting. Rigid bronchoscopy with or without jet ventilation has been corner stone of therapeutics and palliation of central airway obstruction. Read More

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October 2020

High-Frequency Jet Ventilation in Pediatric Acute Respiratory Failure.

Respir Care 2021 Feb 2;66(2):191-198. Epub 2020 Oct 2.

Division of Pediatric Critical Care Medicine, Duke Children's Hospital, Durham, North Carolina.

Background: High-frequency jet ventilation (HFJV) is primarily used in premature neonates; however, its use in pediatric patients with acute respiratory failure has been reported. The objective of this study was to evaluate HFJV use in the pediatric critical care setting. We hypothesized that HFJV would be associated with improvements in oxygenation and ventilation. Read More

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February 2021

Effect of ventilator modes on neonatal cerebral and peripheral oxygenation using near-infrared spectroscopy.

Acta Paediatr 2021 04 18;110(4):1151-1156. Epub 2020 Oct 18.

Division of Perinatal-Neonatal Medicine, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York, NY, USA.

Aim: The effect of ventilator modes on regional tissue oxygenation in premature neonates with respiratory distress syndrome (RDS) has yet to be delineated. Previous studies have looked at global oxygen delivery and have not assessed the effects on regional tissue oxygenation. Our aim in this study was to assess such tissue oxygenation in premature babies with RDS in relation to differing modes of ventilation using near-infrared spectroscopy (NIRS). Read More

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